Published in Science on November 24, 2000
ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency. J Virol (2002) 4.11
Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment. J Virol (2001) 3.40
Limited durability of viral control following treated acute HIV infection. PLoS Med (2004) 2.16
A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model. PLoS Pathog (2012) 1.26
CD8+-cell-mediated suppression of virulent simian immunodeficiency virus during tenofovir treatment. J Virol (2004) 1.25
Vaccine-elicited memory cytotoxic T lymphocytes contribute to Mamu-A*01-associated control of simian/human immunodeficiency virus 89.6P replication in rhesus monkeys. J Virol (2005) 1.24
Human immunodeficiency virus-specific CD8(+) T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy. J Virol (2002) 1.20
Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection. J Virol (2002) 1.15
Control of viremia and prevention of AIDS following immunotherapy of SIV-infected macaques with peptide-pulsed blood. PLoS Pathog (2008) 1.10
Considerations in the development of nonhuman primate models of combination antiretroviral therapy for studies of AIDS virus suppression, residual virus, and curative strategies. Curr Opin HIV AIDS (2013) 1.10
HIV therapeutic vaccines: moving towards a functional cure. Curr Opin Immunol (2015) 1.06
Structured treatment interruptions with tenofovir monotherapy for simian immunodeficiency virus-infected newborn macaques. J Virol (2006) 1.05
Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization. J Virol (2006) 1.03
Structured intermittent treatment for HIV disease: Necessary concession or premature compromise? Proc Natl Acad Sci U S A (2002) 0.99
Post-exposure prophylaxis for SIV revisited: animal model for HIV prevention. AIDS Res Ther (2006) 0.96
A cure for AIDS: a matter of timing? Retrovirology (2013) 0.92
Induction of potent human immunodeficiency virus type 1-specific T-cell-restricted immunity by genetically modified dendritic cells. J Virol (2001) 0.90
Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS. Retrovirology (2013) 0.89
Cytokine-adjuvanted HIV-DNA vaccination strategies. Springer Semin Immunopathol (2006) 0.87
Interruption of antiretroviral therapy to augment immune control of chronic HIV-1 infection: risk without reward. Proc Natl Acad Sci U S A (2002) 0.86
Using mathematical modeling and control to develop structured treatment interruption strategies for HIV infection. Drug Alcohol Depend (2007) 0.86
Persistence of gut mucosal innate immune defenses by enteric α-defensin expression in the simian immunodeficiency virus model of AIDS. J Immunol (2010) 0.84
Immune escape mutations detected within HIV-1 epitopes associated with viral control during treatment interruption. J Acquir Immune Defic Syndr (2010) 0.81
Prospects for immune reconstitution in HIV-1 infection. Clin Exp Immunol (2002) 0.81
Complementary antiviral efficacy of hydroxyurea and protease inhibitors in human immunodeficiency virus-infected dendritic cells and lymphocytes. J Virol (2002) 0.76
Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome. AIDS (2009) 0.76
Structured Treatment Interruptions and Low Doses of IL-2 in Patients with Primary HIV Infection. Inflammatory, Virological and Immunological Outcomes. PLoS One (2015) 0.76
HIV-specific cellular immune responses are stimulated by structured treatment interruption in chronically HIV-1 infected Koreans. Yonsei Med J (2006) 0.75
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature (2000) 13.45
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med (1999) 12.68
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies. Nat Med (2000) 11.90
Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science (2000) 9.92
Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies. J Virol (1999) 9.11
Smoking in China: findings of the 1996 National Prevalence Survey. JAMA (1999) 8.67
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science (2000) 8.56
Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science (1997) 8.16
Receptor specificity of the fibroblast growth factor family. J Biol Chem (1996) 7.58
Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science (1997) 5.40
Air pollution and mortality in Philadelphia, 1974-1988. Am J Epidemiol (1997) 5.35
Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science (1996) 5.06
Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals. Proc Natl Acad Sci U S A (1990) 4.80
