The anandamide transport inhibitor AM404 activates vanilloid receptors.

PubWeight™: 1.50‹?› | Rank: Top 4%

🔗 View Article (PMID 10822052)

Published in Eur J Pharmacol on May 12, 2000

Authors

P M Zygmunt1, H Chuang, P Movahed, D Julius, E D Högestätt

Author Affiliations

1: Department of Clinical Pharmacology, Institute of Laboratory Medicine, Lund University, SE-221 85, Lund, Sweden. peter.zygmunt@klinfarm.lu.se

Articles citing this

The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev (2006) 6.80

Cannabinoids and the gastrointestinal tract. Gut (2001) 1.81

Cellular accumulation of anandamide: consensus and controversy. Br J Pharmacol (2003) 1.66

N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochem J (2000) 1.55

Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. Br J Pharmacol (2001) 1.54

The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids. AAPS J (2005) 1.50

Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts. Br J Pharmacol (2002) 1.41

TRPV1 in brain is involved in acetaminophen-induced antinociception. PLoS One (2010) 1.25

Fatty acid-binding proteins transport N-acylethanolamines to nuclear receptors and are targets of endocannabinoid transport inhibitors. J Biol Chem (2011) 1.17

A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. Br J Pharmacol (2001) 1.11

The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology (2008) 1.07

Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels. Br J Pharmacol (2001) 1.05

Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. Pharmacol Res (2010) 1.04

The complications of promiscuity: endocannabinoid action and metabolism. Br J Pharmacol (2007) 1.02

Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia. Trends Pharmacol Sci (2008) 1.01

AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain. Br J Pharmacol (2006) 0.99

Divergent effects of anandamide transporter inhibitors with different target selectivity on social play behavior in adolescent rats. J Pharmacol Exp Ther (2008) 0.96

Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta. Br J Pharmacol (2007) 0.96

Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate. Br J Pharmacol (2005) 0.94

Intracellular mechanisms of N-acylethanolamine-mediated neuroprotection in a rat model of stroke. Neuroscience (2009) 0.94

The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro. J Physiol (2003) 0.94

The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1. Br J Pharmacol (2009) 0.94

"Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain control. ACS Chem Neurosci (2012) 0.93

Evidence for bidirectional endocannabinoid transport across cell membranes. J Biol Chem (2012) 0.91

Effects of opioids, cannabinoids, and vanilloids on body temperature. Front Biosci (Schol Ed) (2011) 0.90

The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats. Br J Pharmacol (2012) 0.87

[Cannabinoids--signal transduction and mode of action]. Schmerz (2005) 0.87

Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. PLoS One (2013) 0.86

Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats. Immunology (2008) 0.85

Fatty acid amide hydrolase-dependent generation of antinociceptive drug metabolites acting on TRPV1 in the brain. PLoS One (2013) 0.85

Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks. J Neurosci (2012) 0.84

A role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal sensory neurons. Neuropharmacology (2005) 0.84

Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig. Cough (2007) 0.84

Acetaminophen modulation of hydrocodone reward in rats. Pharmacol Biochem Behav (2011) 0.83

Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons. Neuropharmacology (2011) 0.82

Induction of TRPV1 desensitization by a biased receptor agonist. Channels (Austin) (2011) 0.81

AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking. J Psychopharmacol (2013) 0.81

2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons. Psychopharmacology (Berl) (2015) 0.79

Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. J Neurophysiol (2008) 0.79

The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial. Drug Des Devel Ther (2015) 0.79

Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors. Br J Pharmacol (2007) 0.78

Terpenes and lipids of the endocannabinoid and transient-receptor-potential-channel biosignaling systems. ACS Chem Neurosci (2014) 0.77

Acetaminophen and non-steroidal anti-inflammatory drugs interact with morphine and tramadol analgesia for the treatment of neuropathic pain in rats. J Anesth (2014) 0.77

Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. Pharmacol Res (2016) 0.76

Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys. Psychopharmacology (Berl) (2016) 0.76

Precondition of right frontal region with anodal tDCS can restore the fear memory impairment induced by ACPA in male mice. EXCLI J (2017) 0.75

Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain. Anesth Pain Med (2016) 0.75

Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1. Sci Rep (2017) 0.75

[Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management]. Schmerz (2014) 0.75

Articles by these authors

The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (1997) 30.59

Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science (2000) 15.16

The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron (1998) 13.03

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature (1999) 10.05

The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci (2001) 6.65

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature (2001) 6.26

A capsaicin-receptor homologue with a high threshold for noxious heat. Nature (1999) 5.85

Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway. Cell (1984) 5.53

Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature (2001) 5.51

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor. Cell (1984) 5.26

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature (1994) 4.61

Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature (1995) 4.36

Yeast alpha factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase. Cell (1983) 4.24

Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science (1991) 3.73

Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc Natl Acad Sci U S A (1993) 3.68

Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature (1993) 3.57

Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci U S A (2000) 3.55

Characterizing quality of life among patients with chronic mental illness: a critical examination of the self-report methodology. Am J Psychiatry (1997) 3.07

Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery. Br J Pharmacol (1996) 2.21

Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels. Acta Physiol Scand (1983) 2.20

Anandamide - the other side of the coin. Trends Pharmacol Sci (2000) 1.78

Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases. Clin Exp Allergy (2004) 1.54

Sense and specificity: a molecular identity for nociceptors. Curr Opin Neurobiol (1999) 1.49

Characterization of the potassium channels involved in EDHF-mediated relaxation in cerebral arteries. Br J Pharmacol (1997) 1.47

Nervous system distribution of the serotonin 5-HT3 receptor mRNA. Proc Natl Acad Sci U S A (1993) 1.42

5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proc Natl Acad Sci U S A (1989) 1.39

Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors. Biochem Biophys Res Commun (1999) 1.35

Vanilloid receptors on capsaicin-sensitive sensory nerves mediate relaxation to methanandamide in the rat isolated mesenteric arterial bed and small mesenteric arteries. Br J Pharmacol (2000) 1.32

ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor. Proc Natl Acad Sci U S A (2001) 1.25

Involvement of voltage-dependent potassium channels in the EDHF-mediated relaxation of rat hepatic artery. Br J Pharmacol (1997) 1.24

Scanning mutagenesis of the putative transmembrane segments of Kir2.1, an inward rectifier potassium channel. Proc Natl Acad Sci U S A (1997) 1.22

Studies on the effects of anandamide in rat hepatic artery. Br J Pharmacol (1997) 1.19

Endothelial P2Y receptors induce hyperpolarisation of vascular smooth muscle by release of endothelium-derived hyperpolarising factor. Eur J Pharmacol (1999) 1.16

Effects of inhibitors of small- and intermediate-conductance calcium-activated potassium channels, inwardly-rectifying potassium channels and Na(+)/K(+) ATPase on EDHF relaxations in the rat hepatic artery. Br J Pharmacol (2000) 1.13

Inactivation of a serotonin-gated ion channel by a polypeptide toxin from marine snails. Science (1998) 1.12

Signaling by extracellular nucleotides. Annu Rev Cell Dev Biol (1996) 1.09

Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery. Br J Pharmacol (1996) 1.08

Electrospray mass spectrometry of testosterone esters: potential for use in doping control. Steroids (1997) 1.07

Gene-gene and gene-environment interactions on IgE production in prenatal stage. Allergy (2009) 1.06

Regular tai chi chuan exercise enhances functional mobility and CD4CD25 regulatory T cells. Br J Sports Med (2006) 1.05

Interaction of maternal atopy, CTLA-4 gene polymorphism and gender on antenatal immunoglobulin E production. Clin Exp Allergy (2007) 1.02

