beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 381285)

Published in J Clin Invest on September 01, 2000

Authors

P Varghese1, R W Harrison, R A Lofthouse, D Georgakopoulos, D E Berkowitz, J M Hare

Author Affiliations

1: Department of Medicine, Cardiology Division, and. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

Articles citing this

Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase. J Am Coll Cardiol (2012) 1.72

Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc Natl Acad Sci U S A (2006) 1.36

Modulation of cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice. J Physiol (2003) 1.36

Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. J Mol Cell Cardiol (2009) 1.24

PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation. Basic Res Cardiol (2010) 1.21

Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. Proc Natl Acad Sci U S A (2012) 1.18

Endothelial nitric oxide synthase decreases beta-adrenergic responsiveness via inhibition of the L-type Ca2+ current. Am J Physiol Heart Circ Physiol (2008) 1.11

beta3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current. J Clin Invest (2008) 1.01

Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component? Philos Trans R Soc Lond B Biol Sci (2004) 0.96

Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness. Exp Gerontol (2012) 0.90

Genetically changed mice with chronic deficiency or overexpression of the beta-adrenoceptors--what can we learn for the therapy of heart failure? Pflugers Arch (2007) 0.85

miR-222 contributes to sex-dimorphic cardiac eNOS expression via ets-1. Physiol Genomics (2013) 0.84

Nebivolol protects against myocardial infarction injury via stimulation of beta 3-adrenergic receptors and nitric oxide signaling. PLoS One (2014) 0.82

A pathway and network review on beta-adrenoceptor signaling and beta blockers in cardiac remodeling. Heart Fail Rev (2014) 0.79

Prolonged Action Potential and After depolarizations Are Not due to Changes in Potassium Currents in NOS3 Knockout Ventricular Myocytes. J Signal Transduct (2012) 0.79

Role of nitric oxide in the pathophysiology of heart failure. Heart Fail Rev (2003) 0.78

β3-Adrenoreceptor stimulation protects against myocardial infarction injury via eNOS and nNOS activation. PLoS One (2014) 0.78

Articles cited by this

Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature (1995) 9.86

Nitric oxide synthases: which, where, how, and why? J Clin Invest (1997) 3.81

Effective arterial elastance as index of arterial vascular load in humans. Circulation (1992) 3.42

Nitric oxide synthase activities in human myocardium. Lancet (1993) 2.72

Continuous measurement of left ventricular volume in animals and humans by conductance catheter. Circulation (1984) 2.57

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc Natl Acad Sci U S A (1993) 2.32

Functional beta3-adrenoceptor in the human heart. J Clin Invest (1996) 2.32

Targeted disruption of the beta 3-adrenergic receptor gene. J Biol Chem (1995) 2.27

Expression of inducible nitric oxide synthase in human heart failure. Circulation (1996) 2.26

Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols. J Gen Physiol (1996) 2.24

Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes. Proc Natl Acad Sci U S A (1991) 2.15

Is there a third heart beta-adrenoceptor? Trends Pharmacol Sci (1989) 2.02

Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the alpha- and beta-subtypes. Br J Pharmacol (1988) 1.97

Nitric oxide regulates cardiac Ca2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation. J Biol Chem (1993) 1.96

The pathogenesis of familial hypertrophic cardiomyopathy: early and evolving effects from an alpha-cardiac myosin heavy chain missense mutation. Nat Med (1999) 1.93

Comparative influence of load versus inotropic states on indexes of ventricular contractility: experimental and theoretical analysis based on pressure-volume relationships. Circulation (1987) 1.90

The human beta 3-adrenoceptor: the search for a physiological function. Trends Pharmacol Sci (1994) 1.76

The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle. J Clin Invest (1998) 1.66

Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J (1991) 1.65

Transgenic mouse model of stunned myocardium. Science (2000) 1.62

8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes. Circ Res (1994) 1.55

Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study using transgenic and gene knockout mice. J Biol Chem (1997) 1.53

Determination of left ventricular end-systolic pressure-volume relationships by the conductance (volume) catheter technique. Circulation (1986) 1.47

Determinants of left ventricular filling and of the diastolic pressure-volume relation. Circ Res (1989) 1.41

Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. Proc Natl Acad Sci U S A (1993) 1.41

Age-associated differences in TNF-alpha and nitric oxide production in endotoxic mice. J Immunol (1996) 1.38

Beta-adrenoceptors in cardiac disease. Pharmacol Ther (1993) 1.37

cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation. Am J Physiol Heart Circ Physiol (2000) 1.34

Modulation of mouse cardiac function in vivo by eNOS and ANP. Am J Physiol Heart Circ Physiol (2000) 1.25

Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs. J Clin Invest (1995) 1.22

Regulation of the L-type Ca2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase-mediated inhibition. FASEB J (1999) 1.21

p38-2, a novel mitogen-activated protein kinase with distinct properties. J Biol Chem (1997) 1.18

Beta-adrenergic regulation of constitutive nitric oxide synthase in cardiac myocytes. Am J Physiol (1997) 1.16

Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve. Proc Natl Acad Sci U S A (1996) 1.15

Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elements. Proc Natl Acad Sci U S A (1992) 1.14

Nitric oxide inhibits the positive inotropic response to beta-adrenergic stimulation in humans with left ventricular dysfunction. Circulation (1995) 1.09

Four beta-adrenoceptor subtypes in the mammalian heart. Trends Pharmacol Sci (1997) 1.09

Comparison of measures of left ventricular contractile performance derived from pressure-volume loops in conscious dogs. Circulation (1989) 1.08

Molecular cloning of human p38 MAP kinase. Biochim Biophys Acta (1995) 1.07

Contribution of caveolin protein abundance to augmented nitric oxide signaling in conscious dogs with pacing-induced heart failure. Circ Res (2000) 1.07

Regulation of beta-adrenoceptor signaling in cardiac function and disease. Pharmacol Rev (1999) 1.03

Effects of 8-bromo-cyclic GMP on contraction and on inotropic response of ferret cardiac muscle. J Mol Cell Cardiol (1991) 1.03

Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1 beta and IFN-gamma. Am J Physiol (1995) 0.99

Interspecies differences in the cardiac negative inotropic effects of beta(3)-adrenoceptor agonists. J Pharmacol Exp Ther (1999) 0.98

Differences in beta 3-adrenergic receptor cardiovascular regulation in conscious primates, rats and dogs. J Pharmacol Exp Ther (1996) 0.98

NOS: modulator, not mediator of cardiac performance. Nat Med (1999) 0.94

Role of nitric oxide in the regulation of myocardial function. Prog Cardiovasc Dis (1995) 0.90

The development of the entire end-systolic pressure-volume and ejection fraction-afterload relations: a new concept of systolic myocardial stiffness. Circulation (1987) 0.87

Endotoxin-induced alteration in the expression of leptin and beta3-adrenergic receptor in adipose tissue. Am J Physiol (1998) 0.83

Beta-3 adrenergic receptor agonists cause an increase in gastrointestinal transit time in wild-type mice, but not in mice lacking the beta-3 adrenergic receptor. J Pharmacol Exp Ther (1998) 0.81

Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements. Diabetes (1998) 0.80

Pertussis toxin-sensitive G proteins influence nitric oxide synthase III activity and protein levels in rat heart. J Clin Invest (1998) 0.80

Comparative efficacy of three indexes of left ventricular performance derived from pressure-volume loops in heart failure induced by tachypacing. J Am Coll Cardiol (1994) 0.79

Articles by these authors

Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N Engl J Med (2000) 6.27

Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol (1994) 5.02

Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation (1993) 4.53

Long-term outcome of fulminant myocarditis as compared with acute (nonfulminant) myocarditis. N Engl J Med (2000) 3.70

Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block. Circulation (2000) 2.90

The causes of dilated cardiomyopathy: a clinicopathologic review of 673 consecutive patients. J Am Coll Cardiol (1994) 2.38

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc Natl Acad Sci U S A (2001) 2.36

In vivo murine left ventricular pressure-volume relations by miniaturized conductance micromanometry. Am J Physiol (1998) 2.22

Benefit-risk considerations in preventive treatment for tuberculosis in elderly persons. Ann Intern Med (1987) 2.18

Echocardiographic findings in fulminant and acute myocarditis. J Am Coll Cardiol (2000) 2.12

Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility. Br Heart J (1995) 2.09

Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes. Proteins (2001) 2.08

Leptin prevents respiratory depression in obesity. Am J Respir Crit Care Med (1999) 2.08

Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy. Circulation (2001) 2.07

Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice. J Clin Invest (1999) 2.02

Model structure of decorin and implications for collagen fibrillogenesis. J Biol Chem (1996) 1.88

Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure. FASEB J (2001) 1.81

Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age. Circulation (1999) 1.76

Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level. J Clin Invest (1994) 1.72

Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure. Circ Res (1999) 1.71

Acute endothelin A receptor blockade causes selective pulmonary vasodilation in patients with chronic heart failure. Circulation (2000) 1.69

Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling. Proc Natl Acad Sci U S A (2001) 1.63

