The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-gamma expression.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMID 10903740)

Published in J Immunol on August 01, 2000

Authors

S Zhang1, M H Kaplan

Author Affiliations

1: Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Articles citing this

Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J Clin Immunol (2003) 2.93

STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. Proc Natl Acad Sci U S A (2002) 1.69

GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J (2004) 1.50

Direct inhibition of T-lymphocyte activation by anthrax toxins in vivo. Infect Immun (2005) 1.43

Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses. EMBO J (2003) 1.39

Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii. J Exp Med (2008) 1.33

Stat4-dependent, T-bet-independent regulation of IL-10 in NK cells. Genes Immun (2008) 1.26

STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection. J Immunol (2004) 1.06

IL-6 and IL-12 specifically regulate the expression of Rab5 and Rab7 via distinct signaling pathways. EMBO J (2006) 1.04

The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells. Arthritis Res Ther (2006) 1.03

Impaired interferon-gamma production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma. Blood (2005) 0.97

Helminth-excreted/secreted products are recognized by multiple receptors on DCs to block the TLR response and bias Th2 polarization in a cRAF dependent pathway. FASEB J (2013) 0.95

The Mycobacterium tuberculosis early secreted antigenic target of 6 kDa inhibits T cell interferon-γ production through the p38 mitogen-activated protein kinase pathway. J Biol Chem (2011) 0.93

Lck mediates Th2 differentiation through effects on T-bet and GATA-3. J Immunol (2010) 0.92

Molecular mechanisms underlying β-adrenergic receptor-mediated cross-talk between sympathetic neurons and immune cells. Int J Mol Sci (2015) 0.90

Control of Borrelia burgdorferi-specific CD4+-T-cell effector function by interleukin-12- and T-cell receptor-induced p38 mitogen-activated protein kinase activity. Infect Immun (2006) 0.90

ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury. J Immunol (2009) 0.86

Effects of interleukin-18 on natural killer cells: costimulation of activation through Fc receptors for immunoglobulin. Cancer Immunol Immunother (2013) 0.86

Adjuvant effect of anti-4-1BB mAb administration in adoptive T cell therapy of cancer. Int J Biol Sci (2007) 0.85

Long-term dynamic profiling of inflammatory mediators in double-hit burn and sepsis animal models. Cytokine (2012) 0.85

Signal transducer and activation of transcription (STAT) 4beta, a shorter isoform of interleukin-12-induced STAT4, is preferentially activated by estrogen. Endocrinology (2008) 0.84

p38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals. J Biol Chem (2012) 0.79

Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK. J Immunol (2015) 0.78

Invasive Surgery Impairs the Regulatory Function of Human CD56 bright Natural Killer Cells in Response to Staphylococcus aureus. Suppression of Interferon-γ Synthesis. PLoS One (2015) 0.78

Intestine immune homeostasis after alcohol and burn injury. Shock (2015) 0.77

Articles by these authors

(truncated to the top 100)

The role of mononuclear phagocytes in HTLV-III/LAV infection. Science (1986) 17.33

Origin and interstate spread of a New York City multidrug-resistant Mycobacterium tuberculosis clone family. JAMA (1996) 9.45

Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin. J Immunol (1974) 5.35

Human herpesvirus-like nucleic acid in various forms of Kaposi's sarcoma. Lancet (1995) 4.31

Immunopathologic studies of systemic lupus erythematosus. II. Antinuclear reaction of gamma-globulin eluted from homogenates and isolated glomeruli of kidneys from patients with lupus nephritis. J Clin Invest (1967) 4.31

Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science (1997) 3.92

Specificity of C-reactive protein for choline phosphate residues of pneumococcal C-polysaccharide. Proc Soc Exp Biol Med (1971) 3.32

Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine. N Engl J Med (1995) 3.26

The importance of classifying initial co-morbidity in evaluating the outcome of diabetes mellitus. J Chronic Dis (1974) 3.01

Bacteremia and fungemia complicating neoplastic disease. A study of 364 cases. Am J Med (1977) 2.92

