Published in Nat Struct Biol on November 01, 2000
MAMMOTH (matching molecular models obtained from theory): an automated method for model comparison. Protein Sci (2002) 5.47
Identification of protein biochemical functions by similarity search using the molecular surface database eF-site. Protein Sci (2003) 2.98
Annotation transfer for genomics: measuring functional divergence in multi-domain proteins. Genome Res (2001) 2.81
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
U2AF homology motifs: protein recognition in the RRM world. Genes Dev (2004) 2.34
Annotation in three dimensions. PINTS: Patterns in Non-homologous Tertiary Structures. Nucleic Acids Res (2003) 2.14
A new, structurally nonredundant, diverse data set of protein-protein interfaces and its implications. Protein Sci (2004) 2.11
Functional coverage of the human genome by existing structures, structural genomics targets, and homology models. PLoS Comput Biol (2005) 2.04
Automated prediction of protein function and detection of functional sites from structure. Proc Natl Acad Sci U S A (2004) 1.96
A genomic overview of pyridoxal-phosphate-dependent enzymes. EMBO Rep (2003) 1.77
Parameter optimized surfaces (POPS): analysis of key interactions and conformational changes in the ribosome. Nucleic Acids Res (2002) 1.47
The rough guide to in silico function prediction, or how to use sequence and structure information to predict protein function. PLoS Comput Biol (2008) 1.44
HotPatch: a statistical approach to finding biologically relevant features on protein surfaces. J Mol Biol (2007) 1.32
SUPFAM--a database of potential protein superfamily relationships derived by comparing sequence-based and structure-based families: implications for structural genomics and function annotation in genomes. Nucleic Acids Res (2002) 1.26
Functional annotation by identification of local surface similarities: a novel tool for structural genomics. BMC Bioinformatics (2005) 1.11
Fishing new proteins in the twilight zone of genomes: the test case of outer membrane proteins in Escherichia coli K12, Escherichia coli O157:H7, and other Gram-negative bacteria. Protein Sci (2003) 1.08
Target selection and determination of function in structural genomics. IUBMB Life (2003) 1.05
Identification of the ligand binding sites on the molecular surface of proteins. Protein Sci (2005) 1.04
McVol - a program for calculating protein volumes and identifying cavities by a Monte Carlo algorithm. J Mol Model (2009) 1.02
Homology modelling and structural analysis of human arylamine N-acetyltransferase NAT1: evidence for the conservation of a cysteine protease catalytic domain and an active-site loop. Biochem J (2001) 1.02
Structural characterization of proteins using residue environments. Proteins (2005) 1.02
Rapid detection of similarity in protein structure and function through contact metric distances. Nucleic Acids Res (2006) 1.01
FoldMiner and LOCK 2: protein structure comparison and motif discovery on the web. Nucleic Acids Res (2004) 0.99
Predicting gene ontology functions from protein's regional surface structures. BMC Bioinformatics (2007) 0.95
Improved protein surface comparison and application to low-resolution protein structure data. BMC Bioinformatics (2010) 0.95
Ligand-binding site prediction of proteins based on known fragment-fragment interactions. Bioinformatics (2010) 0.91
A glimpse at the organization of the protein universe. Proc Natl Acad Sci U S A (2005) 0.90
Localization of binding sites in protein structures by optimization of a composite scoring function. Protein Sci (2006) 0.89
A comprehensive analysis of the structure-function relationship in proteins based on local structure similarity. PLoS One (2009) 0.89
MARINE-EXPRESS: taking advantage of high throughput cloning and expression strategies for the post-genomic analysis of marine organisms. Microb Cell Fact (2010) 0.89
A new protein-ligand binding sites prediction method based on the integration of protein sequence conservation information. BMC Bioinformatics (2011) 0.88
Structure- and sequence-based function prediction for non-homologous proteins. J Struct Funct Genomics (2012) 0.87
