Published in Br J Haematol on October 27, 2009
Platelet geometry sensing spatially regulates α-granule secretion to enable matrix self-deposition. Blood (2015) 1.40
Autoimmunity in wiskott-Aldrich syndrome: an unsolved enigma. Front Immunol (2012) 1.27
Role of WASP in cell polarity and podosome dynamics of myeloid cells. Eur J Cell Biol (2010) 1.20
Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation. PLoS One (2011) 0.98
Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia. Blood (2015) 0.86
Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome. Dis Model Mech (2013) 0.80
Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex. Nat Commun (2015) 0.79
Wiskott-Aldrich syndrome: diagnosis, current management, and emerging treatments. Appl Clin Genet (2014) 0.78
Single-platelet nanomechanics measured by high-throughput cytometry. Nat Mater (2016) 0.75
Increased uptake by splenic red pulp macrophages contributes to rapid platelet turnover in WASP(-) mice. Exp Hematol (2013) 0.75
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell (1991) 11.51
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature (2000) 4.51
Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A (2003) 4.03
Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex. J Cell Biol (2000) 3.12
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol (2002) 2.92
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity (1998) 2.92
Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med (1999) 2.81
Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function. Nature (1999) 2.71
Platelet activation and blood coagulation. Thromb Haemost (2002) 2.68
A multiinstitutional survey of the Wiskott-Aldrich syndrome. J Pediatr (1994) 2.39
The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood (2008) 2.22
The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments. J Cell Biol (1991) 2.11
The Wiskott-Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets. Blood (1980) 1.91
Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets. Eur J Biochem (1982) 1.61
Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment. Blood (2006) 1.56
Pathological events in platelets of Wiskott-Aldrich syndrome patients. Br J Haematol (1999) 1.53
Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets. J Biol Chem (1991) 1.48
Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and "clinical restenosis". J Clin Invest (1996) 1.39
Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function. J Biol Chem (2000) 1.37
Tyrosine phosphorylation of the beta3 cytoplasmic domain mediates integrin-cytoskeletal interactions. J Biol Chem (1998) 1.34
Wiskott-Aldrich syndrome: qualitative platelet defects and short platelet survival. Br J Haematol (1969) 1.32
The platelet cytoskeleton. Thromb Haemost (1993) 1.29
Lactadherin blocks thrombosis and hemostasis in vivo: correlation with platelet phosphatidylserine exposure. J Thromb Haemost (2008) 1.22
Sheep, pig, and human platelet-material interactions with model cardiovascular biomaterials. J Biomed Mater Res (1999) 1.16
Normal Arp2/3 complex activation in platelets lacking WASp. Blood (2002) 1.14
A role for PKCtheta in outside-in alpha(IIb)beta3 signaling. J Thromb Haemost (2006) 1.13
Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clots. J Biol Chem (1997) 1.10
Formation and fate of platelet microparticles. Blood Cells Mol Dis (2006) 1.10
Regulation and function of WASp in platelets by the collagen receptor, glycoprotein VI. Blood (1999) 1.07
Rapid platelet turnover in WASP(-) mice correlates with increased ex vivo phagocytosis of opsonized WASP(-) platelets. Exp Hematol (2008) 1.06
Fibrin clot retraction by human platelets correlates with alpha(IIb)beta(3) integrin-dependent protein tyrosine dephosphorylation. J Biol Chem (2000) 1.03
Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion. EMBO Rep (2006) 1.02
Role of the membrane skeleton in preventing the shedding of procoagulant-rich microvesicles from the platelet plasma membrane. J Cell Biol (1990) 1.01
Platelet-associated immunoglobulin, platelet size, and the effect of splenectomy in the Wiskott-Aldrich syndrome. Blood (1985) 1.00
Nature of the platelet defect in the Wiskott-Aldrich syndrome. Ann N Y Acad Sci (1972) 0.98
Shedding of procoagulant microparticles from unstimulated platelets by integrin-mediated destabilization of actin cytoskeleton. FEBS Lett (2006) 0.95
Platelet-derived microparticle formation involves glycoprotein IIb-IIIa. Inhibition by RGDS and a Glanzmann's thrombasthenia defect. J Biol Chem (1993) 0.91
Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading. Blood (2007) 0.89
WASP localizes to the membrane skeleton of platelets. Br J Haematol (2007) 0.88
Correction of the murine Wiskott-Aldrich syndrome phenotype by hematopoietic stem cell transplantation. Blood (2002) 0.86
Hereditary thrombocytopenia with an intrinsic platelet defect. N Engl J Med (1969) 0.84
The thrombocytopenia of WAS: a familial form of ITP? Immunol Res (2009) 0.83
Molecular biology of the Wiskott-Aldrich syndrome. Rev Immunogenet (2000) 0.81
Wiskott-Aldrich syndrome protein and platelets. Immunol Rev (2000) 0.79
Differential effect of the GPIIb/IIIa antagonist orbofiban on human platelet aggregate formation in vitro. Thromb Res (2003) 0.78