Deleted HTLV-I provirus in blood and cutaneous lesions of patients with mycosis fungoides. Science (1991) 2.56

Tuberculosis complicating neoplastic disease. A review of 201 cases. Cancer (1974) 2.36

Malarial antibodies and autoantibodies to heart and other tissues in the immigrant and indigenous peoples of Uganda. Lancet (1968) 2.35

The immunoglobulin heavy-chain matrix-associating regions are bound by Bright: a B cell-specific trans-activator that describes a new DNA-binding protein family. Genes Dev (1995) 2.19

Angiogenic properties of Kaposi's sarcoma-derived cells after long-term culture in vitro. Science (1988) 2.17

Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma. Blood (1995) 1.84

Autoimmunity to the heart in cardiac disease. Current concepts of the relation of autoimmunity to rheumatic fever, postcardiotomyand postinfarction syndromes and cardiomyopathies. Am J Cardiol (1969) 1.79

Staphylococcus epidermidis extracted slime inhibits the antimicrobial action of glycopeptide antibiotics. J Infect Dis (1990) 1.75

A QUANTITATIVE STUDY OF THE FIBRINOLYSIN-ANTIFIBRINOLYSIN REACTION. Science (1945) 1.74

Isolation and characterization of the Lyme disease spirochete from the skin of patients with erythema chronicum migrans. J Am Acad Dermatol (1985) 1.71

Fatal adenovirus disease and human immunodeficiency virus infection. Pediatr Infect Dis J (1990) 1.69

Interaction of C-reactive protein complexes with the complement system. II. Consumption of guinea pig complement by CRP complexes: requirement for human C1q. J Immunol (1974) 1.68

Rapid detection of respiratory syncytial virus in nasopharyngeal aspirates by a commercial enzyme immunoassay. J Clin Microbiol (1986) 1.67

Clinical and serological features of human herpesvirus-6 infection in three adults. Lancet (1988) 1.61

Antibodies to mycobacteria in human tuberculosis. I. Development of antibodies before and after antimicrobial therapy. J Infect Dis (1980) 1.56

Demonstration of an antibody to proximal tubular antigen in the pathogenesis of experimental autoimmune nephrosis in rats. J Lab Clin Med (1969) 1.55

In vitro and in vivo activation of human mononuclear phagocytes by interferon-gamma. Studies with normal and AIDS monocytes. J Immunol (1987) 1.51

Group B coxsackievirus infections in infants younger than three months of age: a serious childhood illness. Rev Infect Dis (1984) 1.51

Cryptococcosis in a cancer hospital: clinical and pathological correlates in forty-six patients. Cancer (1977) 1.49

Detection and titration of human herpesvirus-8-specific antibodies in sera from blood donors, acquired immunodeficiency syndrome patients, and Kaposi's sarcoma patients using a whole virus enzyme-linked immunosorbent assay. Blood (1998) 1.49

Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus. Eur J Immunol (2001) 1.45

Effects of specimen collection, processing, and storage conditions on stability of human immunodeficiency virus type 1 RNA levels in plasma. J Clin Microbiol (1997) 1.43

Clinical manifestations and therapy of Lactobacillus endocarditis: report of a case and review of the literature. Rev Infect Dis (1986) 1.41

Encoding a superantigen by Staphylococcus aureus does not affect clinical characteristics of infected atopic dermatitis lesions. Br J Dermatol (2010) 1.40

Cross-reaction of group A streptococci and heart tissue: varying serologic specificity of cross-reactive antisera and relation to carrier-hapten specificity. Transplant Proc (1969) 1.39

IL-13-induced airway hyperreactivity during respiratory syncytial virus infection is STAT6 dependent. J Immunol (2001) 1.39

Steroids for Pneumocystis carinii pneumonia and respiratory failure in the acquired immunodeficiency syndrome. A reassessment. Arch Intern Med (1990) 1.38

Chlamydia trachomatis in suburban adolescents. J Pediatr (1987) 1.36

Viridans streptococcal endocarditis: clinical, microbiological, and echocardiographic correlations. J Infect Dis (1986) 1.35

Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides. Proc Natl Acad Sci U S A (1991) 1.34

Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways. J Immunol (2000) 1.33

Autoantibodies to heart and rheumatic fever: the induction of autoimmunity to heart by streptococcal antigen cross-reactive with heart. Ann N Y Acad Sci (1965) 1.29

Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells. J Immunol (2001) 1.28

Rapid detection of cytomegalovirus in cell culture by indirect immunoperoxidase staining with monoclonal antibody to an early nuclear antigen. J Clin Microbiol (1985) 1.28

Cutaneous nocardiosis. Case reports and review. J Am Acad Dermatol (1985) 1.28

Immunopathologic studies of systemic lupus erythematosus (SLE). I. Tissue-bound immunoglobulins in relation to serum antinuclear immunoglobulins in systemic lupus and in chronic liver disease with LE cell factor. J Clin Invest (1967) 1.22

Dermatologic findings and manifestations of acquired immunodeficiency syndrome (AIDS). J Am Acad Dermatol (1987) 1.17

Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice. J Biol Chem (1998) 1.17

Cutaneous infection at dog bite wounds associated with fulminant DF-2 septicemia. Am J Med (1985) 1.16

Cutting edge: differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4. J Immunol (2000) 1.15

Autoimmunity to heart and its relation to heart disease. Prog Allergy (1969) 1.13

Epidemiologic, clinical, and laboratory features of Coxsackie B1-B5 infections in the United States, 1970-79. Public Health Rep (1984) 1.12

Comparison of two rapid culture methods for detection of cytomegalovirus in clinical specimens. J Clin Microbiol (1987) 1.10

Fall in human herpesvirus 6 seropositivity with age. Lancet (1988) 1.09

Cytokine-stimulated T lymphocyte proliferation is regulated by p27Kip1. J Immunol (2000) 1.09

"Nonspecific" stimulation of lymphocyte transformation by cellular fractions and acid extracts of group A streptococci. J Immunol (1971) 1.08

Rapid detection of influenza virus in cell culture by indirect immunoperoxidase staining with type-specific monoclonal antibodies. Diagn Microbiol Infect Dis (1987) 1.07

Continuous varicella-zoster infection associated with acyclovir resistance in a child with AIDS. JAMA (1988) 1.07

Cutaneous lesions in disseminated mucormycosis. JAMA (1973) 1.07

Multiple isolates and characteristics of human T-cell leukemia virus type II. J Virol (1992) 1.07

Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. J Exp Med (2001) 1.04

Staphylococcus aureus: cellular biology and clinical application. Am J Med (1982) 1.04

Comparison of levels of human immunodeficiency virus type 1 RNA in plasma as measured by the NucliSens nucleic acid sequence-based amplification and Quantiplex branched-DNA assays. J Clin Microbiol (1999) 1.03

Antigenic analysis of human heart tissue. Identification of antigens with specificity restricted to heart and skeletal muscle in acid extracts of myocardium. J Immunol (1968) 1.03

Rothia dentocariosa pneumonia in an immunocompromised patient. Lung (1987) 1.02

Phycomycosis of the gastrointestinal tract. Am J Gastroenterol (1979) 1.02

Humoral reactions in human endocarditis due to Streptococcus bovis: evidence for a common S bovis antigen. J Infect Dis (1983) 1.01

Antibodies to mycobacteria in human tuberculosis. II. Response to nine defined mycobacterial antigens with evidence for an antibody common to tuberculosis and lepromatous leprosy. J Infect Dis (1980) 1.01

The CC chemokine CK beta-11/MIP-3 beta/ELC/Exodus 3 mediates tumor rejection of murine breast cancer cells through NK cells. J Immunol (2000) 1.01

Human herpesvirus-6 infection in children with first febrile seizures. J Pediatr (1995) 1.00

Detection of the herpesvirus-like DNA sequences in matched specimens of semen and blood from patients with AIDS-related Kaposi's sarcoma by polymerase chain reaction in situ hybridization. Am J Pathol (1997) 0.99

