Published in Science on April 14, 2000
Cellular and molecular mechanisms of pain. Cell (2009) 9.36
TRP channels. Annu Rev Biochem (2007) 8.09
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol Rev (2010) 4.31
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med (2010) 4.23
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2007) 4.10
Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci U S A (2009) 3.98
The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. Genes Dev (2005) 3.89
Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell (2009) 3.61
Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci U S A (2000) 3.55
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. EMBO J (2005) 3.21
The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev (2009) 3.18
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc Natl Acad Sci U S A (2002) 3.16
Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc Natl Acad Sci U S A (2002) 3.05
TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci U S A (2009) 2.96
TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron (2008) 2.94
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain (2007) 2.91
Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci (2011) 2.90
Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov (2009) 2.88
Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol (2001) 2.88
Central control of thermogenesis in mammals. Exp Physiol (2008) 2.74
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci U S A (2003) 2.58
Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane. J Gen Physiol (2006) 2.58
TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat. J Pain (2008) 2.56
VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron (2010) 2.54
The coding of temperature in the Drosophila brain. Cell (2011) 2.53
Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda) (2008) 2.51
Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2003) 2.50
Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature (2009) 2.45
A subpopulation of nociceptors specifically linked to itch. Nat Neurosci (2012) 2.41
Recommendations for the management of cough in adults. Thorax (2006) 2.41
Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci U S A (2001) 2.36
A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells. J Neurosci (2009) 2.35
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control. J Clin Invest (2004) 2.28
Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. J Physiol (2007) 2.26
VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. Neuron (2010) 2.22
Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc Natl Acad Sci U S A (2001) 2.17
A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Natl Acad Sci U S A (2009) 2.16
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol (2001) 2.15
The cells and circuitry for itch responses in mice. Science (2013) 2.14
Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Neuron (2009) 2.14
Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metab (2010) 2.11
A role for ASIC3 in the modulation of high-intensity pain stimuli. Proc Natl Acad Sci U S A (2002) 2.11
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Curr Opin Neurobiol (2007) 2.08
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. J Physiol (2006) 2.07
TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci (2009) 2.07
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. Nat Neurosci (2010) 1.98
The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception. EMBO J (2009) 1.98
Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol (2004) 1.97
Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proc Natl Acad Sci U S A (2002) 1.94
Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain (2005) 1.94
Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J (2008) 1.93
Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci U S A (2003) 1.92
Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. FASEB J (2012) 1.86
Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest (2010) 1.85
The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant. J Physiol (2004) 1.85
Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor. J Physiol (2003) 1.84
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature (2011) 1.84
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br J Pharmacol (2006) 1.83
[The capsaicin receptor. "TRPing" transduction for painful stimuli]. Schmerz (2006) 1.83
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proc Natl Acad Sci U S A (2005) 1.82
Hedgehog signaling regulates nociceptive sensitization. Curr Biol (2011) 1.81
ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation. Pain (2006) 1.79
General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Proc Natl Acad Sci U S A (2008) 1.78
TRPV1-lineage neurons are required for thermal sensation. EMBO J (2010) 1.77
Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A (2008) 1.77
Mechanisms of acid-induced activation of airway afferent nerve fibres in guinea-pig. J Physiol (2002) 1.76
Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Proc Natl Acad Sci U S A (2001) 1.74
Nociceptors: the sensors of the pain pathway. J Clin Invest (2010) 1.72
A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat Neurosci (2008) 1.71
The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol (2012) 1.69
Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron (2015) 1.69
Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties. J Gen Physiol (2007) 1.68
TRPA1 contributes to cold hypersensitivity. J Neurosci (2010) 1.68
Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels. Nat Neurosci (2008) 1.66
Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nat Neurosci (2012) 1.66
Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel. J Biol Chem (2010) 1.63
The TRPM2 ion channel is required for sensitivity to warmth. Nature (2016) 1.63
Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice. J Physiol (2004) 1.63
Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors. Pain (2007) 1.60
Emerging roles of resolvins in the resolution of inflammation and pain. Trends Neurosci (2011) 1.60
Capsaicin-evoked iCGRP release from human dental pulp: a model system for the study of peripheral neuropeptide secretion in normal healthy tissue. Pain (2009) 1.59
Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. J Neurosci (2011) 1.58
Emerging targets in neuroinflammation-driven chronic pain. Nat Rev Drug Discov (2014) 1.57
Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. Cell Rep (2012) 1.56
Peripheral mechanisms of pain and analgesia. Brain Res Rev (2008) 1.55
Deletion of transient receptor potential vanilloid type 1 receptors exaggerates renal damage in deoxycorticosterone acetate-salt hypertension. Hypertension (2008) 1.55
Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons. J Biol Chem (2006) 1.53
Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2. J Neurosci (2008) 1.53
A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission. Neuron (2014) 1.52
Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology (2009) 1.52
Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell (2008) 1.52
Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. J Neurosci (2011) 1.51
Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons. Proc Natl Acad Sci U S A (2010) 1.51
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC Neurol (2007) 1.51
Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide. Br J Pharmacol (2004) 1.49
Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. EMBO J (2005) 1.48
The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (1997) 30.59
The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron (1998) 13.03
In vitro antimicrobial susceptibility of anaerobic bacteria isolated from clinical specimens. Antimicrob Agents Chemother (1972) 11.05
Evaluation of accuracy of multitest micromethod system for identification of Enterobacteriaceae. Appl Microbiol (1971) 10.28
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature (1999) 10.05
Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction. J Exp Med (1988) 9.10
Molecular mechanisms of nociception. Nature (2001) 7.75
The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci (2001) 6.65
Clinical utility of thoracoscopy. Chest (1992) 6.34
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature (2001) 6.26
A capsaicin-receptor homologue with a high threshold for noxious heat. Nature (1999) 5.85
Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway. Cell (1984) 5.53
Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature (2001) 5.51
Practical method for isolation of anerobic bacteria in the clinical laboratory. Appl Microbiol (1971) 5.45
Identification of members of the family Enterobacteriaceae by the R-B system. Appl Microbiol (1970) 5.27
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor. Cell (1984) 5.26
Comparison of three blood culture media for recovery of anaerobic bacteria. Appl Microbiol (1973) 5.22
Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci (1984) 4.87
Anaerobic bacteremia. Mayo Clin Proc (1972) 4.79
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature (1994) 4.61
Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature (2000) 4.53
Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature (1995) 4.36
Microwave oven for melting laboratory media. J Clin Microbiol (1978) 4.33
Collaborative investigation of the AutoMicrobic System Enterobacteriaceae biochemical card. J Clin Microbiol (1980) 4.28
Yeast alpha factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase. Cell (1983) 4.24
Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science (1991) 3.73
Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc Natl Acad Sci U S A (1993) 3.68
Evaluation of reagent-impregnated strips for identification of Enterobacteriaceae. Am J Med Technol (1971) 3.60
Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature (1993) 3.57
Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci U S A (2000) 3.55
Isolation and indentification of anaerobic bacteria in the clinical laboratory. A 2-year experience. Mayo Clin Proc (1974) 3.54
Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus. J Infect Dis (1988) 3.52
Silent embolism in diagnostic cerebral angiography and neurointerventional procedures: a prospective study. Lancet (1999) 3.20
Intradendritic recordings from hippocampal neurons. Proc Natl Acad Sci U S A (1979) 3.18
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nat Med (2001) 3.17
Cell to cell interaction in the immune response. IV. Site of action of antilymphocyte globulin. J Exp Med (1968) 3.16
Klebsiella in faecal flora of renal-transplant patients. Lancet (1970) 3.14
Evaluation of the enterotube system for identification of members of the family Enterobacteriaceae. Appl Microbiol (1971) 3.11
Evaluation of enrichment, storage, and age of blood agar medium in relation to its ability to support growth of anaerobic bacteria. J Clin Microbiol (1976) 3.09
Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. Science (1997) 2.98
Primary afferent tachykinins are required to experience moderate to intense pain. Nature (1998) 2.97
Complex Regional Pain Syndromes: guidelines for therapy. Clin J Pain (1998) 2.90
