Published in J Biol Chem on September 15, 2000
ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nat Genet (2004) 2.85
Kir6.2 is required for adaptation to stress. Proc Natl Acad Sci U S A (2002) 2.60
On the mechanism of MgATP-dependent gating of CFTR Cl- channels. J Gen Physiol (2003) 2.39
Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel. J Gen Physiol (2010) 2.09
Muscle KATP channels: recent insights to energy sensing and myoprotection. Physiol Rev (2010) 2.06
Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating. J Gen Physiol (2003) 2.03
ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch (2006) 1.47
ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart. J Mol Cell Cardiol (2005) 1.38
The molecular basis of the specificity of action of K(ATP) channel openers. EMBO J (2000) 1.27
Nucleotide-gated KATP channels integrated with creatine and adenylate kinases: amplification, tuning and sensing of energetic signals in the compartmentalized cellular environment. Mol Cell Biochem (2004) 1.26
Gating mechanism of KATP channels: function fits form. J Gen Physiol (2003) 1.17
Potassium channel regulation. EMBO Rep (2003) 1.07
Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor. J Biol Chem (2008) 1.03
Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides. Br J Pharmacol (2002) 1.03
A novel ABCC8 (SUR1)-dependent mechanism of metabolism-excitation uncoupling. J Biol Chem (2008) 0.95
Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels. J Physiol (2005) 0.95
Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. Biochem J (2004) 0.93
Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1. J Gen Physiol (2010) 0.92
Two neonatal diabetes mutations on transmembrane helix 15 of SUR1 increase affinity for ATP and ADP at nucleotide binding domain 2. J Biol Chem (2012) 0.89
ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding. J Lipid Res (2011) 0.88
Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2. J Physiol (2004) 0.88
Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating. J Gen Physiol (2011) 0.88
Role for SUR2A ED domain in allosteric coupling within the K(ATP) channel complex. J Gen Physiol (2008) 0.87
K(ATP) channels process nucleotide signals in muscle thermogenic response. Crit Rev Biochem Mol Biol (2010) 0.87
Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding. EMBO J (2002) 0.87
Binding and effect of K ATP channel openers in the absence of Mg2+. Br J Pharmacol (2003) 0.85
Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes. Diabetes (2011) 0.84
Remodelling of the SUR-Kir6.2 interface of the KATP channel upon ATP binding revealed by the conformational blocker rhodamine 123. J Physiol (2007) 0.83
Sensitivity of KATP channels to cellular metabolic disorders and the underlying structural basis. Acta Pharmacol Sin (2016) 0.83
K(ATP) channel action in vascular tone regulation: from genetics to diseases. Sheng Li Xue Bao (2012) 0.82
The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits. J Physiol (2007) 0.80
Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study. J Gen Physiol (2014) 0.79
Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31. Br J Pharmacol (2002) 0.79
Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: possible role in glucose sensing. J Cell Biochem (2013) 0.78
Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels. Philos Trans R Soc Lond B Biol Sci (2016) 0.77
The mutation Y1206S increases the affinity of the sulphonylurea receptor SUR2A for glibenclamide and enhances the effects of coexpression with Kir6.2. Br J Pharmacol (2005) 0.77
A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening. J Physiol (2012) 0.76
The Nucleotide-Binding Sites of SUR1: A Mechanistic Model. Biophys J (2015) 0.75
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell (1986) 8.53
Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci U S A (1987) 5.65
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc Natl Acad Sci U S A (1987) 4.43
Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J Biol Chem (2000) 4.02
A simple method for determining the modulation transfer function in digital radiography. IEEE Trans Med Imaging (1992) 3.79
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science (1992) 3.41
ADP-ribosylation. Annu Rev Biochem (1985) 3.30
The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation. J Biol Chem (1987) 3.13
Poly(ADP-ribose) and ADP-ribosylation of proteins. Annu Rev Biochem (1977) 3.08
A principal target of human immunity to malaria identified by molecular population genetic and immunological analyses. Nat Med (2000) 3.06
Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study. Neurology (1995) 2.99
Bleed of and biologic response to triglyceride filler used in radiolucent breast implants. Plast Reconstr Surg (1996) 2.69
Role of the unfolded protein response in cell death. Apoptosis (2006) 2.39
Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem (1992) 2.14
