Published in Physiol Rev on October 01, 2000
Osmotic stress signaling and osmoadaptation in yeasts. Microbiol Mol Biol Rev (2002) 8.02
Cell wall integrity signaling in Saccharomyces cerevisiae. Microbiol Mol Biol Rev (2005) 5.46
Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol Ther (2006) 2.71
Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A (2001) 2.64
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. Proc Natl Acad Sci U S A (2003) 2.62
Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61
Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice. Proc Natl Acad Sci U S A (2002) 2.56
NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. EMBO J (2003) 2.24
PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. Genes Dev (2008) 2.15
NFAT: ubiquitous regulator of cell differentiation and adaptation. J Cell Biol (2002) 2.04
Calcineurin is essential for Candida albicans survival in serum and virulence. Eukaryot Cell (2003) 1.98
A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants. Mol Cell (2009) 1.95
Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol (2004) 1.91
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol (2015) 1.88
Interaction of calcineurin with substrates and targeting proteins. Trends Cell Biol (2010) 1.84
Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice. Mol Cell Biol (2003) 1.71
Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. J Cell Biol (2003) 1.69
BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J Cell Biol (2007) 1.66
Changes in gene expression profiles in developing B cells of murine bone marrow. Genome Res (2002) 1.60
Dysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease. J Neurochem (2011) 1.56
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol (2009) 1.56
Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes. J Physiol (2002) 1.54
Defective T cell development and function in calcineurin A beta -deficient mice. Proc Natl Acad Sci U S A (2002) 1.53
GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes Dev (2003) 1.46
Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc Natl Acad Sci U S A (2004) 1.37
Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryot Cell (2008) 1.37
The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses. J Neurosci (2010) 1.35
Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis. Proc Natl Acad Sci U S A (2008) 1.35
Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest (2006) 1.33
Second messengers and membrane trafficking direct and organize growth cone steering. Nat Rev Neurosci (2011) 1.32
Calcineurin is required for Candida albicans to survive calcium stress in serum. Infect Immun (2005) 1.29
Inactivation of host Akt/protein kinase B signaling by bacterial pore-forming toxins. Mol Biol Cell (2008) 1.26
Targeting protein serine/threonine phosphatases for drug development. Mol Pharmacol (2009) 1.25
Calcineurin A-alpha but not A-beta is required for normal kidney development and function. Am J Pathol (2004) 1.24
Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments. Eukaryot Cell (2006) 1.23
Mechanism of the phosphatase component of Clostridium thermocellum polynucleotide kinase-phosphatase. RNA (2005) 1.21
Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes. J Physiol (2003) 1.19
The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner. J Cell Biol (2001) 1.19
Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor. Curr Genet (2005) 1.18
GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling. Nat Neurosci (2013) 1.17
Characterization of the 2',3' cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage lambda phosphatase. Nucleic Acids Res (2007) 1.17
Structure-function analysis of yeast RNA debranching enzyme (Dbr1), a manganese-dependent phosphodiesterase. Nucleic Acids Res (2005) 1.17
Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus. Mol Microbiol (2011) 1.14
Proteasome inhibition suppresses essential immune functions of human CD4+ T cells. Immunology (2008) 1.14
Regulation of the voltage-gated potassium channel KCNQ4 in the auditory pathway. Pflugers Arch (2005) 1.13
Pacing-induced calcineurin activation controls cardiac Ca2+ signalling and gene expression. J Physiol (2003) 1.12
Calcineurin-responsive zinc finger transcription factor CRZ1 of Botrytis cinerea is required for growth, development, and full virulence on bean plants. Eukaryot Cell (2008) 1.10
Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi. Mol Biol Cell (2006) 1.08
The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin. Proc Natl Acad Sci U S A (2007) 1.08
Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in yeast. Mol Cell Biol (2009) 1.07
Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506? Cell Commun Signal (2009) 1.06
Regulation of calcineurin through transcriptional induction of the calcineurin A beta promoter in vitro and in vivo. Mol Cell Biol (2005) 1.06
Determinants for Substrate Specificity of Protein Phosphatase 2A. Enzyme Res (2011) 1.06
A phosphate-binding histidine of binuclear metallophosphodiesterase enzymes is a determinant of 2',3'-cyclic nucleotide phosphodiesterase activity. J Biol Chem (2008) 1.06