Transgenic mouse model of stunned myocardium. Science (2000) 1.62

Structural and kinetic analysis of drug resistant mutants of HIV-1 protease. Eur J Biochem (1999) 1.60

Effect of leptin deficiency on metabolic rate in ob/ob mice. Am J Physiol (1999) 1.51

Upregulation of the nitric oxide-cGMP pathway in aged myocardium: physiological response to l-arginine. Circ Res (2001) 1.51

Characterization of a monoclonal antibody to the rat liver glucocorticoid receptor. Endocrinology (1984) 1.50

Late ventricular arrhythmia is rare after early repair of tetralogy of Fallot. J Am Coll Cardiol (1994) 1.45

ACTION OF SYNTHETIC DETERGENTS ON THE METABOLISM OF BACTERIA. J Exp Med (1941) 1.44

Mesenchymal stem cells for cardiac regenerative therapy. Handb Exp Pharmacol (2007) 1.40

Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus. Proc Natl Acad Sci U S A (1992) 1.40

Angiogenesis in the mouse lung. Am J Pathol (2000) 1.38

Complications of transvenous right ventricular endomyocardial biopsy in adult patients with cardiomyopathy: a seven-year survey of 546 consecutive diagnostic procedures in a tertiary referral center. J Am Coll Cardiol (1992) 1.38

cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation. Am J Physiol Heart Circ Physiol (2000) 1.34

Murine cardiac function: a cautionary tail. Circ Res (1998) 1.34

Comparison of two murine models of familial hypertrophic cardiomyopathy. Circ Res (2001) 1.30

Myocarditis and long-term survival in peripartum cardiomyopathy. Am Heart J (2000) 1.29

Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol Cell Biol (2001) 1.28

The spectrum of dilated cardiomyopathy. The Johns Hopkins experience with 1,278 patients. Medicine (Baltimore) (1999) 1.25

Oxidative stress and apoptosis in heart failure progression. Circ Res (2001) 1.25

Effect of baseline or changes in adrenergic activity on clinical outcomes in the beta-blocker evaluation of survival trial. Circulation (2004) 1.24

Arterial reactivity is significantly impaired in normotensive young adults after successful repair of aortic coarctation in childhood. Circulation (1994) 1.23

In vivo measurement of water diffusion in the human heart. Magn Reson Med (1994) 1.23

Glucocorticoid uptake into human placental membrane vesicles. J Biol Chem (1979) 1.21

Crystal structure at 1.5-A resolution of d(CGCICICG), an octanucleotide containing inosine, and its comparison with d(CGCG) and d(CGCGCG) structures. Biochemistry (1992) 1.17

Improved mechanoenergetics and cardiac rest and reserve function of in vivo failing heart by calcium sensitizer EMD-57033. Circulation (2000) 1.16

Percutaneous balloon dilatation of the atrial septum: immediate and midterm results. Heart (1996) 1.16

Reduction of obesity, as induced by leptin, reverses endothelial dysfunction in obese (Lep(ob)) mice. J Appl Physiol (1985) (2000) 1.14

The influence of temperature on lysozyme crystals. Structure and dynamics of protein and water. Acta Crystallogr D Biol Crystallogr (1995) 1.14

THE INFLUENCE OF HYDROGEN ION CONCENTRATION UPON THE VISCOSITY OF BACTERIAL SUSPENSIONS. J Bacteriol (1926) 1.12

Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. Proc Natl Acad Sci U S A (1998) 1.12

Homology with a repeated Yersinia pestis DNA sequence IS100 correlates with pesticin sensitivity in Yersinia pseudotuberculosis. J Bacteriol (1997) 1.11

Crystal structure of 15-mer DNA duplex containing unpaired bases. Nature (1988) 1.08

Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia. Diabetes (1999) 1.07

Human immunodeficiency virus, type 1 protease substrate specificity is limited by interactions between substrate amino acids bound in adjacent enzyme subsites. J Biol Chem (1996) 1.07

Glucokinase: structural analysis of a protein involved in susceptibility to diabetes. J Biol Chem (1994) 1.07

Contribution of caveolin protein abundance to augmented nitric oxide signaling in conscious dogs with pacing-induced heart failure. Circ Res (2000) 1.07

Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate. Biochemistry (1998) 1.05

Prediction of new serine proteinase inhibitors. Nat Struct Biol (1994) 1.05

Endothelins. Biochemistry and pathophysiologic actions. Anesthesiology (1994) 1.02

Staphylococcal alpha-toxin: a structure-function study using a monoclonal antibody. Toxicon (1986) 1.02

Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice. J Clin Invest (1998) 1.01

Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates. Eur J Biochem (1997) 0.98

Weight loss is not associated with hyperleptinemia in humans with pancreatic cancer. J Clin Endocrinol Metab (2001) 0.97

Comparison of the substrate specificity of the human T-cell leukemia virus and human immunodeficiency virus proteinases. Eur J Biochem (2000) 0.97

Molybdate-stabilized nonactivated glucocorticoid-receptor complexes contain a 90-kDa non-steroid-binding phosphoprotein that is lost on activation. J Biol Chem (1986) 0.97

Expression of alpha 1-adrenergic receptor subtype mRNA in rat tissues and human SK-N-MC neuronal cells: implications for alpha 1-adrenergic receptor subtype classification. Mol Pharmacol (1994) 0.96

THE BACTERICIDAL ACTION OF SYNTHETIC DETERGENTS. J Exp Med (1941) 0.95

Variational calculation of the normal modes of a large macromolecule: methods and some initial results. Biopolymers (1984) 0.95

NOS: modulator, not mediator of cardiac performance. Nat Med (1999) 0.94

Predicted ligand interactions of 3'5'-cyclic nucleotide-gated channel binding sites: comparison of retina and olfactory binding site models. Protein Eng (1996) 0.93

Effects of Pax3 modifier genes on craniofacial morphology, pigmentation, and viability: a murine model of Waardenburg syndrome variation. Genomics (1996) 0.93

Chronic active myocarditis following acute Bartonella henselae infection (cat scratch disease). Am J Surg Pathol (2001) 0.92

Effect of bolus milrinone on hemodynamic variables and pulmonary vascular resistance in patients with severe left ventricular dysfunction: a rapid test for reversibility of pulmonary hypertension. J Am Coll Cardiol (1996) 0.92

Comparison of glucocorticoid-receptor binding kinetics with predictions from a biomolecular model. J Biol Chem (1980) 0.92

Cardiac nitric oxide production due to angiotensin-converting enzyme inhibition decreases beta-adrenergic myocardial contractility in patients with dilated cardiomyopathy. J Am Coll Cardiol (2001) 0.91

The physiological response to cardiovascular 'orphan' G protein-coupled receptor agonists. Nat Med (1999) 0.91

A novel putative reductase (Cpd1p) and the multidrug exporter Snq2p are involved in resistance to cercosporin and other singlet oxygen-generating photosensitizers in Saccharomyces cerevisiae. Curr Genet (2001) 0.91

INHIBITION BY PHOSPHOLIPIDS OF THE ACTION OF SYNTHETIC DETERGENTS ON BACTERIA. J Exp Med (1941) 0.90

Leptin is essential in maintaining normal vascular compliance independent of body weight. Int J Obes (Lond) (2009) 0.90

Two crystal structures of the leupeptin-trypsin complex. Protein Sci (1996) 0.90

Structural basis for specificity of retroviral proteases. Biochemistry (1998) 0.89

A simple new model of physiologically working heterotopic rat heart transplantation provides hemodynamic performance equivalent to that of an orthotopic heart. J Heart Lung Transplant (1999) 0.89

Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. Circulation (1994) 0.89

Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2. Protein Eng (1997) 0.88

Inhibition of nitric oxide synthase augments myocardial contractile responses to beta-adrenergic stimulation. Am J Physiol (1996) 0.88

Nonlinear isochrones in murine left ventricular pressure-volume loops: how well does the time-varying elastance concept hold? Am J Physiol Heart Circ Physiol (2005) 0.88

Characterization of wild type and mutant glucocorticoid receptors from rat hepatoma and mouse lymphoma cells. J Biol Chem (1985) 0.88

Fulminant and acute lymphocytic myocarditis: the prognostic value of clinicopathological classification. Eur Heart J (2001) 0.88

Ultrastructural localization of glucocorticoid receptor (GR) in hypothalamic paraventricular neurons synthesizing corticotropin releasing factor (CRF). Histochemistry (1987) 0.88

Molecular mechanics analysis of drug-resistant mutants of HIV protease. Protein Eng (1999) 0.87

Augmented age-associated innate immune responses contribute to negative inotropic and lusitropic effects of lipopolysaccharide and interferon gamma. J Mol Cell Cardiol (2001) 0.87

Molecular mechanics calculations on Rous sarcoma virus protease with peptide substrates. Protein Sci (1997) 0.87

Monoclonal antibody to the rat glucocorticoid receptor. Relationship between the immunoreactive and DNA-binding domain. J Biol Chem (1985) 0.87

Estrogen receptors in the chick oviduct. Endocrinology (1975) 0.86