Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset.

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Published in Arthritis Res on March 31, 2000

Authors

R Goldbach-Mansky1, J Lee, A McCoy, J Hoxworth, C Yarboro, J S Smolen, G Steiner, A Rosen, C Zhang, H A Ménard, Z J Zhou, T Palosuo, W J Van Venrooij , R L Wilder, J H Klippel, H R Schumacher, H S El-Gabalawy

Author Affiliations

1: Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskelatal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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Forces exerted by locomoting cells. Semin Cell Biol (1994) 2.53

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Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J Biol Chem (1994) 2.51

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Characterization of recombinant pig enamelysin activity and cleavage of recombinant pig and mouse amelogenins. J Dent Res (1999) 2.50

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Yoga-based intervention for carpal tunnel syndrome: a randomized trial. JAMA (1998) 2.50

Is it mandatory to examine synovial fluids promptly after arthrocentesis? Arthritis Rheum (1989) 2.49

Family history and perceived vulnerability to some common diseases: a study of young people and their parents. J Med Genet (1996) 2.49

Local application of retinoic acid to the limb bond mimics the action of the polarizing region. Nature (1982) 2.48

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis. J Biol Chem (1987) 2.48

Association of markers of systemic inflammation, C reactive protein, serum amyloid A, and fibrinogen, with socioeconomic status. J Epidemiol Community Health (2003) 2.46

Phytochrome signalling is mediated through nucleoside diphosphate kinase 2. Nature (1999) 2.46

Sickle-cell trait as a risk factor for sudden death in physical training. N Engl J Med (1987) 2.44