Published in Neuron on September 01, 2000
Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol (2008) 4.10
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell (2006) 4.10
Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron (2008) 3.46
Linking lipids to Alzheimer's disease: cholesterol and beyond. Nat Rev Neurosci (2011) 2.60
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron (2008) 2.40
Calcium signaling and neurodegenerative diseases. Trends Mol Med (2009) 2.03
Essential role of calcineurin in response to endoplasmic reticulum stress. EMBO J (2002) 2.01
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A (2002) 1.97
Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging Cell (2007) 1.90
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol (2008) 1.84
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol (2004) 1.65
Role of presenilins in neuronal calcium homeostasis. J Neurosci (2010) 1.59
Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism. Proc Natl Acad Sci U S A (2006) 1.48
Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons. Sci Signal (2010) 1.47
Store-Operated Calcium Channels. Physiol Rev (2015) 1.46
The dysregulation of intracellular calcium in Alzheimer disease. Cell Calcium (2010) 1.40
Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. J Cell Biol (2004) 1.39
The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits. J Physiol (2009) 1.34
Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice. Neuron (2014) 1.25
Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment. Chem Biol (2011) 1.25
Arachidonic acid, ARC channels, and Orai proteins. Cell Calcium (2009) 1.21
Regulation of Ca2+ signaling with particular focus on mast cells. Crit Rev Immunol (2009) 1.20
Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury. J Neurosci (2011) 1.09
Orai3--the 'exceptional' Orai? J Physiol (2011) 1.07
Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices. Neurobiol Aging (2008) 1.07
Targets for AD treatment: conflicting messages from γ-secretase inhibitors. J Neurochem (2011) 1.05
Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger. Proc Natl Acad Sci U S A (2000) 1.05
Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease. Brain Struct Funct (2010) 1.04
Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease. J Alzheimers Dis (2010) 1.04
Transient receptor potential channels as novel effectors of brain-derived neurotrophic factor signaling: potential implications for Rett syndrome. Pharmacol Ther (2006) 1.03
Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium. J Biol Chem (2006) 1.02
Presenilins in synaptic function and disease. Trends Mol Med (2011) 1.02
Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex. Dis Model Mech (2010) 1.02
The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration. Mol Neurodegener (2013) 1.01
Stim and Orai proteins in neuronal Ca(2+) signaling and excitability. Front Cell Neurosci (2015) 0.99
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis. Cell Calcium (2011) 0.99
TRPC channels and their implication in neurological diseases. CNS Neurol Disord Drug Targets (2010) 0.97
The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid. Channels (Austin) (2010) 0.94
Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity. J Biol Chem (2011) 0.92
Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease. Front Mol Neurosci (2013) 0.92
Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2008) 0.91
Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases. J Bioenerg Biomembr (2004) 0.91
Some commonly used brominated flame retardants cause Ca2+-ATPase inhibition, beta-amyloid peptide release and apoptosis in SH-SY5Y neuronal cells. PLoS One (2012) 0.89
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc. Cell Death Dis (2011) 0.89
Increased asynchronous release and aberrant calcium channel activation in amyloid precursor protein deficient neuromuscular synapses. Neuroscience (2007) 0.88
Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein. Am J Physiol Cell Physiol (2011) 0.88
Emerging roles of canonical TRP channels in neuronal function. Adv Exp Med Biol (2011) 0.87
Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis. PLoS One (2013) 0.87
Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. J Cell Mol Med (2009) 0.87
Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function. Brain Res (2012) 0.86
Calcium homeostasis in aging neurons. Front Genet (2012) 0.86
Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity. Neural Plast (2012) 0.86
Store-operated calcium entry promotes the degradation of the transcription factor Sp4 in resting neurons. Sci Signal (2014) 0.86
gamma-Secretase activity modulates store-operated Ca2+ entry into rat sensory neurons. Neurosci Lett (2008) 0.85
Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling. Antioxid Redox Signal (2010) 0.84
STIM and Orai proteins and the non-capacitative ARC channels. Front Biosci (Landmark Ed) (2012) 0.84
Calcium signaling and neurodegeneration. Acta Naturae (2010) 0.83
Stabilizers of neuronal and mitochondrial calcium cycling as a strategy for developing a medicine for Alzheimer's disease. ACS Chem Neurosci (2012) 0.82
Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease. Semin Cell Dev Biol (2015) 0.82
