Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Rabbit liver fructose 1,6-diphosphatase. Properties of the native enzyme and their modification by subtilisin.
|
Arch Biochem Biophys
|
1972
|
1.82
|
2
|
Extralysosomal protein degradation.
|
Annu Rev Biochem
|
1986
|
1.74
|
3
|
The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid.
|
J Biol Chem
|
1986
|
1.46
|
4
|
Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation.
|
Proc Natl Acad Sci U S A
|
1987
|
1.34
|
5
|
Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase.
|
Proc Natl Acad Sci U S A
|
1985
|
1.33
|
6
|
The calpains.
|
Trends Neurosci
|
1989
|
1.29
|
7
|
Specific degradation of troponin T and I by mu-calpain and its modulation by substrate phosphorylation.
|
Biochem J
|
1995
|
1.26
|
8
|
Fructose 1,6-bisphosphatase: properties of the neutral enzyme and its modification by proteolytic enzymes.
|
Adv Enzymol Relat Areas Mol Biol
|
1975
|
1.21
|
9
|
Stimulated astrocytes release high-mobility group 1 protein, an inducer of LAN-5 neuroblastoma cell differentiation.
|
Neuroscience
|
1998
|
1.18
|
10
|
Role of full-length osteoprotegerin in tumor cell biology.
|
Cell Mol Life Sci
|
2009
|
1.14
|
11
|
Isozymes of protein kinase C in human neutrophils and their modification by two endogenous proteinases.
|
J Biol Chem
|
1990
|
1.10
|
12
|
Secretion and binding of HMG1 protein to the external surface of the membrane are required for murine erythroleukemia cell differentiation.
|
FEBS Lett
|
1997
|
1.10
|
13
|
Phosphorylation and proteolytic modification of specific cytoskeletal proteins in human neutrophils stimulated by phorbol 12-myristate 13-acetate.
|
Proc Natl Acad Sci U S A
|
1987
|
1.10
|
14
|
Biochemical responses in activated human neutrophils mediated by protein kinase C and a Ca2+-requiring proteinase.
|
J Biol Chem
|
1986
|
1.09
|
15
|
Conversion of neutral to alkaline liver fructose 1,6-bisphosphatase: changes in molecular properties of the enzyme.
|
Proc Natl Acad Sci U S A
|
1973
|
1.07
|
16
|
Effects of a monoclonal anti-calpain antibody on responses of stimulated human neutrophils. Evidence for a role for proteolytically modified protein kinase C.
|
J Biol Chem
|
1988
|
1.05
|
17
|
Extracellular high-mobility group 1 protein is essential for murine erythroleukaemia cell differentiation.
|
Biochem J
|
1996
|
1.04
|
18
|
Fructose 1,6-bisphosphatase: the role of lysosomal enzymes in the modification of catalytic and structural properties.
|
Proc Natl Acad Sci U S A
|
1973
|
1.04
|
19
|
Fine tuning of protein kinase C (PKC) isoforms in cancer: shortening the distance from the laboratory to the bedside.
|
Mini Rev Med Chem
|
2011
|
1.04
|
20
|
Cytosolic Ca2+-dependent neutral proteinases from rabbit liver: activation of the proenzymes by Ca2+ and substrate.
|
Proc Natl Acad Sci U S A
|
1984
|
1.04
|
21
|
Cytolytic effects of neutrophils: role for a membrane-bound neutral proteinase.
|
Proc Natl Acad Sci U S A
|
1986
|
1.03
|
22
|
Activation of Ca(2+)-dependent proteolysis in skeletal muscle and heart in cancer cachexia.
|
Br J Cancer
|
2001
|
1.03
|
23
|
Reversible activation of human neutrophil calpain promoted by interaction with plasma membranes.
|
Biochem Int
|
1985
|
1.02
|
24
|
Cytosolic calcium dependent proteinase of human erythrocytes: formation of an enzyme-natural inhibitor complex induced by Ca2+ ions.
|
Biochem Biophys Res Commun
|
1982
|
1.02
|
25
|
Autolysis of human erythrocyte calpain produces two active enzyme forms with different cell localization.
|
FEBS Lett
|
1996
|
1.01
|
26
|
Binding to erythrocyte membrane is the physiological mechanism for activation of Ca2+-dependent neutral proteinase.