Linkage between the poly-L-lysine gene and the locus controlling the major histocompatibility antigens in strain 2 guinea pigs. Proc Natl Acad Sci U S A (1970) 2.89
Biochemical and clinical characteristics and antibiotic susceptibility of atypical Enterobacter cloacae. Appl Microbiol (1969) 2.87
Pneumocystis carinii pneumonia. Differences in lung parasite number and inflammation in patients with and without AIDS. Am Rev Respir Dis (1989) 2.86
Evaluation of the Auxotab Enteric 1 System for identification of Enterobacteriaceae. Appl Microbiol (1972) 2.85
In vitro studies of piperacilin, a new semisynthetic penicillin. Antimicrob Agents Chemother (1978) 2.82
Clinical isolation of Yersinia enterocolitica: cold temperature enrichment. J Clin Microbiol (1975) 2.76
Towards a mechanism-based classification of pain? Pain (1998) 2.73
Endogenous pain control mechanisms: review and hypothesis. Ann Neurol (1978) 2.63
Genetic control of immune responsiveness to a glutamic acid, alanine, tyrosine copolymer in mice. I. Linkage of responsiveness to H-2 genotype. J Immunol (1971) 2.60
API and Minitek systems in identification of clinical isolates of anaerobic gram-negative bacilli and Clostridium species. J Clin Microbiol (1979) 2.54
Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol (1990) 2.53
Coagulase-negative staphylococcal bacteremia in patients receiving immunosuppressive therapy. Arch Intern Med (1983) 2.53
Epidemiologic significance of Klebsiella pneumoniae. A 3-month study. Mayo Clin Proc (1971) 2.51
Prevalence of serotypes of Salmonella. Appl Microbiol (1969) 2.50
Clinical and bacteriologic studies of anaerobic gram-positive cocci. Mayo Clin Proc (1972) 2.48
Diverticula of the Small Bowel. Ann Surg (1934) 2.44
Heamophilus vaginalis (Corynebacterium vaginal): method for isolation and rapid biochemical identification. Health Lab Sci (1977) 2.37
Bacteroides bacteremia. Minn Med (1970) 2.36
Bacterial (suppurative) arthritis in the adult. J Bone Joint Surg Am (1970) 2.26
Evaluation of the MS-2 system for rapid identification of Enterobacteriaceae. J Clin Microbiol (1980) 2.26
Rapid identification and antimicrobial susceptibility testing of gram-negative bacilli from blood cultures by the AutoMicrobic system. J Clin Microbiol (1981) 2.24
Comparative in vitro activity of moxalactam, cefotaxime, cefoperazone, piperacillin, and aminoglycosides against gram-negative bacilli. Antimicrob Agents Chemother (1980) 2.23
Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science (1995) 2.12
Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer. J Exp Med (1985) 2.12
Clinical evaluation of a lysis-centrifugation technique for the detection of septicemia. JAMA (1983) 2.12
A role for BDNF in mechanosensation. Nat Neurosci (1998) 2.08
Analysis of DNA sequences in forty-year-old paraffin-embedded thin-tissue sections: a bridge between molecular biology and classical histology. Cancer Res (1988) 2.06
Rapid detection of cytomegalovirus in bronchoalveolar lavage specimens by a monoclonal antibody method. J Clin Microbiol (1986) 2.05
Comparison of rates of virus isolation from leukocyte populations separated from blood by conventional and Ficoll-Paque/Macrodex methods. J Clin Microbiol (1979) 2.04
Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice. Pain (2001) 1.97
The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron (2001) 1.97
Hemagglutinin-specific cytotoxic T-cell response during influenza infection. J Exp Med (1977) 1.97
Clinical evaluation of the AutoMicrobic system Yeast Biochemical Card for rapid identification of medically important yeasts. J Clin Microbiol (1981) 1.94
Histocompatibility type and immune responsiveness in random bred Hartley strain guinea pigs. J Exp Med (1970) 1.90
Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates. Pain (1998) 1.90
Gram-negative rod bacteremia: microbiologic, immunologic, and therapeutic considerations. Ann Intern Med (1977) 1.90
Brain abscess with Corynebacterium hemolyticum: report of a case. Am J Clin Pathol (1971) 1.87
Non-radioactive single strand conformation polymorphism (SSCP) using the Pharmacia 'PhastSystem'. Nucleic Acids Res (1991) 1.86
Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis. J Neurosci (1986) 1.84
Nosocomially acquired bacteriuria due to Proteus rettgeri and Providencia stuartii. Am J Clin Pathol (1973) 1.83
Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro. J Neurophysiol (1992) 1.82
Serratia marcescens. Biochemical characteristics, antibiotic susceptibility patterns, and clinical significance. JAMA (1970) 1.80
Intraneuronal substance P contributes to the severity of experimental arthritis. Science (1984) 1.77
Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord. J Neurosci (1990) 1.77
Novel classes of nociceptors: beyond Sherrington. Trends Neurosci (1990) 1.72
In vitro susceptibility of gram-negative bacilli to gentamicin. Mayo Clin Proc (1970) 1.72
Noradrenaline-evoked pain in neuralgia. Pain (1995) 1.70
Cell-adhesive motif in region II of malarial circumsporozoite protein. Science (1990) 1.69
An analgesia circuit activated by cannabinoids. Nature (1998) 1.68
Anti-Salmonella agglutinins in chronic active liver disease. Lancet (1971) 1.67
NMDA-receptor regulation of substance P release from primary afferent nociceptors. Nature (1997) 1.65
Expression of yeast apurinic/apyrimidinic endonuclease (APN1) protects lung epithelial cells from bleomycin toxicity. Am J Respir Cell Mol Biol (2001) 1.63
Leukotriene and prostaglandin sensitization of cutaneous high-threshold C- and A-delta mechanonociceptors in the hairy skin of rat hindlimbs. Neuroscience (1987) 1.62