Store-operated Ca2+ Entry-associated Regulatory factor (SARAF) Plays an Important Role in the Regulation of Arachidonate-regulated Ca2+ (ARC) Channels. J Biol Chem (2016) 0.82
Can the calcium hypothesis explain synaptic loss in Alzheimer's disease? Neurodegener Dis (2013) 0.80
Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase. Proc Natl Acad Sci U S A (2016) 0.79
Sequence analyses of presenilin mutations linked to familial Alzheimer's disease. Cell Stress Chaperones (2008) 0.79
Presenilins, Alzheimer's disease, and capacitative calcium entry. Neuron (2000) 0.78
Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease β-amyloid peptide secretion. J Biol Chem (2013) 0.78
The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained. Cell Calcium (2016) 0.78
Interactions of endoplasmic reticulum and mitochondria Ca(2+) stores with capacitative calcium entry. Metab Brain Dis (2014) 0.77
Non-Dioxin-Like Polychlorinated Biphenyls Inhibit G-Protein Coupled Receptor-Mediated Ca2+ Signaling by Blocking Store-Operated Ca2+ Entry. PLoS One (2016) 0.76
Modulation of transient receptor potential melastatin related 7 channel by presenilins. Dev Neurobiol (2012) 0.76
Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity? Biochem Biophys Res Commun (2016) 0.75
Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain. Front Pharmacol (2016) 0.75
Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry. Sci Signal (2016) 0.75
Polychlorinated biphenyl 19 blocks the most common form of store-operated Ca(2+) entry through Orai. Naunyn Schmiedebergs Arch Pharmacol (2017) 0.75
A polymorphic DNA marker genetically linked to Huntington's disease. Nature (1984) 16.71
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature (1995) 13.80
Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics. J Bacteriol (1997) 12.21
Role of the INK4a locus in tumor suppression and cell mortality. Cell (1996) 11.41
Biochemical and genetic conservation of fission yeast Dsk1 and human SR protein-specific kinase 1. Mol Cell Biol (2000) 9.92
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature (1996) 9.77
Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N Engl J Med (1999) 8.32
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science (1987) 8.29
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature (1999) 8.28
NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet (2000) 7.98
Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell (2000) 7.87
College binge drinking in the 1990s: a continuing problem. Results of the Harvard School of Public Health 1999 College Alcohol Study. J Am Coll Health (2000) 7.87
SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell (1995) 7.73
Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation (2000) 7.50
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet (1996) 7.35
Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet (1998) 7.26
Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol (2001) 7.22
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol Cell Biol (1995) 6.99
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol (2001) 6.43
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol (2001) 5.82
A compendium of gene expression in normal human tissues. Physiol Genomics (2001) 5.66
Diagnosis of Chlamydia trachomatis infections in men and women by testing first-void urine by ligase chain reaction. J Clin Microbiol (1994) 5.61
Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (1994) 5.34
Increased levels of cigarette use among college students: a cause for national concern. JAMA (1998) 4.85
Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A (2000) 4.71
Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem (1998) 4.57
Skeletal and CNS defects in Presenilin-1-deficient mice. Cell (1997) 4.50
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron (2001) 4.42
Involvement of Brca2 in DNA repair. Mol Cell (1998) 4.41
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. J Biol Chem (2000) 4.37
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science (2001) 4.18
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med (1997) 4.10
Open-reading-frame sequence tags (OSTs) support the existence of at least 17,300 genes in C. elegans. Nat Genet (2001) 4.03
Changes in binge drinking and related problems among American college students between 1993 and 1997. Results of the Harvard School of Public Health College Alcohol Study. J Am Coll Health (1998) 4.03
Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology (2004) 4.00
Diagnosis of Chlamydia trachomatis urethral infection in symptomatic and asymptomatic men by testing first-void urine in a ligase chain reaction assay. J Infect Dis (1994) 3.93
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology (2005) 3.90
A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev (1999) 3.88
Orientation selectivity of thalamic input to simple cells of cat visual cortex. Nature (1996) 3.61
The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science (1987) 3.59
Evaluation of ligase chain reaction for use with urine for identification of Neisseria gonorrhoeae in females attending a sexually transmitted disease clinic. J Clin Microbiol (1995) 3.47