Membrane phosphatidylserine regulates surface charge and protein localization. Science (2008) 5.37
Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science (2010) 4.22
Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. Proc Natl Acad Sci U S A (2002) 2.32
Inflammation induces hemorrhage in thrombocytopenia. Blood (2008) 2.28
SerpinB1 protects the mature neutrophil reserve in the bone marrow. J Leukoc Biol (2011) 1.60
Procoagulant activity and phosphatidylserine of amniotic fluid cells. Thromb Haemost (2009) 1.43
The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection. J Exp Med (2007) 1.37
Lactadherin binds selectively to membranes containing phosphatidyl-L-serine and increased curvature. Biochim Biophys Acta (2004) 1.33
Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites. Blood (2002) 1.32
Lactadherin detects early phosphatidylserine exposure on immortalized leukemia cells undergoing programmed cell death. Cytometry A (2006) 1.19
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain. J Biol Chem (2004) 1.18
Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity. Blood (2009) 1.14
SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol (2006) 1.13
Crystal structure of lactadherin C2 domain at 1.7A resolution with mutational and computational analyses of its membrane-binding motif. J Biol Chem (2007) 1.13
The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates. Proc Natl Acad Sci U S A (2005) 1.09
Genotype-proteotype linkage in the Wiskott-Aldrich syndrome. J Immunol (2005) 1.06
Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis. J Am Soc Nephrol (2004) 1.05
A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function. Blood (2010) 1.04
Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Genomics (2002) 1.03
Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1). J Biol Chem (2002) 1.02
A serpinB1 regulatory mechanism is essential for restricting neutrophil extracellular trap generation. J Immunol (2012) 0.99
Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Biochem Biophys Res Commun (2010) 0.97
Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection. J Infect Dis (2011) 0.95
Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation. J Clin Invest (2014) 0.95
Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease. J Leukoc Biol (2008) 0.94
Aerosol treatment with MNEI suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection. Pediatr Pulmonol (2005) 0.93
Membrane-binding properties of the Factor VIII C2 domain. Biochem J (2011) 0.90
Relationship of proteinases and proteinase inhibitors with microbial presence in chronic lung disease of prematurity. Thorax (2010) 0.89
Lactadherin binds to phosphatidylserine-containing vesicles in a two-step mechanism sensitive to vesicle size and composition. Biochim Biophys Acta (2011) 0.88
WASP localizes to the membrane skeleton of platelets. Br J Haematol (2007) 0.88
Endothelial cell phagocytosis of senescent neutrophils decreases procoagulant activity. Thromb Haemost (2013) 0.87
An Alu-mediated deletion at Xp11.23 leading to Wiskott-Aldrich syndrome. Hum Genet (2002) 0.87
Wiskott-Aldrich syndrome in a female. Blood (2002) 0.86
Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. J Immunol (2010) 0.86
DNase 2 is the main DNA-degrading enzyme of the stratum corneum. PLoS One (2011) 0.85
Daunorubicin induces procoagulant activity of cultured endothelial cells through phosphatidylserine exposure and microparticles release. Thromb Haemost (2010) 0.84
Mosaicism of NK cells in a patient with Wiskott-Aldrich syndrome. Blood (2005) 0.84
SerpinB1 regulates homeostatic expansion of IL-17+ γδ and CD4+ Th17 cells. J Leukoc Biol (2013) 0.83
SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G. Blood (2013) 0.82
Bovine lactadherin as a calcium-independent imaging agent of phosphatidylserine expressed on the surface of apoptotic HeLa cells. J Histochem Cytochem (2009) 0.82
Phagocytosis by macrophages and endothelial cells inhibits procoagulant and fibrinolytic activity of acute promyelocytic leukemia cells. Blood (2011) 0.81
Evolution of highly polymorphic T cell populations in siblings with the Wiskott-Aldrich Syndrome. PLoS One (2008) 0.81
DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants. J Leukoc Biol (2013) 0.80
High incidence of lymphomas in a subgroup of Wiskott-Aldrich syndrome patients. Br J Haematol (2003) 0.80
SerpinB1 deficiency is not associated with increased susceptibility to pulmonary emphysema in mice. Am J Physiol Lung Cell Mol Physiol (2013) 0.79
Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells. PLoS One (2013) 0.77
A substrate-based approach to convert SerpinB1 into a specific inhibitor of proteinase 3, the Wegener's granulomatosis autoantigen. FASEB J (2011) 0.76
Daunorubicin induces procoagulant response through phosphatidylserine exposure in red blood cells. Thromb Res (2009) 0.76
Increased surfactant protein D fails to improve bacterial clearance and inflammation in serpinB1-/- mice. Am J Respir Cell Mol Biol (2012) 0.75
Lysine 5 and phenylalanine 9 of the factor IX omega-loop interact with phosphatidylserine in a membrane-mimetic environment. Biochemistry (2004) 0.75
Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1. Biol Chem (2016) 0.75
Backbone resonance assignments of the C2 domain of coagulation factor VIII. Biomol NMR Assign (2012) 0.75