Octamer-binding sequence is a key element for the autoregulation of Kaposi's sarcoma-associated herpesvirus ORF50/Lyta gene expression. J Virol (2001) 2.13
S phase specific formation of the human Rad51 protein nuclear foci in lymphocytes. Oncogene (1996) 2.09
Studies on the polymer of adenosine diphosphate ribose. I. Enzymic formation from nicotinamide adenine dinuclotide in mammalian nuclei. J Biol Chem (1967) 2.08
Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis. J Biol Chem (1998) 2.04
Migration of Escherichia coli dnaB protein on the template DNA strand as a mechanism in initiating DNA replication. Proc Natl Acad Sci U S A (1977) 2.03
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J Biol Chem (1992) 2.01
dnaB protein of Escherichia coli. Purification and role in the replication of phiX174 DNA. J Biol Chem (1978) 1.91
Current status of organ transplantation in Japan. Am J Transplant (2011) 1.89
Site of action of adrenocorticotropic hormone (ACTH) in adrenal cell cultures. Biochem Biophys Res Commun (1968) 1.87
Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem (1993) 1.87
Poly(ADP-ribose) synthetase, a main acceptor of poly(ADP-ribose) in isolated nuclei. J Biol Chem (1981) 1.78
Detection of the minus strand of hepatitis C virus RNA by reverse transcription and polymerase chain reaction: implications for hepatitis C virus replication in infected tissue. Hepatology (1992) 1.77
Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver. Pharmacol Rev (1998) 1.76
Observation of the intrinsic pinning of a magnetic domain wall in a ferromagnetic nanowire. Nat Mater (2011) 1.76
Snake venom phosphodiesterase: simple purification with Blue Sepharose and its application to poly(ADP-ribose) study. Biochem Biophys Res Commun (1978) 1.71
Transcriptional regulation of the Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor gene. J Virol (2000) 1.71
The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem Biophys Res Commun (1986) 1.71
Cloning and sequencing of cDNA that encodes goat growth hormone. FEBS Lett (1988) 1.70
Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET. Eur J Biochem (2001) 1.68
Correlation between the blood supply and grade of malignancy of hepatocellular nodules associated with liver cirrhosis: evaluation by CT during intraarterial injection of contrast medium. AJR Am J Roentgenol (1999) 1.68
Beneficial effect of prodromal angina pectoris is lost in elderly patients with acute myocardial infarction. Am Heart J (2000) 1.66
Implications of prodromal angina pectoris in anterior wall acute myocardial infarction: acute angiographic findings and long-term prognosis. J Am Coll Cardiol (1997) 1.66
Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator. Proc Natl Acad Sci U S A (2001) 1.65
Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization. J Cell Biol (1999) 1.65
Physical and genetic mapping of the Salmonella dublin virulence plasmid pSDL2. Relationship to plasmids from other Salmonella strains. J Clin Invest (1988) 1.63
Cortical hyperostosis following long-term administration of prostaglandin E1 in infants with cyanotic congenital heart disease. J Pediatr (1980) 1.62
A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc Natl Acad Sci U S A (1988) 1.60
Identification and analysis of the K5 gene of Kaposi's sarcoma-associated herpesvirus. J Virol (2000) 1.58
Chick embryo DNA polymerase alpha. Polypeptide components and their microheterogeneity. J Biol Chem (1982) 1.57
Deficiency of serum cholesteryl-ester transfer activity in patients with familial hyperalphalipoproteinaemia. Atherosclerosis (1985) 1.55
Bone metastasis and poor performance status are prognostic factors for survival of carcinoma of unknown primary site in patients treated with systematic chemotherapy. Ann Oncol (2009) 1.54
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem (1990) 1.54
Enzymic adenosine diphosphoribosylation of nuclear proteins. Cold Spring Harb Symp Quant Biol (1969) 1.54
Stearylated arginine-rich peptides: a new class of transfection systems. Bioconjug Chem (2001) 1.53
Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP. J Biol Chem (1999) 1.52
Predominant activation and expansion of V gamma 9-bearing gamma delta T cells in vivo as well as in vitro in Salmonella infection. J Clin Invest (1992) 1.52
Natural occurrence of poly(ADP-ribosyl) histones in rat liver. Proc Natl Acad Sci U S A (1975) 1.52
Human cytotoxic T-lymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1 ) product. Immunogenetics (2000) 1.51
Effect of T-cell transfer on Pneumocystis carinii infection in nude mice. Jpn J Exp Med (1984) 1.50
Induction of anaesthesia in the lateral decubitus position in morbidly obese patients. Br J Anaesth (1999) 1.49
Acute eosinophilic pneumonia caused by cigarette smoking. Intern Med (2000) 1.49
Transcriptional activator Tax of HTLV-1 binds to the NF-kappa B precursor p105. Oncogene (1992) 1.49
Inhibition of oxidation of low-density lipoprotein with red wine. Lancet (1994) 1.48
