Published in Nat Biotechnol on November 01, 2000
VANTED: a system for advanced data analysis and visualization in the context of biological networks. BMC Bioinformatics (2006) 4.38
Extension of the visualization tool MapMan to allow statistical analysis of arrays, display of corresponding genes, and comparison with known responses. Plant Physiol (2005) 4.34
Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nat Protoc (2011) 4.13
Highly sensitive feature detection for high resolution LC/MS. BMC Bioinformatics (2008) 3.70
Thirteen years of building constraint-based in silico models of Escherichia coli. J Bacteriol (2003) 3.52
Brachypodium distachyon. A new model system for functional genomics in grasses. Plant Physiol (2001) 3.42
Integration of transcriptomics and metabolomics for understanding of global responses to nutritional stresses in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2004) 3.41
Exploring the temperature-stress metabolome of Arabidopsis. Plant Physiol (2004) 3.30
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci U S A (2005) 3.18
A novel approach for nontargeted data analysis for metabolomics. Large-scale profiling of tomato fruit volatiles. Plant Physiol (2005) 2.95
Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks. Comp Funct Genomics (2001) 2.68
Differential metabolic networks unravel the effects of silent plant phenotypes. Proc Natl Acad Sci U S A (2004) 2.63
Metabolic profiling of transgenic tomato plants overexpressing hexokinase reveals that the influence of hexose phosphorylation diminishes during fruit development. Plant Physiol (2003) 2.40
Integration of metabolite with transcript and enzyme activity profiling during diurnal cycles in Arabidopsis rosettes. Genome Biol (2006) 2.25
Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research. Metabolomics (2009) 2.21
Arabidopsis cytochrome P450 monooxygenase 71A13 catalyzes the conversion of indole-3-acetaldoxime in camalexin synthesis. Plant Cell (2007) 2.19
Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics (2009) 2.03
Metabolite profiling of human colon carcinoma--deregulation of TCA cycle and amino acid turnover. Mol Cancer (2008) 2.02
Arabidopsis seed development and germination is associated with temporally distinct metabolic switches. Plant Physiol (2006) 2.01
NMR-based metabolomic analysis of plants. Nat Protoc (2010) 1.92
RNA expression analysis using an antisense Bacillus subtilis genome array. J Bacteriol (2001) 1.89
Nonlinear data alignment for UPLC-MS and HPLC-MS based metabolomics: quantitative analysis of endogenous and exogenous metabolites in human serum. Anal Chem (2006) 1.81
Parallel analysis of transcript and metabolic profiles: a new approach in systems biology. EMBO Rep (2003) 1.76
Rose scent: genomics approach to discovering novel floral fragrance-related genes. Plant Cell (2002) 1.76
Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops. Proc Natl Acad Sci U S A (2005) 1.75
The Cinderella story of metabolic profiling: does metabolomics get to go to the functional genomics ball? Philos Trans R Soc Lond B Biol Sci (2006) 1.63
Identifying decomposition products in extracts of cellular metabolites. Anal Biochem (2006) 1.62
Recommendations for reporting metabolite data. Plant Cell (2011) 1.61
Profiling of Arabidopsis secondary metabolites by capillary liquid chromatography coupled to electrospray ionization quadrupole time-of-flight mass spectrometry. Plant Physiol (2004) 1.58
MetaMapp: mapping and visualizing metabolomic data by integrating information from biochemical pathways and chemical and mass spectral similarity. BMC Bioinformatics (2012) 1.56
Measurement of internal body time by blood metabolomics. Proc Natl Acad Sci U S A (2009) 1.56
Microbial metabolomics: replacing trial-and-error by the unbiased selection and ranking of targets. J Ind Microbiol Biotechnol (2005) 1.54
Combining genetic diversity, informatics and metabolomics to facilitate annotation of plant gene function. Nat Protoc (2010) 1.51
Metabolomics as a tool for cardiac research. Nat Rev Cardiol (2011) 1.51
Saliva: diagnostics and therapeutic perspectives. Oral Dis (2010) 1.50
MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis. Plant Physiol (2007) 1.50
Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database. Nat Protoc (2013) 1.49
Network analysis of enzyme activities and metabolite levels and their relationship to biomass in a large panel of Arabidopsis accessions. Plant Cell (2010) 1.41
Lotus japonicus metabolic profiling. Development of gas chromatography-mass spectrometry resources for the study of plant-microbe interactions. Plant Physiol (2005) 1.40
Metabolome-based genome-wide association study of maize kernel leads to novel biochemical insights. Nat Commun (2014) 1.40
Proton-transfer-reaction mass spectrometry as a new tool for real time analysis of root-secreted volatile organic compounds in Arabidopsis. Plant Physiol (2004) 1.40
Systems analysis of a maize leaf developmental gradient redefines the current C4 model and provides candidates for regulation. Plant Cell (2011) 1.38
Metabolic fluxes in an illuminated Arabidopsis rosette. Plant Cell (2013) 1.36
A metabolic signature of long life in Caenorhabditis elegans. BMC Biol (2010) 1.36
Metabolic engineering of dhurrin in transgenic Arabidopsis plants with marginal inadvertent effects on the metabolome and transcriptome. Proc Natl Acad Sci U S A (2005) 1.34
PIP5K9, an Arabidopsis phosphatidylinositol monophosphate kinase, interacts with a cytosolic invertase to negatively regulate sugar-mediated root growth. Plant Cell (2007) 1.34
Genomics and bioinformatics resources for crop improvement. Plant Cell Physiol (2010) 1.33
Metabolite profiling in plant biology: platforms and destinations. Genome Biol (2004) 1.33
High-resolution metabolic phenotyping of genetically and environmentally diverse potato tuber systems. Identification of phenocopies. Plant Physiol (2001) 1.32
Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis. Curr Bioinform (2012) 1.31
Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology. J Clin Epidemiol (2010) 1.31
A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experiments. BMC Bioinformatics (2007) 1.29
Systems analysis of plant functional, transcriptional, physical interaction, and metabolic networks. Plant Cell (2012) 1.27
Inter-laboratory reproducibility of fast gas chromatography-electron impact-time of flight mass spectrometry (GC-EI-TOF/MS) based plant metabolomics. Metabolomics (2009) 1.27
Metabolic discrimination of Catharanthus roseus leaves infected by phytoplasma using 1H-NMR spectroscopy and multivariate data analysis. Plant Physiol (2004) 1.26
Comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry analysis of metabolites in fermenting and respiring yeast cells. Anal Chem (2006) 1.25
Unbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana. BMC Syst Biol (2007) 1.25
New connections across pathways and cellular processes: industrialized mutant screening reveals novel associations between diverse phenotypes in Arabidopsis. Plant Physiol (2008) 1.24
Population dynamics and metabolite target analysis of lactic acid bacteria during laboratory fermentations of wheat and spelt sourdoughs. Appl Environ Microbiol (2007) 1.21
Willow leaves' extracts contain anti-tumor agents effective against three cell types. PLoS One (2007) 1.21
Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives. Metabolomics (2010) 1.21
Update on plant ionomics. Plant Physiol (2004) 1.20
Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine. Plant Physiol (2006) 1.20
Physiological and molecular adaptations to drought in Andean potato genotypes. J Exp Bot (2008) 1.19
Relative quantification of carboxylic acid metabolites by liquid chromatography-mass spectrometry using isotopic variants of cholamine. Anal Chem (2007) 1.18
Class selection of amino acid metabolites in body fluids using chemical derivatization and their enhanced 13C NMR. Proc Natl Acad Sci U S A (2007) 1.17
Interactions between co-expressed Arabidopsis sucrose transporters in the split-ubiquitin system. BMC Biochem (2003) 1.17
Metabolomics as a Hypothesis-Generating Functional Genomics Tool for the Annotation of Arabidopsis thaliana Genes of "Unknown Function". Front Plant Sci (2012) 1.17
Metabotyping of Caenorhabditis elegans reveals latent phenotypes. Proc Natl Acad Sci U S A (2007) 1.16