|
Biochem Biophys Res Commun
|
1985
|
1.01
|
27
|
Epidemiological study of urinary tract stones in a northern Italian city.
|
Br J Urol
|
1990
|
1.00
|
28
|
Changes in rabbit-liver lysosomes and fructose 1,6-bisphosphatase induced by cold and fasting.
|
Proc Natl Acad Sci U S A
|
1973
|
0.99
|
29
|
Supravital exposure to propidium iodide identifies apoptosis on adherent cells.
|
Cytometry
|
2001
|
0.99
|
30
|
Evidence for an interaction between fructose 1,6-bisphosphatase and fructose 1,6-bisphosphate aldolase.
|
Arch Biochem Biophys
|
1979
|
0.98
|
31
|
Isovalerylcarnitine is a specific activator of the high calcium requiring calpain forms.
|
Biochem Biophys Res Commun
|
1990
|
0.97
|
32
|
Site-directed activation of calpain is promoted by a membrane-associated natural activator protein.
|
Biochem J
|
1993
|
0.96
|
33
|
Activation of neutrophil calpain following its translocation to the plasma membrane induced by phorbol ester or fMet-Leu-Phe.
|
Biochem Biophys Res Commun
|
1989
|
0.96
|
34
|
Changes in activity and molecular properties of fructose 1, 6-bisphosphatase during fasting and refeeding.
|
Proc Natl Acad Sci U S A
|
1974
|
0.95
|
35
|
Echocardiographic parameters and indices in the normal beagle dog.
|
Lab Anim
|
1992
|
0.95
|
36
|
Changes in intracellular localization of calpastatin during calpain activation.
|
Biochem J
|
1999
|
0.95
|
37
|
Ca2+-dependent neutral proteinase from human erythrocytes: activation by Ca2+ ions and substrate and regulation by the endogenous inhibitor.
|
Biochem Int
|
1984
|
0.94
|
38
|
On the mechanism of inhibition of fructose 1,6-bisphosphatase by fructose 2,6-bisphosphate.
|
Arch Biochem Biophys
|
1982
|
0.94
|
39
|
The plasma membrane calcium pump is the preferred calpain substrate within the erythrocyte.
|
Cell Calcium
|
1994
|
0.94
|
40
|
Activation of NADPH oxidase and phosphorylation of membrane proteins in human neutrophils: coordinate inhibition by a surface antigen-directed monoclonal antibody.
|
Biochem Biophys Res Commun
|
1986
|
0.93
|
41
|
Characterization of three rabbit liver lysosomal proteinases with fructose 1,6-bisphosphatase converting enzyme activity.
|
Arch Biochem Biophys
|
1981
|
0.93
|
42
|
Role of phospholipids in the activation of the Ca2+-dependent neutral proteinase of human erythrocytes.
|
Biochem Biophys Res Commun
|
1985
|
0.93
|
43
|
Extinction and absorption coefficients and scattering phase functions of human tissues in vitro.
|
Appl Opt
|
1989
|
0.92
|
44
|
Identification of two calpastatin forms in rat skeletal muscle and their susceptibility to digestion by homologous calpains.
|
Arch Biochem Biophys
|
1991
|
0.92
|
45
|
Acute intravenous toxicity of dimethyl sulfoxide, polyethylene glycol 400, dimethylformamide, absolute ethanol, and benzyl alcohol in inbred mouse strains.
|
Arzneimittelforschung
|
1994
|
0.92
|
46
|
Mechanism of action of the calpain activator protein in rat skeletal muscle.
|
Eur J Biochem
|
1991
|
0.92
|
47
|
Following association to the membrane, human erythrocyte procalpain is converted and released as fully active calpain.
|
Biochim Biophys Acta
|
1985
|
0.91
|
48
|
Identification of the proteolytically activated form of protein kinase C in stimulated human neutrophils.
|
Proc Natl Acad Sci U S A
|
1990
|
0.91
|
49
|
The interference of leukocytes and platelets with measurement of clucose-6-phosphate dehydrogenase activity of erythrocytes with low activity variants of the enzyme.
|
Blood
|
1981
|
0.91
|
50
|
Reversible inactivation of calpain isoforms by nitric oxide.
