Antiviral CD4 and CD8 T-cell memory: differences in the size of the response and activation requirements.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMC 1692741)

Published in Philos Trans R Soc Lond B Biol Sci on March 29, 2000

Authors

J K Whitmire1, K Murali-Krishna, J Altman, R Ahmed

Author Affiliations

1: Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Articles citing this

Frequency of epitope-specific naive CD4(+) T cells correlates with immunodominance in the human memory repertoire. J Immunol (2012) 2.09

T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes. J Exp Med (2004) 1.88

IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory. Proc Natl Acad Sci U S A (2004) 1.79

Control of homeostatic proliferation by regulatory T cells. J Clin Invest (2005) 1.40

Tracking the dynamics of T-cell activation in response to Salmonella infection. Immunology (2005) 1.31

A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection. J Immunol (2008) 1.05

Memory T-cell-specific therapeutics in organ transplantation. Curr Opin Organ Transplant (2009) 1.02

Differential effects of HIV viral load and CD4 count on proliferation of naive and memory CD4 and CD8 T lymphocytes. Blood (2011) 1.00

Characterization of homologous and heterologous rotavirus-specific T-cell responses in infant and adult mice. J Virol (2005) 0.93

CD4 T-cell memory generation and maintenance. Crit Rev Immunol (2014) 0.81

Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection. J Immunol (2013) 0.79

Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course. Retrovirology (2008) 0.79

Co-expression of sCD40LIg and CTLA4Ig mediated by adenovirus prolonged mouse skin allograft survival. J Zhejiang Univ Sci B (2006) 0.79

Enhanced responses to tumor immunization following total body irradiation are time-dependent. PLoS One (2013) 0.77

Absence of CD4 T-cell help provides a robust CD8 T-cell response while inducing effective memory in a preclinical model of melanoma. Immunotherapy (2012) 0.76

Estimating point and interval frequency of antigen-specific CD4+ T cells based on short in vitro expansion and improved poisson distribution analysis. PLoS One (2012) 0.75

Novel Injectable Pentablock Copolymer Based Thermoresponsive Hydrogels for Sustained Release Vaccines. AAPS J (2015) 0.75

Articles cited by this

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol (1994) 22.96

Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity (1998) 17.27

Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science (1997) 15.09

Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med (1998) 14.39

Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat Med (1997) 12.08

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature (1994) 11.22

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J Exp Med (1984) 10.66

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol (1994) 10.03

Immunological memory and protective immunity: understanding their relation. Science (1996) 10.02

Cytotoxic T-cell memory without antigen. Nature (1994) 6.55

Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. Immunity (1998) 6.29

Persistence of memory CD8 T cells in MHC class I-deficient mice. Science (1999) 6.20

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells. J Exp Med (1996) 6.08

Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV. Nature (1994) 5.68

T cell activation determined by T cell receptor number and tunable thresholds. Science (1996) 5.51

Mice deficient for the CD40 ligand. Immunity (1994) 4.45

The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J Virol (1996) 4.45

Large clonal expansions of CD8+ T cells in acute infectious mononucleosis. Nat Med (1996) 3.94

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. J Virol (1996) 3.39

Humoral immune responses in CD40 ligand-deficient mice. J Exp Med (1994) 3.32

4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med (1997) 3.31

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature (1995) 3.07

T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses. J Virol (1988) 2.76

Immediate early and early lytic cycle proteins are frequent targets of the Epstein-Barr virus-induced cytotoxic T cell response. J Exp Med (1997) 2.76

Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response. J Virol (1987) 2.72

Lymphoproliferative disease in mice infected with murine gammaherpesvirus 68. Am J Pathol (1994) 2.49

CD4-positive T lymphocytes are required for the generation of the primary but not the secondary CD8-positive cytolytic T lymphocyte response to herpes simplex virus in C57BL/6 mice. Cell Immunol (1991) 2.36

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression. J Exp Med (1991) 2.24

Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity (1996) 2.24

CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response. J Exp Med (1996) 2.21

Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections. J Exp Med (1996) 2.14

Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection. J Exp Med (1998) 2.13

CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity (1996) 2.11

Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity (1996) 2.05

Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. Proc Natl Acad Sci U S A (1997) 1.99

CD8 T cell memory in B cell-deficient mice. J Exp Med (1996) 1.97

Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection. J Immunol (1995) 1.84

CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection. J Virol (1996) 1.74

4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. J Immunol (1999) 1.63

CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions. J Exp Med (1996) 1.62

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants. J Immunol (1984) 1.59

Tuning into immunological dissonance: an experimental model for infectious mononucleosis. Curr Opin Immunol (1997) 1.56

