Published in Methods on April 03, 2014
The Ecdysone and Notch Pathways Synergistically Regulate Cut at the Dorsal-Ventral Boundary in Drosophila Wing Discs. J Genet Genomics (2016) 0.78
In vivo analysis of internal ribosome entry at the Hairless locus by genome engineering in Drosophila. Sci Rep (2016) 0.75
RNA sequencing analysis to capture the transcriptome landscape during skin ulceration syndrome progression in sea cucumber Apostichopus japonicus. BMC Genomics (2016) 0.75
Notch Signaling in Ischemic Damage and Fibrosis: Evidence and Clues from the Heart. Front Pharmacol (2017) 0.75
The APC/C Coordinates Retinal Differentiation with G1 Arrest through the Nek2-Dependent Modulation of Wingless Signaling. Dev Cell (2016) 0.75
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Analysis of genetic mosaics in developing and adult Drosophila tissues. Development (1993) 13.43
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Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics (2013) 8.56
Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci (2001) 6.99
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell (1994) 5.37
Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron (1996) 4.69
Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev (1995) 4.47
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol (2003) 4.43
Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila. Sci STKE (2004) 4.40
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell (2006) 4.28
Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell (1990) 4.07
Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev (1993) 3.86
The Notch locus of Drosophila melanogaster. Cell (1983) 3.58
Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell (1993) 3.53
Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell (1997) 3.48
Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell (2006) 3.42
Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell (1993) 3.35
The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes Dev (1995) 3.24
The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell (2002) 3.16
Calcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol (2000) 3.15
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell (2008) 3.09
Highly specific and efficient CRISPR/Cas9-catalyzed homology-directed repair in Drosophila. Genetics (2014) 3.07
Expression of the cut locus in the Drosophila wing margin is required for cell type specification and is regulated by a distant enhancer. Development (1991) 3.03
Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. Cell (1992) 2.95
Genetic duplication in the white-split interval of the X chromosome in Drosophila melanogaster. Chromosoma (1972) 2.89
New Drosophila transgenic reporters: insulated P-element vectors expressing fast-maturing RFP. Biotechniques (2004) 2.82
Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature (1996) 2.74
numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell (1989) 2.72
Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science (1999) 2.71
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem (2001) 2.71
A model Notch response element detects Suppressor of Hairless-dependent molecular switch. Curr Biol (2001) 2.65
The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. Dev Cell (2008) 2.55
SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation. Proc Natl Acad Sci U S A (2002) 2.51
An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature (1993) 2.49
Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila. Nature (1988) 2.47
Fringe modulates Notch-ligand interactions. Nature (1997) 2.44
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J Cell Biol (2008) 2.32
Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition. Dev Cell (2010) 2.29
Requirement for dynamin during Notch signaling in Drosophila neurogenesis. Dev Biol (1997) 2.26
Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch. Development (2004) 2.25
Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature (1999) 2.20
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes Dev (2006) 2.20
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers. Genes Dev (2007) 2.19
A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics (1996) 2.17
Patterns of expression of cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos. Genes Dev (1990) 2.16
Ectopic gene expression in Drosophila using GAL4 system. Methods (1998) 2.10
Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye. Nature (1999) 2.09
The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development (1994) 2.07
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev (2006) 2.06
Simple and efficient generation of marked clones in Drosophila. Curr Biol (1993) 2.00
Cell proliferation control by Notch signaling in Drosophila development. Development (1998) 1.98
Direct response to Notch activation: signaling crosstalk and incoherent logic. Sci Signal (2009) 1.91
Notch signalling mediates segmentation of the Drosophila leg. Development (1998) 1.90
Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Genes Dev (2000) 1.87
Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Genes Dev (2002) 1.87
Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development (2003) 1.87
Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature (2006) 1.85
JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. Dev Biol (2009) 1.83
Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes Dev (1996) 1.82
Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division. Nature (2009) 1.81
Antagonistic interactions between wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila Leg. Science (1996) 1.79
Regulation of Notch signalling by non-visual beta-arrestin. Nat Cell Biol (2005) 1.79
Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus. Cell (1987) 1.75
Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development. Development (1996) 1.75
Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis. Development (1997) 1.74
Unequal segregation of Neuralized biases Notch activation during asymmetric cell division. Dev Cell (2003) 1.74
Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. Development (1994) 1.73
Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing. Development (1997) 1.68
Spatially restricted factors cooperate with notch in the regulation of Enhancer of split genes. Dev Biol (2000) 1.67
fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell (1994) 1.64
The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Development (1997) 1.63
Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila. Development (2005) 1.63
A biological solution to a fundamental distributed computing problem. Science (2011) 1.62
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development (2003) 1.60
Endocytic regulation of Notch signaling. Curr Opin Genet Dev (2009) 1.59
Bre1 is required for Notch signaling and histone modification. Dev Cell (2005) 1.58
Temperature-sensitive periods and autonomy of pleiotropic effects of l(1)Nts1, a conditional notch lethal in Drosophila. Dev Biol (1978) 1.56
Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundary. Nature (1994) 1.55
Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis. Curr Biol (2006) 1.52
Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs. EMBO Rep (2005) 1.49
Regulation of post-embryonic neuroblasts by Drosophila Grainyhead. Mech Dev (2005) 1.47
The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands. Development (1996) 1.46
CRISPR/Cas9 and genome editing in Drosophila. J Genet Genomics (2013) 1.44
Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila. Development (1998) 1.43
Altering the insertional specificity of a Drosophila transposable element. Proc Natl Acad Sci U S A (1992) 1.43
The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family. Development (2000) 1.43
Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila. Dev Cell (2003) 1.42
The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking. Dev Cell (2006) 1.41
Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless. Development (2005) 1.41
Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev Cell (2002) 1.40
The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation. Development (1994) 1.39
A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. Dev Cell (2010) 1.38
R7 photoreceptor specification requires Notch activity. Curr Biol (2000) 1.35
Use of FLP/FRT system to study Drosophila development. Methods (1998) 1.35
Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function. Dev Biol (1999) 1.34
The emergence of sense organs in the wing disc of Drosophila. Development (1991) 1.33
Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways. Development (2007) 1.33
Dissecting the mechanisms of suppressor of hairless function. Dev Biol (2000) 1.32
Numb localizes at endosomes and controls the endosomal sorting of notch after asymmetric division in Drosophila. Curr Biol (2013) 1.29