|
Biochem Biophys Res Commun
|
1995
|
0.91
|
51
|
Activation by hemoglobin of the Ca2+-requiring neutral proteinase of human erythrocytes: structural requirements.
|
Biochem Biophys Res Commun
|
1984
|
0.90
|
52
|
An endogenous activator of the Ca2+-dependent proteinase of human neutrophils that increases its affinity for Ca2+.
|
Proc Natl Acad Sci U S A
|
1988
|
0.89
|
53
|
Role of delta-PKC on the differentiation process of murine erythroleukemia cells.
|
Biochem Biophys Res Commun
|
1993
|
0.89
|
54
|
Evidence for formation of a rabbit liver aldolase--rabbit liver fructose-1,6-bisphosphatase complex.
|
Proc Natl Acad Sci U S A
|
1980
|
0.89
|
55
|
Phosphorylation by protein kinase C of a 20-kDa cytoskeletal polypeptide enhances its susceptibility to digestion by calpain.
|
Proc Natl Acad Sci U S A
|
1987
|
0.89
|
56
|
Age-dependent degradation of calpastatin in kidney of hypertensive rats.
|
J Biol Chem
|
2001
|
0.89
|
57
|
Interactions of Zn2+ and Mg2+ with rabbit liver fructose 1,6 bisphosphatase.
|
Arch Biochem Biophys
|
1978
|
0.89
|
58
|
Differential expression of protein kinase C isoform genes in three murine erythroleukemia cell variants: implication for chemical induced differentiation.
|
Biochem Biophys Res Commun
|
1994
|
0.88
|
59
|
Cytosolic calcium dependent neutral proteinase of human erythrocytes: the role of calcium ions on the molecular and catalytic properties of the enzyme.
|
Biochem Biophys Res Commun
|
1982
|
0.88
|
60
|
Characterization of the single peptide generated from the amino-terminus end of alpha- and beta-hemoglobin chains by the Ca2+-dependent neutral proteinase.
|
Biochim Biophys Acta
|
1984
|
0.88
|
61
|
Regulation of fructose, 1,6-bisphosphatase by histidine under gluconeogenic conditions.
|
Proc Natl Acad Sci U S A
|
1974
|
0.87
|
62
|
Phosphorylation of proteins in human neutrophils activated with phorbol myristate acetate or with chemotactic factor.
|
Arch Biochem Biophys
|
1986
|
0.87
|
63
|
Activation of PKC-beta isoforms mediates HNE-induced MCP-1 release by macrophages.
|
Biochem Biophys Res Commun
|
2002
|
0.87
|
64
|
Ethanol-induced effects on expression level, activity, and distribution of protein kinase C isoforms in rat liver Golgi apparatus.
|
Chem Biol Interact
|
1998
|
0.86
|
65
|
Changes in activity of fructose-1,6-bisphosphate aldolase in livers of fasted rabbits and accumulation of crossreacting immune material.
|
Proc Natl Acad Sci U S A
|
1979
|
0.86
|
66
|
Modulation of calpastatin specificity in rat tissues by reversible phosphorylation and dephosphorylation.
|
Biochem Biophys Res Commun
|
1994
|
0.86
|
67
|
Antisense oligodeoxynucleotide inhibition of delta protein kinase C expression accelerates induced differentiation of murine erythroleukaemia cells.
|
Biochem J
|
1995
|
0.86
|
68
|
Identification of an endogenous activator of calpain in rat skeletal muscle.
|
Biochem Biophys Res Commun
|
1990
|
0.86
|
69
|
Cathepsin M: a lysosomal proteinase with aldolase-inactivating activity.
|
Arch Biochem Biophys
|
1982
|
0.86
|
70
|
FELASA guidelines for education of specialists in laboratory animal science (Category D). Report of the Federation of Laboratory Animal Science Associations Working Group on Education of Specialists (Category D) accepted by the FELASA Board of Management.
|
Lab Anim
|
1999
|
0.85
|
71
|
Changes in intracellular calpastatin localization are mediated by reversible phosphorylation.
|
Biochem J
|
2001
|
0.85
|
72
|
Identification of proteolytic activities in the cytosolic compartment of mature human erythrocytes.