The endothelium mediates a nitric oxide-independent hyperpolarization and relaxation in the rat hepatic artery. Acta Physiol Scand (1994) 1.02

A non-nitrergic smooth muscle relaxant factor released from rat urinary bladder by muscarinic receptor stimulation. J Urol (1999) 1.01

Regional differences in endothelium-dependent relaxation in the rat: contribution of nitric oxide and nitric oxide-independent mechanisms. Acta Physiol Scand (1995) 1.01

Characterization of vascular neuropeptide Y receptors. Br J Pharmacol (1992) 1.00

MicroRNA-21 expression in neonatal blood associated with antenatal immunoglobulin E production and development of allergic rhinitis. Clin Exp Allergy (2010) 0.99

Regular Tai Chi Chuan exercise improves T cell helper function of patients with type 2 diabetes mellitus with an increase in T-bet transcription factor and IL-12 production. Br J Sports Med (2008) 0.97

On the postjunctional alpha-adrenoreceptors in rat cerebral and mesenteric arteries. J Auton Pharmacol (1984) 0.95

Differential contribution of TRPV1 to thermal responses and tissue injury-induced sensitization of dorsal horn neurons in laminae I and V in the mouse. Pain (2006) 0.95

Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein. Br J Pharmacol (1996) 0.94

Endothelium-dependent relaxation resistant to N omega-nitro-L-arginine in the rat hepatic artery and aorta. Acta Physiol Scand (1994) 0.92

Interactions between endothelium-derived relaxing factors in the rat hepatic artery: focus on regulation of EDHF. Br J Pharmacol (1998) 0.91

Light-dependent effects of zinc protoporphyrin IX on endothelium-dependent relaxation resistant to N omega-nitro-L-arginine. Acta Physiol Scand (1994) 0.91

Capsaicin receptor in the pain pathway. Jpn J Pharmacol (2000) 0.90

Calcium channels at the adrenergic neuroeffector junction in the rabbit ear artery. Naunyn Schmiedebergs Arch Pharmacol (1993) 0.87

Hydrolysis of big endothelin-1 by a serine protease in the membrane fraction of human lung. Regul Pept (1997) 0.87

Haem oxygenase activity in blood vessel homogenates as measured by carbon monoxide production. Acta Physiol Scand (1995) 0.86

Substance P-induced relaxation and hyperpolarization in human cerebral arteries. Br J Pharmacol (1995) 0.86

Effects of omega-conotoxin on adrenergic, cholinergic and NANC neurotransmission in the rabbit urethra and detrusor. Br J Pharmacol (1993) 0.86

Unmasking the vasoconstrictor response to neuropeptide Y and its interaction with vasodilating agents in vitro. Eur J Pharmacol (1992) 0.84

Vascular effects of helodermin, helospectin I and helospectin II: a comparison with vasoactive intestinal peptide (VIP). Br J Pharmacol (1990) 0.84

Expression of a serotonin-gated ion channel in embryonic neural and nonneural tissues. Mol Cell Neurosci (1995) 0.84

TRPV1-mediated itch in seasonal allergic rhinitis. Allergy (2009) 0.84

Influence of extracellular calcium and nifedipine on alpha 1- and alpha 2-adrenoceptor-mediated contractile responses in isolated rat and cat cerebral and mesenteric arteries. Acta Physiol Scand (1985) 0.83

Effects of nimodipine, Bay K 8644 and pinacidil on alpha 1- and alpha 2-adrenoceptor-mediated vasoconstriction in human hand veins. Acta Physiol Scand (1988) 0.83

Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain. Neuroscience (2009) 0.83

Mechanisms behind the biphasic contractile response to potassium depolarization in isolated rat cerebral arteries. J Pharmacol Exp Ther (1984) 0.83

Prenatal and postnatal probiotics reduces maternal but not childhood allergic diseases: a randomized, double-blind, placebo-controlled trial. Clin Exp Allergy (2012) 0.83

