Substrate-assisted catalysis of the PAR1 thrombin receptor. Enhancement of macromolecular association and cleavage.

PubWeight™: 1.05‹?› | Rank: Top 15%

🔗 View Article (PMID 11005807)

Published in J Biol Chem on December 29, 2000

Authors

S L Jacques1, M LeMasurier, P J Sheridan, S K Seeley, A Kuliopulos

Author Affiliations

1: Molecular Cardiology Research Institute, Division of Hematology/Oncology, New England Medical Center and Departments of Medicine and Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

Articles citing this

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46. Blood (2012) 1.35

In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. Integr Biol (Camb) (2012) 1.11

N-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization. J Biol Chem (2010) 1.08

Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions. J Biol Chem (2005) 1.06

Matrix metalloproteases and PAR1 activation. Blood (2012) 1.05

Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by α-thrombin. J Biol Chem (2013) 1.04

Thrombin inhibits nuclear factor kappaB and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C. Thromb Haemost (2009) 1.02

Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage. Biochem J (2003) 0.99

Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site. Biochemistry (2007) 0.97

Bivalirudin is a dual inhibitor of thrombin and collagen-dependent platelet activation in patients undergoing percutaneous coronary intervention. Circ Cardiovasc Interv (2011) 0.95

Suppression of arterial thrombosis without affecting hemostatic parameters with a cell-penetrating PAR1 pepducin. Circulation (2012) 0.94

Cofactoring and dimerization of proteinase-activated receptors. Pharmacol Rev (2013) 0.92

Protein targets of inflammatory serine proteases and cardiovascular disease. J Inflamm (Lond) (2010) 0.88

Protease-activated receptor 4: from structure to function and back again. Br J Pharmacol (2016) 0.85

Fibrinogen-elongated gamma chain inhibits thrombin-induced platelet response, hindering the interaction with different receptors. J Biol Chem (2008) 0.85

Targeting the anionic region of human protease-activated receptor 4 inhibits platelet aggregation and thrombosis without interfering with hemostasis. J Thromb Haemost (2014) 0.79

Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1. PLoS One (2013) 0.79

Development and characterization of monoclonal antibodies against Protease Activated Receptor 4 (PAR4). Thromb Res (2015) 0.77

Protease-activated receptors in hemostasis. Blood (2016) 0.76

Thrombin-Induced Podocyte Injury Is Protease-Activated Receptor Dependent. J Am Soc Nephrol (2017) 0.75

Articles by these authors

Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA (1990) 5.04

Single streptomyces lividans K(+) channels: functional asymmetries and sidedness of proton activation. J Gen Physiol (1999) 3.42

Rapid and precise quantification of HIV-1 RNA in plasma using a branched DNA signal amplification assay. J Acquir Immune Defic Syndr Hum Retrovirol (1995) 3.23

Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry (1991) 2.30

The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. J R Soc Med (1996) 1.98

Disruption of the mouse mu-calpain gene reveals an essential role in platelet function. Mol Cell Biol (2001) 1.97

Sensitivity of Types 1 and 2 Herpes Simplex Virus to 5-Iodo-2'-Deoxyuridine and 9-beta-d-Arabinofuranosyladenine. Infect Immun (1970) 1.77

Medically induced gingival hyperplasia. Mayo Clin Proc (1998) 1.75

Plasmin desensitization of the PAR1 thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy. Biochemistry (1999) 1.73

Quantitative interpretations of double mutations of enzymes. Arch Biochem Biophys (1992) 1.58

Environments and mechanistic roles of the tyrosine residues of delta 5-3-ketosteroid isomerase. Biochemistry (1993) 1.53

Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets. Biochemistry (2000) 1.48

Increased prevalence of the Taq I A1 allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report. Pharmacogenetics (1996) 1.43

Direct and quantitative detection of HIV-1 RNA in human plasma with a branched DNA signal amplification assay. AIDS (1993) 1.42

Oral ulcerations are associated with the loss of response to infliximab in Crohn's disease. J Oral Pathol Med (2005) 1.38

Sinus tracts to the chin and jaw of dental origin. J Am Acad Dermatol (1983) 1.36

Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour. Pharmacogenetics (1995) 1.35

Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells. Cancer Res (2001) 1.28

Allelic association of the D2 dopamine receptor gene with cocaine dependence. Drug Alcohol Depend (1993) 1.27

Structural studies of spider silk proteins in the fiber. J Mol Recognit (1997) 1.14

Orofacial manifestations of Melkersson-Rosenthal syndrome. A study of 42 patients and review of 220 cases from the literature. Oral Surg Oral Med Oral Pathol (1992) 1.11

