Published in FEBS Lett on June 09, 2000
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. EMBO J (2002) 1.94
PIKfyve: Partners, significance, debates and paradoxes. Cell Biol Int (2008) 1.87
A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2008) 1.85
PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. EMBO J (2006) 1.45
Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells. Biochem J (2001) 1.41
The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation. Proc Natl Acad Sci U S A (2003) 1.37
A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5P and other phosphoinositides. Biochem J (2010) 1.34
Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron. Am J Physiol Renal Physiol (2008) 1.22
Identification of a new polyphosphoinositide in plants, phosphatidylinositol 5-monophosphate (PtdIns5P), and its accumulation upon osmotic stress. Biochem J (2001) 1.21
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. Proc Natl Acad Sci U S A (2005) 1.11
Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase. J Gen Physiol (2007) 1.07
Deciphering interplay between Salmonella invasion effectors. PLoS Pathog (2008) 1.04
A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation. PLoS One (2013) 1.00
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep (2012) 0.98
Type IIalpha phosphatidylinositol phosphate kinase associates with the plasma membrane via interaction with type I isoforms. Biochem J (2002) 0.98
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636. Am J Physiol Cell Physiol (2012) 0.96
Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice. PLoS Genet (2012) 0.93
Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development. Proc Natl Acad Sci U S A (2013) 0.90
Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates. Mol Pharmacol (2009) 0.89
Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases. Adv Enzyme Regul (2009) 0.88
Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain. J Comp Neurol (2009) 0.86
PtdIns5P: news and views of its appearance, disappearance and deeds. Arch Biochem Biophys (2013) 0.86
Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012). Bioessays (2014) 0.86
Regulation of type II PIP kinase by PKD phosphorylation. Cell Signal (2006) 0.84
The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness. J Biol Chem (2011) 0.83
Involvement of phosphatidylinositol 5-phosphate in insulin-stimulated glucose uptake in the L6 myotube model of skeletal muscle. Pflugers Arch (2011) 0.83
Measurement of phosphoinositides in the zebrafish Danio rerio. Nat Protoc (2013) 0.81
A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples. Biochem J (2012) 0.79
New methods for capturing the mystery lipid, PtdIns5P. Biochem J (2010) 0.76
The Effect of Gap Junctional Coupling on the Spatiotemporal Patterns of Ca2+ Signals and the Harmonization of Ca2+-Related Cellular Responses. PLoS Comput Biol (2016) 0.75
Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature (1984) 25.71
Inositol phosphates and cell signalling. Nature (1989) 17.78
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature (1983) 10.90
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J (1983) 10.35
Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices. Biochem J (1985) 5.79
The inositol tris/tetrakisphosphate pathway--demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues. Nature (1986) 5.41
Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+. Biochem J (1986) 4.84
Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands. Biochem J (1985) 4.19
myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver. J Biol Chem (1984) 4.11
Inositol trisphosphates in carbachol-stimulated rat parotid glands. Biochem J (1984) 4.05
How is the level of free arachidonic acid controlled in mammalian cells? Biochem J (1982) 3.96
The second messenger linking receptor activation to internal Ca release in liver. Nature (1984) 3.73
Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils. Nature (1991) 3.41
Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate. Nature (1984) 3.35
Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channels. Nature (1988) 3.29
Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor. Biochem J (1984) 3.07
Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland. Biochem J (1986) 3.04
Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells. Biochem J (1985) 2.82
Inositol (1,4,5)trisphosphate-promoted Ca2+ release from microsomal fractions of rat liver. Biochem Biophys Res Commun (1984) 2.66
Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. Nature (1992) 2.61
Phospholipid signalling in plants. Biochim Biophys Acta (1998) 2.52
Liberation of [3H]arachidonic acid and changes in cytosolic free calcium in fura-2-loaded human platelets stimulated by ionomycin and collagen. Biochem J (1986) 2.50
Phospholipid signaling. Cell (1995) 2.43
Specificity of inositol phosphate-stimulated Ca2+ mobilization from Swiss-mouse 3T3 cells. Biochem J (1986) 2.30
Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family. Nature (1995) 2.20
Specificity of inositol trisphosphate-induced calcium release from permeabilized Swiss-mouse 3T3 cells. Biochem J (1984) 2.18
Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate. Nature (1984) 2.11
Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity. Biochem J (1998) 2.05
Inositol tetrakis- and pentakisphosphates in GH4 cells. J Exp Biol (1985) 2.02
Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes. Biochem J (1984) 2.01
Effect of inositol-1,4,5-trisphosphate on isolated subcellular fractions of rat pancreas. J Membr Biol (1984) 2.00
myo-Inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors. Nature (1984) 1.96
Stepwise phosphorylation of myo-inositol leading to myo-inositol hexakisphosphate in Dictyostelium. Nature (1990) 1.87
Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate. Biochem J (1987) 1.86
