Published in Biochem Biophys Res Commun on June 07, 2000
Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch (2003) 3.33
Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin. Mol Pharmacol (2008) 2.11
Galectin-4 in normal tissues and cancer. Glycoconj J (2004) 1.42
Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol Sci (2008) 1.22
Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers. Toxicol Sci (2008) 0.86
Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice. Toxicol Appl Pharmacol (2011) 0.77
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A (2001) 4.58
Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol (1999) 2.95
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Drug Metab Dispos (2001) 1.70
Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Mol Pharmacol (2001) 1.48
Studies on the mechanism of phenobarbital-enhanced sulfobromophthalein disappearance. J Pharmacol Exp Ther (1968) 1.37
Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology. Drug Metab Dispos (2000) 1.34
Increase in metallothionein produced by chemicals that induce oxidative stress. Toxicol Appl Pharmacol (1991) 1.31
Mechanisms of bile formation, hepatic uptake, and biliary excretion. Pharmacol Rev (1984) 1.29
Protective effect of metallothionein against the toxicity of cadmium and other metals(1). Toxicology (2001) 1.23
Comparison of the biochemical alterations elicited in livers from rats treated with carbon tetrachloride, chloroform, 1,1,2-trichloroethane and 1,1,1-trichloroethane. Biochem Pharmacol (1969) 1.20
Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family. Drug Metab Dispos (2003) 1.18
Biliary flow after microsomal enzyme induction. J Pharmacol Exp Ther (1969) 1.17
Cadmium-induced apoptosis in mouse liver. Toxicol Appl Pharmacol (1998) 1.14
Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice. Zhongguo Yao Li Xue Bao (1995) 1.11
Biliary excretion of drugs in man. Clin Pharmacokinet (1980) 1.11
Role of metallothionein in carcinogenesis. Toxicol Appl Pharmacol (1994) 1.10
Comparison of the effectiveness of several chelators after single administration on the toxicity, excretion, and distribution of cadmium. Toxicol Appl Pharmacol (1981) 1.09
Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats. Toxicol Appl Pharmacol (1994) 1.09
Maximum biliary excretion of bilirubin and sulfobromophthalein during anesthesia-induced alteration of rectal temperature. Proc Soc Exp Biol Med (1967) 1.07
Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha. Biochem Pharmacol (2006) 1.07
Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity. Toxicol Appl Pharmacol (1998) 1.06
trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors. Mol Pharmacol (2006) 1.06
Cadmium-binding proteins of rat testes. Characterization of a low-molecular-mass protein that lacks identity with metallothionein. Biochem J (1984) 1.04
Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation. Toxicol Sci (2000) 1.03
UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism. Toxicol Appl Pharmacol (1992) 1.03
Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study. Toxicol Sci (1998) 1.02
Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels. Drug Metab Dispos (2002) 1.02
Disposition of metals in rats: a comparative study of fecal, urinary, and biliary excretion and tissue distribution of eighteen metals. Toxicol Appl Pharmacol (1986) 1.02
Decreased effectiveness of chelation therapy with time after acute cadmium poisoning. Toxicol Appl Pharmacol (1982) 1.01
Toxicity and distribution of cadmium administered to rats at sublethal doses. Toxicol Appl Pharmacol (1977) 1.00
Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity. J Pharmacol Exp Ther (1999) 1.00
Effect of oleanolic acid on hepatic toxicant-activating and detoxifying systems in mice. J Pharmacol Exp Ther (1995) 1.00
Minimal role of metallothionein in decreased chelator efficacy for cadmium. Toxicol Appl Pharmacol (1983) 0.99
Gas-liquid-chromatographic determination of bile acids in bile. Clin Chim Acta (1971) 0.99
Plasma disappearance and biliary excretion of indocyanine green in rats, rabbits, and dogs. Toxicol Appl Pharmacol (1969) 0.98
Biliary excretion of manganese in rats, rabbits, and dogs. Toxicol Appl Pharmacol (1974) 0.98
Relative in vitro affinity of hepatic metallothionein for metals. Toxicol Lett (1984) 0.98
Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice. Toxicology (2000) 0.98
Studies on the increased biliary flow produced by phenobarbital in rats. J Pharmacol Exp Ther (1971) 0.98
Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice. J Pharmacol Exp Ther (1993) 0.98
Production of metallothionein and heat-shock proteins in response to metals. Fundam Appl Toxicol (1993) 0.98
Relative effects of various chlorinated hydrocarbons on liver and kidney function in mice. Toxicol Appl Pharmacol (1966) 0.97
Cadmium-induced hepatic and renal injury in chronically exposed rats: likely role of hepatic cadmium-metallothionein in nephrotoxicity. Toxicol Appl Pharmacol (1985) 0.97
Isolation and characterization of metallothionein which is highly concentrated in newborn rat liver. J Biol Chem (1979) 0.96
Induction of metallothionein by adrenocortical steroids. Toxicology (1981) 0.96
Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy. Toxicol Appl Pharmacol (1999) 0.95
Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways. Drug Metab Dispos (2006) 0.95
Hepatic extraction of bile acids in rats. Biochem Pharmacol (1982) 0.95