The Human Connectome Project: a data acquisition perspective. Neuroimage (2012) 4.64
Activation of PPARgamma coactivator-1 through transcription factor docking. Science (1999) 4.33
Transport of hemolysin across the outer membrane of Escherichia coli requires two functions. J Bacteriol (1983) 4.27
ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency. J Virol (2002) 4.11
Ia antigen expression on human epidermal Langerhans cells. Nature (1977) 4.05
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Mol Cell (1999) 4.02
Visual acuity and quality of life in patients with cataract in Doumen County, China. Ophthalmology (1999) 3.82
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet (2002) 3.67
Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003. Lancet (2003) 3.66
A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem. Proc Natl Acad Sci U S A (1999) 3.63
Tumour-specific antibodies in human malignant melanoma and their relationship to the extent of the disease. Br Med J (1969) 3.37
Possible immunological factors in human malignant melanoma in Uganda. Lancet (1967) 3.16
Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature (1995) 3.07
The SPOROCYTELESS gene of Arabidopsis is required for initiation of sporogenesis and encodes a novel nuclear protein. Genes Dev (1999) 3.07
Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med (1995) 2.98
Autoimmunization with irradiated tumour cells in human malignant melanoma. Br Med J (1970) 2.91
Functional neuronavigation combined with intra-operative 3D ultrasound: initial experiences during surgical resections close to eloquent brain areas and future directions in automatic brain shift compensation of preoperative data. Acta Neurochir (Wien) (2007) 2.89
Formation of native hepatitis C virus glycoprotein complexes. J Virol (1997) 2.87
Human cytomegalovirus latent gene expression in granulocyte-macrophage progenitors in culture and in seropositive individuals. Proc Natl Acad Sci U S A (1996) 2.87
Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet (1996) 2.87
High interlaboratory reproducibility of DNA sequence-based typing of bacteria in a multicenter study. J Clin Microbiol (2006) 2.80
Characteristics of prostate cancer in families potentially linked to the hereditary prostate cancer 1 (HPC1) locus. JAMA (1997) 2.73
The classification of malignant melanoma and its histologic reporting. Cancer (1973) 2.67
Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics. J Virol (1994) 2.64
Titration and characterization of two rhesus-derived SIVmac challenge stocks. AIDS Res Hum Retroviruses (1994) 2.63
Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins (2005) 2.59
Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein. Oncogene (1997) 2.58
Correlation of the highest-energy cosmic rays with nearby extragalactic objects. Science (2007) 2.57
Control of HIV despite the discontinuation of antiretroviral therapy. N Engl J Med (1999) 2.54
Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation. J Thromb Haemost (2011) 2.51
Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase. J Virol (1997) 2.39
Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science (1996) 2.36
Molecular diagnosis of infective endocarditis--a new Duke's criterion. Scand J Infect Dis (2001) 2.36
Pioneer factors, genetic competence, and inductive signaling: programming liver and pancreas progenitors from the endoderm. Cold Spring Harb Symp Quant Biol (2008) 2.34
Disability in optic neuritis correlates with diffusion tensor-derived directional diffusivities. Neurology (2008) 2.33
JNK is required for effector T-cell function but not for T-cell activation. Nature (2000) 2.33
Experience with a three-hour electron microscopy biopsy service. J Clin Pathol (1974) 2.33
Transport of hemolysin by Escherichia coli. J Cell Biochem (1983) 2.23
Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques. Nat Med (1995) 2.23
Immunological studies in nephrotic syndrome associated with extrarenal malignant disease. Lancet (1971) 2.22
A symptom rating scale for delirium. Psychiatry Res (1988) 2.21
Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proc Natl Acad Sci U S A (1997) 2.21
CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response. J Exp Med (1996) 2.21
Acupuncture for pain relief during induced labour in nulliparae: a randomised controlled study. BJOG (2011) 2.19
A survey of blindness and cataract surgery in Doumen County, China. Ophthalmology (1999) 2.15
Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet (1995) 2.09