Biomarker metabolites capturing the metabolite variance present in a rice plant developmental period. BMC Plant Biol (2005) 1.16
GC/MS based metabolomics: development of a data mining system for metabolite identification by using soft independent modeling of class analogy (SIMCA). BMC Bioinformatics (2011) 1.15
Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis. J Biol Chem (2009) 1.15
PlantMetabolomics.org: a web portal for plant metabolomics experiments. Plant Physiol (2010) 1.15
Chemoselective 15N tag for sensitive and high-resolution nuclear magnetic resonance profiling of the carboxyl-containing metabolome. Anal Chem (2009) 1.14
Bioinformatics and systems biology of the lipidome. Chem Rev (2011) 1.14
Symbiodinium-invertebrate symbioses and the role of metabolomics. Mar Drugs (2010) 1.14
Integration of metabolomic and proteomic phenotypes: analysis of data covariance dissects starch and RFO metabolism from low and high temperature compensation response in Arabidopsis thaliana. Mol Cell Proteomics (2008) 1.13
Metabolome phenotyping of inorganic carbon limitation in cells of the wild type and photorespiratory mutants of the cyanobacterium Synechocystis sp. strain PCC 6803. Plant Physiol (2008) 1.12
Functional analysis of cystathionine gamma-synthase in genetically engineered potato plants. Plant Physiol (2003) 1.12
The Arabidopsis halophytic relative Thellungiella halophila tolerates nitrogen-limiting conditions by maintaining growth, nitrogen uptake, and assimilation. Plant Physiol (2008) 1.12
Metabolic labeling of plant cell cultures with K(15)NO3 as a tool for quantitative analysis of proteins and metabolites. Plant Methods (2006) 1.12
Rapid classification of phenotypic mutants of Arabidopsis via metabolite fingerprinting. Plant Physiol (2007) 1.11
System response of metabolic networks in Chlamydomonas reinhardtii to total available ammonium. Mol Cell Proteomics (2012) 1.11
Clarification of pathway-specific inhibition by Fourier transform ion cyclotron resonance/mass spectrometry-based metabolic phenotyping studies. Plant Physiol (2006) 1.11
Identification of enzyme activity quantitative trait loci in a Solanum lycopersicum x Solanum pennellii introgression line population. Plant Physiol (2011) 1.09
Organization and metabolism of plastids and mitochondria in arbuscular mycorrhizal roots of Medicago truncatula. Plant Physiol (2005) 1.08
Profiling of diurnal patterns of metabolite and transcript abundance in potato (Solanum tuberosum) leaves. Planta (2005) 1.07
Metabolomics unravel contrasting effects of biodiversity on the performance of individual plant species. PLoS One (2010) 1.07
Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method. Anal Bioanal Chem (2011) 1.07
Metabolomic and transcriptomic analysis of the rice response to the bacterial blight pathogen Xanthomonas oryzae pv. oryzae. Metabolomics (2010) 1.06
Metabolomics of human breast cancer: new approaches for tumor typing and biomarker discovery. Genome Med (2012) 1.06
Metabolic and transcriptomic phenotyping of inorganic carbon acclimation in the Cyanobacterium Synechococcus elongatus PCC 7942. Plant Physiol (2011) 1.06
A plastid-localized glycogen synthase kinase 3 modulates stress tolerance and carbohydrate metabolism. Plant J (2007) 1.05
Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery. Drug Discov Today (2013) 1.03
Review of mass spectrometry-based metabolomics in cancer research. Cancer Epidemiol Biomarkers Prev (2013) 1.03
Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene. J Biomed Biotechnol (2005) 1.03
Global mass spectrometry based metabolomics profiling of erythrocytes infected with Plasmodium falciparum. PLoS One (2013) 1.03
Predicting interpretability of metabolome models based on behavior, putative identity, and biological relevance of explanatory signals. Proc Natl Acad Sci U S A (2006) 1.02
Metabolomics of neural progenitor cells: a novel approach to biomarker discovery. Cold Spring Harb Symp Quant Biol (2008) 1.02
Improved method for the isolation of RNA from plant tissues. Anal Biochem (1987) 16.74
