Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection.

PubWeight™: 0.79‹?›

🔗 View Article (PMC 3879805)

Published in J Immunol on October 21, 2013

Authors

Ichiro Misumi1, Mehrdad Alirezaei, Boreth Eam, Maureen A Su, J Lindsay Whitton, Jason K Whitmire

Author Affiliations

1: Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC 27599;

Articles cited by this

Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol (2003) 15.51

In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57

Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol Cell Biol (1998) 11.07

Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science (2003) 10.22

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature (2003) 10.16

Defective CD8 T cell memory following acute infection without CD4 T cell help. Science (2003) 9.67

Molecular and functional profiling of memory CD8 T cell differentiation. Cell (2002) 8.06

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature (1989) 7.52

CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat Immunol (2004) 6.80

Cytotoxic T-cell memory without antigen. Nature (1994) 6.55

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J Exp Med (1976) 6.33

Persistence of memory CD8 T cells in MHC class I-deficient mice. Science (1999) 6.20

Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory. Nat Med (2001) 5.74

Direct observation of ligand recognition by T cells. Nature (2002) 5.21

Programmed contraction of CD8(+) T cells after infection. Nat Immunol (2002) 5.16

Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection. Immunity (2007) 4.92

Naive and memory CD4+ T cell survival controlled by clonal abundance. Science (2006) 4.67

Cutting edge: naive T cells masquerading as memory cells. J Immunol (2000) 4.27

Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. Immunity (2008) 4.25

T cells compete for access to antigen-bearing antigen-presenting cells. J Exp Med (2000) 4.16

CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help. Nature (2009) 4.03

Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. J Immunol (2002) 3.96

Class II-independent generation of CD4 memory T cells from effectors. Science (1999) 3.96

T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol (2004) 3.85

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol (2003) 3.82

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature (2005) 3.81

Interleukin 7 regulates the survival and generation of memory CD4 cells. J Exp Med (2003) 3.76

Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol (1998) 3.52

CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function. J Exp Med (2002) 3.28

Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. Blood (2002) 3.19

Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med (2005) 3.14

CD8+ T cell contraction is controlled by early inflammation. Nat Immunol (2004) 3.13

Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR. Nat Immunol (2001) 3.08

Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration. Immunity (2006) 2.78

Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation. J Exp Med (2005) 2.59

Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory. Immunity (2008) 2.56

Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat Immunol (2002) 2.42

Lymphoid reservoirs of antigen-specific memory T helper cells. Nat Immunol (2007) 2.41

Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design. Annu Rev Immunol (2005) 2.39

Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cells. Nat Immunol (2007) 2.22

Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection. J Exp Med (2010) 2.22

Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. J Immunol (2007) 2.04

Different dynamics of CD4+ and CD8+ T cell responses during and after acute lymphocytic choriomeningitis virus infection. J Immunol (2003) 2.03

Visualizing T cell competition for peptide/MHC complexes: a specific mechanism to minimize the effect of precursor frequency. Immunity (2000) 1.83

IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory. Proc Natl Acad Sci U S A (2004) 1.79

Precursor frequency, nonlinear proliferation, and functional maturation of virus-specific CD4+ T cells. J Immunol (2006) 1.76

Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells. Proc Natl Acad Sci U S A (2007) 1.71

Clonal competition inhibits the proliferation and differentiation of adoptively transferred TCR transgenic CD4 T cells in response to infection. J Immunol (2006) 1.69

Persistent antigen presentation after acute vesicular stomatitis virus infection. J Virol (2006) 1.68

Prolonged antigen half-life in the lymphoid follicles of specifically immunized mice. Immunology (1979) 1.57

CD8 T cell competition for dendritic cells in vivo is an early event in activation. Proc Natl Acad Sci U S A (2006) 1.46

Long-term CD4 Th1 and Th2 memory following acute lymphocytic choriomeningitis virus infection. J Virol (1998) 1.33

Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies. J Immunol (2000) 1.32

Massive number of antigen-specific CD4 T cells during vaccination with live attenuated Salmonella causes interclonal competition. J Immunol (2004) 1.32

Stability of virus-specific CD4+ T cell frequencies from acute infection into long term memory. J Immunol (1998) 1.29

Tentative T cells: memory cells are quick to respond, but slow to divide. PLoS Pathog (2008) 1.25

Duration of antigen availability influences the expansion and memory differentiation of T cells. J Immunol (2011) 1.24

The route of priming influences the ability of respiratory virus-specific memory CD8+ T cells to be activated by residual antigen. J Exp Med (2010) 1.24

Rapid production of TNF-alpha following TCR engagement of naive CD8 T cells. J Immunol (2005) 1.19

In situ imaging reveals different responses by naïve and memory CD8 T cells to late antigen presentation by lymph node DC after influenza virus infection. Eur J Immunol (2008) 1.16

Unique ability of activated CD4+ T cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation. J Biol Chem (2006) 1.15

