Published in J Biol Chem on December 25, 1987
PET Scan of Brain Metabolism in Relation to Age and Disease | NCT00001972
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc Natl Acad Sci U S A (1988) 4.68
Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains. Mol Cell Biol (1989) 3.09
Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc Natl Acad Sci U S A (1990) 2.41
Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro. J Cell Biol (1992) 2.20
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state. EMBO J (1992) 2.16
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Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family. Mol Cell Biol (1989) 1.92
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Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments. J Alzheimers Dis (2008) 1.43
Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site. Biochem J (1991) 1.42
Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration. Biochem J (1997) 1.42
Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation. J Cell Biol (1989) 1.40
Tau phosphorylation sites work in concert to promote neurotoxicity in vivo. Mol Biol Cell (2007) 1.37
Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease. Demonstration with a panel of antibodies against Tau proteins. Acta Neuropathol (1990) 1.31
Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. Proc Natl Acad Sci U S A (1989) 1.29
Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau. Proc Natl Acad Sci U S A (1992) 1.26
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. Pharmacol Res (2010) 1.20
A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau. J Cell Biol (1993) 1.20
Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases. Proc Natl Acad Sci U S A (1990) 1.13
Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors. Exp Neurol (2009) 1.08
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases. J Neurochem (2009) 1.08
Phospholipase D in brain function and Alzheimer's disease. Biochim Biophys Acta (2010) 1.06
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A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities. Biochem J (1991) 1.04
Translocation of CaMKII to dendritic microtubules supports the plasticity of local synapses. J Cell Biol (2012) 1.04
Quantitative measurement of in vivo phosphorylation states of Cdk5 activator p35 by Phos-tag SDS-PAGE. Mol Cell Proteomics (2010) 1.03
Heterogeneity of tau proteins in Alzheimer's disease. Evidence for increased expression of an isoform and preferential distribution of a phosphorylated isoform in neurites. Am J Pathol (1993) 1.02
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Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease. Am J Pathol (1994) 0.97
Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated. Biochem J (1991) 0.94
The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures. Biochem J (1995) 0.93
Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner. Brain Res (2010) 0.87
Modulation of the phosphorylation state of tau in situ: the roles of calcium and cyclic AMP. Biochem J (1995) 0.86
Altered phosphorylation of tau protein in heat-shocked rats and patients with Alzheimer disease. Proc Natl Acad Sci U S A (1991) 0.83
Expression and phosphorylation of a three-repeat isoform of tau in transfected non-neuronal cells. Biochem J (1992) 0.82
Alz-50 and ubiquitin immunoreactivity is induced by permanent focal cerebral ischaemia in the cat. Acta Neuropathol (1993) 0.82
Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau. Mol Neurodegener (2006) 0.82
Calcium/calmodulin-dependent kinase II and Alzheimer's disease. Mol Brain (2015) 0.81
Hyperactivation of mitogen-activated protein kinase increases phospho-tau immunoreactivity within human neuroblastoma: additive and synergistic influence of alteration of additional kinase activities. Cell Mol Neurobiol (1999) 0.79
The order of exposure of tau to signal transduction kinases alters the generation of "AD-like" phosphoepitopes. Cell Mol Neurobiol (1999) 0.78
Phosphorylation of tau alters its association with the plasma membrane. Cell Mol Neurobiol (2000) 0.78
Ribosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII. Aging Cell (2015) 0.77
Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia. F1000Res (2014) 0.75
Alpha 1-Antichymotrypsin, an Inflammatory Protein Overexpressed in the Brains of Patients with Alzheimer's Disease, Induces Tau Hyperphosphorylation through c-Jun N-Terminal Kinase Activation. Int J Alzheimers Dis (2013) 0.75
Phosphorylation affects the ability of tau protein to promote microtubule assembly. J Biol Chem (1984) 3.36
On the aminoethylation of proteins. J Biol Chem (1966) 2.40
Amino acid sequence of Cro regulatory protein of bacteriophage lambda. Nature (1977) 2.18
The resolution of four lysine-rich histones derived from calf thymus. J Biol Chem (1966) 1.68
The purification of tau protein and the occurrence of two phosphorylation states of tau in brain. J Biol Chem (1984) 1.56
Isolation of mitotic apparatus containing vesicles with calcium sequestration activity. Cell (1980) 1.52
