Published in Am J Physiol Heart Circ Physiol on March 01, 2000
Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A. J Clin Invest (2003) 2.37
NO/redox disequilibrium in the failing heart and cardiovascular system. J Clin Invest (2005) 1.94
Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling. Proc Natl Acad Sci U S A (2003) 1.76
Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics. Pharmacol Ther (2009) 1.66
Cardiovascular roles of nitric oxide: a review of insights from nitric oxide synthase gene disrupted mice. Cardiovasc Res (2008) 1.53
Pathological cardiac hypertrophy alters intracellular targeting of phosphodiesterase type 5 from nitric oxide synthase-3 to natriuretic peptide signaling. Circulation (2012) 1.51
Nitric oxide signaling and the regulation of myocardial function. J Mol Cell Cardiol (2008) 1.50
Modulation of cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice. J Physiol (2003) 1.36
Endothelial nitric oxide synthase transgenic models of endothelial dysfunction. Pflugers Arch (2010) 1.22
Endothelial nitric oxide synthase decreases beta-adrenergic responsiveness via inhibition of the L-type Ca2+ current. Am J Physiol Heart Circ Physiol (2008) 1.11
The role of NOS in heart failure: lessons from murine genetic models. Heart Fail Rev (2002) 1.08
Nitric oxide synthases in heart failure. Antioxid Redox Signal (2012) 1.07
beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility. J Clin Invest (2000) 1.00
Displacement-encoded and manganese-enhanced cardiac MRI reveal that nNOS, not eNOS, plays a dominant role in modulating contraction and calcium influx in the mammalian heart. Am J Physiol Heart Circ Physiol (2011) 0.99
Inotropic response to beta-adrenergic receptor stimulation and anti-adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts. J Physiol (2001) 0.99
Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component? Philos Trans R Soc Lond B Biol Sci (2004) 0.96
Muscarinic inhibitory and stimulatory regulation of the L-type Ca2+ current is not altered in cardiac ventricular myocytes from mice lacking endothelial nitric oxide synthase. J Physiol (2000) 0.93
Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes. J Mol Cell Cardiol (2009) 0.89
Effects of exercise training on pathological cardiac hypertrophy related gene expression and apoptosis. Eur J Appl Physiol (2006) 0.88
IL-33 independently induces eosinophilic pericarditis and cardiac dilation: ST2 improves cardiac function. Circ Heart Fail (2012) 0.88
Endothelium-driven myocardial growth or nitric oxide at the crossroads. Trends Cardiovasc Med (2008) 0.86
Role of NO synthase in the development of Trypanosoma cruzi-induced cardiomyopathy in mice. Am J Trop Med Hyg (2009) 0.85
Nitric oxide-cyclic GMP signaling in stem cell differentiation. Free Radic Biol Med (2011) 0.85
miR-222 contributes to sex-dimorphic cardiac eNOS expression via ets-1. Physiol Genomics (2013) 0.84
Increased mitochondrial prooxidant activity mediates up-regulation of Complex I S-glutathionylation via protein thiyl radical in the murine heart of eNOS(-/-). Free Radic Biol Med (2014) 0.81
Effects of ozone and particulate matter on cardiac mechanics: role of the atrial natriuretic peptide gene. Toxicol Sci (2012) 0.80
Prolonged Action Potential and After depolarizations Are Not due to Changes in Potassium Currents in NOS3 Knockout Ventricular Myocytes. J Signal Transduct (2012) 0.79
Role of nitric oxide in the pathophysiology of heart failure. Heart Fail Rev (2003) 0.78
Effect of crocin on nitric oxide synthase expression in post-ischemic isolated rat heart. Avicenna J Phytomed (2015) 0.76
Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature (1995) 9.86
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest (1998) 5.95
Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science (1994) 5.15
Targeted disruption of the neuronal nitric oxide synthase gene. Cell (1993) 5.02
Prevention of vertebrate neuronal death by the crmA gene. Science (1994) 4.09
Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci U S A (2001) 3.88
Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development (1996) 3.63
Gridlock, a localized heritable vascular patterning defect in the zebrafish. Nat Med (1995) 3.59
Zebrafish genetic map with 2000 microsatellite markers. Genomics (1999) 3.56
Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science (1996) 3.32
Gridlock signalling pathway fashions the first embryonic artery. Nature (2001) 3.30
Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature (1995) 3.15
Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development (1998) 3.07
A microsatellite genetic linkage map for zebrafish (Danio rerio). Nat Genet (1998) 3.06
Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages. Development (1995) 3.05
Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation (2001) 3.01
Impaired metabolic modulation of alpha-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle. Proc Natl Acad Sci U S A (1998) 3.00
Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature (1996) 2.94
gridlock, an HLH gene required for assembly of the aorta in zebrafish. Science (2000) 2.90
Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine. J Cereb Blood Flow Metab (1996) 2.78
Potassium current suppression by quinidine reveals additional calcium currents in neuroblastoma cells. Proc Natl Acad Sci U S A (1981) 2.45
Hematopoietic mutations in the zebrafish. Development (1996) 2.25
Myocardial ischemia-reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase. Am J Physiol (1999) 2.13