|
Eur J Biochem
|
1980
|
0.85
|
73
|
A dual role for the Ca2+-requiring proteinase in the degradation of hemoglobin by erythrocyte membrane proteinases.
|
Proc Natl Acad Sci U S A
|
1984
|
0.85
|
74
|
Calcium-binding properties of human erythrocyte calpain.
|
Biochem J
|
1997
|
0.85
|
75
|
Differential degradation of calpastatin by mu- and m-calpain in Ca(2+)-enriched human neuroblastoma LAN-5 cells.
|
FEBS Lett
|
2000
|
0.84
|
76
|
Protein kinase C isoforms in murine erythroleukemia cells and their involvement in the differentiation process.
|
FEBS Lett
|
1994
|
0.84
|
77
|
Cooperation between soluble and membrane-bound proteinases in the degradation of beta-hemoglobin chains in intact human erythrocytes.
|
Arch Biochem Biophys
|
1982
|
0.84
|
78
|
Extracellular processing of amphoterin generates a peptide active on erythroleukaemia cell differentiation.
|
Biochem J
|
2001
|
0.84
|
79
|
Localization of two lysosomal proteinases on the external surface of the lysosomal membrane.
|
Biochem Biophys Res Commun
|
1982
|
0.83
|
80
|
Transformation of neutral to alkaline fructose 1,6-bisphosphatase. Converting enzyme activity in the large-particle fraction from rabbit liver.
|
Arch Biochem Biophys
|
1974
|
0.83
|
81
|
ATP induces the release of a neutral serine proteinase and enhances the production of superoxide anion in membranes from phorbol ester-activated neutrophils.
|
J Biol Chem
|
1986
|
0.83
|
82
|
Harmonization of animal clinical pathology testing in toxicity and safety studies. The Joint Scientific Committee for International Harmonization of Clinical Pathology Testing.
|
Fundam Appl Toxicol
|
1996
|
0.83
|
83
|
Two cytosolic, Ca2+-dependent, neutral proteinases from rabbit liver: purification and properties of the proenzymes.
|
Arch Biochem Biophys
|
1984
|
0.83
|
84
|
Inactivation of liver aldolase in fasting rabbits: evidence for the accumulation of two different immunoreactive forms.
|
Arch Biochem Biophys
|
1980
|
0.83
|
85
|
Isolation and partial characterization of three acidic proteinases in erythrocyte membranes.
|
Biochem J
|
1979
|
0.83
|
86
|
Effects of calpain inhibition on dopaminergic markers and motor function following intrastriatal 6-hydroxydopamine administration in rats.
|
Neuroscience
|
2008
|
0.82
|
87
|
FELASA recommendations for the education and training of persons carrying out animal experiments (Category B). Report of the Federation of European Laboratory Animal Science Associations Working Group on Education of Persons Carrying out Animal Experiments (Category B) accepted by the FELASA Board of Management.
|
Lab Anim
|
2000
|
0.82
|
88
|
Correlation between levels of delta protein kinase C and resistance to differentiation in murine erythroleukemia cells.
|
Biochem Biophys Res Commun
|
1996
|
0.82
|
89
|
Modulation of rat brain calpastatin efficiency by post-translational modifications.
|
FEBS Lett
|
1997
|
0.82
|
90
|
In vitro apoptotic cell death during erythroid differentiation.
|
Apoptosis
|
2004
|
0.82
|
91
|
In vitro correction of erythrocyte glucose 6-phosphate dehydrogenase (G6PD) deficiency.
|
Arch Biochem Biophys
|
1979
|
0.81
|
92
|
Fructose-1, 6-diphosphatase from rabbit liver.
|
Methods Enzymol
|
1975
|
0.81
|
93
|
Endogenous inhibitors of lysosomal proteinases.
|
Proc Natl Acad Sci U S A
|
1983
|
0.81
|
94
|
Rat brain contains multiple mRNAs for calpastatin.
|
FEBS Lett
|
1998
|
0.81
|
95
|
Laser phototherapy following HpD administration in superficial neoplastic lesions.
|
Tumori
|
1984
|
0.81
|
96
|
Protein kinase C-theta is specifically localized on centrosomes and kinetochores in mitotic cells.
|
Biochem J
|
1999
|
0.81
|
97
|
Ligand-induced conformational states of rabbit liver fructose 1,6-bisphosphatase as revealed by digestion with subtilisin.