Chromosomal proteins. Annu Rev Biochem (1969) 1.39
Species and organ specificity in very lysine-rich histones. J Biol Chem (1968) 1.36
The molecular weight of lysine-rich histone. Biochem Biophys Res Commun (1965) 1.30
Purification and characterization of bovine liver beta-glucuronidase. Arch Biochem Biophys (1966) 1.25
Reversible in vitro polymerization of tubulin from a cultured cell line (rat glial cell clone C6). Proc Natl Acad Sci U S A (1976) 1.25
Amino acid sequence and sequence variability of the amino-terminal regions of lysine-rich histones. J Biol Chem (1971) 1.17
Membrane phospholipids associated with nuclei and chromatin: melting profile, template activity and stability of chromatin. J Mol Biol (1972) 1.16
Histone H10 accumulates in growth-inhibited cultured cells. Nature (1980) 1.15
A minireview of microheterogeneity in H1 histone and its possible significance. Anal Biochem (1984) 1.14
Histone structure: asymmetric distribution of lysine residues in lysine-rich histone. Science (1969) 1.13
Separation of the different microtubule-associated tau protein species from bovine brain and their mode II phosphorylation by Ca2+/phospholipid-dependent protein kinase C. J Biol Chem (1987) 1.07
Bisection of a lysine-rich histone by N-bromosuccinimide. J Biol Chem (1969) 1.07
Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II. J Biol Chem (1988) 1.07
Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C. Biochemistry (1987) 1.06
Histone biosynthesis in the mammary gland during development and lactation. J Biol Chem (1969) 1.02
The distribution of H1 histone is nonuniform in chromatin and correlates with different degrees of condensation. J Biol Chem (1984) 1.02
Demonstration and partial characterization of multiple forms of bovine liver beta-glucuronidase. Biochemistry (1967) 1.01
Competence of soluble cell extracts as microtubule assembly systems. Comparison of simian virus 40 transformed and nontransformed mouse 3T3 fibroblasts. J Biol Chem (1977) 1.01
Protein kinase C substrates from bovine brain. Purification and characterization of neuromodulin, a neuron-specific calmodulin-binding protein. J Biol Chem (1989) 1.01
Histone H1 subfractions and H10 turnover at different rates in nondividing cells. Biochemistry (1982) 1.01
An improved preparation of highly specific tublin antibodies. Exp Cell Res (1976) 1.00
The amino acid sequence of ferredoxin from Clostridium acidi-urici. Biochemistry (1969) 0.99
Non-histone chromosomal protein HMG1 modulates the histone H1-induced condensation of DNA. J Biol Chem (1987) 0.99
A structural comparison of different lysine-rich histones of calf thymus. J Biol Chem (1966) 0.98
Chemical cross-linking of H1 histone to the nucleosomal histones. J Biol Chem (1979) 0.98
Eruptive syringomas in Down's syndrome. Arch Dermatol (1981) 0.97
The tryptic digestion of S-aminoethylated ribonuclease. J Biol Chem (1967) 0.96
Shell formation by capsid protein of f2 bacteriophage. J Mol Biol (1972) 0.96
H1 histone and the condensation of chromatin and DNA. Cold Spring Harb Symp Quant Biol (1978) 0.95
Bovine H10 histone subfractions contain an invariant sequence which matches histones H5 rather than H1. Biochemistry (1981) 0.95
An unusual group of lysine-rich histones from gonads of a sea cucumber, Holothuria tubulosa. Eur J Biochem (1972) 0.94
Structure of histone H1-DNA complex: effect of histone H1 on DNA condensation. Proc Natl Acad Sci U S A (1977) 0.94
Regions of high and low cationic charge in a lysine-rich histone. J Biol Chem (1970) 0.92
Selective displacement of histone H1 from whole HeLa nuclei: effect on chromatin structure in situ as probed by micrococcal nuclease. Biochemistry (1979) 0.92
The amino acid sequence of residues 1-104 of CTL-1, a bovine H1 histone. J Biol Chem (1981) 0.92
Flanking sequences of Xenopus 5 S RNA genes determine differential inhibition of transcription by H1 histone in vitro. Mitotic phosphorylation of H1 decreases its inhibitory power. J Biol Chem (1990) 0.89
Sodium/liquid ammonia reduction of proline-containing peptides. Biochem Biophys Res Commun (1965) 0.89
Microtubule protein preparations from C6 glial cells and their spontaneous polymer formation. J Cell Biol (1979) 0.89
Effects of chemical modification of f2 viral coat protein on its shell-forming activity. J Mol Biol (1972) 0.89
Polymerising ability of C6 glial cell microtubule protein decays much faster than its colchicine-binding activity. Nature (1977) 0.88
Differences among subfractions of H1 histone in their interactions with linear and superhelical DNA. Circular dichroism. J Biol Chem (1981) 0.88
Loss of chromosomal high mobility group proteins HMG1 and HMG2 when mouse neuroblastoma and Friend erythroleukemia cells become committed to differentiation. Proc Natl Acad Sci U S A (1981) 0.87
Extension of the amino acid sequence of a lysine-rich histone. J Biol Chem (1974) 0.87
The isolation of histone from Neurospora crassa. J Biol Chem (1973) 0.87
Localization of the ATP binding site on alpha-tubulin. Arch Biochem Biophys (1983) 0.86
Differences among subfractions of H1 histone in retention of linear and superhelical DNA on filters. J Biol Chem (1980) 0.85