Effects of targeted neuronal nitric oxide synthase gene disruption and nitroG-L-arginine methylester on the threshold for isoflurane anesthesia. Anesthesiology (1995) 2.13
Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development (1996) 2.12
Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J Cereb Blood Flow Metab (1996) 2.01
Vessel patterning in the embryo of the zebrafish: guidance by notochord. Dev Biol (1997) 1.99
Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J Exp Med (1997) 1.89
An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice. Proc Natl Acad Sci U S A (2000) 1.89
Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice. Circulation (2001) 1.89
Cardiovascular development in the zebrafish. I. Myocardial fate map and heart tube formation. Development (1993) 1.85
Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development (1997) 1.84
Neuroprotection mediated by changes in the endothelial actin cytoskeleton. J Clin Invest (2000) 1.76
Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J Neurosci (1996) 1.73
Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice. Am J Physiol (1999) 1.72
G0 is a major growth cone protein subject to regulation by GAP-43. Nature (1990) 1.72
Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J Clin Invest (1998) 1.72
Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell (1995) 1.71
The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Invest (1999) 1.71
A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms. Development (1996) 1.67
Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. J Clin Invest (1998) 1.65
Growth and function of the embryonic heart depend upon the cardiac-specific L-type calcium channel alpha1 subunit. Dev Cell (2001) 1.65
Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Circ Res (1997) 1.63
Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice. Circulation (2001) 1.63
Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase. Cell (1996) 1.61
Mutations affecting development of zebrafish digestive organs. Development (1996) 1.58
Cloning of complementary DNA for GAP-43, a neuronal growth-related protein. Science (1987) 1.57
Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice. Invest Ophthalmol Vis Sci (2001) 1.57
Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. Science (1994) 1.56
Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice. Br J Pharmacol (1999) 1.54
nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle. Physiol Genomics (2000) 1.54
Partitioning of tissue expression accompanies multiple duplications of the Na+/K+ ATPase alpha subunit gene. Genome Res (2001) 1.50
A membrane-targeting signal in the amino terminus of the neuronal protein GAP-43. Nature (1989) 1.49
G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart. Proc Natl Acad Sci U S A (1997) 1.48
Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke (2001) 1.47
Pre-pattern in the pronephric kidney field of zebrafish. Development (2001) 1.43
Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. Circ Res (1999) 1.41
Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. J Exp Med (1999) 1.38
Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice. J Neurosci (1997) 1.38
Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells. Proc Natl Acad Sci U S A (1985) 1.36
Neuronal constitutive nitric oxide synthase is involved in murine enteric inhibitory neurotransmission. J Clin Invest (1996) 1.35
Simvastatin exerts both anti-inflammatory and cardioprotective effects in apolipoprotein E-deficient mice. Circulation (2001) 1.34
Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice. Circulation (2001) 1.31
Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin. Proc Natl Acad Sci U S A (1999) 1.30
Defective "pacemaker" current (Ih) in a zebrafish mutant with a slow heart rate. Proc Natl Acad Sci U S A (1997) 1.30
MAP 30: a new inhibitor of HIV-1 infection and replication. FEBS Lett (1990) 1.30
Regulation in the heart field of zebrafish. Development (1998) 1.29
A gene defect that causes conduction system disease and dilated cardiomyopathy maps to chromosome 1p1-1q1. Nat Genet (1994) 1.28
Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul. Curr Biol (2001) 1.27
A long purine-pyrimidine homopolymer acts as a transcriptional diode. J Biol Chem (1995) 1.27
ACh dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms. Am J Physiol (1996) 1.26
Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles. Physiol Genomics (2001) 1.25
Patterning the zebrafish heart tube: acquisition of anteroposterior polarity. Dev Biol (1992) 1.24
Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1998) 1.23
Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice. J Cereb Blood Flow Metab (1999) 1.23
Genetics of heart development. Trends Genet (2000) 1.23
Anti-HIV and anti-tumor activities of recombinant MAP30 from bitter melon. Gene (1995) 1.22
Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase. J Physiol (1998) 1.22
Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts. Proc Natl Acad Sci U S A (2005) 1.21
Endogenous digitalis-like activity in mammalian brain. Proc Natl Acad Sci U S A (1979) 1.21
The neuronal growth-associated protein GAP-43 induces filopodia in non-neuronal cells. Science (1989) 1.19
Inhibition of the integrase of human immunodeficiency virus (HIV) type 1 by anti-HIV plant proteins MAP30 and GAP31. Proc Natl Acad Sci U S A (1995) 1.18
Oxygen chemoreception by carotid body cells in culture. Proc Natl Acad Sci U S A (1985) 1.17