Role of interleukin-12 and stat-4 in the regulation of airway inflammation and hyperreactivity in respiratory syncytial virus infection. Am J Pathol (2001) 0.99

Morphologic and clinical observations in human infection with Babesia microti. J Infect Dis (1983) 0.98

Application of a standardized cytomegalovirus antigenemia assay in the management of patients with AIDS. Diagn Microbiol Infect Dis (1998) 0.98

Immunological studies in endomyocardial fibrosis and other forms of heart-disease in the tropics. Lancet (1967) 0.98

Importance of exfoliatin toxin A production by Staphylococcus aureus strains isolated from clustered epidemics of neonatal pustulosis. J Clin Microbiol (1986) 0.98

Clostridium sordellii bacteremia: case report and review. Clin Infect Dis (1992) 0.98

Improved detection of cytomegalovirus viremia in AIDS patients using shell vial and indirect immunoperoxidase methodologies. J Med Virol (1992) 0.97

Neoplastic complications of HTLV-III infection. Lymphomas and solid tumors. Am J Med (1987) 0.97

Spontaneous production of C-C chemokines by individuals infected with human T lymphotropic virus type II (HTLV-II) alone and HTLV-II/HIV-1 coinfected individuals. J Immunol (2000) 0.96

The cross-reaction of group A streptococci with heart tissue and its relation to induced autoimmunity in rheumatic fever. Bull Rheum Dis (1969) 0.95

Use of the cytomegalovirus antigenemia (CMV-Ag) assay for the detection of CMV in the blood of AIDS patients. Can J Microbiol (1993) 0.95

Human babesiosis. Clinical and therapeutic considerations. JAMA (1982) 0.95

Neuropathy associated with cryoglobulinemia. Muscle Nerve (1986) 0.94

Comparison of detection of varicella-zoster virus by the Tzanck smear, direct immunofluorescence with a monoclonal antibody, and virus isolation. J Am Acad Dermatol (1987) 0.94

Virus antibody levels and delayed hypersensitivity in rheumatoid arthritis. Ann Rheum Dis (1976) 0.93

Antigenic analysis of human heart tissue. Antigens with restricted organ distribution in acid extracts of human myocardium. J Immunol (1970) 0.90

Membrane and soluble forms of Fas (CD95) and Fas ligand in peripheral blood mononuclear cells and in plasma from human immunodeficiency virus-infected persons. J Infect Dis (1998) 0.90

Apnea during treatment with sodium colistimethate. JAMA (1965) 0.90

Two coagulase-variant forms of Staphylococcus aureus isolated from blood cultures. J Clin Microbiol (1984) 0.89

Inhibition of HIV replication by Hyssop officinalis extracts. Antiviral Res (1990) 0.89

Isolation, cloning, and complete nucleotide sequence of a phenotypically distinct Brazilian isolate of human T-lymphotropic virus type II (HTLV-II). Virology (2000) 0.89

Babesiosis in two infants from Eastern Long Island, NY. Am J Dis Child (1986) 0.88

Intestinal microsporidiosis. Report of five cases. Ann Clin Lab Sci (1995) 0.88

Unusual features of scabies complicating human T-lymphotropic virus type III infection. J Am Acad Dermatol (1986) 0.88

Rheumatic fever, rheumatic heart disease, and the streptococcal connection: the role of streptococcal antigens cross-reactive with heart tissue. Rev Infect Dis (1980) 0.88

Seroepidemiology of cytomegalovirus in patients with advanced HIV disease: influence on disease expression and survival. J Acquir Immune Defic Syndr Hum Retrovirol (1996) 0.86

Antiviral susceptibility testing-flow cytometric analysis (AST-FCA) for the detection of cytomegalovirus drug resistance. Diagn Microbiol Infect Dis (1997) 0.86

Atypical measles syndrome: pathologic and serologic findings. Pediatrics (1982) 0.86

Papulosquamous dermatoses of AIDS. J Am Acad Dermatol (1990) 0.86