Cerebral veins: fluorescence histochemistry, electron microscopy, and in vitro reactivity. J Cereb Blood Flow Metab (1983) 0.83

Neuronal expression of the 5HT3 serotonin receptor gene requires nuclear factor 1 complexes. J Neurosci (1998) 0.83

Serotonin receptor 1c gene assigned to X chromosome in human (band q24) and mouse (bands D-F4). Hum Mol Genet (1992) 0.82

Contractile effect of big endothelin-1 and its conversion to endothelin-1 in rabbit cerebral arteries. Naunyn Schmiedebergs Arch Pharmacol (1996) 0.82

Differential actions of anandamide, potassium ions and endothelium-derived hyperpolarizing factor in guinea-pig basilar artery. Naunyn Schmiedebergs Arch Pharmacol (2000) 0.82

Endothelium-dependent relaxation and effects of prostacyclin, endothelin and platelet-activating factor in human hand veins and arteries. Acta Physiol Scand (1991) 0.81

Effects of various cyclooxygenase and lipoxygenase metabolites on guinea-pig cerebral arteries. Gen Pharmacol (1992) 0.81

Characterization of endothelium- dependent relaxation in guinea pig basilar artery - effect of hypoxia and role of cytochrome P450 mono-oxygenase. J Vasc Res (1998) 0.81

Effects of nifedipine on potassium-induced contraction and noradrenaline release in cerebral and extracranial arteries from rabbit. Acta Physiol Scand (1982) 0.81

Characterization of two different calcium entry pathways in small mesenteric arteries from rat. Acta Physiol Scand (1984) 0.81

NIDA's naltrexone research program. NIDA Res Monogr (1976) 0.81

Differential effects of nifedipine, verapamil, and diltiazem on noradrenaline-induced contractions, adrenergic transmitter release, and alpha-adrenoceptor binding in the female rabbit urethra. Naunyn Schmiedebergs Arch Pharmacol (1984) 0.80

The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14. Somat Cell Mol Genet (1990) 0.80

Actions of some prostaglandins and leukotrienes on rat cerebral and mesenteric arteries. Gen Pharmacol (1987) 0.79

Pharmacology. Home for an orphan endorphin. Nature (1995) 0.79

NANC neurotransmission in lamina propria of the rabbit urethra: regulation by different subsets of calcium channels. Br J Pharmacol (1995) 0.78

On the mechanism of action of calcium antagonists. Acta Med Scand Suppl (1984) 0.78

Endothelium dependence of prostanoid-induced relaxation in human hand veins. Acta Physiol Scand (1994) 0.78

Characterization of contraction-mediating prostanoid receptors in human hand veins: effects of the thromboxane receptor antagonists BM13,505 and AH23848. Acta Physiol Scand (1991) 0.77

Epoxide hydrase activity in liver nuclei: hydration of benzo[a]pyrene-4,5-oxide and styrene oxide. Chem Biol Interact (1978) 0.77

A new wave of serotonin receptors. Curr Opin Neurobiol (1993) 0.77

Enhancement of depolarization-induced contractions after endothelium denudation is not related to an impaired production of nitric oxide or prostacyclin in the rabbit basilar artery. Acta Physiol Scand (1993) 0.77

Contractile effects of various vasoactive agents in small rat portal veins and hepatic arteries and the influence of sympathetic denervation on the noradrenaline response. Acta Physiol Scand (1986) 0.77

A non-nitrergic smooth muscle relaxant factor released from the contracting rat urinary bladder. Acta Physiol Scand (1998) 0.77

Preparation and characterization of diaspirin cross-linked hemoglobin solutions for preclinical studies. Biomater Artif Cells Immobilization Biotechnol (1992) 0.76

ATP receptors in sickness, pain and death. Chem Biol (1996) 0.76

Studies on diabetes mellitus. I. The hypoglycemic activity of phytosterin on alloxan diabetic rats. Taiwan Yi Xue Hui Za Zhi (1967) 0.76