Requirement for math5 in the development of retinal ganglion cells. Genes Dev (2001) 3.26
The Arabidopsis LOS5/ABA3 locus encodes a molybdenum cofactor sulfurase and modulates cold stress- and osmotic stress-responsive gene expression. Plant Cell (2001) 3.26
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science (2000) 3.16
Susceptible chiasmate configurations of chromosome 21 predispose to non-disjunction in both maternal meiosis I and meiosis II. Nat Genet (1996) 3.13
Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere. Cell (1987) 3.11
Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase. J Neurosci (2000) 3.10
Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea. J Infect (2006) 3.04
DNA markers for nervous system diseases. Science (1984) 3.02
Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response. J Exp Med (2000) 3.00
Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes. Circulation (2000) 2.95
CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev (1998) 2.91
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat Cell Biol (2000) 2.84
Isolation of polymorphic DNA fragments from human chromosome 4. Nucleic Acids Res (1987) 2.83
Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing. Genes Dev (1993) 2.82
Are chronic psychiatric patients at increased risk for developing breast cancer? Am J Psychiatry (1996) 2.78
Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem (1998) 2.78
FIERY1 encoding an inositol polyphosphate 1-phosphatase is a negative regulator of abscisic acid and stress signaling in Arabidopsis. Genes Dev (2001) 2.73
Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells. EMBO J (1996) 2.68
The relationship between tobacco access and use among adolescents: a four community study. Soc Sci Med (1999) 2.64
Ligase chain reaction for detection of Neisseria gonorrhoeae in urogenital swabs. J Clin Microbiol (1995) 2.62
Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther (2007) 2.61
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry (1999) 2.58
Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. J Virol (1997) 2.57
Increased use of marijuana and other illicit drugs at US colleges in the 1990s: results of three national surveys. Addiction (2000) 2.57
Genetics of aging. Science (1997) 2.57
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J Biol Chem (1999) 2.57
Genome-wide identification of NBS genes in japonica rice reveals significant expansion of divergent non-TIR NBS-LRR genes. Mol Genet Genomics (2004) 2.56
Extent of microstructural white matter injury in postconcussive syndrome correlates with impaired cognitive reaction time: a 3T diffusion tensor imaging study of mild traumatic brain injury. AJNR Am J Neuroradiol (2008) 2.55
Detection of Chlamydia trachomatis infection in urine samples from men and women by ligase chain reaction. J Clin Microbiol (1995) 2.50
Porous hollow carbon@sulfur composites for high-power lithium-sulfur batteries. Angew Chem Int Ed Engl (2011) 2.50
Relationship between colonial morphology and adherence of Streptococcus pneumoniae. Infect Immun (1995) 2.50
Synthesis and stability of developmentally regulated dictyostelium mRNAs are affected by cell--cell contact and cAMP. Cell (1981) 2.47
HOS1, a genetic locus involved in cold-responsive gene expression in arabidopsis. Plant Cell (1998) 2.47
Identification of a protein binding site on the surface of the alphavirus nucleocapsid and its implication in virus assembly. Structure (1996) 2.46
Genomic organization of the human SCN5A gene encoding the cardiac sodium channel. Genomics (1996) 2.44
Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med (1996) 2.43
Acupuncture for pain relief in labour: a systematic review and meta-analysis. BJOG (2010) 2.43
Homozygotes for Huntington's disease. Nature (1987) 2.40
Users' guides to the medical literature. IV. How to use an article about harm. Evidence-Based Medicine Working Group. JAMA (1994) 2.40
Human aneuploidy: incidence, origin, and etiology. Environ Mol Mutagen (1996) 2.38
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell (1995) 2.37
TLR engagement prevents transplantation tolerance. Am J Transplant (2006) 2.36
Roles for Fgf signaling during zebrafish fin regeneration. Dev Biol (2000) 2.36
Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med (2000) 2.34
Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk. Proc Natl Acad Sci U S A (1998) 2.33
Course of cerebral amyloid angiopathy-related inflammation. Neurology (2007) 2.33
The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel. J Med Genet (2004) 2.33
Essential role for Gab2 in the allergic response. Nature (2001) 2.32
APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron (2001) 2.31
Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. Hum Mol Genet (1995) 2.30
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem (1999) 2.30
Acquired immunodeficiency with reversed T4/T8 ratios in infants born to promiscuous and drug-addicted mothers. JAMA (1983) 2.29
HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway. J Biol Chem (2000) 2.29
Mapping, cloning and genetic characterization of the region containing the Wilson disease gene. Nat Genet (1993) 2.29
Jasmonic acid signaling modulates ozone-induced hypersensitive cell death. Plant Cell (2000) 2.27