Published in Nat Med on July 01, 2000
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer (2008) 6.10
REST maintains self-renewal and pluripotency of embryonic stem cells. Nature (2008) 3.06
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature (2008) 2.46
The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells. J Neurosci (2011) 1.87
Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol (2006) 1.83
Medulloblastoma stem cells. J Clin Oncol (2008) 1.71
REST controls self-renewal and tumorigenic competence of human glioblastoma cells. PLoS One (2012) 1.58
Oct4 targets regulatory nodes to modulate stem cell function. PLoS One (2007) 1.52
Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Nat Cell Biol (2011) 1.49
Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death. Proc Natl Acad Sci U S A (2012) 1.48
Cancer stem cells in glioblastoma--molecular signaling and therapeutic targeting. Protein Cell (2010) 1.45
The many faces of neuroendocrine differentiation in prostate cancer progression. Front Oncol (2014) 1.43
Activation of REST/NRSF target genes in neural stem cells is sufficient to cause neuronal differentiation. Mol Cell Biol (2004) 1.35
Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level. Genome Res (2009) 1.30
Medulloblastoma: from molecular pathology to therapy. Clin Cancer Res (2008) 1.30
Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells. J Biol Chem (2009) 1.28
REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions. Cell Cycle (2010) 1.24
Regulation of non-coding RNA networks in the nervous system--what's the REST of the story? Neurosci Lett (2009) 1.16
Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma. Neuro Oncol (2007) 1.16
REST regulates DYRK1A transcription in a negative feedback loop. J Biol Chem (2011) 1.14
MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression. J Biol Chem (2008) 1.13
Conversion of myoblasts to physiologically active neuronal phenotype. Genes Dev (2004) 1.11
BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. J Biol Chem (2006) 1.10
REST and the RESTless: in stem cells and beyond. Future Neurol (2009) 1.06
Involvement of long noncoding RNAs in diseases affecting the central nervous system. RNA Biol (2012) 1.04
REST regulates oncogenic properties of glioblastoma stem cells. Stem Cells (2012) 1.00
The transcriptional repressor REST/NRSF modulates hedgehog signaling. Dev Biol (2010) 0.97
The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes. Elife (2014) 0.96
Squelching glioblastoma stem cells by targeting REST for proteasomal degradation. Trends Neurosci (2009) 0.95
The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit. Cell Cycle (2013) 0.94
SPARC stimulates neuronal differentiation of medulloblastoma cells via the Notch1/STAT3 pathway. Cancer Res (2011) 0.91
The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1). Mol Cell Biol (2001) 0.89
EWS-FLI-1 regulates the neuronal repressor gene REST, which controls Ewing sarcoma growth and vascular morphology. Cancer (2014) 0.88
Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres. J Oncol (2011) 0.88
A genome-wide screen for genetic variants that modify the recruitment of REST to its target genes. PLoS Genet (2012) 0.86
The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation. Oncogene (2012) 0.85
REST is a novel prognostic factor and therapeutic target for medulloblastoma. Mol Cancer Ther (2012) 0.85
Reconstitution of enhancer function in paternal pronuclei of one-cell mouse embryos. Mol Cell Biol (2001) 0.85
A REST derived gene signature stratifies glioblastomas into chemotherapy resistant and responsive disease. BMC Genomics (2012) 0.85
ChIP-Seq Data Mining: Remarkable Differences in NRSF/REST Target Genes between Human ESC and ESC-Derived Neurons. Bioinform Biol Insights (2013) 0.85
The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife (2016) 0.85
Ubiquitination and deubiquitination of REST and its roles in cancers. FEBS Lett (2012) 0.84
The RE1 binding protein REST regulates oligodendrocyte differentiation. J Neurosci (2011) 0.84
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The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1. BMB Rep (2014) 0.83
Eradicating the mediators of neuronal death with a fine-tooth comb. Sci Signal (2010) 0.80
Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders. Int Rev Neurobiol (2003) 0.79
Involvement of REST corepressor 3 in prognosis of human hepatitis B. Acta Pharmacol Sin (2011) 0.79
Stem cells have different needs for REST. PLoS Biol (2008) 0.79
DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis. Mol Cell Oncol (2015) 0.79
Binding of hnRNP H and U2AF65 to respective G-codes and a poly-uridine tract collaborate in the N50-5'ss selection of the REST N exon in H69 cells. PLoS One (2012) 0.78
Chromatin-modifying agents for epigenetic reprogramming and endogenous neural stem cell-mediated repair in stroke. Transl Stroke Res (2011) 0.78
Myoblast-derived neuronal cells form glutamatergic neurons in the mouse cerebellum. Stem Cells (2010) 0.78
Regulation of neural gene transcription by optogenetic inhibition of the RE1-silencing transcription factor. Proc Natl Acad Sci U S A (2015) 0.77
Selective repression of gene expression in neuropathic pain by the neuron-restrictive silencing factor/repressor element-1 silencing transcription (NRSF/REST). Neurosci Lett (2015) 0.77
Epigenetics, nervous system tumors, and cancer stem cells. Cancers (Basel) (2011) 0.77
Regulation of mGluR1 expression in human melanocytes and melanoma cells. Biochim Biophys Acta (2012) 0.76
The REST gene signature predicts drug sensitivity in neuroblastoma cell lines and is significantly associated with neuroblastoma tumor stage. Int J Mol Sci (2014) 0.76
Stepwise assembly of functional C-terminal REST/NRSF transcriptional repressor complexes as a drug target. Protein Sci (2017) 0.75
An expression based REST signature predicts patient survival and therapeutic response for glioblastoma multiforme. Sci Rep (2016) 0.75
The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma. Mol Brain (2015) 0.75
The Importance of REST for Development and Function of Beta Cells. Front Cell Dev Biol (2017) 0.75
RE1 silencing transcription factor (REST) negatively regulates ALL1-fused from chromosome 1q (AF1q) gene transcription. BMC Mol Biol (2015) 0.75
REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer. Sci Rep (2017) 0.75
CDRI-08 Attenuates REST/NRSF-Mediated Expression of NMDAR1 Gene in PBDE-209-Exposed Mice Brain. Evid Based Complement Alternat Med (2015) 0.75
Regulation of USP37 Expression by REST-associated G9a-dependent Histone Methylation. Mol Cancer Res (2017) 0.75
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet (2000) 5.28
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