Published in EMBO J on July 17, 2000
Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells. PLoS One (2014) 0.84
A competition mechanism for a homeotic neuron identity transformation in C. elegans. Dev Cell (2015) 0.82
The Homeobox Genes of Caenorhabditis elegans and Insights into Their Spatio-Temporal Expression Dynamics during Embryogenesis. PLoS One (2015) 0.76
Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene (1989) 60.30
Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J (1991) 23.69
The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev (1988) 8.11
Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans. Dev Biol (1981) 4.93
The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell (1990) 4.87
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature (2000) 4.01
Mutations that lead to reiterations in the cell lineages of C. elegans. Cell (1981) 3.89
Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors. Proc Natl Acad Sci U S A (1997) 3.32
The mec-3 gene of Caenorhabditis elegans requires its own product for maintained expression and is expressed in three neuronal cell types. Genes Dev (1989) 3.00
Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons. Science (1989) 2.73
A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Nature (1988) 2.62
Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans. Dev Biol (1981) 2.55
A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors. Cell (1992) 2.43
The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J (1992) 2.36
Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron (1997) 2.34
mec-7 is a beta-tubulin gene required for the production of 15-protofilament microtubules in Caenorhabditis elegans. Genes Dev (1989) 2.33
Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. Science (1991) 2.27
Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3. Science (1993) 2.07
A stomatin-like protein necessary for mechanosensation in C. elegans. Nature (1995) 2.00
Recognition of the surface of a homeo domain protein. Genes Dev (1992) 1.85
Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility. Genes Dev (1997) 1.70
The mec-3 gene contains cis-acting elements mediating positive and negative regulation in cells produced by asymmetric cell division in Caenorhabditis elegans. Genes Dev (1991) 1.64
The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the Lim-homeodomain gene Lim3/Lhx3. Mol Endocrinol (1998) 1.61
Regulation of touch receptor differentiation by the Caenorhabditis elegans mec-3 and unc-86 genes. Development (1998) 1.57
Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3. EMBO J (1992) 1.45
Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements. Science (1991) 1.36
Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans. Development (1993) 1.35
Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B. Genes Dev (1996) 1.32
M-phase-specific phosphorylation of the POU transcription factor GHF-1 by a cell cycle-regulated protein kinase inhibits DNA binding. Mol Cell Biol (1995) 1.25
Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Genes Dev (1996) 1.24
Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface. Genes Dev (1999) 1.15
OCA-B is a functional analog of VP16 but targets a separate surface of the Oct-1 POU domain. Mol Cell Biol (1997) 1.15
Coactivator OBF-1 makes selective contacts with both the POU-specific domain and the POU homeodomain and acts as a molecular clamp on DNA. Mol Cell Biol (1998) 1.12
The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors. J Biol Chem (1997) 1.02
The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron. Genes Dev (1999) 1.02
Synergistic activation of the rat growth hormone promoter by Pit-1 and the thyroid hormone receptor. Mol Endocrinol (1992) 1.02
Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression. Mol Cell Biol (1997) 1.01
Functional roles of amino acid residues involved in forming the alpha-helix-turn-alpha-helix operator DNA binding motif of Tet repressor from Tn10. Proteins (1992) 0.99
CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression. J Clin Invest (1999) 0.93
Identification of amino acid residues in the Caenorhabditis elegans POU protein UNC-86 that mediate UNC-86-MEC-3-DNA ternary complex formation. Mol Cell Biol (2000) 0.83
A direct protein-protein interaction is involved in the cooperation between thyroid hormone and retinoic acid receptors and the transcription factor GHF-1. FASEB J (1998) 0.81