|
Arch Biochem Biophys
|
1973
|
0.81
|
98
|
Different susceptibility of red cell membrane proteins to calpain degradation.
|
Arch Biochem Biophys
|
1992
|
0.81
|
99
|
Differentiation of murine erythroleukemia cells by hexamethylenebisacetamide involves secretion and binding to membranes of a differentiation enhancing factor.
|
Biochem Biophys Res Commun
|
1991
|
0.81
|
100
|
N,N-dialkylaminosubstituted chromones and isoxazoles as potential anti-inflammatory agents.
|
Farmaco
|
1999
|
0.80
|
101
|
Effect of low-energy laser irradiation on colony formation capability in different human tumor cells in vitro.
|
Lasers Surg Med
|
1989
|
0.80
|
102
|
Characterization of the inactive form of fructose-1,6-bisphosphate aldolase isolated from livers of fasted rabbits.
|
Proc Natl Acad Sci U S A
|
1982
|
0.80
|
103
|
In vitro photosensitizing properties of rhodamine 123 on different human tumor cell lines.
|
Photochem Photobiol
|
1988
|
0.80
|
104
|
The carboxy-terminal amino acid sequence of rabbit liver fructose 1,6-bisphosphatase.
|
Arch Biochem Biophys
|
1981
|
0.80
|
105
|
Acute effect of indapamide on urine calcium excretion in nephrolithiasis and human essential hypertension.
|
Pharmacology
|
1988
|
0.80
|
106
|
Modulation of inhibitory efficiency of rat skeletal muscle calpastatin by phosphorylation.
|
Biochem Biophys Res Commun
|
1992
|
0.80
|
107
|
IGF-I induced rapid recruitment of integrin beta1 to lipid rafts is Caveolin-1 dependent.
|
Biochem Biophys Res Commun
|
2009
|
0.80
|
108
|
Isovalerylcarnitine is a specific activator of calpain of human neutrophils.
|
Biochem Biophys Res Commun
|
1987
|
0.80
|
109
|
Decay of proteinase and peptidase activities of human and rabbit erythrocytes during cellular aging.
|
Biochim Biophys Acta
|
1981
|
0.80
|
110
|
Photodynamic therapy by topical meso-tetraphenylporphinesulfonate tetrasodium salt administration in superficial basal cell carcinomas.
|
Cancer Res
|
1990
|
0.80
|
111
|
Phosphorylation of rat brain calpastatins by protein kinase C.
|
FEBS Lett
|
1999
|
0.79
|
112
|
Changes in calpastatin localization and expression during calpain activation: a new mechanism for the regulation of intracellular Ca(2+)-dependent proteolysis.
|
Cell Mol Life Sci
|
2003
|
0.79
|
113
|
Effects of ethanol metabolism on PKC activity in isolated rat hepatocytes.
|
Chem Biol Interact
|
1996
|
0.79
|
114
|
Inactivation of fructose 1,6-bisphosphatase by a lysosomal proteinase is reversed by cystamine.
|
Arch Biochem Biophys
|
1982
|
0.79
|
115
|
Regulation of the Ca2+-dependent neutral proteinases from rabbit liver by an endogenous inhibitor.
|
Arch Biochem Biophys
|
1984
|
0.79
|
116
|
Erythrocyte deficiency in calpain inhibitor activity in essential hypertension.
|
Hypertension
|
1988
|
0.79
|
117
|
A vincristine-resistant murine erythroleukemia cell line secretes a differentiation enhancing factor.
|
Biochem Biophys Res Commun
|
1990
|
0.79
|
118
|
Temperature rise in biological tissue during Nd:YAG laser irradiation.
|
Lasers Surg Med
|
1985
|
0.79
|
119
|
Origin of tryptophan in fructose 1,6-bisphosphatase purified from livers of fed rabbits.
|
Arch Biochem Biophys
|
1978
|
0.79
|
120
|
Differentiation of HL60 promyelocytic cells is promoted by a 'differentiation enhancing factor' produced by erythroleukemia cells.
|
FEBS Lett
|
1993
|
0.79
|
121
|
Limited proteolysis of liver aldolase and fructose 1,6-bisphosphatase by lysosomal proteinases: effect on complex formation.
