Published in Biophys J on October 01, 2000
Analysis of single-molecule FRET trajectories using hidden Markov modeling. Biophys J (2006) 5.52
Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling. Biophys J (2004) 3.42
Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Science (2012) 2.98
Learning rates and states from biophysical time series: a Bayesian approach to model selection and single-molecule FRET data. Biophys J (2009) 2.39
Hidden Markov modeling for single channel kinetics with filtering and correlated noise. Biophys J (2000) 2.25
Maximum likelihood estimation of ion channel kinetics from macroscopic currents. Biophys J (2005) 2.18
Graded recruitment and inactivation of single InsP3 receptor Ca2+-release channels: implications for quantal [corrected] Ca2+release. J Physiol (2006) 2.03
Using independent open-to-closed transitions to simplify aggregated Markov models of ion channel gating kinetics. Proc Natl Acad Sci U S A (2005) 1.87
Structure and dynamics of a processive Brownian motor: the translating ribosome. Annu Rev Biochem (2010) 1.84
An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1. EMBO J (2002) 1.63
Applying hidden Markov models to the analysis of single ion channel activity. Biophys J (2002) 1.55
Decoding the pattern of photon colors in single-molecule FRET. J Phys Chem B (2009) 1.54
Allosteric potentiation of glycine receptor chloride currents by glutamate. Nat Neurosci (2010) 1.52
Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons. Sci Signal (2010) 1.47
Maximum likelihood estimation of molecular motor kinetics from staircase dwell-time sequences. Biophys J (2006) 1.35
Real-time kinetic modeling of voltage-gated ion channels using dynamic clamp. Biophys J (2008) 1.33
Transport dynamics in a glutamate transporter homologue. Nature (2013) 1.25
The RSC chromatin remodelling ATPase translocates DNA with high force and small step size. EMBO J (2011) 1.24
Mode switching is the major mechanism of ligand regulation of InsP3 receptor calcium release channels. J Gen Physiol (2007) 1.24
Gain-of-function mutations reveal expanded intermediate states and a sequential action of two gates in MscL. J Gen Physiol (2005) 1.22
Use of the covariance matrix in directly fitting kinetic parameters: application to GABAA receptors. Biophys J (2004) 1.20
Single Molecule Analysis Research Tool (SMART): an integrated approach for analyzing single molecule data. PLoS One (2012) 1.17
Extracting dwell time sequences from processive molecular motor data. Biophys J (2006) 1.16
Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents. Nat Neurosci (2014) 1.14
Voltage-dependent gating of the cystic fibrosis transmembrane conductance regulator Cl- channel. J Gen Physiol (2003) 1.14
Model-based fitting of single-channel dwell-time distributions. Biophys J (2004) 1.13
Modes of glutamate receptor gating. J Physiol (2011) 1.10
Calcium regulation of single ryanodine receptor channel gating analyzed using HMM/MCMC statistical methods. J Gen Physiol (2004) 1.06
Plasticity of acetylcholine receptor gating motions via rate-energy relationships. Biophys J (2005) 1.06
Using Markov models to simulate electron spin resonance spectra from molecular dynamics trajectories. J Phys Chem B (2008) 1.05
MATLAB-based Simulation of Whole-Cell and Single-Channel Currents. J Undergrad Neurosci Educ (2006) 1.04
Highly anisotropic stability and folding kinetics of a single coiled coil protein under mechanical tension. J Am Chem Soc (2011) 1.03
Empirical Bayes methods enable advanced population-level analyses of single-molecule FRET experiments. Biophys J (2014) 1.02
Quantitative analysis of DNA-looping kinetics from tethered particle motion experiments. Methods Enzymol (2010) 1.01
The ion channel inverse problem: neuroinformatics meets biophysics. PLoS Comput Biol (2006) 1.00
Conformational dynamics of the alphaM3 transmembrane helix during acetylcholine receptor channel gating. Biophys J (2007) 1.00
