Published in Cell Mol Neurobiol on August 01, 2000
The role of tau in neurodegeneration. Mol Neurodegener (2009) 1.54
Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies. J Alzheimers Dis (2008) 1.22
The importance of tau phosphorylation for neurodegenerative diseases. Front Neurol (2013) 1.05
Ectosomes: a new mechanism for non-exosomal secretion of tau protein. PLoS One (2014) 0.92
Roles of tau protein in health and disease. Acta Neuropathol (2017) 0.80
The distribution of tau in the mammalian central nervous system. J Cell Biol (1985) 7.47
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem (1986) 6.91
Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol Biol Cell (1992) 5.11
Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol (1977) 4.42
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci (1992) 4.10
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron (1993) 3.45
Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains. Mol Cell Biol (1989) 3.09
Tau protein function in living cells. J Cell Biol (1986) 2.89
Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons. Nature (1990) 2.79
Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau. J Cell Sci (1992) 2.42
Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain. J Cell Biol (1995) 2.29
The microtubule binding domain of tau protein. Neuron (1989) 2.17
Tau interacts with src-family non-receptor tyrosine kinases. J Cell Sci (1998) 2.11
The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. Proc Natl Acad Sci U S A (1993) 1.99
Defective brain microtubule assembly in Alzheimer's disease. Lancet (1986) 1.89
Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids. J Biol Chem (1987) 1.81
Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF. Brain Res (1993) 1.74
Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci U S A (1997) 1.73
Distribution of tau proteins in the normal human central and peripheral nervous system. J Histochem Cytochem (1989) 1.71
Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner. J Neurosci (1996) 1.61
Tau is enriched on dynamic microtubules in the distal region of growing axons. J Neurosci (1996) 1.59
Tau in Alzheimer's disease. Trends Cell Biol (1998) 1.50
Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation. J Cell Biol (1989) 1.40
Microtubule-binding domain of tau proteins. J Biol Chem (1988) 1.23
Amyloid beta protein potentiates Ca2+ influx through L-type voltage-sensitive Ca2+ channels: a possible involvement of free radicals. J Neurochem (1997) 1.21
The effect of tau antisense oligonucleotides on neurite formation of cultured cerebellar macroneurons. J Neurosci (1991) 1.18
Both adult and juvenile tau microtubule-associated proteins are axon specific in the developing and adult rat cerebellum. Neuroscience (1988) 1.08
Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5. Mol Cell Biochem (1997) 1.07
Proteolysis of tau by calpain. Biochem Biophys Res Commun (1989) 1.04
Tau confers drug stability but not cold stability to microtubules in living cells. J Cell Sci (1994) 1.01
Identification of tau protein regions required for process formation in PC12 cells. J Cell Sci (1994) 0.99
Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline-dependent protein kinases and GSK-3. FEBS Lett (1995) 0.96
Modulation of GSK-3-catalyzed phosphorylation of microtubule-associated protein tau by non-proline-dependent protein kinases. FEBS Lett (1995) 0.93
Calpain-induced proteolysis of normal human tau and tau associated with paired helical filaments. Eur J Biochem (1995) 0.93
beta-Amyloid peptide fragment 25-35 potentiates the calcium-dependent release of excitatory amino acids from depolarized hippocampal slices. J Neurosci Res (1995) 0.90
Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein. J Neurochem (1993) 0.89
Microtubule-associated protein tau is required for axonal neurite elaboration by neuroblastoma cells. J Neurosci Res (1992) 0.89
Molecular dissection of the paired helical filament. Neurobiol Aging (1995) 0.86
Phosphorylation, calpain proteolysis and tubulin binding of recombinant human tau isoforms. Brain Res (1993) 0.86
Microtubule-associated proteins, phosphorylation gradients, and the establishment of neuronal polarity. Perspect Dev Neurobiol (1996) 0.85
Neurodegeneration mediated by glutamate and beta-amyloid peptide: a comparison and possible interaction. Brain Res (1995) 0.85
Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: involvement of calpain-mediated hydrolysis of protein kinase C. J Neurochem (1996) 0.84
Respective roles of neurofilaments, microtubules, MAP1B, and tau in neurite outgrowth and stabilization. Mol Biol Cell (1994) 0.84
Calpain-mediated proteolysis of microtubule-associated protein 2 (MAP-2) is inhibited by phosphorylation by cAMP-dependent protein kinase, but not by Ca2+/calmodulin-dependent protein kinase II. J Neurosci Res (1993) 0.83
