Published in J Neurosci on May 15, 2000
Neuron-type-specific signals for reward and punishment in the ventral tegmental area. Nature (2012) 5.37
The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons? J Physiol (2006) 3.97
Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring. Schizophr Bull (2009) 3.82
Cortico-Basal Ganglia reward network: microcircuitry. Neuropsychopharmacology (2010) 3.81
Glutamatergic afferents of the ventral tegmental area in the rat. J Neurosci (2007) 2.80
Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA. Neuron (2008) 2.69
Opponency revisited: competition and cooperation between dopamine and serotonin. Neuropsychopharmacology (2010) 2.34
A 4 Hz oscillation adaptively synchronizes prefrontal, VTA, and hippocampal activities. Neuron (2011) 2.33
Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proc Natl Acad Sci U S A (2006) 2.29
Glutamate transmission in addiction. Neuropharmacology (2008) 2.19
Role of lateral hypothalamic orexin neurons in reward processing and addiction. Neuropharmacology (2008) 2.06
Reward, addiction, withdrawal to nicotine. Annu Rev Neurosci (2011) 1.83
Glutamatergic and nonglutamatergic neurons of the ventral tegmental area establish local synaptic contacts with dopaminergic and nondopaminergic neurons. J Neurosci (2010) 1.82
Fos activation of selective afferents to ventral tegmental area during cue-induced reinstatement of cocaine seeking in rats. J Neurosci (2012) 1.79
Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction. Brain Res (2009) 1.79
Genetic variation in dopaminergic neuromodulation influences the ability to rapidly and flexibly adapt decisions. Proc Natl Acad Sci U S A (2009) 1.76
The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideas. Brain (2010) 1.69
Reward and aversion in a heterogeneous midbrain dopamine system. Neuropharmacology (2013) 1.67
Ultrastructural analysis of local collaterals of rat ventral tegmental area neurons: GABA phenotype and synapses onto dopamine and GABA cells. Synapse (2009) 1.64
Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping. Cell (2015) 1.64
Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci Biobehav Rev (2010) 1.61
The therapeutic role of 5-HT1A and 5-HT2A receptors in depression. J Psychiatry Neurosci (2004) 1.61
The inhibitory influence of the lateral habenula on midbrain dopamine cells: ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental nucleus. J Comp Neurol (2011) 1.59
Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacol Ther (2003) 1.57
GABAergic interneuron origin of schizophrenia pathophysiology. Neuropharmacology (2011) 1.55
Lateral habenula projections to dopamine and GABA neurons in the rat ventral tegmental area. Eur J Neurosci (2009) 1.53
Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. Proc Natl Acad Sci U S A (2012) 1.44
Braking dopamine systems: a new GABA master structure for mesolimbic and nigrostriatal functions. J Neurosci (2012) 1.42
Molecular profiling of midbrain dopamine regions in cocaine overdose victims. J Neurochem (2003) 1.42
Convergent processing of both positive and negative motivational signals by the VTA dopamine neuronal populations. PLoS One (2011) 1.36
Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1. J Neurochem (2003) 1.29
Multiple roles for orexin/hypocretin in addiction. Prog Brain Res (2012) 1.26
Glutamate synaptic inputs to ventral tegmental area neurons in the rat derive primarily from subcortical sources. Neuroscience (2007) 1.25
Prominent activation of brainstem and pallidal afferents of the ventral tegmental area by cocaine. Neuropsychopharmacology (2007) 1.23
rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex. PLoS One (2009) 1.22
Cholinergic axons in the rat ventral tegmental area synapse preferentially onto mesoaccumbens dopamine neurons. J Comp Neurol (2006) 1.22
Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. Neurotoxicol Teratol (2006) 1.22
Individual variation in resisting temptation: implications for addiction. Neurosci Biobehav Rev (2013) 1.21
Burst-timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons. Neuron (2009) 1.20
Electrical stimulation of the lateral habenula produces enduring inhibitory effect on cocaine seeking behavior. Neuropharmacology (2010) 1.19
Exposure to nicotine and sensitization of nicotine-induced behaviors. Prog Neuropsychopharmacol Biol Psychiatry (2007) 1.19
GABAergic and glutamatergic efferents of the mouse ventral tegmental area. J Comp Neurol (2014) 1.19
Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area. Neuropharmacology (2007) 1.15
Serotonin modulation of cortical neurons and networks. Front Integr Neurosci (2013) 1.15
Role of the bed nucleus of the stria terminalis in the control of ventral tegmental area dopamine neurons. Prog Neuropsychopharmacol Biol Psychiatry (2009) 1.15
Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man. Psychopharmacology (Berl) (2005) 1.14
Functional implications of glutamatergic projections to the ventral tegmental area. Rev Neurosci (2008) 1.11
Optogenetic modulation of neural circuits that underlie reward seeking. Biol Psychiatry (2011) 1.09
Activation of afferents to the ventral tegmental area in response to acute amphetamine: a double-labelling study. Eur J Neurosci (2007) 1.08
The dopamine hypothesis of drug addiction and its potential therapeutic value. Front Psychiatry (2011) 1.08
The medial prefrontal and orbitofrontal cortices differentially regulate dopamine system function. Neuropsychopharmacology (2011) 1.08
Corticotropin-releasing factor binding protein within the ventral tegmental area is expressed in a subset of dopaminergic neurons. J Comp Neurol (2008) 1.08
Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences. J Neurosci (2010) 1.07
The comorbidity of insomnia, chronic pain, and depression: dopamine as a putative mechanism. Sleep Med Rev (2012) 1.07
New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system. J Neurosci (2013) 1.07
An update on the connections of the ventral mesencephalic dopaminergic complex. Neuroscience (2014) 1.06
Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms. Neuroscience (2011) 1.05
Region-specific changes in the subcellular distribution of AMPA receptor GluR1 subunit in the rat ventral tegmental area after acute or chronic morphine administration. J Neurosci (2008) 1.05
Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs. Int Rev Neurobiol (2010) 1.05
Amygdala inputs drive feedforward inhibition in the medial prefrontal cortex. J Neurophysiol (2013) 1.04
Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions. Front Mol Neurosci (2012) 1.04
The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT. Eur J Neurosci (2009) 1.03
Amelioration of binge eating by nucleus accumbens shell deep brain stimulation in mice involves D2 receptor modulation. J Neurosci (2013) 1.01
Noninvasive remote activation of the ventral midbrain by transcranial direct current stimulation of prefrontal cortex. Transl Psychiatry (2013) 1.00
The contribution of NMDA receptor signaling in the corticobasal ganglia reward network to appetitive Pavlovian learning. J Neurosci (2011) 0.99
Neurotransmitters and prefrontal cortex-limbic system interactions: implications for plasticity and psychiatric disorders. J Neural Transm (Vienna) (2009) 0.99
The medial prefrontal cortex regulates the differential expression of morphine-conditioned place preference following a single exposure to controllable or uncontrollable stress. Neuropsychopharmacology (2008) 0.98
Acute cocaine exposure weakens GABA(B) receptor-dependent G-protein-gated inwardly rectifying K+ signaling in dopamine neurons of the ventral tegmental area. J Neurosci (2011) 0.98
Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptors. Cereb Cortex (2008) 0.98
On the origin of cortical dopamine: is it a co-transmitter in noradrenergic neurons? Curr Neuropharmacol (2006) 0.96
The laterodorsal tegmentum contributes to behavioral sensitization to amphetamine. Neuroscience (2007) 0.96
Intramembrane receptor-receptor interactions: a novel principle in molecular medicine. J Neural Transm (Vienna) (2006) 0.95
Flexible frequency control of cortical oscillations enables computations required for working memory. Proc Natl Acad Sci U S A (2013) 0.94
Involvement of alpha1-adrenergic receptors in tranylcypromine enhancement of nicotine self-administration in rat. Psychopharmacology (Berl) (2007) 0.94
Dysregulation of dopamine and glutamate release in the prefrontal cortex and nucleus accumbens following methamphetamine self-administration and during reinstatement in rats. Neuropsychopharmacology (2013) 0.94
Understanding opioid reward. Trends Neurosci (2015) 0.93
Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons. J Neurosci (2013) 0.92
Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors. J Comp Neurol (2011) 0.92
DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience. Cortex (2012) 0.92
Effects of prefrontal cortical inactivation on neural activity in the ventral tegmental area. J Neurosci (2013) 0.92
Age-dependent effects of low-dose nicotine treatment on cocaine-induced behavioral plasticity in rats. Psychopharmacology (Berl) (2009) 0.91
Subcircuit-specific neuromodulation in the prefrontal cortex. Front Neural Circuits (2014) 0.91
Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART). Postgrad Med (2009) 0.90
Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice. Brain Res (2009) 0.90
The role of neuromodulators in selective attention. Trends Cogn Sci (2011) 0.90
Periaqueductal gray afferents synapse onto dopamine and GABA neurons in the rat ventral tegmental area. J Neurosci Res (2010) 0.90