Altered subcellular distribution of cadmium following cadmium pretreatment: possible mechanism of tolerance to cadmium-induced lethality. Toxicol Appl Pharmacol (1983) 0.95
Metallothioneins in brain--the role in physiology and pathology. Toxicol Appl Pharmacol (1997) 0.95
Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice. Biochem Pharmacol (2006) 0.94
Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: a dose-response study. J Pharmacol Exp Ther (1995) 0.94
Studies on the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase. Biochem Pharmacol (1987) 0.94
Species variation in metabolism, storage, and excretion of sulfobromophthalein. Am J Physiol (1967) 0.94
The effect of repeated administration of several chelators on the distribution and excretion of cadmium. Toxicol Appl Pharmacol (1982) 0.94
Induction of metallothionein by arsenicals in mice. Fundam Appl Toxicol (1993) 0.93
Does bile acid secretion determine canalicular bile production in rats? Am J Physiol (1971) 0.93
The effects of 10 triterpenoid compounds on experimental liver injury in mice. Fundam Appl Toxicol (1994) 0.93
Neurotoxic effects of cadmium in young rats. Toxicol Appl Pharmacol (1982) 0.93
Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity. Toxicol Appl Pharmacol (1995) 0.93
Oleanolic acid protects against cadmium hepatotoxicity by inducing metallothionein. J Pharmacol Exp Ther (1993) 0.92
Induction of digitoxigenin monodigitoxoside UDP-glucuronosyltransferase activity by glucocorticoids and other inducers of cytochrome P-450p in primary monolayer cultures of adult rat hepatocytes and in human liver. J Biol Chem (1986) 0.92
Relative effects of various chlorinated hydrocarbons on liver and kidney function in dogs. Toxicol Appl Pharmacol (1967) 0.92
Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites. Drug Metab Dispos (2003) 0.92
Dose-response effects of various metal ions on rat liver metallothionein, glutathione, heme oxygenase, and cytochrome P-450. Toxicol Appl Pharmacol (1980) 0.92
Binding of glutathione-depleting agents to metallothionein. Toxicol Appl Pharmacol (1980) 0.91
Lipoic acid impairs glycine conjugation of benzoic acid and renal excretion of benzoylglycine. Drug Metab Dispos (1996) 0.91
Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium. Toxicol Sci (2000) 0.91
Characterization of metallothionein-I-transgenic mice. Toxicol Appl Pharmacol (1995) 0.91
Depletion of hepatic UDP-glucuronic acid by drugs that are glucuronidated. J Pharmacol Exp Ther (1986) 0.91
Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes. Toxicol Appl Pharmacol (1980) 0.91
The effect of Chinese hepatoprotective medicines on experimental liver injury in mice. J Ethnopharmacol (1994) 0.91
The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture. Toxicol Appl Pharmacol (1991) 0.91
Metallothionein plays less of a protective role in cadmium-metallothionein-induced nephrotoxicity than in cadmium chloride-induced hepatotoxicity. J Pharmacol Exp Ther (1996) 0.90
National Cancer Institute workshop on the possible roles of metallothionein in carcinogenesis. Cancer Res (1993) 0.90
Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice. Toxicol Appl Pharmacol (2001) 0.89
Glucuronidation and biliary excretion of acetaminophen in rats. J Pharmacol Exp Ther (1984) 0.89
Species variation in toxication and detoxication of acetaminophen in vivo: a comparative study of biliary and urinary excretion of acetaminophen metabolites. J Pharmacol Exp Ther (1988) 0.89
Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats. Toxicology (1995) 0.89
Species variations in biliary excretion of glutathione-related thiols and methylmercury. Toxicol Appl Pharmacol (1988) 0.88
Induction of metallothionein by steroids in rat primary hepatocyte cultures. Toxicol Appl Pharmacol (1987) 0.88
Metallothionein-null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic CdCl2 exposure. Toxicol Appl Pharmacol (1999) 0.88
Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene. Biochem Biophys Res Commun (2000) 0.88
Concentration of metallothionein in major organs of rats after administration of various metals. Fundam Appl Toxicol (1985) 0.88
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides. J Pharmacol Exp Ther (1974) 0.88
Susceptibility of MT-null mice to chronic CdCl2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex. Toxicol Sci (1998) 0.88
Determination of sulfobromophthalein storage and exertory rate in small animals. J Appl Physiol (1967) 0.88
Effects of phenobarbital on the plasma disappearance and biliary excretion of drugs in rats. J Pharmacol Exp Ther (1970) 0.88
Redistribution of cadmium to blood of rats. Toxicol Appl Pharmacol (1981) 0.87
First-pass effect of morphine in rats. J Pharmacol Exp Ther (1977) 0.87
Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers. Xenobiotica (2009) 0.87
In vitro and in vivo studies on the degradation of metallothionein. Environ Health Perspect (1994) 0.87
Comparison of methods for estimating hepatic metallothionein in rats. Toxicol Appl Pharmacol (1977) 0.87
Metabolism and biliary excretion of ethacrynic acid. J Pharmacol Exp Ther (1974) 0.87
Tissue-specific expression of rat sulfotransferase messenger RNAs. Drug Metab Dispos (1998) 0.87
Distribution and retention of cadmium in metallothionein I and II null mice. Toxicol Appl Pharmacol (1996) 0.87
Ontogeny and hormonal basis of female-dominant rat hepatic sulfotransferases. J Pharmacol Exp Ther (1996) 0.86
Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury. Toxicol Sci (2000) 0.86
Pharmacokinetics of rose bengal in the rat, rabbit, dog and guinea pig. Toxicol Appl Pharmacol (1976) 0.86