Characterization of rabies viruses recovered from persistently infected BHK cells. Virology (1975) 1.47
Cellular and humoral immune responses of mice subclinically infected with Pneumocystis carinii. Infect Immun (1985) 1.45
N-methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K). Clin Pharmacol Ther (2012) 1.45
Enzymic adenosine diphosphate ribosylation of histone and poly adenosine diphosphate ribose synthesis in rat liver nuclei. J Biol Chem (1968) 1.45
Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer. J Natl Cancer Inst (1990) 1.44
Aberrant gastric venous drainage in cirrhotic livers: imaging findings in focal areas of liver parenchyma. Radiology (1995) 1.44
Dermis-fat graft after parotidectomy to prevent Frey's syndrome and the concave deformity. Ann Plast Surg (1993) 1.44
Haptoglobin therapy for acute favism: a Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara. Br J Haematol (1995) 1.42
Long PCR amplification of Plasmodium falciparum DNA extracted from filter paper blots. Exp Parasitol (2001) 1.41
Features and outcome of advanced neuroblastoma with distant lymph node metastasis. Pediatr Hematol Oncol (1992) 1.41
Reversed-phase high-performance liquid chromatographic assay method for quantitating 6-mercaptopurine and its methylated and non-methylated metabolites in a single sample. J Chromatogr B Biomed Sci Appl (1998) 1.41
HeLa ZIP kinase induces diphosphorylation of myosin II regulatory light chain and reorganization of actin filaments in nonmuscle cells. Oncogene (2001) 1.41
Cohort effect on HTLV-I seroprevalence in southern Japan. Lancet (1989) 1.41
LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. Biochem J (2001) 1.40
Allelic diversity and antibody recognition of Plasmodium falciparum merozoite surface protein 1 during hypoendemic malaria transmission in the Brazilian amazon region. Infect Immun (1999) 1.40
Decreasing trend in incidence and mortality from stroke in Hisayama residents, Japan. Stroke (1981) 1.40
Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro. Oncogene (1999) 1.40
Blood pressure measurement in preschool children: the Hisayama Study. J Paediatr Child Health (1997) 1.39
Intrauterine depressed skull fracture. A report of two cases. Pediatr Neurosci (1989) 1.39
Clinical effect of canal plugging on paroxysmal positional vertigo. J Laryngol Otol (2000) 1.39
Long-term effect of retrobulbar hematomas on the vision of cynomolgus monkeys. Plast Reconstr Surg (1992) 1.39
Infantile multiple sclerosis with extensive white matter lesions. Pediatr Neurol (1989) 1.39
Henoch-Schönlein purpura in an elderly patient with unusual manifestation. Endoscopy (2007) 1.39
Liposteroid against refractory pulmonary haemorrhage in idiopathic pulmonary haemosiderosis. Eur J Pediatr (1994) 1.39
Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide. Proc Natl Acad Sci U S A (1999) 1.39
Repeated quantitative angiograms in coronary arterial aneurysm in Kawasaki disease. Am J Cardiol (1985) 1.39
Successful zonisamide treatment for infants with hypsarrhythmia. Pediatr Neurol (2000) 1.38
ADP-ribosylation of histone H1. Identification of glutamic acid residues 2, 14, and the COOH-terminal lysine residue as modification sites. J Biol Chem (1980) 1.38
Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J Pharmacol Exp Ther (1992) 1.35
Amplification by polymerase chain reaction of Plasmodium falciparum DNA from Giemsa-stained thin blood smears. Mol Biochem Parasitol (1995) 1.35
Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors. Cancer Res (1991) 1.34
Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8. J Gen Virol (2001) 1.34
The chloroplast clpP gene, encoding a proteolytic subunit of ATP-dependent protease, is indispensable for chloroplast development in tobacco. Plant Cell Physiol (2001) 1.32
Relationship between progressive microvascular damage and intramyocardial hemorrhage in patients with reperfused anterior myocardial infarction: myocardial contrast echocardiographic study. Circulation (1997) 1.32
Long-term efficacy of low-density lipoprotein apheresis on coronary heart disease in familial hypercholesterolemia. Hokuriku-FH-LDL-Apheresis Study Group. Am J Cardiol (1998) 1.32
Experimental Pneumocystis carinii infection in nude rats. Jpn J Exp Med (1984) 1.31
Inflammatory cytokines in virus-associated hemophagocytic syndrome. Interferon-gamma as a sensitive indicator of disease activity. Am J Pediatr Hematol Oncol (1993) 1.30
Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomes. Hum Mol Genet (2000) 1.30
The development of real-time two-dimensional Doppler echocardiography and its clinical significance in acquired valvular diseases. With special reference to the evaluation of valvular regurgitation. Jpn Heart J (1984) 1.30
Differential localization of non-muscle myosin II isoforms and phosphorylated regulatory light chains in human MRC-5 fibroblasts. FEBS Lett (2001) 1.30
An in vitro system for infection with hepatitis B virus that uses primary human fetal hepatocytes. Proc Natl Acad Sci U S A (1989) 1.30