Vesicular stomatitis virus infection of the central nervous system activates both innate and acquired immunity. J Virol (1995) 1.52

Long-term CD4 Th1 and Th2 memory following acute lymphocytic choriomeningitis virus infection. J Virol (1998) 1.33

Bone marrow contains virus-specific cytotoxic T lymphocytes. Blood (1997) 1.09

Virus-lymphoid cell interactions. Proc Natl Acad Sci U S A (1996) 1.08

Articles by these authors

Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity (1998) 17.27

Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med (1998) 14.39

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J Exp Med (1984) 10.66

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol (1994) 10.03

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Nat Immunol (2001) 9.23

Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol (1965) 9.18

A new Chlamydia psittaci strain, TWAR, isolated in acute respiratory tract infections. N Engl J Med (1986) 8.03

Cytotoxic T-cell memory without antigen. Nature (1994) 6.55

Humoral immunity due to long-lived plasma cells. Immunity (1998) 6.35

Persistence of memory CD8 T cells in MHC class I-deficient mice. Science (1999) 6.20

Virus-specific CD8+ T cells in primary and secondary influenza pneumonia. Immunity (1998) 5.98

Cutting edge: naive T cells masquerading as memory cells. J Immunol (2000) 4.27

Immune function in mice lacking the perforin gene. Proc Natl Acad Sci U S A (1994) 4.06

Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J Comp Neurol (1969) 4.01

Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressors. J Immunol (2000) 3.83

Phage-typing scheme for Escherichia coli O157:H7. J Infect Dis (1987) 3.62

Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus. J Virol (1993) 3.51

Cutting edge: increased expression of Bcl-2 in antigen-specific memory CD8+ T cells. J Immunol (2000) 3.34

Bone marrow is a major site of long-term antibody production after acute viral infection. J Virol (1995) 3.32

Characterization of Escherichia coli serotype O157:H7. J Clin Microbiol (1988) 3.01

Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology (1993) 3.00

Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection. J Exp Med (1999) 2.98

Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer. J Comp Neurol (1972) 2.84

Necrotising fasciitis in the head and neck region. Br J Plast Surg (1992) 2.66

Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity. Proc Natl Acad Sci U S A (1995) 2.66

Autoradiographic and histological studies of postnatal neurogenesis. 3. Dating the time of production and onset of differentiation of cerebellar microneurons in rats. J Comp Neurol (1969) 2.61

Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective immunity. Cell (1998) 2.59

Effective clearance of a persistent viral infection requires cooperation between virus-specific Lyt2+ T cells and nonspecific bone marrow-derived cells. J Virol (1987) 2.59

Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice. J Exp Med (1990) 2.59

Effective vaccination against papilloma development by immunization with L1 or L2 structural protein of cottontail rabbit papillomavirus. Virology (1992) 2.53

Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layer. J Comp Neurol (1972) 2.52

Identification of Db- and Kb-restricted subdominant cytotoxic T-cell responses in lymphocytic choriomeningitis virus-infected mice. Virology (1998) 2.31

Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc Natl Acad Sci U S A (2001) 2.29

Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans. J Exp Med (2000) 2.29

Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol (1996) 2.24

Role of the host cell in persistent viral infection: coevolution of L cells and reovoirus during persistent infection. Cell (1981) 2.23

Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection. J Exp Med (1998) 2.13

Postnatal development of the cerebellar cortex in the rat. 3. Maturation of the components of the granular layer. J Comp Neurol (1972) 2.13

Long-lived plasma cells: a mechanism for maintaining persistent antibody production. Curr Opin Immunol (1998) 2.10

Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques. Nat Med (2001) 2.10

In vivo selection of lymphocyte-tropic and macrophage-tropic variants of lymphocytic choriomeningitis virus during persistent infection. J Virol (1990) 2.03

Post-natal origin of microneurones in the rat brain. Nature (1965) 2.03

B cell memory and the long-lived plasma cell. Curr Opin Immunol (1999) 2.03

Virus-lymphocyte interaction: T cells of the helper subset are infected with lymphocytic choriomeningitis virus during persistent infection in vivo. J Virol (1987) 1.99

CD8 T cell memory in B cell-deficient mice. J Exp Med (1996) 1.97

Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly-IC-induced IFN-alpha in vitro. Virology (2001) 1.97

Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory. J Immunol (2001) 1.96

Evidence that Chlamydia pneumoniae causes pneumonia and bronchitis. J Infect Dis (1993) 1.89

A role for perforin in downregulating T-cell responses during chronic viral infection. J Virol (1999) 1.84

Experimental measles. I. Pathogenesis in the normal and the immunized host. Virology (1997) 1.83