The functional role of calcineurin in hypertrophy, regeneration, and disorders of skeletal muscle. J Biomed Biotechnol (2010) 1.05
A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells. Proc Natl Acad Sci U S A (2005) 1.05
The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin. J Mol Cell Cardiol (2009) 1.05
NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene. Physiol Genomics (2009) 1.03
Regulation of L-type calcium current by intracellular magnesium in rat cardiac myocytes. J Physiol (2003) 1.03
Calcineurin regulation in fungi and beyond. Eukaryot Cell (2007) 1.02
Structure of the calcineurin-NFAT complex: defining a T cell activation switch using solution NMR and crystal coordinates. Structure (2007) 1.02
Dermcidin expression in hepatic cells improves survival without N-glycosylation, but requires asparagine residues. Br J Cancer (2006) 1.01
Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. J Biol Chem (2007) 1.00
Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells. Exp Cell Res (2009) 1.00
Calcineurin-Crz1 signaling in lower eukaryotes. Eukaryot Cell (2014) 1.00
Protease activation during in vivo pancreatitis is dependent on calcineurin activation. Am J Physiol Gastrointest Liver Physiol (2009) 0.99
Calcineurin: a poorly understood regulator of muscle mass. Int J Biochem Cell Biol (2013) 0.99
High-throughput screening of one-bead-one-compound libraries: identification of cyclic peptidyl inhibitors against calcineurin/NFAT interaction. ACS Comb Sci (2011) 0.99
Discovery of protein phosphatase 2C inhibitors by virtual screening. J Med Chem (2006) 0.98
Conditional Degradation of Plasmodium Calcineurin Reveals Functions in Parasite Colonization of both Host and Vector. Cell Host Microbe (2015) 0.97
Ca2+/calcineurin regulation of cloned vascular K ATP channels: crosstalk with the protein kinase A pathway. Br J Pharmacol (2009) 0.97
A role for calcineurin in Alzheimer's disease. Curr Neuropharmacol (2011) 0.97
Lack of trehalose accelerates H2O2-induced Candida albicans apoptosis through regulating Ca2+ signaling pathway and caspase activity. PLoS One (2011) 0.97
Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease. Mol Brain (2009) 0.96
Calmodulin mediates Fas-induced FADD-independent survival signaling in pancreatic cancer cells via activation of Src-extracellular signal-regulated kinase (ERK). J Biol Chem (2011) 0.96
Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: how important is BDNF? Br J Pharmacol (2014) 0.96
PP2B-dependent NO production in the medullary thick ascending limb during diabetes. Am J Physiol Renal Physiol (2009) 0.95
Shaggy/glycogen synthase kinase 3β and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis. Proc Natl Acad Sci U S A (2012) 0.95
Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII. PLoS One (2012) 0.95
Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin. J Biol Chem (2012) 0.95
Calcium phosphatase calcineurin influences tau metabolism. Neurobiol Aging (2012) 0.95
Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus. PLoS Pathog (2013) 0.94
The calcineurin pathway inhibitor tacrolimus enhances the in vitro activity of azoles against Mucorales via apoptosis. Eukaryot Cell (2013) 0.93
VE-cadherin signaling induces EB3 phosphorylation to suppress microtubule growth and assemble adherens junctions. Mol Cell (2012) 0.93
Mitochondria as a potential regulator of myogenesis. ScientificWorldJournal (2013) 0.92
Structural basis for activation of calcineurin by calmodulin. J Mol Biol (2011) 0.92
Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor. Eukaryot Cell (2011) 0.92
Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum. J Struct Biol (2012) 0.92
Retracted Cardiac glycoside induces cell death via FasL by activating calcineurin and NF-AT, but apoptosis initially proceeds through activation of caspases. Apoptosis (2007) 0.92
Calcineurin selectively docks with the dynamin Ixb splice variant to regulate activity-dependent bulk endocytosis. J Biol Chem (2011) 0.91
Calcineurin homologous protein: a multifunctional Ca2+-binding protein family. Am J Physiol Renal Physiol (2011) 0.91
Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells. J Exp Med (2001) 0.91
The reinforcing effects of chronic D-amphetamine and morphine are impaired in a line of memory-deficient mice overexpressing calcineurin. Eur J Neurosci (2005) 0.91
A novel library screen identifies immunosuppressors that promote osteoblast differentiation. Bone (2012) 0.91
Phosphorylation alters the pharmacology of Ca(2+)-activated Cl channels in rabbit pulmonary arterial smooth muscle cells. Br J Pharmacol (2009) 0.90
Downregulation of Calcineurin Gene Is Associated with Glucantime(®) Resiatance in Leishmania infantum. Iran J Parasitol (2013) 0.90
The use of automated parameter searches to improve ion channel kinetics for neural modeling. J Comput Neurosci (2011) 0.90
Expression of protein phosphatase 2B (calcineurin) subunit A isoforms in rat hippocampus after traumatic brain injury. J Neurotrauma (2010) 0.90
Trypanosomatid protein phosphatases. Mol Biochem Parasitol (2010) 0.90
Molecular changes during egg activation. Curr Top Dev Biol (2013) 0.90
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