Catalytic mechanism of an active-site mutant (D38N) of delta 5-3-ketosteroid isomerase. Direct spectroscopic evidence for dienol intermediates. Biochemistry (1991) 1.08

The heart is a target organ for androgen. Science (1980) 1.06

Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism. Alcohol (1992) 1.05

Development and treatment of retrograde peri-implantitis involving a site with a history of failed endodontic and apicoectomy procedures: a series of reports. Int J Oral Maxillofac Implants (2001) 1.03

D2 dopamine receptor TaqI A alleles in medically ill alcoholic and nonalcoholic patients. Alcohol Alcohol (1994) 0.99

Animal models for brain tumors: historical perspectives and future directions. J Neurosurg (1994) 0.96

Nuclear uptake of sex steroid hormones in the cardiovascular system of the baboon. Circ Res (1981) 0.96

Reduced leucine-enkephalin--like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure. Science (1982) 0.95

Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon. Oral Surg Oral Med Oral Pathol (1987) 0.94

Substrate polarization by residues in delta 5-3-ketosteroid isomerase probed by site-directed mutagenesis and UV resonance Raman spectroscopy. Protein Sci (1992) 0.94

The D2 dopamine receptor gene as a predictor of compulsive disease: Bayes' theorem. Funct Neurol (1995) 0.93

Estrogen receptors in the temporomandibular joint of the baboon (Papio cynocephalus): an autoradiographic study. Oral Surg Oral Med Oral Pathol (1986) 0.93

Genetic predisposition in alcoholism: association of the D2 dopamine receptor TaqI B1 RFLP with severe alcoholics. Alcohol (1993) 0.92

Equilibrium: the intracellular distribution of steroid receptors. Nature (1979) 0.92

Oral manifestations of histoplasmosis. Oral Surg Oral Med Oral Pathol (1972) 0.92

Localization of the factor IX propeptide binding site on recombinant vitamin K dependent carboxylase using benzoylphenylalanine photoaffinity peptide inactivators. Biochemistry (1995) 0.92

In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells. Proc Natl Acad Sci U S A (1993) 0.90

Loss of heterozygosity on chromosome 10 in human glioblastoma multiforme. Genomics (1989) 0.90

PAR1 thrombin receptor-G protein interactions. Separation of binding and coupling determinants in the galpha subunit. J Biol Chem (2000) 0.90

The nucleus interstitialis striae terminalis and the nucleus amygdaloideus medialis: prime targets for androgen in the rat forebrain. Endocrinology (1979) 0.89

Autoradiographic evidence of sex steroid receptors in laryngeal tissues of the baboon (Papio cynocephalus). Laryngoscope (1983) 0.88

Quantification of human immunodeficiency virus type 1 RNA levels in plasma by using small-volume-format branched-DNA assays. J Clin Microbiol (1998) 0.86

Androgen receptor in the rat brain--assays and properties. Brain Res (1979) 0.86

Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. Gene Ther (2005) 0.84

Proto-oncogene analyses in brain tumors. J Neurosurg (1989) 0.84

Towards a new model for the mechanism of action of steroids. J Steroid Biochem (1982) 0.83

Observations of mercury-containing aerosols. Environ Sci Technol (2006) 0.83

Estrogen binding in the neonatal neocortex. Brain Res (1979) 0.83

Autoradiographic localization of 3H-estradiol or its metabolites in the central nervous system of the developing rat. Endocrinology (1974) 0.82

Sex steroid receptors in the stomach, liver, pancreas, and gastrointestinal tract of the baboon. Gastroenterology (1987) 0.82

Localization of progestin receptors in the islets of Langerhans. Pancreas (1987) 0.82

Cellular localization of estradiol in the harderian gland of the female armadillo. J Exp Zool (1983) 0.81

Localization of androgen- and estrogen-concentrating neurons in the diencephalon and telencephalon of the mouse. Endocrinology (1978) 0.81

Uptake and retention of androgen in neurons of the brain of the golden hamster. Brain Res (1981) 0.80

Lyophilized bone allografts in periodontal intraosseous defects. J Periodontol (1979) 0.80

Estrogen induced prolactin mRNA accumulation in adult male rat pituitary as revealed by in situ hybridization. Endocrinol Jpn (1985) 0.80

Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis. Am J Physiol Gastrointest Liver Physiol (2012) 0.80

Prolonged P300 latency in a neuropsychiatric population with the D2 dopamine receptor A1 allele. Pharmacogenetics (1994) 0.80