Premonitory symptoms in migraine: an electronic diary study. Neurology (2003) 1.81

Postnatal development of locomotion in the laboratory rat. Anim Behav (1975) 1.80

T cell memory. Long-term persistence of virus-specific cytotoxic T cells. J Exp Med (1989) 1.76

Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity. Trends Microbiol (1996) 1.76

Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions. J Comp Neurol (1966) 1.76

The S RNA segment of lymphocytic choriomeningitis virus codes for the nucleoprotein and glycoproteins 1 and 2. J Virol (1985) 1.74

CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection. J Virol (1996) 1.74

Recruitment times, proliferation, and apoptosis rates during the CD8(+) T-cell response to lymphocytic choriomeningitis virus. J Virol (2001) 1.72

Passive transfer of antibodies protects immunocompetent and imunodeficient mice against lethal Ebola virus infection without complete inhibition of viral replication. J Virol (2001) 1.68

Bacillus cereus and Bacillus thuringiensis isolated in a gastroenteritis outbreak investigation. Lett Appl Microbiol (1995) 1.67

Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells. Curr Opin Immunol (1998) 1.66

Evolution of the T cell repertoire during primary, memory, and recall responses to viral infection. J Immunol (2000) 1.66

Stimulation of in vitro human skin collagenase expression by platelet-derived growth factor. Proc Natl Acad Sci U S A (1985) 1.65

4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. J Immunol (1999) 1.63

Inflammatory linear verrucose epidermal nevus. Arch Dermatol (1971) 1.61

Genetic mapping of lymphocytic choriomeningitis virus pathogenicity: virulence in guinea pigs is associated with the L RNA segment. J Virol (1985) 1.60

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants. J Immunol (1984) 1.59

Virus and immune responses: lymphocytic choriomeningitis virus as a prototype model of viral pathogenesis. Br Med Bull (1985) 1.52

Gene expression in antigen-specific CD8+ T cells during viral infection. J Immunol (2001) 1.50

Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance. J Immunol (2001) 1.49

Disseminated acanthamebiasis in patients with AIDS. A report of five cases and a review of the literature. Arch Dermatol (1995) 1.47

Limiting dilution analysis of virus-specific memory B cells by an ELISPOT assay. J Immunol Methods (1996) 1.47

Sclerosteosis: neurogenetic and pathophysiologic analysis of an American kinship. Neurology (1983) 1.47

Development of the cranial nerve ganglia and related nuclei in the rat. Adv Anat Embryol Cell Biol (1982) 1.45

The development of the rat spinal cord. Adv Anat Embryol Cell Biol (1984) 1.44

Chlamydia pneumoniae strain TWAR, Mycoplasma pneumoniae, and viral infections in acute respiratory disease in a university student health clinic population. Am J Epidemiol (1990) 1.42

Virus-induced immunosuppression: a murine model of susceptibility to opportunistic infection. J Infect Dis (1988) 1.40

The development of the rat hypothalamus. Adv Anat Embryol Cell Biol (1986) 1.39

Role of the S4 gene in the establishment of persistent reovirus infection in L cells. Cell (1982) 1.38

CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2. J Immunol (1998) 1.38

In vivo dynamics of anti-viral CD8 T cell responses to different epitopes. An evaluation of bystander activation in primary and secondary responses to viral infection. Adv Exp Med Biol (1998) 1.38

Persistent infections in L cells with temperature-sensitive mutants of reovirus. J Virol (1977) 1.37

Development of the diencephalon in the rat. I. Autoradiographic study of the time of origin and settling patterns of neurons of the hypothalamus. J Comp Neurol (1978) 1.36

DNA vaccination against persistent viral infection. J Virol (1995) 1.33

Long-term CD4 Th1 and Th2 memory following acute lymphocytic choriomeningitis virus infection. J Virol (1998) 1.33

Uncovering subdominant cytotoxic T-lymphocyte responses in lymphocytic choriomeningitis virus-infected BALB/c mice. J Virol (1997) 1.32

An international outbreak of salmonellosis associated with raw almonds contaminated with a rare phage type of Salmonella enteritidis. J Food Prot (2005) 1.31

Prenatal development of the cerebellar system in the rat. I. Cytogenesis and histogenesis of the deep nuclei and the cortex of the cerebellum. J Comp Neurol (1978) 1.30

Virus specificity of cytotoxic T lymphocytes generated during acute lymphocytic choriomeningitis virus infection: role of the H-2 region in determining cross-reactivity for different lymphocytic choriomeningitis virus strains. J Virol (1984) 1.30

CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses. J Immunol (1999) 1.28