Phospholipids alter tau conformation, phosphorylation, proteolysis, and association with microtubules: implication for tau function under normal and degenerative conditions. J Neurosci Res (1997) 0.82
Hyperphosphorylation of the cytoskeletal protein Tau by the MAP-kinase PK40erk2: regulation by prior phosphorylation with cAMP-dependent protein kinase A. Biochem Biophys Res Commun (1995) 0.82
beta-Amyloid protein amplifies calcium signalling in central neurons from the adult mouse. Biochem Biophys Res Commun (1993) 0.80
Hyperphosphorylation of human TAU by brain kinase PK40erk beyond phosphorylation by cAMP-dependent PKA: relation to Alzheimer's disease. Biochem Biophys Res Commun (1994) 0.79
Hyperactivation of mitogen-activated protein kinase increases phospho-tau immunoreactivity within human neuroblastoma: additive and synergistic influence of alteration of additional kinase activities. Cell Mol Neurobiol (1999) 0.79
Beta-amyloid and ionophore A23187 evoke tau hyperphosphorylation by distinct intracellular pathways: differential involvement of the calpain/protein kinase C system. J Neurosci Res (1997) 0.78
The order of exposure of tau to signal transduction kinases alters the generation of "AD-like" phosphoepitopes. Cell Mol Neurobiol (1999) 0.78
Hyperphosphorylation of Tau and filopodial retraction following microinjection of protein kinase C catalytic subunits. J Neurosci Res (1995) 0.78
Phosphorylation events mediated by protein kinase C alpha and epsilon participate in regulation of tau steady-state levels and generation of certain "Alzheimer-like" phospho-epitopes. Int J Dev Neurosci (1997) 0.76
Kinesin-mediated transport of neurofilament protein oligomers in growing axons. J Cell Sci (1999) 1.29
Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. Ann N Y Acad Sci (1994) 1.24
Homocysteine potentiates beta-amyloid neurotoxicity: role of oxidative stress. J Neurochem (2001) 1.17
Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration. J Biol Chem (1999) 1.05
Phospho-dependent association of neurofilament proteins with kinesin in situ. Cell Motil Cytoskeleton (2000) 1.04
Dynamics of neuronal intermediate filaments: a developmental perspective. Cell Motil Cytoskeleton (1992) 1.03
Effect of retinoic acid on growth and morphological differentiation of mouse NB2a neuroblastoma cells in culture. Brain Res (1985) 1.01
Toxicity and intracellular localization of carbaryl and 1-naphthol in cell cultures derived from goldfish. Bull Environ Contam Toxicol (1983) 0.97
Neurofilaments consist of distinct populations that can be distinguished by C-terminal phosphorylation, bundling, and axonal transport rate in growing axonal neurites. J Neurosci (2001) 0.93
The predominant form in which neurofilament subunits undergo axonal transport varies during axonal initiation, elongation, and maturation. Cell Motil Cytoskeleton (2001) 0.92
Dietary and genetic compromise in folate availability reduces acetylcholine, cognitive performance and increases aggression: critical role of S-adenosyl methionine. J Nutr Health Aging (2008) 0.91
Differential expression and subcellular localization of protein kinase C alpha, beta, gamma, delta, and epsilon isoforms in SH-SY5Y neuroblastoma cells: modifications during differentiation. J Neurochem (1993) 0.88
Spectrin-actin interaction is required for neurite extension in NB 2a/dl neuroblastoma cells. J Neurosci Res (1996) 0.88
Enhancement of goldfish virus-2 in vitro replication by the pesticides carbaryl and toxaphene. Appl Environ Microbiol (1983) 0.88
Beta-amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation. Brain Res Mol Brain Res (2000) 0.88
Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system. J Neurosci Res (1997) 0.88
Regulation of neurofilament axonal transport by phosphorylation in optic axons in situ. Cell Motil Cytoskeleton (1999) 0.86
Uptake and toxicity of toxaphene to cell cultures derived from goldfish (Carassius auratus). Bull Environ Contam Toxicol (1982) 0.86
Role of vimentin in early stages of neuritogenesis in cultured hippocampal neurons. Int J Dev Neurosci (1996) 0.86
Selective accumulation of the high molecular weight neurofilament subunit within the distal region of growing axonal neurites. Cell Motil Cytoskeleton (2001) 0.85
Dietary supplementation with apple juice concentrate alleviates the compensatory increase in glutathione synthase transcription and activity that accompanies dietary- and genetically-induced oxidative stress. J Nutr Health Aging (2004) 0.84
C-terminal phosphorylation of the high molecular weight neurofilament subunit correlates with decreased neurofilament axonal transport velocity. Brain Res (2000) 0.84
Selective activation by bryostatin-1 demonstrates unique roles for PKC epsilon in neurite extension and tau phosphorylation. Int J Dev Neurosci (1997) 0.83
Toxicity of certain insecticides to protozoa. Bull Environ Contam Toxicol (1982) 0.83
Unoccupied and occupied estrogen receptors in myometrial cytosol and nuclei from nonpregnant and pregnant women. J Clin Endocrinol Metab (1980) 0.83