Bayesian Statistical Inference in Ion-Channel Models with Exact Missed Event Correction. Biophys J (2016) 0.98
Single-molecule observation of helix staggering, sliding, and coiled coil misfolding. Proc Natl Acad Sci U S A (2012) 0.98
Single-channel analysis of ethanol enhancement of glycine receptor function. J Pharmacol Exp Ther (2009) 0.97
Utilizing the information content in two-state trajectories. Proc Natl Acad Sci U S A (2006) 0.96
Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis. Elife (2015) 0.96
Automating single subunit counting of membrane proteins in mammalian cells. J Biol Chem (2012) 0.94
Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation. Proc Natl Acad Sci U S A (2010) 0.93
Robust reconstruction of the rate constant distribution using the phase function method. Biophys J (2006) 0.93
Estimation of ion channel kinetics from fluctuations of macroscopic currents. Biophys J (2007) 0.90
Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks). Proc Natl Acad Sci U S A (2013) 0.90
Kinetic schemes for post-synchronized single molecule dynamics. Biophys J (2012) 0.90
Optimal estimation of ion-channel kinetics from macroscopic currents. PLoS One (2012) 0.90
C-terminal domains of N-methyl-D-aspartic acid receptor modulate unitary channel conductance and gating. J Biol Chem (2012) 0.90
Quantifying short-lived events in multistate ionic current measurements. ACS Nano (2014) 0.89
Signal processing for molecular and cellular biological physics: an emerging field. Philos Trans A Math Phys Eng Sci (2012) 0.89
Two-dimensional kinetic analysis suggests nonsequential gating of mechanosensitive channels in Xenopus oocytes. Biophys J (2001) 0.88
A state-mutating genetic algorithm to design ion-channel models. Proc Natl Acad Sci U S A (2009) 0.88
Redox-regulated heterogeneous thresholds for ligand recruitment among InsP3R Ca2+-release channels. Biophys J (2010) 0.87
Analysis of kinetics in noisy systems: application to single molecule tethered particle motion. Biophys J (2007) 0.87
Kinetically coupled folding of a single HIV-1 glycoprotein 41 complex in viral membrane fusion and inhibition. Proc Natl Acad Sci U S A (2015) 0.84
Real-time observation of the conformational dynamics of mitochondrial Hsp70 by spFRET. EMBO J (2013) 0.84
Dynamics of the preprotein translocation channel of the outer membrane of mitochondria. Biophys J (2008) 0.82
Fast single-molecule FRET spectroscopy: theory and experiment. Phys Chem Chem Phys (2014) 0.82
Monte carlo simulations of protein assembly, disassembly, and linear motion on DNA. Biophys J (2008) 0.82
Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating. J Gen Physiol (2012) 0.81
Single-molecule dataset (SMD): a generalized storage format for raw and processed single-molecule data. BMC Bioinformatics (2015) 0.80
Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer's Disease-Causing Mutants in Presenilins. PLoS Comput Biol (2015) 0.80
High-resolution optical tweezers for single-molecule manipulation. Yale J Biol Med (2013) 0.80
Structure and dynamics underlying elementary ligand binding events in human pacemaking channels. Elife (2016) 0.80
Likelihood functions for the analysis of single-molecule binned photon sequences. Chem Phys (2012) 0.79
Hidden Markov analysis of improved bandwidth mechanosensitive ion channel data. Eur Biophys J (2015) 0.79
Inhibition of GluN2A-containing N-methyl-D-aspartate receptors by 2-naphthoic acid. Mol Pharmacol (2013) 0.78
ICON: An Adaptation of Infinite HMMs for Time Traces with Drift. Biophys J (2017) 0.78
Kinetic modeling and fitting software for interconnected reaction schemes: VisKin. Anal Biochem (2006) 0.78
Amplitude histogram-based method of analysis of patch clamp recordings that involve extreme changes in channel activity levels. J Mol Neurosci (2008) 0.78
Is realistic neuronal modeling realistic? J Neurophysiol (2016) 0.77
Hidden Markov Modeling with Detailed Balance and Its Application to Single Protein Folding. Biophys J (2016) 0.77
