Published in Development on August 01, 2000
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs. Genes Dev (2005) 5.78
SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation. Proc Natl Acad Sci U S A (2002) 2.51
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers. Genes Dev (2007) 2.19
The effect of polymorphisms in the enhancer of split gene complex on bristle number variation in a large wild-caught cohort of Drosophila melanogaster. Genetics (2005) 1.52
microRNA control of cell-cell signaling during development and disease. Cell Cycle (2008) 1.32
Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development. Proc Natl Acad Sci U S A (2001) 1.24
OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. PLoS Biol (2008) 1.22
Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. Development (2010) 1.01
Phylogenetic footprinting analysis in the upstream regulatory regions of the Drosophila enhancer of split genes. Genetics (2007) 0.99
Complex interplay of three transcription factors in controlling the tormogen differentiation program of Drosophila mechanoreceptors. Dev Biol (2009) 0.96
Regulation of epithelial polarity by the E3 ubiquitin ligase Neuralized and the Bearded inhibitors in Drosophila. Nat Cell Biol (2012) 0.94
The Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybee. BMC Evol Biol (2005) 0.92
JAK/Stat signaling regulates heart precursor diversification in Drosophila. Development (2011) 0.92
Genomics of ecological adaptation in cactophilic Drosophila. Genome Biol Evol (2014) 0.91
Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development. EMBO J (2011) 0.91
Role of architecture in the function and specificity of two Notch-regulated transcriptional enhancer modules. PLoS Genet (2012) 0.90
Genome engineering-based analysis of Bearded family genes reveals both functional redundancy and a nonessential function in lateral inhibition in Drosophila. Genetics (2009) 0.88
Evolution of a genomic regulatory domain: the role of gene co-option and gene duplication in the Enhancer of split complex. Genome Res (2010) 0.87
Spitz from the retina regulates genes transcribed in the second mitotic wave, peripodial epithelium, glia and plasmatocytes of the Drosophila eye imaginal disc. Dev Biol (2007) 0.87
Notch regulates numb: integration of conditional and autonomous cell fate specification. Development (2010) 0.86
Drosophila tufted is a gain-of-function allele of the proneural gene amos. Genetics (2003) 0.86
Ancestral and conserved cis-regulatory architectures in developmental control genes. Dev Biol (2011) 0.84
Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta. Dev Biol (2009) 0.84
Apprehending multicellularity: regulatory networks, genomics, and evolution. Birth Defects Res C Embryo Today (2009) 0.84
Sequence conservation and combinatorial complexity of Drosophila neural precursor cell enhancers. BMC Genomics (2008) 0.84
Tools and methods for studying Notch signaling in Drosophila melanogaster. Methods (2014) 0.82
An expanded Notch-Delta model exhibiting long-range patterning and incorporating MicroRNA regulation. PLoS Comput Biol (2014) 0.81
Characterization of the gene BmEm4, a homologue of Drosophila E(spl)m4, from the silkworm, Bombyx mori. Comp Funct Genomics (2009) 0.79
A combination of computational and experimental approaches identifies DNA sequence constraints associated with target site binding specificity of the transcription factor CSL. Nucleic Acids Res (2014) 0.77
Origin and evolution of the enhancer of split complex. BMC Genomics (2015) 0.76
Mef2 interacts with the Notch pathway during adult muscle development in Drosophila melanogaster. PLoS One (2014) 0.75
The Enhancer of split complex arose prior to the diversification of schizophoran flies and is strongly conserved between Drosophila and stalk-eyed flies (Diopsidae). BMC Evol Biol (2011) 0.75
The structure and evolution of the human beta-globin gene family. Cell (1980) 21.24
Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev (1995) 4.47
GFP and beta-galactosidase transformation vectors for promoter/enhancer analysis in Drosophila. Biotechniques (2000) 3.98
Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the Drosophila germ line. Cell (1983) 3.83
The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression. Development (1997) 3.75
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature (1997) 3.54
The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts. Development (1998) 3.52
extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins. Cell (1990) 3.15
Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. Cell (1992) 2.95
Development of adult sensilla on the wing and notum of Drosophila melanogaster. Development (1989) 2.36
Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Dev Biol (1999) 2.07