Axonal transport of microtubule-associated protein 1B (MAP1B) in the sciatic nerve of adult rat: distinct transport rates of different isoforms. J Neurosci (2000) 0.83
Hypophosphorylated neurofilament subunits undergo axonal transport more rapidly than more extensively phosphorylated subunits in situ. Cell Motil Cytoskeleton (2000) 0.83
S-adenosyl methionine: A connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer's disease. J Nutr Health Aging (2006) 0.82
Proteolysis of protein kinase C: mM and microM calcium-requiring calpains have different abilities to generate, and degrade the free catalytic subunit, protein kinase M. FEBS Lett (1995) 0.81
Apple juice prevents oxidative stress and impaired cognitive performance caused by genetic and dietary deficiencies in mice. J Nutr Health Aging (2004) 0.81
Distinct mechanisms of differentiation of SH-SY5Y neuroblastoma cells by protein kinase C activators and inhibitors. J Neurochem (1992) 0.81
Intracellular delivery of protein kinase C-alpha or -epsilon isoform-specific antibodies promotes acquisition of a morphologically differentiated phenotype in neuroblastoma cells. FEBS Lett (1992) 0.81
Macrophages exposed in vitro to conduritol B epoxide resemble Gaucher cells. Exp Mol Pathol (1988) 0.81
Chronic exposure of goldfish-derived cell cultures to toxaphene alters the replication of Goldfish Virus-2. Bull Environ Contam Toxicol (1982) 0.80
Expression and distribution of microtubule-associated protein 2 (MAP2) in neuroblastoma and primary neuronal cells. Brain Res (1986) 0.79
Free PKC catalytic subunits (PKM) phosphorylate tau via a pathway distinct from that utilized by intact PKC. Brain Res (1999) 0.79
A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. J Nutr Health Aging (2010) 0.79
Hyperactivation of mitogen-activated protein kinase increases phospho-tau immunoreactivity within human neuroblastoma: additive and synergistic influence of alteration of additional kinase activities. Cell Mol Neurobiol (1999) 0.79
Hyperphosphorylation of Tau and filopodial retraction following microinjection of protein kinase C catalytic subunits. J Neurosci Res (1995) 0.78
Altered secretion and accumulation of kidney glycosphingolipids by mouse pigmentation mutants with lysosomal dysfunctions. J Biol Chem (1985) 0.78
Suppression of interferon synthesis by the pesticide carbaryl as a mechanism for enhancement of goldfish virus-2 replication. Appl Environ Microbiol (1984) 0.78
Differential appearance of extensively phosphorylated forms of the high molecular weight neurofilament protein in regions of mouse brain during postnatal development. J Neuroimmunol (1991) 0.77
Supplementation with apple juice can compensate for folate deficiency in a mouse model deficient in methylene tetrahydrofolate reductase activity. J Nutr Health Aging (2011) 0.77
Biochemical and morphological characterization of primary kidney cell cultures from beige mutant mice. Cell Tissue Res (1987) 0.77
Phosphorylation events mediated by protein kinase C alpha and epsilon participate in regulation of tau steady-state levels and generation of certain "Alzheimer-like" phospho-epitopes. Int J Dev Neurosci (1997) 0.76
Expression of a plasma membrane proteolipid during differentiation of neuronal and glial cells in primary culture. J Neurochem (1986) 0.76
Toxicity of carbaryl and 1-naphthol to goldfish (Carassius auratus) and killifish (Fundulus heteroclitus). Bull Environ Contam Toxicol (1983) 0.76
SP3: a flagellotropic bacteriophage of Bacillus subtilis. J Gen Virol (1984) 0.76
Effects of retinoic acid on expression of the transformed phenotype in C6 glioma cells. Life Sci (1987) 0.75
Amyloid precursor protein as a glial-derived growth factor. Trends Neurosci (1994) 0.75
Neurofilament subunits can undergo axonal transport without incorporation into Triton-insoluble structures. Cell Motil Cytoskeleton (1998) 0.75
Phospholipids inhibit proteolysis of protein kinase C alpha by mM calcium-requiring calpain. Neurochem Res (1995) 0.75
Small-Pox and Vaccination. J Mass Assoc Boards Health (1902) 0.75
Electron microscopy of the morphogenesis of Bacillus subtilis bacteriophage SP3. J Gen Virol (1979) 0.75
Effects of carbaryl on differentiated and undifferentiated neuroblastoma cells: inhibition of growth rates and direct cell toxicity. Bull Environ Contam Toxicol (1987) 0.75
Carbaryl inhibition of interferon synthesis in cultured goldfish cells. Bull Environ Contam Toxicol (1985) 0.75
Differential efficacy of lipophilic and cytosolic antioxidants on generation of reactive oxygen species by amyloid-ß. J Alzheimers Dis (2001) 0.75
Proper Isolation of Infectious Diseases. J Mass Assoc Boards Health (1898) 0.75
Dibutyryl cyclic AMP stimulates expression of ependymin mRNA and the synthesis and release of the protein into the culture medium by neuroblastoma cells (NB2a/d1). J Neurosci Res (1992) 0.75