Published in Cell on August 04, 2000
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol (2008) 3.94
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The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK. EMBO J (2004) 1.25
Dual role of Cdc42 in spindle orientation control of adherent cells. Mol Cell Biol (2009) 1.24
PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway. J Biol Chem (2008) 1.24
Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer. Biochem Pharmacol (2010) 1.24
Molecular pathways: targeting p21-activated kinase 1 signaling in cancer--opportunities, challenges, and limitations. Clin Cancer Res (2012) 1.22
Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes. J Am Chem Soc (2008) 1.21
Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts. J Virol (2004) 1.20
Autoinhibition mechanism of proto-Dbl. Mol Cell Biol (2001) 1.18
GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. Mol Cell Biol (2003) 1.18
Biochemical and structural characterization of the Pak1-LC8 interaction. J Biol Chem (2008) 1.17
P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration. J Cell Biol (2002) 1.17
Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Mol Cell Biol (2006) 1.16
Localized activation of p21-activated kinase controls neuronal polarity and morphology. J Neurosci (2007) 1.15
A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nat Cell Biol (2014) 1.15
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PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. Mol Biol Cell (2005) 1.12
Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J (2003) 1.12
Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1. Proc Natl Acad Sci U S A (2001) 1.09
Dictyostelium PAKc is required for proper chemotaxis. Mol Biol Cell (2004) 1.09
P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion. J Biol Chem (2012) 1.07
PAK family kinases: Physiological roles and regulation. Cell Logist (2012) 1.06
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The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells. J Clin Invest (2009) 1.05
Molecular basis of actin nucleation factor cooperativity: crystal structure of the Spir-1 kinase non-catalytic C-lobe domain (KIND)•formin-2 formin SPIR interaction motif (FSI) complex. J Biol Chem (2011) 1.05
Genetic analysis of the interface between Cdc42p and the CRIB domain of Ste20p in Saccharomyces cerevisiae. Genetics (2003) 1.04
Oligomerization of DH domain is essential for Dbl-induced transformation. Mol Cell Biol (2001) 1.03
Mitotic exit regulation through distinct domains within the protein kinase Cdc15. Mol Cell Biol (2003) 1.03
Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc Natl Acad Sci U S A (2000) 1.02
Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration. Am J Respir Crit Care Med (2007) 1.01
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Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin. Mol Biol Cell (2010) 1.00
Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp. Biochem J (2007) 1.00
Regulation of cardiac excitation and contraction by p21 activated kinase-1. Prog Biophys Mol Biol (2009) 0.99
Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. Mol Cell Biol (2001) 0.99
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. Mol Cell Biol (2001) 0.99
Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration. J Biol Chem (2009) 0.98
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc Natl Acad Sci U S A (2012) 0.98
p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils. Blood (2005) 0.97
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A measured approach: determining the PLCγ1 docking site on Itk using a biochemical ruler. J Mol Biol (2012) 0.95
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PAK1-Nck regulates cyclin D1 promoter activity in response to prolactin. Mol Endocrinol (2011) 0.94
XPak3 promotes cell cycle withdrawal during primary neurogenesis in Xenopus laevis. EMBO J (2002) 0.94
Oxidized LDL/CD36 interaction induces loss of cell polarity and inhibits macrophage locomotion. Mol Biol Cell (2012) 0.94
Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway. Cell Death Dis (2011) 0.92
Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture. Structure (2008) 0.92
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