Identification of DNA sequences required for the regulation of Drosophila alcohol dehydrogenase gene expression. Cold Spring Harb Symp Quant Biol (1985) 2.03
The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes. Development (1991) 2.03
Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete. Genes Dev (1994) 1.85
A dual function of the Notch gene in Drosophila sensillum development. Dev Biol (1990) 1.75
A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology. Cell (2000) 1.70
Posterior stripe expression of hunchback is driven from two promoters by a common enhancer element. Development (1995) 1.63
Regulation of Drosophila neurogenesis by RNA:RNA duplexes? Cell (1998) 1.62
Mitochondrial DNA sequences in the nuclear genome of Strongylocentrotus purpuratus. J Mol Biol (1983) 1.60
Organization and expression of multiple actin genes in the sea urchin. Mol Cell Biol (1981) 1.52
Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis. Development (1994) 1.52
Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling. Genes Dev (1994) 1.49
The Drosophila gene knirps-related is a member of the steroid-receptor gene superfamily. Nature (1988) 1.46
Mitochondrial growth and division during the cell cycle in HeLa cells. J Cell Biol (1977) 1.45
Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae. Genes Dev (1992) 1.42
Repetitive sequence transcripts in development. Nature (1982) 1.41
Hairless is required for the development of adult sensory organ precursor cells in Drosophila. Development (1991) 1.35
Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling. Development (1996) 1.34
The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development. Genes Dev (1992) 1.34
The Drosophila gene Bearded encodes a novel small protein and shares 3' UTR sequence motifs with multiple Enhancer of split complex genes. Development (1997) 1.25
Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes. Development (2000) 1.25
The cell cycle program of polypeptide labeling in Chlamydomonas reinhardtii. J Cell Biol (1977) 1.25
Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway. Dev Biol (1995) 1.19
An essential role for the Drosophila Pax2 homolog in the differentiation of adult sensory organs. Development (1999) 1.12
Repetitive sequences of the sea urchin genome. III. Nucleotide sequences of cloned repeat elements. J Mol Biol (1981) 1.11
Repetitive sequences of the sea urchin genome. Distribution of members of specific repetitive families. J Mol Biol (1981) 1.10
Dpbx, a new homeobox gene closely related to the human proto-oncogene pbx1 molecular structure and developmental expression. Mech Dev (1993) 1.08
Morphological heterogeneity of HeLa cell mitochondria visualized by a modified diaminobenzidine staining technique. J Cell Sci (1975) 1.07
Sensillum development in the absence of cell division: the sensillum phenotype of the Drosophila mutant string. Dev Biol (1990) 1.06
Nucleotide sequence of a fragment of HeLa-cell mitochondrial DNA containing the precisely localized origin of replication. Cold Spring Harb Symp Quant Biol (1979) 1.05
Repetitive sequences of the sea urchin genome. II. Subfamily structure and evolutionary conservation. J Mol Biol (1981) 1.03
Interspersed sequence organization and developmental representation of cloned poly(A) RNAs from sea urchin eggs. J Mol Biol (1983) 0.94
Evolutionary conservation of repetitive sequence expression in sea urchin egg RNA's. Science (1980) 0.93
Sequence relationship between long and short repetitive DNA of the rat: a preliminary report. Proc Natl Acad Sci U S A (1977) 0.87
Gain-of-function alleles of Bearded interfere with alternative cell fate decisions in Drosophila adult sensory organ development. Dev Biol (1996) 0.86
Molecular structure of maternal RNA. Chromosoma (1981) 0.85
Comparison of sea urchin and human mtDNA: evolutionary rearrangement. Proc Natl Acad Sci U S A (1983) 0.80
Transcripts of three mitochondrial genes in the RNA of sea urchin eggs and embryos. Dev Biol (1983) 0.80
A small region surrounding the distal promoter of the hunchback gene directs maternal expression. Dev Biol (1994) 0.79
Birds on a wire and tiling the inner ear. Nat Genet (1999) 0.75
Response to "Sertraline and isocarboxazid cause a serotonin syndrome". J Clin Psychopharmacol (1995) 0.75
The sequence similarity of the Drosophila suppressor of hairless protein to the integrase domain has no functional significance in vivo. Dev Biol (1994) 0.75
Thrombus precursor protein as a measure of prothrombotic activity in a patient with factor VIII inhibitor treated with activated prothrombin complex concentrates. Thromb Haemost (1999) 0.75
Mitochondrial and nuclear gene interaction in HeLa cells. Brookhaven Symp Biol (1979) 0.75