The combined action of IL-15 and IL-12 gene transfer can induce tumor cell rejection without T and NK cell involvement.

PubWeight™: 0.82‹?›

🔗 View Article (PMID 10975824)

Published in J Immunol on September 15, 2000

Authors

E Di Carlo1, A Comes, S Basso, A De Ambrosis, R Meazza, P Musiani, K Moelling, A Albini, S Ferrini

Author Affiliations

1: Dipartimento di Oncologia e Neuroscienze, Università di Chieti, Chieti, Italy.

Articles by these authors

A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res (1987) 7.43

Phosphorylation and regulation of Raf by Akt (protein kinase B). Science (1999) 5.61

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science (1999) 4.10

Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus. Nature (1982) 3.64

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice. EMBO J (1995) 3.48

Therapy of tuberculosis in mice by DNA vaccination. Nature (1999) 2.99

The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood (2001) 2.92

Two subsets of human T lymphocytes expressing gamma/delta antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor. J Exp Med (1988) 2.86

Specific binding of HIV-1 nucleocapsid protein to PSI RNA in vitro requires N-terminal zinc finger and flanking basic amino acid residues. EMBO J (1994) 2.86

Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins. Nature (1985) 2.82

DNA vaccination against rat her-2/Neu p185 more effectively inhibits carcinogenesis than transplantable carcinomas in transgenic BALB/c mice. J Immunol (2000) 2.65

Identification and characterization of HIV-specific RNase H by monoclonal antibody. EMBO J (1988) 2.56

Biochemical properties of p15-associated protease in an avian RNA tumor virus. J Virol (1978) 2.55

Interaction of HIV-1 ribonuclease H with polypurine tract containing RNA-DNA hybrids. Biochemistry (1990) 2.29

Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Blood (1999) 2.28

Characterization of reverse transcriptase and RNase H from friend-murine leukemia virus. Virology (1974) 2.28

CD3-negative lymphokine-activated cytotoxic cells express the CD3 epsilon gene. J Immunol (1988) 2.22

DNA-binding activity is associated with purified myb proteins from AMV and E26 viruses and is temperature-sensitive for E26 ts mutants. Cell (1985) 2.11

Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice. J Exp Med (1998) 2.08

RNase H activity associated with bacterially expressed reverse transcriptase of human T-cell lymphotropic virus III/lymphadenopathy-associated virus. J Biol Chem (1987) 2.01

Effect of p15-associated protease from an avian RNA tumor virus on avian virus-specific polyprotein precursors. J Virol (1980) 1.94

Properties of the avian viral protein p12. J Gen Virol (1981) 1.90

Mutations within the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase abolish virus infectivity. J Gen Virol (1991) 1.80

The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity. Int J Cancer (2000) 1.71

A monoclonal antibody specific for a common determinant of the human T cell receptor gamma/delta directly activates CD3+WT31- lymphocytes to express their functional program(s). J Exp Med (1988) 1.71

Mutagenesis and selection of PDZ domains that bind new protein targets. Nat Biotechnol (1999) 1.69

HIV-1 Tat protein mimicry of chemokines. Proc Natl Acad Sci U S A (1998) 1.67

Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol. J Biol Chem (2001) 1.67

Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2/neu transgenic mice. J Exp Med (2001) 1.66

Specific recognition of human CD3-CD16+ natural killer cells requires the expression of an autosomic recessive gene on target cells. J Exp Med (1990) 1.63

Electrocardiographic signs of chronic cor pulmonale: A negative prognostic finding in chronic obstructive pulmonary disease. Circulation (1999) 1.63

Prospective monitoring of polyomavirus BK replication and impact of pre-emptive intervention in pediatric kidney recipients. Am J Transplant (2007) 1.61

Analysis of precursors to the envelope glycoproteins of avian RNA tumor viruses in chicken and quail cells. J Virol (1977) 1.61

A comparative study of the avian reticuloendotheliosis virus: relationship to murine leukemia virus and viruses of the avian sarcoma-leukosis complex. Virology (1975) 1.59

TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis. Int J Cancer (1998) 1.58

Reverse transcriptase and RNase H: present in a murine virus and in both subunits of an avian virus. Cold Spring Harb Symp Quant Biol (1975) 1.58

Reduction of a conserved Cys is essential for Myb DNA-binding. Nucleic Acids Res (1992) 1.55

Further characterization of the Friend murine leukemia virus reverse transcriptase-RNase H complex. J Virol (1976) 1.55

Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int Immunol (1995) 1.51

Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. EMBO J (1998) 1.50

c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro. Proc Natl Acad Sci U S A (1999) 1.49

Partial purification and substrate analysis of bacterially expressed HIV protease by means of monoclonal antibody. EMBO J (1988) 1.46

Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons. Mol Cell Neurosci (2001) 1.45

Mutations of basic amino acids of NCp7 of human immunodeficiency virus type 1 affect RNA binding in vitro. J Virol (1996) 1.43

HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons. Biochem Biophys Res Commun (2001) 1.39

Preemptive therapy of EBV-related lymphoproliferative disease after pediatric haploidentical stem cell transplantation. Am J Transplant (2007) 1.39

Characterization of CD3+, CD4-, CD8- clones expressing the putative T cell receptor gamma gene product. Analysis of the activation pathways leading to interleukin 2 production and triggering of the lytic machinery. J Exp Med (1987) 1.37

Analysis of mammary carcinoma onset and progression in HER-2/neu oncogene transgenic mice reveals a lobular origin. Lab Invest (1999) 1.37

Synthetic peptides as substrates and inhibitors of human immune deficiency virus-1 protease. J Biol Chem (1988) 1.35

T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function. Eur J Immunol (1994) 1.33

The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain. J Cell Biol (1999) 1.33

Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size. J Biol Chem (1997) 1.32

Conformational and nucleic acid binding studies on the synthetic nucleocapsid protein of HIV-1. J Mol Biol (1993) 1.31

Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi's sarcoma. Am J Pathol (1996) 1.30

Antitumor efficacy of adenocarcinoma cells engineered to produce interleukin 12 (IL-12) or other cytokines compared with exogenous IL-12. J Natl Cancer Inst (1997) 1.30

Further analysis of the T cell receptor gamma/delta+ peripheral lymphocyte subset. The V delta 1 gene segment is expressed with either C alpha or C delta. J Exp Med (1990) 1.29

Amino acid requirements of the nucleocapsid protein of HIV-1 for increasing catalytic activity of a Ki-ras ribozyme in vitro. J Mol Biol (1994) 1.29

Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice. Am J Pathol (1997) 1.28

Phenotypic and functional characterization of recombinant interleukin 2 (rIL 2)-induced activated killer cells: analysis at the population and clonal levels. J Immunol (1987) 1.27

KSHV sequences in biopsies and cultured spindle cells of epidemic, iatrogenic and Mediterranean forms of Kaposi's sarcoma. Res Virol (1997) 1.27

Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells. J Biol Chem (2001) 1.26

Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate. Cancer (2001) 1.26

Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1. Oncogene (1996) 1.25

DNA damage induced by auramine O in liver, kidney, and bone marrow of rats and mice, and in a human cell line (alkaline elution assay and SCE induction). J Toxicol Environ Health (1982) 1.24

The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein. J Virol (1995) 1.24

Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility. J Cell Biol (1994) 1.24

Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory. J Immunol (1995) 1.23

14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. J Biol Chem (1997) 1.22

The isolation of avian viral RNA and polypeptides. J Biol Chem (1979) 1.21

Selective DNA binding of the human cellular myb protein isolated by immunoaffinity chromatography using a monoclonal antibody. Oncogene (1987) 1.20

Vascular endothelial growth factor-C stimulates the migration and proliferation of Kaposi's sarcoma cells. J Biol Chem (1999) 1.18