Efficient maximum likelihood estimation of kinetic rate constants from macroscopic currents. PLoS One (2011) 0.76
MOSAIC: A Modular Single-Molecule Analysis Interface for Decoding Multistate Nanopore Data. Anal Chem (2016) 0.75
ATP-sensitive potassium channels exhibit variance in the number of open channels below the limit predicted for identical and independent gating. PLoS One (2012) 0.75
Elucidation of molecular kinetic schemes from macroscopic traces using system identification. PLoS Comput Biol (2017) 0.75
MCMC for Ion-Channel Sojourn-Time Data: A Good Proposal. Biophys J (2016) 0.75
Identifiability, reducibility, and adaptability in allosteric macromolecules. J Gen Physiol (2017) 0.75
Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor. Brain Res (2016) 0.75
Computing rates of Markov models of voltage-gated ion channels by inverting partial differential equations governing the probability density functions of the conducting and non-conducting states. Math Biosci (2016) 0.75
On the stochastic properties of single ion channels. Proc R Soc Lond B Biol Sci (1981) 11.30
Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events. Biophys J (1996) 7.66
Estimating kinetic constants from single channel data. Biophys J (1983) 6.14
A general solution to the time interval omission problem applied to single channel analysis. Biophys J (1985) 5.04
Maximum likelihood estimation of aggregated Markov processes. Proc Biol Sci (1997) 4.96
Characterization of single channel currents using digital signal processing techniques based on Hidden Markov Models. Philos Trans R Soc Lond B Biol Sci (1990) 3.75
Sampling, log binning, fitting, and plotting durations of open and shut intervals from single channels and the effects of noise. Pflugers Arch (1987) 3.67
Equivalence of aggregated Markov models of ion-channel gating. Proc R Soc Lond B Biol Sci (1989) 2.67
A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics. J Physiol (1999) 2.49
Maximum likelihood estimation and identification directly from single-channel recordings. Proc Biol Sci (1992) 2.43
Estimating kinetic parameters for single channels with simulation. A general method that resolves the missed event problem and accounts for noise. Biophys J (1990) 2.36
Identifying kinetic gating mechanisms for ion channels by using two-dimensional distributions of simulated dwell times. Proc Biol Sci (1990) 1.89
Adaptive processing techniques based on hidden Markov models for characterizing very small channel currents buried in noise and deterministic interferences. Philos Trans R Soc Lond B Biol Sci (1991) 1.35
How powerful is the dwell-time analysis of multichannel records? J Membr Biol (1998) 1.20
Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events. Biophys J (1996) 7.66
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev (1994) 5.90
Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle. J Physiol (1984) 5.57
Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell (1993) 5.12
Maximum likelihood estimation of aggregated Markov processes. Proc Biol Sci (1997) 4.96
Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science (1989) 4.80
Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL. J Gen Physiol (1999) 4.10
Mapping the conformational wave of acetylcholine receptor channel gating. Nature (2000) 4.00
The automated analysis of data from single ionic channels. Pflugers Arch (1982) 3.91
Essential role of Mash-2 in extraembryonic development. Nature (1994) 3.36
Flickering of a nicotinic ion channel to a subconductance state. Biophys J (1983) 2.92
Quantitative video microscopy of patch clamped membranes stress, strain, capacitance, and stretch channel activation. Biophys J (1991) 2.80
Does curare affect transmitter release? J Physiol (1971) 2.80
Single ionic channels observed in tissue-cultured muscle. Nature (1980) 2.63
Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity. Neuron (1995) 2.55