Identification of ligand templates using local structure alignment for structure-based drug design. J Chem Inf Model (2012) 0.87
Functional enrichment analyses and construction of functional similarity networks with high confidence function prediction by PFP. BMC Bioinformatics (2010) 0.85
Efficient identification of critical residues based only on protein structure by network analysis. PLoS One (2007) 0.83
Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase. J Biol Chem (2013) 0.82
Predicting nucleic acid binding interfaces from structural models of proteins. Proteins (2011) 0.82
Evaluation of function predictions by PFP, ESG,and PSI-BLAST for moonlighting proteins. BMC Proc (2012) 0.82
Structure-guided comparative analysis of proteins: principles, tools, and applications for predicting function. PLoS Comput Biol (2008) 0.79
De-DUFing the DUFs: Deciphering distant evolutionary relationships of Domains of Unknown Function using sensitive homology detection methods. Biol Direct (2015) 0.79
In-depth performance evaluation of PFP and ESG sequence-based function prediction methods in CAFA 2011 experiment. BMC Bioinformatics (2013) 0.77
SAHG, a comprehensive database of predicted structures of all human proteins. Nucleic Acids Res (2010) 0.76
Comparison analysis of primary ligand-binding sites in seven-helix membrane proteins. Biopolymers (2011) 0.76
Landscape of protein-small ligand binding modes. Protein Sci (2016) 0.75
Synapses in the spotlight with synthetic optogenetics. EMBO Rep (2017) 0.75
Study of Functional and Allosteric Sites in Protein Superfamilies. Acta Naturae (2016) 0.75
The PFP and ESG protein function prediction methods in 2014: effect of database updates and ensemble approaches. Gigascience (2015) 0.75
Evolutionary Trails of Plant Group II Pyridoxal Phosphate-Dependent Decarboxylase Genes. Front Plant Sci (2016) 0.75
The CATH database: an extended protein family resource for structural and functional genomics. Nucleic Acids Res (2003) 8.36
Protein structure alignment. J Mol Biol (1989) 6.90
Evolution of function in protein superfamilies, from a structural perspective. J Mol Biol (2001) 6.63
Assigning genomic sequences to CATH. Nucleic Acids Res (2000) 4.22
TESS: a geometric hashing algorithm for deriving 3D coordinate templates for searching structural databases. Application to enzyme active sites. Protein Sci (1997) 3.50
The CATH Database provides insights into protein structure/function relationships. Nucleic Acids Res (1999) 2.57
The use of risperidone for psychosis and agitation in demented patients with Parkinson's disease. J Neuropsychiatry Clin Neurosci (1997) 2.00
Solvent-induced distortions and the curvature of alpha-helices. Nature (1984) 1.92
Comparison of conformational characteristics in structurally similar protein pairs. Protein Sci (1993) 1.84
Protein folds and functions. Structure (1998) 1.69
The CATH Dictionary of Homologous Superfamilies (DHS): a consensus approach for identifying distant structural homologues. Protein Eng (2000) 1.67
Functional impairment in COPD patients: the impact of anxiety and depression. Psychosomatics (2001) 1.66
Multiple protein structure alignment. Protein Sci (1994) 1.62
A rapid classification protocol for the CATH Domain Database to support structural genomics. Nucleic Acids Res (2001) 1.61
Evolution of protein function, from a structural perspective. Curr Opin Chem Biol (1999) 1.61
From protein structure to function. Curr Opin Struct Biol (1999) 1.58
Protein folds, functions and evolution. J Mol Biol (1999) 1.51
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Combining sensitive database searches with multiple intermediates to detect distant homologues. Protein Eng (1999) 1.47
FFPred: an integrated feature-based function prediction server for vertebrate proteomes. Nucleic Acids Res (2008) 1.44
VIDA: a virus database system for the organization of animal virus genome open reading frames. Nucleic Acids Res (2001) 1.43
One session cognitive behavioural therapy for elderly patients with chronic obstructive pulmonary disease. Psychol Med (2001) 1.42
Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements. J Virol (1997) 1.27
Using the CATH domain database to assign structures and functions to the genome sequences. Biochem Soc Trans (2000) 1.22
Genomewide function conservation and phylogeny in the Herpesviridae. Genome Res (2001) 1.19
Correlation of observed fold frequency with the occurrence of local structural motifs. J Mol Biol (1999) 1.19
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Genome analysis: Assigning protein coding regions to three-dimensional structures. Protein Sci (1999) 1.16
A holistic approach to protein structure alignment. Protein Eng (1989) 1.04
Mutagenesis studies of interleukin-8. Identification of a second epitope involved in receptor binding. J Biol Chem (1996) 1.01
Systematic computational prediction of protein interaction networks. Phys Biol (2011) 1.00
The active site of ribonuclease A from the crystallographic studies of ribonuclease-A-inhibitor complexes. Eur J Biochem (1983) 0.98
Contemporary approaches to protein structure classification. Bioessays (1998) 0.93
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Inhibition of bovine nasal cartilage degradation by selective matrix metalloproteinase inhibitors. Biochem J (1997) 0.87
Where to from here: patients of a day hospital rehabilitation programme perceived needs following stroke. Contemp Nurse (1998) 0.85
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Rehospitalization of older psychiatric inpatients: an investigation of predictors. Gerontologist (1999) 0.83
Tolerability of clonazepam in demented and non-demented geropsychiatric patients. Int J Geriatr Psychiatry (1997) 0.80
Outcomes of decreased length of hospital stay among geriatric patients with dementia. Psychiatr Serv (2001) 0.80
Interactions between estrogen and EGF in uterine growth and function. Adv Exp Med Biol (1987) 0.79
Behavioral disturbances in geropsychiatric inpatients across dementia types. J Geriatr Psychiatry Neurol (2000) 0.79
Contribution of psychosis and depression to behavioral disturbances in geropsychiatric inpatients with dementia. J Gerontol A Biol Sci Med Sci (1999) 0.79
Cognitive decline in patients on an acute geropsychiatric unit. J Neuropsychiatry Clin Neurosci (1998) 0.78
Nonalcohol-related use disorders in geropsychiatric patients. J Geriatr Psychiatry Neurol (2000) 0.78
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Regulation of the uterine epidermal growth factor receptor by estrogen. Prog Clin Biol Res (1990) 0.78
The efficacy and tolerability of divalproex sodium in elderly demented patients with behavioral disturbances. Int J Geriatr Psychiatry (1998) 0.78
Contribution of PTSD/POW history to behavioral disturbances in dementia. Int J Geriatr Psychiatry (2001) 0.77
Delirium in geropsychiatric patients: patient characteristics and treatment outcomes. J Geriatr Psychiatry Neurol (1997) 0.76
Tolerability and effectiveness of atypical antipsychotics in male geriatric inpatients. Int J Geriatr Psychiatry (2001) 0.76
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Depression in male geropsychiatric inpatients with and without dementia: a naturalistic study. J Affect Disord (1997) 0.75
The contribution of cognitive impairment, medical burden, and psychopathology to the functional status of geriatric psychiatric inpatients. Gen Hosp Psychiatry (1998) 0.75
Ribonuclease A. Analysis of the hydrogen bond geometry, and spatial accessibility at the active site. Biochim Biophys Acta (1987) 0.75
Guardianship applications for elderly patients: why do they fail? Psychiatr Serv (2000) 0.75
Measuring aggression in older adults: a latent variable modeling approach. Aging Ment Health (2002) 0.75
A multidisciplinary ethics teaching conference on a geropsychiatric service. Gerontologist (1999) 0.75
Outcome of psychiatric hospitalization for very low-functioning demented patients. J Geriatr Psychiatry Neurol (1997) 0.75
Contribution of cognitive impairment, depression, and psychosis to the outcome of agitated geropsychiatric inpatients with dementia. J Nerv Ment Dis (1998) 0.75