Reduction of epidermal growth factor receptor affinity by heterologous ligands: evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C. Biochem Biophys Res Commun (1984) 1.83
Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms. Biochem J (1984) 1.77
Hydrolysis of membrane phospholipids by phospholipases of rat liver lysosomes. Biochem J (1979) 1.77
The hydrolysis of phosphatidylinositol by lysosomal enzymes of rat liver and brain. Biochem J (1978) 1.74
Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells. Biochem J (1984) 1.67
A rapid separation method for inositol phosphates and their isomers. Biochem J (1987) 1.64
Inositides and the nucleus and inositides in the nucleus. Cell (1993) 1.61
myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate. Biochem J (1991) 1.57
Inositol-containing lipids in suspension-cultured plant cells: an isotopic study. Plant Physiol (1988) 1.55
Effects of bombesin and insulin on inositol (1,4,5)trisphosphate and inositol (1,3,4)trisphosphate formation in Swiss 3T3 cells. Cell (1986) 1.55
Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment. J Biol Chem (2000) 1.54
PIPkins1, their substrates and their products: new functions for old enzymes. Biochim Biophys Acta (1998) 1.52
A family IIb xylan-binding domain has a similar secondary structure to a homologous family IIa cellulose-binding domain but different ligand specificity. Structure (1999) 1.52
Inositol 1,3,4,5-tetrakisphosphate is essential for sustained activation of the Ca2+-dependent K+ current in single internally perfused mouse lacrimal acinar cells. J Membr Biol (1989) 1.52
Long-chain unsaturated diacylglycerols cause a perturbation in the structure of phospholipid bilayers rendering them susceptible to phospholipase attack. Biochem Biophys Res Commun (1984) 1.52
The enzymology of stimulated inositol lipid turnover. Cell Calcium (1982) 1.51
Relationship between secretagogue-induced Ca2+ release and inositol polyphosphate production in permeabilized pancreatic acinar cells. J Biol Chem (1985) 1.45
Inositol(1,3,4,5)tetrakisphosphate-induced activation of sea urchin eggs requires the presence of inositol trisphosphate. Biochem Biophys Res Commun (1987) 1.44
Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation. Biochem J (1987) 1.43
Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells. Biochem J (2001) 1.41
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes. J Biol Chem (1987) 1.41
Phosphatidylinositol(4,5)bisphosphate and Phosphatidylinositol(4)phosphate in Plant Tissues. Plant Physiol (1989) 1.38
Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus. J Biol Chem (2001) 1.35
Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate. Biochem J (1989) 1.33
The calcium-dependent phosphatidylinositol-phosphodiesterase of rat brain. Mechanisms of suppression and stimulation. Eur J Biochem (1979) 1.28
Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7. Biochem J (2000) 1.26
Diacylglycerol potentiates phospholipase attack upon phospholipid bilayers: possible connection with cell stimulation. Biochem Biophys Res Commun (1983) 1.26
Inositol(3,4)bisphosphate and inositol(1,3)bisphosphate in GH4 cells--evidence for complex breakdown of inositol(1,3,4)trisphosphate. Biochem Biophys Res Commun (1987) 1.26
The distribution of calcium-dependent phosphatidylinositol-specific phosphodiesterase in rat brain. J Neurochem (1978) 1.25
Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase. Biochem J (1979) 1.25
Phosphatidylinositol phosphodiesterase in higher plants. Biochem J (1980) 1.25
The effect of ethylene on (1-14C)glycerol incorporation into phospholipids of etiolated pea stems. Biochem J (1973) 1.24
Phosphatidylinositol 4,5-bisphosphate phosphodiesterase in higher plants. Biochem J (1988) 1.23
Accumulation of inositol polyphosphate isomers in agonist-stimulated cerebral-cortex slices. Comparison with metabolic profiles in cell-free preparations. Biochem J (1989) 1.22
Synergistic control of Ca2+ mobilization in permeabilized mouse L1210 lymphoma cells by inositol 2,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate. Biochem J (1990) 1.21
Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform beta 1 is specifically, but not predominantly, located in the nucleus. Biochem J (1993) 1.21
Specific binding sites for [3H]inositol(1,3,4,5)tetrakisphosphate on membranes of HL-60 cells. Biochem Biophys Res Commun (1987) 1.19
PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase. FEBS Lett (1999) 1.19
Extraction and recovery of inositol phosphates from tissues. Biochem J (1987) 1.18
Spatial dynamics of intracellular calcium in agonist-stimulated vascular smooth muscle cells. Am J Physiol (1990) 1.17
Phosphatidylinositol-degrading enzymes in liver lysosomes. Biochem J (1977) 1.17
Inositol 1,3,4,5-tetrakisphosphate and inositol 1,4,5-trisphosphate act by different mechanisms when controlling Ca2+ in mouse lacrimal acinar cells. FEBS Lett (1989) 1.17
Metabolism and possible compartmentalization of inositol lipids in isolated rat-liver nuclei. Biochem J (1997) 1.16
Transfer of arachidonic acid between phospholipids in rat liver microsomes. Biochem Biophys Res Commun (1979) 1.16
Heterogeneity of the calcium-dependent phosphatidylinositol phosphodiesterase in rat brain. Biochem J (1982) 1.15
Proteolytic activation can produce a phosphatidylinositol phosphodiesterase highly sensitive to Ca2+. Biochem J (1982) 1.14
The hydrolysis of phosphatidylinositol monolayers at an air/water interface by the calcium-ion-dependent phosphatidylinositol phosphodiesterase of pig brain. Biochem J (1981) 1.13
Identification of diacylglycerol pyrophosphate as a novel metabolic product of phosphatidic acid during G-protein activation in plants. J Biol Chem (1996) 1.12
The cloning and sequence of the C isoform of PtdIns4P 5-kinase. Biochem J (1995) 1.11
Heterogeneity of the calcium-dependent phosphatidylinositol-phosphodiesterase of rat liver kidney, as revealed by column chromatofocusing. Biochem Biophys Res Commun (1982) 1.11