17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation. J Neurophysiol (1999) 2.08
New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo. J Biol Chem (2000) 2.07
Completely diverted tube ileostomy compared with loop ileostomy for protection of low colorectal anastomosis: a pilot study. Colorectal Dis (2014) 2.06
The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Nat Genet (1995) 2.02
Primary care, infant mortality, and low birth weight in the states of the USA. J Epidemiol Community Health (2004) 2.01
Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions. J Steroid Biochem Mol Biol (1999) 2.00
Gene expression of osteoprotegerin ligand, osteoprotegerin, and receptor activator of NF-kappaB in giant cell tumor of bone: possible involvement in tumor cell-induced osteoclast-like cell formation. Am J Pathol (2000) 1.99
Central diabetes insipidus in children and young adults. N Engl J Med (2000) 1.97
Retinal nerve fibre layer thickness measurement reproducibility improved with spectral domain optical coherence tomography. Br J Ophthalmol (2009) 1.97
Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. Science (1994) 1.96
Weighing the care: physicians' reactions to the size of a patient. Int J Obes Relat Metab Disord (2001) 1.96
Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations. Am J Hum Genet (2000) 1.94
BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis. Am J Hum Genet (1993) 1.90
P504S: a new molecular marker for the detection of prostate carcinoma. Am J Surg Pathol (2001) 1.86
The impact of ethnicity and sex on subclinical cardiovascular disease: the Diabetes Heart Study. Diabetologia (2005) 1.84
VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma. Br J Cancer (2008) 1.84
Dynamic changes in Rad51 distribution on chromatin during meiosis in male and female vertebrates. Chromosoma (1995) 1.83
Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics (1994) 1.81
An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science (1993) 1.81
Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone. EMBO J (1999) 1.78
First evidence of pep solar neutrinos by direct detection in Borexino. Phys Rev Lett (2012) 1.77
Diffusing wave spectroscopy microrheology of actin filament networks. Biophys J (1999) 1.77
Complications of cancer immunotherapy with levamisole. Lancet (1977) 1.76
Pan1p, End3p, and S1a1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis. Mol Cell Biol (2000) 1.76
The specificity of surface membrane immunofluorescence in human malignant melanoma. Int J Cancer (1972) 1.75
Phonon density of states of iron up to 153 gigapascals. Science (2001) 1.74
Mechanisms of protection induced by attenuated simian immunodeficiency virus. II. Lymphocyte depletion does not abrogate protection. AIDS Res Hum Retroviruses (1998) 1.73
Circulating endothelial cells and endothelial progenitors as predictive markers of clinical response to bevacizumab-based first-line treatment in advanced colorectal cancer patients. Ann Oncol (2010) 1.73
Detection of incidental colorectal tumours with 18F-labelled 2-fluoro-2-deoxyglucose positron emission tomography/computed tomography scans: results of a prospective study. Colorectal Dis (2011) 1.73
Frameless neuronavigation in intracranial endoscopic neurosurgery. J Neurosurg (2001) 1.72
Does weather confound or modify the association of particulate air pollution with mortality? An analysis of the Philadelphia data, 1973-1980. Environ Res (1998) 1.71
Effects of lipopolysaccharide priming on acute ischemic brain injury. Stroke (2000) 1.70
Pore formation by the Escherichia coli hemolysin: evidence for an association-dissociation equilibrium of the pore-forming aggregates. Infect Immun (1989) 1.69
Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. Oncogene (2011) 1.69
Headache attributed to infection: observations on the IHS classification (ICHD-II). Cephalalgia (2006) 1.69
Global monitoring of wetlands--the value of ENVISAT ASAR Global mode. J Environ Manage (2008) 1.68
Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model. Am J Transplant (2010) 1.68
Transcriptional complementarity in breast cancer: application to detection of circulating tumor cells. Mol Diagn (2001) 1.67
Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases. Neuroscience (2002) 1.66
Porcine small intestine submucosa (SIS) is not an acellular collagenous matrix and contains porcine DNA: possible implications in human implantation. J Biomed Mater Res B Appl Biomater (2005) 1.66