A nuclease hypersensitive element in the human c-myc promoter adopts several distinct i-tetraplex structures.

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc Natl Acad Sci U S A (2002) 9.60

Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. J Am Chem Soc (2004) 3.74

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov (2011) 3.54

Circular dichroism and conformational polymorphism of DNA. Nucleic Acids Res (2009) 3.20

Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions. Biochimie (2008) 2.38

The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression. J Med Chem (2009) 2.03

The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics. Nat Rev Cancer (2009) 1.71

Growth suppression by acute promyelocytic leukemia-associated protein PLZF is mediated by repression of c-myc expression. Mol Cell Biol (2003) 1.61

Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene. J Am Chem Soc (2007) 1.53

Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb). Nucleic Acids Res (2006) 1.49

Targeting MYC Expression through G-Quadruplexes. Genes Cancer (2010) 1.29

Multiple biochemical activities of NM23/NDP kinase in gene regulation. J Bioenerg Biomembr (2003) 1.23

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1). Mol Cancer Ther (2009) 1.19

Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene. Nucleic Acids Res (2008) 1.16

Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci (2014) 1.16

Kinetic resolution of bimolecular hybridization versus intramolecular folding in nucleic acids by surface plasmon resonance: application to G-quadruplex/duplex competition in human c-myc promoter. Nucleic Acids Res (2005) 1.07

The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern. J Am Chem Soc (2009) 1.04

A thermodynamic overview of naturally occurring intramolecular DNA quadruplexes. Nucleic Acids Res (2008) 1.02

Increased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphoma. Haematologica (2010) 1.00

Retracted Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue. Proc Natl Acad Sci U S A (2004) 0.97

The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements. Pure Appl Chem (2010) 0.94

Genomic c-Myc quadruplex DNA selectively kills leukemia. Mol Cancer Ther (2011) 0.89

The fragile X chromosome (GCC) repeat folds into a DNA tetraplex at neutral pH. Nucleic Acids Res (2001) 0.89

DNA and the chromosome - varied targets for chemotherapy. Cell Chromosome (2004) 0.88

Nucleoside diphosphate kinase from Mycobacterium tuberculosis cleaves single strand DNA within the human c-myc promoter in an enzyme-catalyzed reaction. Nucleic Acids Res (2005) 0.88

Molecular modeling and biophysical analysis of the c-MYC NHE-III1 silencer element. J Mol Model (2007) 0.86

I-motif structures formed in the human c-MYC promoter are highly dynamic--insights into sequence redundancy and I-motif stability. PLoS One (2010) 0.85

A direct and nondestructive approach to determine the folding structure of the I-motif DNA secondary structure by NMR. J Am Chem Soc (2009) 0.83

Biophysical characterization of an ensemble of intramolecular i-motifs formed by the human c-MYC NHE III1 P1 promoter mutant sequence. Biophys J (2010) 0.82

Silver (I) as DNA glue: Ag(+)-mediated guanine pairing revealed by removing Watson-Crick constraints. Sci Rep (2015) 0.81

Spectroscopic characterization of i-motif forming c-myc derived sequences double-labeled with pyrene. J Fluoresc (2013) 0.75

Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA. Nucleic Acids Res (2015) 0.75

Probing the Potential Role of Non-B DNA Structures at Yeast Meiosis-Specific DNA Double-Strand Breaks. Biophys J (2017) 0.75