Mefloquine effects on ventral tegmental area dopamine and GABA neuron inhibition: a physiologic role for connexin-36 GAP junctions. Synapse (2011) 0.89
Pharmacotherapeutics for substance-use disorders: a focus on dopaminergic medications. Expert Opin Investig Drugs (2013) 0.89
Insulin receptor substrate-2 in the ventral tegmental area regulates behavioral responses to cocaine. Behav Neurosci (2008) 0.89
Dopaminergic and cholinergic learning mechanisms in nicotine addiction. Ann N Y Acad Sci (2015) 0.89
Quantitative unit classification of ventral tegmental area neurons in vivo. J Neurophysiol (2012) 0.89
Reward circuitry is perturbed in the absence of the serotonin transporter. Neuroimage (2009) 0.88
Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents. PLoS One (2010) 0.88
Postmortem investigations of the pathophysiology of schizophrenia: the role of susceptibility genes. J Psychiatry Neurosci (2004) 0.88
Hypocretin mechanisms in nicotine addiction: evidence and speculation. Psychopharmacology (Berl) (2009) 0.87
Viral-mediated expression of extracellular signal-regulated kinase-2 in the ventral tegmental area modulates behavioral responses to cocaine. Behav Brain Res (2010) 0.87
Light and electron microscopic localization of alpha-1 adrenergic receptor immunoreactivity in the rat striatum and ventral midbrain. Neuroscience (2008) 0.87
Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors. PLoS One (2013) 0.86
Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization. J Comp Neurol (2001) 1.95
GABA-containing neurons in the rat ventral tegmental area project to the prefrontal cortex. Synapse (2000) 1.78
Hippocampal afferents to the rat prefrontal cortex: synaptic targets and relation to dopamine terminals. J Comp Neurol (1996) 1.44
Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. J Comp Neurol (2000) 1.32
Glutamate synaptic inputs to ventral tegmental area neurons in the rat derive primarily from subcortical sources. Neuroscience (2007) 1.25
Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex. Neuroscience (2003) 1.21
Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex. Neuroscience (2010) 1.10
Parvalbumin-immunoreactive axon terminals in macaque monkey and human prefrontal cortex: laminar, regional, and target specificity of type I and type II synapses. J Comp Neurol (1999) 1.06
Synaptic targets of pyramidal neurons providing intrinsic horizontal connections in monkey prefrontal cortex. J Comp Neurol (1998) 1.03
Dopamine axons in primate prefrontal cortex: specificity of distribution, synaptic targets, and development. Adv Pharmacol (1998) 1.02
Dopamine terminals in the rat prefrontal cortex synapse on pyramidal cells that project to the nucleus accumbens. J Neurosci (1999) 0.99
Ultrastructural localization of the serotonin transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to dopamine terminals. J Comp Neurol (2000) 0.97
Ultrastructural immunocytochemical localization of the dopamine D2 receptor within GABAergic neurons of the rat striatum. Brain Res (1997) 0.96
Immunoblot and immunohistochemical comparison of murine monoclonal antibodies specific for the rat D1a and D1b dopamine receptor subtypes. J Neuroimmunol (1999) 0.94
Dopaminergic transmission in the rat retina: evidence for volume transmission. J Chem Neuroanat (1996) 0.94
Callosal terminals in the rat prefrontal cortex: synaptic targets and association with GABA-immunoreactive structures. Synapse (1998) 0.90
Dynorphin-immunoreactive terminals in the rat nucleus accumbens: cellular sites for modulation of target neurons and interactions with catecholamine afferents. J Comp Neurol (1994) 0.86
Limited collateralization of neurons in the rat prefrontal cortex that project to the nucleus accumbens. Neuroscience (2000) 0.86
Terminals from the rat prefrontal cortex synapse on mesoaccumbens VTA neurons. Ann N Y Acad Sci (1999) 0.86
Dopamine terminals synapse on callosal projection neurons in the rat prefrontal cortex. J Comp Neurol (2000) 0.85
Cellular substrates for interactions between dynorphin terminals and dopamine dendrites in rat ventral tegmental area and substantia nigra. Brain Res (1993) 0.84
Cellular basis for interactions between catecholaminergic afferents and neurons containing Leu-enkephalin-like immunoreactivity in rat caudate-putamen nuclei. J Neurosci Res (1992) 0.83
Analysis of synaptic inputs and targets of physiologically characterized neurons in rat frontal cortex: combined in vivo intracellular recording and immunolabeling. Synapse (1994) 0.82
Ultrastructural immunocytochemical localization of neurotensin and the dopamine D2 receptor in the rat nucleus accumbens. J Comp Neurol (1996) 0.81
Dopamine innervation of monkey entorhinal cortex: postsynaptic targets of tyrosine hydroxylase-immunoreactive terminals. Synapse (2000) 0.79
Axosomatic input to subpopulations of cortically projecting pyramidal neurons in primate prefrontal cortex. Synapse (1997) 0.75