Promoter sequences for the establishment of mec-3 expression in the nematode Caenorhabditis elegans. Mech Dev (1996) 0.78
Fine mapping of protein interaction surfaces with a PCR-based mutagenesis screen in yeast. Trends Genet (1996) 0.77
A threonine to alanine exchange at position 40 of Tet repressor alters the recognition of the sixth base pair of tet operator from GC to AT. EMBO J (1988) 2.13
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nat Cell Biol (2000) 1.87
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. J Biol Chem (1999) 1.87
Thermal avoidance in Caenorhabditis elegans: an approach to the study of nociception. Proc Natl Acad Sci U S A (1999) 1.67
The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing. J Biol Chem (1999) 1.21
Amino acids determining operator binding specificity in the helix-turn-helix motif of Tn10 Tet repressor. EMBO J (1991) 1.19
Selection for Tn10 tet repressor binding to tet operator in Escherichia coli: isolation of temperature-sensitive mutants and combinatorial mutagenesis in the DNA binding motif. Genetics (1991) 1.14
C. elegans metallothioneins: new insights into the phenotypic effects of cadmium toxicosis. J Mol Biol (2004) 1.14
Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch. Nat Cell Biol (2000) 1.04
Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1. EMBO J (2002) 1.04
Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch. Proc Natl Acad Sci U S A (2000) 0.96
Presenilin is required for proper morphology and function of neurons in C. elegans. Nature (2000) 0.95
[Postnatal growth of the nasal cavity]. Gegenbaurs Morphol Jahrb (1982) 0.93
[Postnatal development of the width and height of the palate and the palate foramina]. Anat Anz (1984) 0.92
A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells. J Biol Chem (2000) 0.91
A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques. J Biol Chem (2000) 0.90
Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling. Neuroreport (1998) 0.90
The Caenorhabditis elegans Ldb/NLI/Clim orthologue ldb-1 is required for neuronal function. Dev Biol (2000) 0.88
Identification of amino acid residues in the Caenorhabditis elegans POU protein UNC-86 that mediate UNC-86-MEC-3-DNA ternary complex formation. Mol Cell Biol (2000) 0.83
The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation. J Biol Chem (1999) 0.83
In vivo fluorescence microscopy for the assessment of microvascular reperfusion injury in small bowel transplants in rats. Transplantation (1994) 0.83
The Tn10-encoded tetracycline resistance mRNA contains a translational silencer in the 5' nontranslated region. J Bacteriol (1992) 0.81
[Update on special surgical approaches in the therapy for lymphedemas]. Handchir Mikrochir Plast Chir (2012) 0.79
Chylothorax and chylous ascites. Clinical utility of planar scintigraphy and tomographic imaging with SPECT/CT. Nuklearmedizin (2015) 0.77
Comparative investigations on the activity of thiosulphate-sulphur transferase. Naturwissenschaften (1969) 0.77
Magnetic resonance imaging versus lymphoscintigraphy for the assessment of focal lymphatic transport disorders of the lower limb: first experiences. Nuklearmedizin (2014) 0.75
Proteolytic processing of Alzheimer's disease associated proteins. J Neural Transm Suppl (1998) 0.75
[Care of a patient with endogenous paranoid-hallucinatory psychosis]. Dtsch Krankenpflegez (1976) 0.75
[Microvascular facial profile-plasty in facial hemiatrophy]. Laryngol Rhinol Otol (Stuttg) (1988) 0.75
[MR lymphangiography for assessment of focal dermal backflow for presurgical work-up in patients with peripheral lymphoedema]. Handchir Mikrochir Plast Chir (2012) 0.75
What do we learn from a few familial Alzheimer's disease cases? J Neural Transm Suppl (1998) 0.75
Endoscopic-assisted microsurgery: microsurgery in the new millennium? A comparative experimental study. Br J Plast Surg (2003) 0.75
The influence of tobacco smoke and nicotine on thiocyanate metabolism. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol (1969) 0.75
Group A streptococcal toxic shock syndrome with severe necrotizing fasciitis following hysterectomy--a case report. Intensive Care Med (1998) 0.75
[Microvascular palate replacement-plasty]. Laryngorhinootologie (1990) 0.75
[Microsurgical reconstruction of large 3-layer defects of the cheek]. Laryngol Rhinol Otol (Stuttg) (1987) 0.75
The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research. Eur Arch Psychiatry Clin Neurosci (1999) 0.75
[Skin plastic surgery and skin transplantation]. Chirurg (1975) 0.75