Brassinosteroids rescue the deficiency of CYP90, a cytochrome P450, controlling cell elongation and de-etiolation in Arabidopsis. Cell (1996) 8.10
Abscisic acid is involved in the wound-induced expression of the proteinase inhibitor II gene in potato and tomato. Proc Natl Acad Sci U S A (1989) 5.89
Storage of competent cells for Agrobacterium transformation. Nucleic Acids Res (1988) 4.71
Technical advance: simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrometry. Plant J (2000) 4.64
Metabolic profiling allows comprehensive phenotyping of genetically or environmentally modified plant systems. Plant Cell (2001) 4.42
Genetic Identification of functions of TL-DNA transcripts in octopine crown galls. EMBO J (1982) 4.30
Both developmental and metabolic signals activate the promoter of a class I patatin gene. EMBO J (1989) 4.15
Isolation and characterization of a sucrose carrier cDNA from spinach by functional expression in yeast. EMBO J (1992) 3.90
General roles of abscisic and jasmonic acids in gene activation as a result of mechanical wounding. Plant Cell (1992) 3.71
Evidence of the crucial role of sucrose synthase for sink strength using transgenic potato plants (Solanum tuberosum L.). Plant J (1995) 3.08
A subtilisin-like serine protease involved in the regulation of stomatal density and distribution in Arabidopsis thaliana. Genes Dev (2000) 2.97
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A complete BAC-based physical map of the Arabidopsis thaliana genome. Nat Genet (1999) 2.47
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Expression of a tuber-specific storage protein in transgenic tobacco plants: demonstration of an esterase activity. EMBO J (1987) 2.11
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Cloning and functional analysis of a cDNA encoding a novel 139 kDa starch synthase from potato (Solanum tuberosum L.). Plant J (1996) 2.05
Cloning and electrophysiological analysis of KST1, an inward rectifying K+ channel expressed in potato guard cells. EMBO J (1995) 2.05
Further insight on the transferred-DNA of octopine crown gall. Mol Gen Genet (1981) 2.05
Analysis of cis-active sequences involved in the leaf-specific expression of a potato gene in transgenic plants. Proc Natl Acad Sci U S A (1987) 2.02
Analysis of the compartmentation of glycolytic intermediates, nucleotides, sugars, organic acids, amino acids, and sugar alcohols in potato tubers using a nonaqueous fractionation method. Plant Physiol (2001) 1.96
12-Oxophytodienoate reductase 3 (OPR3) is the isoenzyme involved in jasmonate biosynthesis. Planta (2000) 1.93
Two cDNAs from potato are able to complement a phosphate uptake-deficient yeast mutant: identification of phosphate transporters from higher plants. Plant Cell (1997) 1.93
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Inhibition of a starch-granule-bound protein leads to modified starch and repression of cold sweetening. Nat Biotechnol (1998) 1.87
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Inorganic pyrophosphate content and metabolites in potato and tobacco plants expressing E. coli pyrophosphatase in their cytosol. Planta (1992) 1.86
Identification of mutants in metabolically regulated gene expression. Plant J (1997) 1.86
Increased potato tuber size resulting from apoplastic expression of a yeast invertase. Nat Biotechnol (1997) 1.83
Establishment of a high-efficiency SNP-based framework marker set for Arabidopsis. Plant J (2003) 1.82
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A novel DNA binding protein with homology to Myb oncoproteins containing only one repeat can function as a transcriptional activator. EMBO J (1994) 1.50
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Maximizing the reliability of genomic selection by optimizing the calibration set of reference individuals: comparison of methods in two diverse groups of maize inbreds (Zea mays L.). Genetics (2012) 1.34
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Transgenic potato (Solanum tuberosum) tubers synthesize the full spectrum of inulin molecules naturally occurring in globe artichoke (Cynara scolymus) roots. Proc Natl Acad Sci U S A (2000) 1.09
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