Native state of high mobility group chromosomal proteins 1 and 2 is rapidly lost by oxidation of sulfhydryl groups during storage. Biochemistry (1986) 0.85
Condensation of dinucleosomes by individual subfractions of H1 histone. J Biol Chem (1981) 0.84
The combination of DNA methylation and H1 histone binding inhibits the action of a restriction nuclease on plasmid DNA. J Biol Chem (1991) 0.84
A higher order chromatin structure that is lost during differentiation of mouse neuroblastoma cells. J Biol Chem (1986) 0.84
Hormonal effects on amino acid incorporation into lysine-rich histones in the mouse mammary gland. J Mol Biol (1971) 0.84
Differential scanning calorimetry of nuclei reveals the loss of major structural features in chromatin by brief nuclease treatment. Proc Natl Acad Sci U S A (1985) 0.84
Selectivity in the interaction of various DNA sequences with H1 histone. Biochemistry (1994) 0.83
H1 histones from mammalian testes. The widespread occurrence of H1t. Exp Cell Res (1981) 0.83
Modulation in proportions of H1 histone subfractions by differential changes in synthesis and turnover during butyrate treatment of neuroblastoma cells. Biochemistry (1985) 0.83
H1 histone exchange is limited to particular regions of chromatin that differ in aggregation properties. J Biol Chem (1986) 0.83
Purification and analysis of H1 histones. Methods Enzymol (1989) 0.83
Close contacts between H1 histone molecules in nuclei. J Biol Chem (1983) 0.83
Binding of ATP to tubulin. Nature (1982) 0.83
Displacement of histones from deoxynucleoprotein by protamine. Arch Biochem Biophys (1970) 0.82
The use of hypnosis in a course to increase academic and test-taking skills. Int J Clin Exp Hypn (1979) 0.82
Chromatin fractionation related to cell type and chromosome condensation but perhaps not to transcriptional activity. J Biol Chem (1977) 0.81
Identification of nonmitochondrial creatine kinase enzymatic activity in isolated sea urchin mitotic apparatus. J Biol Chem (1983) 0.81
Molecular weight and subunit structure of pyridoxamine pyruvate transaminase. Biochemistry (1968) 0.81
Effects of salt concentration and H1 histone removal on the differential scanning calorimetry of nuclei. Biochemistry (1992) 0.81
Danger of contamination in chromatographically prepared arginine-rich histone. J Biol Chem (1968) 0.80
Specific interaction between H1 histone and high mobility protein HMG1. Biochemistry (1994) 0.80
The Ca2+-binding sequence in bovine brain S100b protein beta-subunit. A spectroscopic study. Biochem J (1989) 0.80
Changes in chromatin structure during the aging of cell cultures as revealed by differential scanning calorimetry. Biochemistry (1989) 0.80
Mechanisms of H1o accumulation in mouse neuroblastoma cells differ with different treatments. J Biol Chem (1986) 0.80
Anomalies encountered in the classification of histones. An example using wheat germ. J Biol Chem (1977) 0.80
Hormonal effects on amino-acid incorporation into lysine-rich histones. Nature (1969) 0.79
Effect of ATP on the kinetics of microtubule assembly. J Biol Chem (1982) 0.79
A high melting (105 degrees C) form of chromatin characterizes the potential of cells for mitosis. J Biol Chem (1987) 0.79
Responsiveness of preneoplastic and neoplastic mouse mammary tissues to hormones: casein and histone syntheses. J Natl Cancer Inst (1972) 0.79
Inhibition of the self-assembly of capsid protein from f2 phage by urea. J Biol Chem (1972) 0.79
Further studies on the biosynthesis of very lysine-rich histones in isolated nuclei. Biochim Biophys Acta (1968) 0.79
Comparsion of histones obtained from mammary gland at different stages of development and lactation. J Biol Chem (1968) 0.78
Differential scanning calorimetry of nuclei as a test for the effects of anticancer drugs on human chromatin. Cancer Res (1989) 0.78
ATP-induced aggregates of tubulin rings. J Biol Chem (1980) 0.78
Differences among H1 histone subfractions in binding to linear and superhelical DNA. Sedimentation velocity studies. J Biol Chem (1981) 0.78
Differences between subfractions of H1 histone in their interactions with DNA. Circular dichroism and viscosity. J Biol Chem (1979) 0.78
An investigation of specific interactions of deoxyribonucleic acid and lysine-rich (F1) histone preparations. Biochemistry (1972) 0.78
Reductive cleavage of acylproline peptide bonds. Biochemistry (1967) 0.78
Partial displacement of histone H1 from chromatin is required before it can be phosphorylated by mitotic H1 kinase in vitro. J Biol Chem (1992) 0.78
Chromatin aggregation changes substantially as pH varies within the physiological range. J Biol Chem (1989) 0.78
Induction of histone H1(0) differs with different treatments among different cell lines. FEBS Lett (1985) 0.77
Histone metabolism during amphibian metamorphosis. Isolation, characterization, and biosynthesis. Dev Biol (1978) 0.77
Quantitative cleavage of a protein with N-bromosuccinimide. J Am Chem Soc (1970) 0.77
Asynchronous appearance of newly synthesized histone H1 subfractions in HeLa chromatin. J Cell Biol (1981) 0.77