Published in J Cell Biol on September 18, 2000
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
Direct real-time observation of actin filament branching mediated by Arp2/3 complex using total internal reflection fluorescence microscopy. Proc Natl Acad Sci U S A (2001) 2.89
Hierarchical regulation of WASP/WAVE proteins. Mol Cell (2008) 2.86
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Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex. Biochem J (2004) 2.08
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Pathogens and polymers: microbe-host interactions illuminate the cytoskeleton. J Cell Biol (2011) 1.63
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An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine. J Cell Biol (2001) 1.58
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The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency. Nature (2008) 1.48
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A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. J Cell Biol (2001) 1.44
Phosphatidylinositol 4,5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in CV1 cells. J Cell Biol (2001) 1.43
Regulation of protein transport from the Golgi complex to the endoplasmic reticulum by CDC42 and N-WASP. Mol Biol Cell (2002) 1.42
Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages. J Cell Sci (2009) 1.41
Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth. J Neurosci (2008) 1.35
Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle. J Cardiovasc Pharmacol Ther (2008) 1.34
N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts. Mol Biol Cell (2006) 1.31
Cdc42p functions at the docking stage of yeast vacuole membrane fusion. EMBO J (2001) 1.31
Role of the WASP family proteins for Mycobacterium marinum actin tail formation. Proc Natl Acad Sci U S A (2005) 1.25
A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. Mol Biol Cell (2005) 1.24
How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility. PLoS Comput Biol (2012) 1.22
A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci U S A (2001) 1.22
Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Mol Cell Biol (2005) 1.21
Btk regulates B cell receptor-mediated antigen processing and presentation by controlling actin cytoskeleton dynamics in B cells. J Immunol (2009) 1.20
A WASp-VASP complex regulates actin polymerization at the plasma membrane. EMBO J (2001) 1.20
Phosphorylation of WASp is a key regulator of activity and stability in vivo. Proc Natl Acad Sci U S A (2009) 1.18
Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry. Proc Natl Acad Sci U S A (2007) 1.16
Rho GTPases in platelet function. J Thromb Haemost (2013) 1.15
c-mip impairs podocyte proximal signaling and induces heavy proteinuria. Sci Signal (2010) 1.12
Lipid rafts and regulation of the cytoskeleton during T cell activation. Philos Trans R Soc Lond B Biol Sci (2005) 1.11
Mechanism of a concentration-dependent switch between activation and inhibition of Arp2/3 complex by coronin. J Biol Chem (2011) 1.10
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Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake. J Exp Med (2003) 1.08
Bacterial subversion of host actin dynamics at the plasma membrane. Cell Microbiol (2011) 1.07
Close packing of Listeria monocytogenes ActA, a natively unfolded protein, enhances F-actin assembly without dimerization. J Biol Chem (2008) 1.07
Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J Immunol (2013) 1.05
Molecular mechanisms of cell-cell spread of intracellular bacterial pathogens. Open Biol (2013) 1.04
Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1. J Cell Biol (2009) 1.02
The small GTPase RhoA regulates the contraction of smooth muscle tissues by catalyzing the assembly of cytoskeletal signaling complexes at membrane adhesion sites. J Biol Chem (2012) 1.01
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Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells. Nat Commun (2011) 0.99
Evaluating the stoichiometry of macromolecular complexes using multisignal sedimentation velocity. Methods (2011) 0.98
Effect of Fgd1 on cortactin in Arp2/3 complex-mediated actin assembly. Biochemistry (2004) 0.98
Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP. Elife (2013) 0.97
Stoichiometry of Nck-dependent actin polymerization in living cells. J Cell Biol (2012) 0.97
Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation. PLoS Pathog (2010) 0.97
Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells. Proc Natl Acad Sci U S A (2004) 0.97
N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer. Clin Exp Metastasis (2007) 0.96
Actin monomers activate inverted formin 2 by competing with its autoinhibitory interaction. J Biol Chem (2013) 0.96
WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling. Br J Haematol (2009) 0.94
How WASP regulates actin polymerization. J Cell Biol (2000) 0.93
Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults. Dev Biol (2007) 0.93
The actin nucleation factor JMY is a negative regulator of neuritogenesis. Mol Biol Cell (2011) 0.93
Arp2/3-mediated F-actin formation controls regulated exocytosis in vivo. Nat Commun (2015) 0.92
N-wasp is essential for the negative regulation of B cell receptor signaling. PLoS Biol (2013) 0.92
WASP is activated by phosphatidylinositol-4,5-bisphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling. Proc Natl Acad Sci U S A (2010) 0.92
Immune pathology associated with altered actin cytoskeleton regulation. Autoimmunity (2010) 0.92
A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanism. Mol Cell Biol (2011) 0.92
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n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation. Biochem J (2012) 0.90
Single cell pattern formation and transient cytoskeletal arrays. Curr Opin Cell Biol (2013) 0.90
Enhanced membrane fusion in sterol-enriched vacuoles bypasses the Vrp1p requirement. Mol Biol Cell (2004) 0.89
Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity. Front Immunol (2014) 0.88
Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation. Immunol Rev (2013) 0.88
N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis. Exp Cell Res (2010) 0.88
Grab your partner with both hands: cytoskeletal remodeling by Arp2/3 signaling. Sci Signal (2009) 0.88
A phosphatidylinositol-transfer protein and phosphatidylinositol-4-phosphate 5-kinase control Cdc42 to regulate the actin cytoskeleton and secretory pathway in yeast. Mol Biol Cell (2009) 0.88
The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation. Biochim Biophys Acta (2013) 0.86
Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem J (2003) 0.85
Surfing the big WAVE: Insights into the role of WAVE3 as a driving force in cancer progression and metastasis. Semin Cell Dev Biol (2012) 0.85
Cytoplasmic actin: purification and single molecule assembly assays. Methods Mol Biol (2013) 0.85
Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling. Respir Res (2015) 0.83
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A novel role for RhoA GTPase in the regulation of airway smooth muscle contraction. Can J Physiol Pharmacol (2014) 0.83
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Novel anti-HIV therapeutics targeting chemokine receptors and actin regulatory pathways. Immunol Rev (2013) 0.80
Autonomous and in trans functions for the two halves of Srv2/CAP in promoting actin turnover. Cytoskeleton (Hoboken) (2014) 0.80
Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse. Cell Mol Life Sci (2014) 0.79
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