Role of soluble mediators in angiogenesis. Eur J Cancer (1996) 1.17

The transforming protein of the MC29-related virus CMII is a nuclear DNA-binding protein whereas MH2 codes for a cytoplasmic RNA-DNA binding polyprotein. EMBO J (1983) 1.17

Human CD3+4-8-WT31- T lymphocyte populations expressing the putative T cell receptor gamma-gene product. A limiting dilution and clonal analysis. Eur J Immunol (1987) 1.17

Role of interleukins 1 and 2 on human thymocyte mitogen activation. Cell Immunol (1981) 1.17

Direct interaction of CREB protein with 21 bp Tax-response elements of HTLV-ILTR. Oncogene (1992) 1.17

Effect of viral RNase H on the avian sarcoma viral genome during early transcription in vitro. J Virol (1979) 1.16

Microencapsulation of DNA using poly(DL-lactide-co-glycolide): stability issues and release characteristics. J Control Release (1999) 1.16

Bcl-2 overexpression and hypoxia synergistically act to modulate vascular endothelial growth factor expression and in vivo angiogenesis in a breast carcinoma line. FASEB J (2000) 1.15

Inhibition of tumor growth and enhancement of metastasis after transfection of the gamma-interferon gene. Int J Cancer (1993) 1.15

Interleukin-15 triggers the proliferation and cytotoxicity of granular lymphocytes in patients with lymphoproliferative disease of granular lymphocytes. Blood (1997) 1.14

Epidermal growth factor receptor expression in human lung cancer cell lines. Cancer Res (1988) 1.14

p185(neu) protein is required for tumor and anchorage-independent growth, not for cell proliferation of transgenic mammary carcinoma. Int J Cancer (2000) 1.14

The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain. Mol Cell Biol (2003) 1.14

Immune events associated with the cure of established tumors and spontaneous metastases by local and systemic interleukin 12. Cancer Res (1999) 1.14

IFN-alpha 1 gene expression into a metastatic murine adenocarcinoma (TS/A) results in CD8+ T cell-mediated tumor rejection and development of antitumor immunity. Comparative studies with IFN-gamma-producing TS/A cells. J Immunol (1994) 1.14

Isolation and characterization of the human cellular myc gene product. Biochemistry (1985) 1.13

Identification of a novel domain of HIV tat involved in monocyte chemotaxis. J Biol Chem (1998) 1.13

Cytokines and chemokines as regulators of angiogenesis in health and disease. Curr Pharm Des (2006) 1.12

Selective increase of a subset of T cell receptor gamma delta T lymphocytes in the peripheral blood of patients with human immunodeficiency virus type 1 infection. J Infect Dis (1992) 1.12

Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities. Endocrinology (2003) 1.12

Association of gag-myc proteins from avian myelocytomatosis virus wild-type and mutants with chromatin. EMBO J (1982) 1.11

The role of the thiol N-acetylcysteine in the prevention of tumor invasion and angiogenesis. Int J Biol Markers (2000) 1.11

Transferrin promotes endothelial cell migration and invasion: implication in cartilage neovascularization. J Cell Biol (1997) 1.11

Chemopreventive properties and mechanisms of N-Acetylcysteine. The experimental background. J Cell Biochem Suppl (1995) 1.11

Adoptive transfer of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T cells with in vitro antitumor activity boosts LMP2-specific immune response in a patient with EBV-related nasopharyngeal carcinoma. Ann Oncol (2004) 1.11

Human cytolytic cell clones lacking surface expression of T cell receptor alpha/beta or gamma/delta. Evidence that surface structures other than CD3 or CD2 molecules are required for signal transduction. J Exp Med (1988) 1.10

Enzymatic analysis of two HIV-1 reverse transcriptase mutants with mutations in carboxyl-terminal amino acid residues conserved among retroviral ribonucleases H. J Biol Chem (1993) 1.10

The alpha 3 beta 1 integrin is involved in melanoma cell migration and invasion. Exp Cell Res (1995) 1.09