A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics. J Physiol (1999) 2.49
Tarantula peptide inhibits atrial fibrillation. Nature (2001) 2.38
Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia. Nat Genet (1996) 2.32
Non-injection methods for the production of embryonic stem cell-embryo chimaeras. Nature (1993) 2.27
Mutation in the M1 domain of the acetylcholine receptor alpha subunit decreases the rate of agonist dissociation. J Gen Physiol (1997) 2.25
Hidden Markov modeling for single channel kinetics with filtering and correlated noise. Biophys J (2000) 2.25
Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse. Hum Mol Genet (1999) 2.20
Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol (2000) 2.09
The structure and dynamics of patch-clamped membranes: a study using differential interference contrast light microscopy. J Cell Biol (1990) 2.06
Single-channel currents from acetylcholine receptors in embryonic chick muscle. Kinetic and conductance properties of gaps within bursts. Biophys J (1984) 2.06
Therapist success and its determinants. Arch Gen Psychiatry (1985) 2.00
The dissociation of acetylcholine from open nicotinic receptor channels. Proc Natl Acad Sci U S A (2001) 1.91
Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonist. J Gen Physiol (2000) 1.83
Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors. Biophys J (1996) 1.82
Single channel properties of P2X2 purinoceptors. J Gen Physiol (1999) 1.78
Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants. J Gen Physiol (2000) 1.75
Activation of recombinant mouse acetylcholine receptors by acetylcholine, carbamylcholine and tetramethylammonium. J Physiol (1995) 1.74
The extracellular linker of muscle acetylcholine receptor channels is a gating control element. J Gen Physiol (2000) 1.74
Heterogeneous kinetic properties of acetylcholine receptor channels in Xenopus myocytes. J Physiol (1986) 1.73
Thermodynamics of mechanosensitivity. Phys Biol (2004) 1.73
Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes. Proc Natl Acad Sci U S A (1999) 1.68
The ultrastructure of patch-clamped membranes: a study using high voltage electron microscopy. J Cell Biol (1991) 1.62
Stretch-activated ion channels in the heart. J Mol Cell Cardiol (1997) 1.61
Identification of a high affinity divalent cation binding site near the entrance of the NMDA receptor channel. Neuron (1996) 1.56
Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors. J Physiol (1996) 1.53
Voltage-induced membrane movement. Nature (2001) 1.50
The breakdown of cell membranes by electrical and mechanical stress. Biophys J (1998) 1.47
Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles. Hum Mol Genet (2000) 1.45
Rare primary CNS anaplastic large cell lymphoma in an immunocompetent adult: a clinical-pathologic case report and review case of the literature. Clin Neuropathol (2006) 1.43
A mutational analysis of the acetylcholine receptor channel transmitter binding site. Biophys J (1999) 1.42
Limit the number of grants per person. Nature (1997) 1.38
Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating. Biophys J (1995) 1.34
Stoichiometry of recombinant N-methyl-D-aspartate receptor channels inferred from single-channel current patterns. J Gen Physiol (1997) 1.34
Acetylcholine noise in tissue culture muscle cells. Nat New Biol (1973) 1.33
Characterization of stretch-activated ion channels in Xenopus oocytes. J Physiol (1990) 1.28
Single-channel electrophysiology: use of the patch clamp. Methods Enzymol (1983) 1.28
Calcium imaging of mechanically induced fluxes in tissue-cultured chick heart: role of stretch-activated ion channels. Am J Physiol (1992) 1.24
Patch clamp studies of single ionic channels. Annu Rev Biophys Bioeng (1984) 1.24
Baroreceptor mechanisms at the cellular level. Fed Proc (1987) 1.21
Stochastic models for mechanical transduction. Biophys J (1991) 1.20
