Wild-derived inbred mouse strains have short telomeres.

PubWeight™: 1.95‹?› | Rank: Top 2%

🔗 View Article (PMC 113886)

Published in Nucleic Acids Res on November 15, 2000

Authors

M T Hemann1, C W Greider

Author Affiliations

1: Predoctoral Training Program in Human Genetics and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Articles citing this

The telomere syndromes. Nat Rev Genet (2012) 4.01

Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med (2011) 3.28

Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell (2008) 2.21

Does caloric restriction extend life in wild mice? Aging Cell (2006) 1.99

Telomerase activity coevolves with body mass not lifespan. Aging Cell (2006) 1.91

Short telomeres are sufficient to cause the degenerative defects associated with aging. Am J Hum Genet (2009) 1.86

Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proc Natl Acad Sci U S A (2004) 1.83

Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis. Cancer Cell (2009) 1.67

Haploinsufficiency of mTR results in defects in telomere elongation. Proc Natl Acad Sci U S A (2002) 1.56

Stress impacts telomere dynamics. Biol Lett (2007) 1.48

Telomere biology in healthy aging and disease. Pflugers Arch (2009) 1.41

Genomic organization of the Drosophila telomere retrotransposable elements. Genome Res (2006) 1.37

Differences in telomere length between homologous chromosomes in humans. Nucleic Acids Res (2001) 1.34

Length regulation and dynamics of individual telomere tracts in wild-type Arabidopsis. Plant Cell (2004) 1.34

Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase. Mol Cell Biol (2011) 1.31

Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells. J Exp Med (2001) 1.30

Telomere attrition due to infection. PLoS One (2008) 1.23

Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia. Leukemia (2011) 1.21

Short telomeres initiate telomere recombination in primary and tumor cells. PLoS Genet (2009) 1.21

Telomere dysfunction causes alveolar stem cell failure. Proc Natl Acad Sci U S A (2015) 1.19

Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy. Nat Cell Biol (2013) 1.07

Uncoupling of longevity and telomere length in C. elegans. PLoS Genet (2005) 1.04

Coevolution of telomerase activity and body mass in mammals: from mice to beavers. Mech Ageing Dev (2008) 1.03

Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis. Cell Rep (2012) 0.98

Physical activity and telomere biology: exploring the link with aging-related disease prevention. J Aging Res (2011) 0.98

Accelerated aging syndromes, are they relevant to normal human aging? Aging (Albany NY) (2011) 0.97

Telomere shortening in neurological disorders: an abundance of unanswered questions. Trends Neurosci (2014) 0.96

Condensin I reveals new insights on mouse meiotic chromosome structure and dynamics. PLoS One (2007) 0.95

Making the most of a little: dosage effects in eukaryotic telomere length maintenance. Chromosome Res (2005) 0.95

Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth. Mech Ageing Dev (2011) 0.94

Differentiation rather than aging of muscle stem cells abolishes their telomerase activity. Biotechnol Prog (2009) 0.90

Telomere dynamics in rhesus monkeys: no apparent effect of caloric restriction. J Gerontol A Biol Sci Med Sci (2011) 0.90

Differential roles of telomere attrition in type I and II endometrial carcinogenesis. Am J Pathol (2008) 0.89

Wild-derived mouse stocks: an underappreciated tool for aging research. Age (Dordr) (2008) 0.89

HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction. Chromosoma (2012) 0.88

The eye of the laboratory mouse remains anatomically adapted for natural conditions. Brain Behav Evol (2005) 0.88

Chronic exercise modifies age-related telomere dynamics in a tissue-specific fashion. J Gerontol A Biol Sci Med Sci (2012) 0.88

FANCC suppresses short telomere-initiated telomere sister chromatid exchange. Hum Mol Genet (2009) 0.87

The role of telomeres in the ageing of human skin. Exp Dermatol (2011) 0.87

Reprogramming murine telomerase rapidly inhibits the growth of mouse cancer cells in vitro and in vivo. Mol Cancer Ther (2010) 0.86

Do telomeres adapt to physiological stress? Exploring the effect of exercise on telomere length and telomere-related proteins. Biomed Res Int (2013) 0.86

Telomeres shorten in response to oxidative stress in mouse skeletal muscle fibers. J Gerontol A Biol Sci Med Sci (2014) 0.86

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction. Nat Commun (2014) 0.85

Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes. Dis Model Mech (2009) 0.84

Cumulative stress in research animals: Telomere attrition as a biomarker in a welfare context? Bioessays (2015) 0.84

Telomerase activity and telomere length in Daphnia. PLoS One (2015) 0.83

Selected telomere length changes and aberrant three-dimensional nuclear telomere organization during fast-onset mouse plasmacytomas. Neoplasia (2012) 0.83

Genetic variation exists for telomeric array organization within and among the genomes of normal, immortalized, and transformed chicken systems. Chromosome Res (2009) 0.83

Tissue-specific differences in the accumulation of sequence rearrangements with age. DNA Repair (Amst) (2008) 0.83

Organ aging and susceptibility to cancer may be related to the geometry of the stem cell niche. Proc Natl Acad Sci U S A (2011) 0.82

Telomere length reveals cumulative individual and transgenerational inbreeding effects in a passerine bird. Mol Ecol (2016) 0.82

Preventing clonal evolutionary processes in cancer: Insights from mathematical models. Proc Natl Acad Sci U S A (2015) 0.80

Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PLoS One (2012) 0.79

Cloning and molecular characterization of telomerase reverse transcriptase (TERT) and telomere length analysis of Peromyscus leucopus. Gene (2015) 0.78

Clinical implications of antitelomeric drugs with respect to the nontelomeric functions of telomerase in cancer. Onco Targets Ther (2013) 0.77

Extending the model of Arabidopsis telomere length and composition across Brassicaceae. Chromosome Res (2014) 0.77

Influence of In Utero Maternal and Neonate Factors on Cord Blood Leukocyte Telomere Length: Clues to the Racial Disparity in Prostate Cancer? Prostate Cancer (2016) 0.75

Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol (2017) 0.75

The paradox of longer sperm telomeres in older men's testes: a birth-cohort effect caused by transgenerational telomere erosion in the female germline. Mol Cytogenet (2016) 0.75

Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. Aging (Albany NY) (2016) 0.75

Articles cited by this

Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res (1965) 21.61

Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34

Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A (1992) 10.19

Genealogies of mouse inbred strains. Nat Genet (2000) 8.06

Essential role of mouse telomerase in highly proliferative organs. Nature (1998) 7.23

Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell (1999) 6.98

Heterogeneity in telomere length of human chromosomes. Hum Mol Genet (1996) 6.55

Telomere loss: mitotic clock or genetic time bomb? Mutat Res (1992) 6.50

Replicative senescence: the human fibroblast comes of age. Science (1990) 4.77

Hypervariable ultra-long telomeres in mice. Nature (1990) 4.76

Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci U S A (1995) 3.86

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med (2000) 2.81

Extensive telomere repeat arrays in mouse are hypervariable. Nucleic Acids Res (1990) 2.56

The telomere hypothesis of cellular aging. Exp Gerontol (1993) 2.39

Progressive cis-inhibition of telomerase upon telomere elongation. EMBO J (1999) 2.37

Telomere length regulation in mice is linked to a novel chromosome locus. Proc Natl Acad Sci U S A (1998) 1.78

Telomere length regulation during postnatal development and ageing in Mus spretus. Nucleic Acids Res (1997) 1.41

For better or worse? Telomerase inhibition and cancer. Cell (1999) 1.06

Longevity, aging and comparative cellular and molecular biology of the house mouse, Mus musculus, and the white-footed mouse, Peromyscus leucopus. Birth Defects Orig Artic Ser (1978) 1.04

Articles by these authors

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17

Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J (1992) 10.97

Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A (1992) 10.19

Essential role of mouse telomerase in highly proliferative organs. Nature (1998) 7.23

Secondary structure of vertebrate telomerase RNA. Cell (2000) 6.37

The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell (2001) 5.98

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell (1999) 5.93

Telomere end-replication problem and cell aging. J Mol Biol (1992) 5.37

Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci U S A (1995) 3.86

RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics (1999) 3.55

Functional characterization and developmental regulation of mouse telomerase RNA. Science (1995) 3.26

Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell (1995) 3.23

Telomerase, cell immortality, and cancer. Cold Spring Harb Symp Quant Biol (1994) 2.76

Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation. Genes Dev (1993) 2.64

Telomere dysfunction increases mutation rate and genomic instability. Cell (2001) 2.62

Telomerase primer specificity and chromosome healing. Nature (1991) 2.58

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell (1999) 2.46

Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events. Mol Cell Biol (2001) 2.34

Identification of a nonprocessive telomerase activity from mouse cells. Proc Natl Acad Sci U S A (1993) 2.24

Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nat Genet (1996) 2.18

Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA. EMBO J (1996) 2.08

Boundary elements of the Tetrahymena telomerase RNA template and alignment domains. Genes Dev (1995) 1.98

Functional reconstitution of wild-type and mutant Tetrahymena telomerase. Genes Dev (1994) 1.97

Telomerase and cancer: revisiting the telomere hypothesis. Trends Biochem Sci (1996) 1.93

Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res (1996) 1.87

Telomere dysfunction triggers developmentally regulated germ cell apoptosis. Mol Biol Cell (2001) 1.85

Telomerase regulation during entry into the cell cycle in normal human T cells. Mol Biol Cell (1996) 1.71

Telomerase activity in germline and embryonic cells of Xenopus. EMBO J (1994) 1.66

Recognition and elongation of telomeres by telomerase. Genome (1989) 1.54

Identification of two RNA-binding proteins associated with human telomerase RNA. Mol Biol Cell (2000) 1.50

Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitro. Nucleic Acids Res (1998) 1.32

G-strand overhangs on telomeres in telomerase-deficient mouse cells. Nucleic Acids Res (1999) 1.31

Utilization of ribonucleotides and RNA primers by Tetrahymena telomerase. EMBO J (1995) 1.29

Recombination in telomere-length maintenance. Trends Biochem Sci (2000) 1.27

The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence. Nucleic Acids Res (1998) 1.19

Telomerase activity in human gliomas. Neurosurgery (1998) 1.08

Telomerase and cancer stem cells. Cold Spring Harb Symp Quant Biol (2005) 1.04

Tetrahymena telomerase RNA levels increase during macronuclear development. Dev Genet (1992) 1.01

Mouse models for the study of telomerase. Ciba Found Symp (1997) 0.90

Telomere length, telomere-binding proteins, and DNA damage signaling. Cold Spring Harb Symp Quant Biol (2000) 0.84

Tetrahymena proteins p80 and p95 are not core telomerase components. Proc Natl Acad Sci U S A (2001) 0.84