|
Proc Natl Acad Sci U S A
|
1982
|
0.79
|
122
|
The role of calpain in the selective increased phosphorylation of the anion-transport protein in red cell of hypertensive subjects.
|
Biochem Biophys Res Commun
|
1988
|
0.78
|
123
|
Comparative patterns of 'in vitro' oxidative hemolysis of normal and glucose 6-phosphate dehydrogenase (G6PD)-deficient erythrocytes.
|
FEBS Lett
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1981
|
0.78
|
124
|
Mechanisms of inactivation of hepatocyte protein kinase C isoforms following acute ethanol treatment.
|
Free Radic Biol Med
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1998
|
0.78
|
125
|
The role of intracellular proteinases in human neutrophil activation.
|
Revis Biol Celular
|
1989
|
0.78
|
126
|
Conversion of "neutral" to "alkaline" fructose 1,6-diphosphatase by controlled digestion with papain.
|
Arch Biochem Biophys
|
1971
|
0.78
|
127
|
Evidence for the selective release of lysosomal proteinases in fasted rabbits.
|
Biochimie
|
1976
|
0.78
|
128
|
The role of calpain and protein kinase C in activation of human neutrophils.
|
Prog Clin Biol Res
|
1988
|
0.78
|
129
|
The expression levels of the pro-apoptotic XAF-1 gene modulate the cytotoxic response to Nutlin-3 in B chronic lymphocytic leukemia.
|
Leukemia
|
2009
|
0.78
|
130
|
A 6 kDa protein homologous to the N-terminus of the HMG1 protein promoting stimulation of murine erythroleukemia cell differentiation.
|
FEBS Lett
|
1996
|
0.78
|
131
|
Mechanisms of perturbation of erythrocyte calcium homeostasis in favism.
|
Cell Calcium
|
1992
|
0.78
|
132
|
Preliminary clinical studies with PDT by topical TPPS administration in neoplastic skin lesions.
|
Lasers Surg Med
|
1987
|
0.77
|
133
|
Hormonal effects on structure and catalytic properties of fructose 1,6-bisphosphatase.
|
Proc Natl Acad Sci U S A
|
1975
|
0.77
|
134
|
Changes in calcium influx affect the differentiation of murine erythroleukaemia cells.
|
Biochem J
|
1995
|
0.77
|
135
|
Evidence for the modification of fructose 1,6-bisphosphatase by two distinct lysosomal proteases.
|
Biochem Biophys Res Commun
|
1974
|
0.77
|
136
|
Decreased level of calpain inhibitor activity in red blood cells from Milan hypertensive rats.
|
Biochem Biophys Res Commun
|
1986
|
0.77
|
137
|
Inactivation of hepatocyte protein kinase C by carbon tetrachloride: involvement of drug's metabolic activation and prooxidant effect.
|
Biochem Biophys Res Commun
|
1990
|
0.77
|
138
|
Participation of protein kinase C in the activation of human neutrophils by phorbol ester.
|
Ital J Biochem
|
1987
|
0.77
|
139
|
Binding of monoclonal antibody to cathepsin M located on the external surface of rabbit lysosomes.
|
Arch Biochem Biophys
|
1984
|
0.77
|
140
|
Modulation of the intracellular Ca(2+)-dependent proteolytic system is critically correlated with the kinetics of differentiation of murine erythroleukemia cells.
|
Eur J Biochem
|
1994
|
0.76
|
141
|
Decreased levels of soluble TNF-related apoptosis-inducing ligand (TRAIL) in the conjunctival sac fluid of patients with diabetes affected by proliferative retinopathy.
|
Diabet Med
|
2011
|
0.76
|
142
|
Protein kinase C-theta is specifically activated in murine erythroleukaemia cells during mitosis.
|
FEBS Lett
|
1999
|
0.76
|
143
|
Enhanced activation of the respiratory burst oxidase in neutrophils from hypertensive patients.
|
Biochem Biophys Res Commun
|
1989
|
0.76
|
144
|
The response of human natural killer cells to interleukin-2.
|
J Endocrinol Invest
|
2004
|
0.76
|
145
|
Differential regulation of mu- and m-calpain in rat hearts perfused with Ca2+ and cAMP.
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