Desquamative gingivitis: clinical, histopathologic, immunopathologic, and therapeutic observations. J Am Acad Dermatol (1982) 0.80

Purification of native bovine carboxylase and expression and purification of recombinant bovine carboxylase. Methods Enzymol (1997) 0.80

Increased lysyl oxidase activity in aortas of hypertensive rats and effect of beta-aminopropionitrile. Exp Mol Pathol (1979) 0.80

Is there an alternative to the cytoplasmic receptor model for the mechanism of action of steroids? Life Sci (1975) 0.80

Root surface demineralization in periodontal therapy: subject review. J Periodontol (1982) 0.79

Autoradiography of diffusible substances--a practical approach. Am J Med Technol (1981) 0.79

Interaction of viper venom serine peptidases with thrombin receptors on human platelets. FEBS Lett (2000) 0.79

Measurement of the distribution of [3H]bicuculline microinjected into the rat hypothalamus. J Neurosci Methods (1992) 0.79

Estrogen receptors in the islets of Langerhans of baboons. Cell Tissue Res (1983) 0.79

Oral manifestations of hemochromatosis. Report of a case. Oral Surg Oral Med Oral Pathol (1972) 0.79

Interaction of exogenous steroids in the developing rat brain. Endocrinology (1974) 0.79

Autoradiographic demonstration of binding sites for oestradiol and dihydrotestosterone in the urinary tract of male and female baboons. Urol Res (1983) 0.79

Autoradiographic localization of 3H-testosterone or its metabolites in the neonatal rat brain. Am J Anat (1974) 0.78

Estrogen receptor in the larynx of the aged baboon (Papio cynocephalus). Ann Otol Rhinol Laryngol (1987) 0.78

The ovulatory surge of gonadotropin and sexual receptivity in the female golden hamster. Physiol Behav (1974) 0.78

Effect of zinc administration on the growth of L1210 and BW5147 tumors in mice. J Natl Cancer Inst (1976) 0.78

Nuclear uptake of sex steroids in gingiva of the baboon. J Periodontol (1981) 0.77

Progesterone--specific binding sites in the kidney of the female baboon. J Urol (1984) 0.77

The effects of opiates on androgen binding in the forebrain of the rat. Int J Fertil (1980) 0.77

Androgen receptors in the brain: what are we measuring? Endocr Rev (1983) 0.77

Intracellular distribution of estrogen receptors: a function of preparation. Experientia (1980) 0.77

Autoradiographic localization of sex steroid hormones in the lymphatic organs of baboons. Cell Tissue Res (1983) 0.77

Serospecificity of a cloned protease-resistant Treponema pallidum--specific antigen expressed in Escherichia coli. J Clin Microbiol (1986) 0.77

Androgen receptor systems in the brain stem of the primate. Brain Res (1982) 0.77

Localization of 3H-dihydrotestosterone in the pituitary gland of the rhesus monkey. Cell Tissue Res (1981) 0.76

An x-ray microanalysis study of differences in concentration of elements in brain cells due to opiates, cell type, and subcellular location. J Neurosci Res (1978) 0.76

Intracellular localization of steroid hormone receptors. A challenging problem. Autoradiographic and biochemical study. Ann Pathol (1986) 0.76

Location of platelet activating factor binding in rat liver. Biochem J (1988) 0.76

Re: Post-rhizotomy periodontal atrophy (J Periodontol 1995; 66:301-302) J Periodontol (1995) 0.75

Abnormal reproductive development in rats after neonatally administered antiestrogen (tamoxifen). Biol Reprod (1979) 0.75

Role of thrombolysis in resuscitation. Lancet (2001) 0.75

Underuse of coronary revascularization procedures. N Engl J Med (2001) 0.75

Androgen-concentrating cells in the periventricular brain of the female rhesus monkey. J Comp Neurol (1982) 0.75

Localization of 3H-estradiol in the reproductive organs of male and female baboons. J Morphol (1982) 0.75

Autoradiographic localization of estrogen target cells in the spinal cord of the armadillo and baboon: a comparative study. Histol Histopathol (1987) 0.75

Expression of three viral oncogenes (v-sis, v-myc, v-fos) in primary human brain tumors of neuroectodermal origin. Neurology (1988) 0.75

Pernicious anemia with associated glossodynia. J Am Dent Assoc (1988) 0.75

Test your diagnostic ability. Northwest Dent (1989) 0.75

Is testosterone metabolized to estrogen in the forebrain of the Rockland-Swiss mouse? Brain Res (1982) 0.75