Stretch-induced voltage changes in the isolated beating heart: importance of the timing of stretch and implications for stretch-activated ion channels. Cardiovasc Res (1996) 1.20
Voltage-dependent membrane displacements measured by atomic force microscopy. J Gen Physiol (1998) 1.19
Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists. Br J Pharmacol (1999) 1.18
Acetylcholine-induced current fluctuations in tissue-cultured muscle cells under voltage clamp. Biophys J (1977) 1.17
Mechanotransducer ion channels in chick skeletal muscle: the effects of extracellular pH. J Physiol (1985) 1.16
Stretch-activated channels in heart cells: relevance to cardiac hypertrophy. J Cardiovasc Pharmacol (1991) 1.15
Stretch-activated ion channels in tissue-cultured chick heart. Am J Physiol (1993) 1.15
A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice. Genetics (1995) 1.14
Models of Ca2+ release channel adaptation. Science (1995) 1.12
Improving performance of motorized slides for micromanipulation. J Neurosci Methods (1989) 1.07
Ion permeation and block of P2X(2) purinoceptors: single channel recordings. J Membr Biol (1999) 1.07
Stretch-activated whole cell currents in adult rat cardiac myocytes. Am J Physiol Heart Circ Physiol (2000) 1.06
Electrotonic spread of slow waves in circular muscle of small intestine. Am J Physiol (1970) 1.06
Human umbilical cord blood: a clinically useful source of transplantable hematopoietic stem/progenitor cells. Int J Cell Cloning (1990) 1.05
Inactivation of P2X2 purinoceptors by divalent cations. J Physiol (2000) 1.05
Mechanical perturbation of cultured human endothelial cells causes rapid increases of intracellular calcium. Am J Physiol (1993) 1.03
Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. Prog Biophys Mol Biol (2011) 1.03
Cytoplasmic solvent structure of single barnacle muscle cells studied by electron spin resonance. Biophys J (1974) 1.01
Stretch-activated ion channels in guinea pig outer hair cells. Hear Res (1991) 1.01
The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety. Proc Natl Acad Sci U S A (2010) 1.00
Whole-cell mechanosensitive currents in rat ventricular myocytes activated by direct stimulation. J Membr Biol (2000) 0.98
Subconductance states of a mutant NMDA receptor channel kinetics, calcium, and voltage dependence. J Gen Physiol (1997) 0.97
Mechanically induced calcium mobilization in cultured endothelial cells is dependent on actin and phospholipase. Arterioscler Thromb (1994) 0.97
Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development. Development (1998) 0.96
Mechanotransducing ion channels in astrocytes. Brain Res (1992) 0.96
Mechanically induced calcium movements in astrocytes, bovine aortic endothelial cells and C6 glioma cells. J Membr Biol (2000) 0.96
Ca2+ uptake in GH3 cells during hypotonic swelling: the sensory role of stretch-activated ion channels. Am J Physiol (1996) 0.95
Biophysics of mechanoreception. Membr Biochem (1986) 0.95
Na(+) occupancy and Mg(2+) block of the n-methyl-d-aspartate receptor channel. J Gen Physiol (2001) 0.94
Mechanically activated currents in chick heart cells. J Membr Biol (1996) 0.94
Inhibiting synthesis of extracellular matrix improves patch clamp seal formation. Pflugers Arch (1991) 0.93
A distinct contribution of the delta subunit to acetylcholine receptor channel activation revealed by mutations of the M2 segment. Biophys J (1998) 0.93
On what bases do patients choose their therapists? J Psychother Pract Res (1993) 0.92
LSP1 modulates leukocyte populations in resting and inflamed peritoneum. Blood (2000) 0.92
The nature of cation-pi binding: interactions between tetramethylammonium ion and benzene in aqueous solution. Biophys J (1993) 0.92
Herpes zoster in a patient with Hodgkin's disease. Treatment with idoxuridine. Arch Intern Med (1968) 0.90
K(+) occupancy of the N-methyl-d-aspartate receptor channel probed by Mg(2+) block. J Gen Physiol (2001) 0.90
Membrane Electromechanics in Biology, with a Focus on Hearing. MRS Bull (2009) 0.90