Binding of the transcription effector ppGpp to Escherichia coli RNA polymerase is allosteric, modular, and occurs near the N terminus of the beta'-subunit.

PubWeight™: 1.35‹?› | Rank: Top 10%

🔗 View Article (PMID 11035017)

Published in J Biol Chem on January 12, 2001

Authors

I I Toulokhonov1, I Shulgina, V J Hernandez

Author Affiliations

1: Department of Microbiology, Center of Microbial Pathogenesis, State University of New York at Buffalo School of Medicine, Buffalo, New York 14214, USA.

Articles citing this

Signal transduction and regulatory mechanisms involved in control of the sigma(S) (RpoS) subunit of RNA polymerase. Microbiol Mol Biol Rev (2002) 5.60

Transcription profiling of the stringent response in Escherichia coli. J Bacteriol (2007) 2.54

Bacillus subtilis functional genomics: global characterization of the stringent response by proteome and transcriptome analysis. J Bacteriol (2002) 2.47

Regulation of sigma factor competition by the alarmone ppGpp. Genes Dev (2002) 2.36

RNA polymerase active center: the molecular engine of transcription. Annu Rev Biochem (2009) 1.94

The magic spot: a ppGpp binding site on E. coli RNA polymerase responsible for regulation of transcription initiation. Mol Cell (2013) 1.80

The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol Cell (2013) 1.73

Control of rRNA synthesis in Escherichia coli: a systems biology approach. Microbiol Mol Biol Rev (2004) 1.73

Still looking for the magic spot: the crystallographically defined binding site for ppGpp on RNA polymerase is unlikely to be responsible for rRNA transcription regulation. J Mol Biol (2008) 1.44

Differential regulation by ppGpp versus pppGpp in Escherichia coli. Nucleic Acids Res (2013) 1.43

Growth rate regulation in Escherichia coli. FEMS Microbiol Rev (2011) 1.23

Physiological analysis of the stringent response elicited in an extreme thermophilic bacterium, Thermus thermophilus. J Bacteriol (2006) 1.07

Global analysis of the Staphylococcus aureus response to mupirocin. Antimicrob Agents Chemother (2011) 1.04

Null mutation of HvrA compensates for loss of an essential relA/spoT-like gene in Rhodobacter capsulatus. J Bacteriol (2004) 1.01

Regulation of cell growth during serum starvation and bacterial survival in macrophages by the bifunctional enzyme SpoT in Helicobacter pylori. J Bacteriol (2008) 0.95

The rpoZ gene, encoding the RNA polymerase omega subunit, is required for antibiotic production and morphological differentiation in Streptomyces kasugaensis. J Bacteriol (2002) 0.94

ppGpp Binding to a Site at the RNAP-DksA Interface Accounts for Its Dramatic Effects on Transcription Initiation during the Stringent Response. Mol Cell (2016) 0.91

Effective symbiosis between Rhizobium etli and Phaseolus vulgaris requires the alarmone ppGpp. J Bacteriol (2005) 0.89

A reduction in growth rate of Pseudomonas putida KT2442 counteracts productivity advances in medium-chain-length polyhydroxyalkanoate production from gluconate. Microb Cell Fact (2011) 0.89

A RelA-SpoT homolog (Cr-RSH) identified in Chlamydomonas reinhardtii generates stringent factor in vivo and localizes to chloroplasts in vitro. Nucleic Acids Res (2002) 0.88

The RNA polymerase omega factor RpoZ is regulated by PhoP and has an important role in antibiotic biosynthesis and morphological differentiation in Streptomyces coelicolor. Appl Environ Microbiol (2011) 0.87

ppGpp-dependent negative control of DNA replication of Shiga toxin-converting bacteriophages in Escherichia coli. J Bacteriol (2013) 0.86

Different effects of ppGpp on Escherichia coli DNA replication in vivo and in vitro. FEBS Open Bio (2013) 0.85

Mutations in rpoBC suppress the defects of a Sinorhizobium meliloti relA mutant. J Bacteriol (2003) 0.84

Guanosine tetra- and pentaphosphate synthase activity in chloroplasts of a higher plant: association with 70S ribosomes and inhibition by tetracycline. Nucleic Acids Res (2004) 0.81

RelA functionally suppresses the growth defect caused by a mutation in the G domain of the essential Der protein. J Bacteriol (2008) 0.80

Strength and Regulation of Seven rRNA Promoters in Escherichia coli. PLoS One (2015) 0.77

Survival strategies in the aquatic and terrestrial world: the impact of second messengers on cyanobacterial processes. Life (Basel) (2014) 0.76

Possible targets of "magic spots" in plant signalling. Plant Signal Behav (2008) 0.75

The Bifunctional Enzyme SpoT Is Involved in the Clarithromycin Tolerance of Helicobacter pylori by Upregulating the Transporters HP0939, HP1017, HP0497, and HP0471. Antimicrob Agents Chemother (2017) 0.75

The dual role of DksA protein in the regulation of Escherichia coli pArgX promoter. Nucleic Acids Res (2016) 0.75

Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor. Sci Rep (2017) 0.75