Regulation of CD4+ T-cell contraction during pathogen challenge. Immunol Rev (2010) 1.14

Antiviral CD4 and CD8 T-cell memory: differences in the size of the response and activation requirements. Philos Trans R Soc Lond B Biol Sci (2000) 1.09

Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses. J Virol (2008) 1.08

Rapid recruitment of virus-specific CD8 T cells restructures immunodominance during protective secondary responses. J Virol (2005) 1.06

Prolonged antigen persistence within nonterminal late endocytic compartments of antigen-specific B lymphocytes. J Immunol (2001) 1.06

Increasing the CD4+ T cell precursor frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality. J Immunol (2008) 1.02

The magnitude of CD4+ T cell recall responses is controlled by the duration of the secondary stimulus. J Immunol (2009) 0.99

Quantification of epitope-specific MHC class-II-restricted T cells following lymphocytic choriomeningitis virus infection. Cell Immunol (1999) 0.95

Cutting edge: activation of virus-specific CD4 T cells throughout γ-herpesvirus latency. J Immunol (2011) 0.89

The initial draining lymph node primes the bulk of the CD8 T cell response and influences memory T cell trafficking after a systemic viral infection. PLoS Pathog (2012) 0.85

Coverage of related pathogenic species by multivalent and cross-protective vaccine design: arenaviruses as a model system. Microbiol Mol Biol Rev (2010) 0.83

Resolution of infection promotes a state of dormancy and long survival of CD4 memory T cells. Immunol Cell Biol (2011) 0.80

T cell memory. Curr Top Microbiol Immunol (2006) 0.78

Immune complex disease in chronic viral infections. J Exp Med (1971) 0.76

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Deletional tolerance mediated by extrathymic Aire-expressing cells. Science (2008) 4.10

An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity (2011) 3.11

Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope. J Virol (2002) 2.64

Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections. J Immunol (2005) 2.22

Interferon-gamma acts directly on CD8+ T cells to increase their abundance during virus infection. J Exp Med (2005) 2.13

Cell cycle status affects coxsackievirus replication, persistence, and reactivation in vitro. J Virol (2002) 1.92

Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection. J Immunol (2003) 1.83

Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clin Microbiol Rev (2006) 1.81

Precursor frequency, nonlinear proliferation, and functional maturation of virus-specific CD4+ T cells. J Immunol (2006) 1.76

Microorganisms and autoimmunity: making the barren field fertile? Nat Rev Microbiol (2003) 1.76

Patients with antineutrophil cytoplasmic antibody-associated vasculitis have defective Treg cell function exacerbated by the presence of a suppression-resistant effector cell population. Arthritis Rheum (2013) 1.70

Vertical transmission of diverse microbes in the tropical sponge Corticium sp. Appl Environ Microbiol (2006) 1.62

A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. J Immunol (2003) 1.59

Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A (2008) 1.48

Coxsackievirus B3 and the neonatal CNS: the roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease. Am J Pathol (2003) 1.48

Immunodominance in virus-induced CD8(+) T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon. J Virol (2002) 1.42

Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo. J Virol (2010) 1.38

Aire and T cell development. Curr Opin Immunol (2010) 1.36

Inhibition of protein trafficking by coxsackievirus b3: multiple viral proteins target a single organelle. J Virol (2006) 1.34

Detection of intracellular cytokines by flow cytometry. Curr Protoc Immunol (2007) 1.32

Short-term fasting induces profound neuronal autophagy. Autophagy (2010) 1.28

Cutting edge: early IFN-gamma signaling directly enhances primary antiviral CD4+ T cell responses. J Immunol (2005) 1.27

Direct interferon-gamma signaling dramatically enhances CD4+ and CD8+ T cell memory. J Immunol (2007) 1.27

Tentative T cells: memory cells are quick to respond, but slow to divide. PLoS Pathog (2008) 1.25

Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination. J Immunol (2005) 1.23

A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia. Glia (2008) 1.19

CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection. Proc Natl Acad Sci U S A (2004) 1.16

Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. Am J Pathol (2006) 1.14

The rapidity with which virus-specific CD8+ T cells initiate IFN-gamma synthesis increases markedly over the course of infection and correlates with immunodominance. J Immunol (2004) 1.12

Astrocytic tissue inhibitor of metalloproteinase-1 (TIMP-1) promotes oligodendrocyte differentiation and enhances CNS myelination. J Neurosci (2011) 1.11

Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period. J Virol (2009) 1.10

Autophagy, inflammation and neurodegenerative disease. Eur J Neurosci (2010) 1.08

Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis. Autophagy (2009) 1.08

Identification of protective Lassa virus epitopes that are restricted by HLA-A2. J Virol (2006) 1.07

Aire deficiency promotes TRP-1-specific immune rejection of melanoma. Cancer Res (2013) 1.06

GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling. Nat Immunol (2013) 1.06

Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal CNS. J Neurosci (2005) 1.06

Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo. Cell Host Microbe (2012) 1.05

A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS. J Neurosci (2010) 1.04

The depletion of NK cells prevents T cell exhaustion to efficiently control disseminating virus infection. J Immunol (2012) 1.03

Evaluating the immunogenicity and protective efficacy of a DNA vaccine encoding Lassa virus nucleoprotein. Virology (2005) 1.03

Increasing the CD4+ T cell precursor frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality. J Immunol (2008) 1.02

Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance. J Exp Med (2014) 1.01

Role of lymphotoxin alpha in T-cell responses during an acute viral infection. J Virol (2002) 0.99

A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy. J Exp Med (2009) 0.99

HLA-A2-restricted protection against lethal lymphocytic choriomeningitis. J Virol (2006) 0.99

"Translocatory proteins" and "protein transduction domains": a critical analysis of their biological effects and the underlying mechanisms. Mol Ther (2003) 0.98

The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens. Proc Natl Acad Sci U S A (2005) 0.98

Coxsackievirus B3 proteins directionally complement each other to downregulate surface major histocompatibility complex class I. J Virol (2007) 0.97

The contraction phase of virus-specific CD8+ T cells is unaffected by a pan-caspase inhibitor. J Immunol (2004) 0.95

Deletions within the 5'UTR of coxsackievirus B3: consequences for virus translation and replication. Virology (2006) 0.94

B cell depletion curtails CD4+ T cell memory and reduces protection against disseminating virus infection. J Immunol (2014) 0.93

Coxsackievirus preferentially replicates and induces cytopathic effects in undifferentiated neural progenitor cells. J Virol (2011) 0.93

An integrated systems analysis implicates EGR1 downregulation in simian immunodeficiency virus encephalitis-induced neural dysfunction. J Neurosci (2009) 0.93

Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway. PLoS Pathog (2009) 0.91

Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation. Traffic (2005) 0.91

IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4. Glia (2007) 0.90

Neonates mount robust and protective adult-like CD8(+)-T-cell responses to DNA vaccines. J Virol (2002) 0.90

Targeting plasmid-encoded proteins to the antigen presentation pathways. Immunol Rev (2004) 0.90

Coxsackievirus replication and the cell cycle: a potential regulatory mechanism for viral persistence/latency. Med Microbiol Immunol (2003) 0.89

Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious CD8 T cell-mediated, TNF-dependent immunopathology. J Clin Invest (2006) 0.89

Analysis of translational initiation in coxsackievirus B3 suggests an alternative explanation for the high frequency of R+4 in the eukaryotic consensus motif. J Virol (2005) 0.89

DNA vaccination can break immunological tolerance to PrP in wild-type mice and attenuates prion disease after intracerebral challenge. J Virol (2006) 0.88

Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency. J Neuroimmunol (2007) 0.87

Type B coxsackieviruses and their interactions with the innate and adaptive immune systems. Future Microbiol (2010) 0.87

The regulation and maturation of antiviral immune responses. Adv Virus Res (2004) 0.86

Coxsackievirus B3 infects the bone marrow and diminishes the restorative capacity of erythroid and lymphoid progenitors. J Virol (2012) 0.86

In vivo ablation of type I interferon receptor from cardiomyocytes delays coxsackieviral clearance and accelerates myocardial disease. J Virol (2014) 0.86

Neural stem cell depletion and CNS developmental defects after enteroviral infection. Am J Pathol (2011) 0.86

Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1. Am J Pathol (2007) 0.86

Fatal neonatal myocarditis caused by a recombinant human enterovirus-B variant. Pediatr Infect Dis J (2008) 0.85

Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo. Virology (2012) 0.84

Mice deficient in stem cell antigen-1 (Sca1, Ly-6A/E) develop normal primary and memory CD4+ and CD8+ T-cell responses to virus infection. Eur J Immunol (2009) 0.83

Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infection. J Virol (2008) 0.82

A multivalent vaccination strategy for the prevention of Old World arenavirus infection in humans. J Virol (2010) 0.82

Interactions between enteroviruses and autophagy in vivo. Autophagy (2012) 0.82

BAFF-ling autoantibodies. J Clin Invest (2013) 0.82

CD8+ memory T cells appear exhausted within hours of acute virus infection. J Immunol (2013) 0.81

Generation and analysis of an RNA vaccine that protects against coxsackievirus B3 challenge. Virology (2004) 0.81

Targeting myelin proteolipid protein to the MHC class I pathway by ubiquitination modulates the course of experimental autoimmune encephalomyelitis. J Neuroimmunol (2008) 0.80

Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency. J Immunol (2013) 0.79

Infectious RNA isolated from the spinal cords of mice chronically infected with Theiler's murine encephalomyelitis virus. J Virol (2006) 0.79

Coxsackievirus can exploit LC3 in both autophagy-dependent and -independent manners in vivo. Autophagy (2015) 0.77