Published in J Clin Invest on December 01, 2000
Heterogeneity in primary and metastatic prostate cancer as defined by cell surface CD profile. Am J Pathol (2004) 1.76
Nonreceptor tyrosine kinases in prostate cancer. Neoplasia (2007) 1.50
FYN is overexpressed in human prostate cancer. BJU Int (2008) 1.22
Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. J Clin Invest (2002) 1.19
Functions of the Lyn tyrosine kinase in health and disease. Cell Commun Signal (2012) 1.11
CD10 expression in urothelial carcinoma of the bladder. Diagn Pathol (2009) 1.09
Integrin signaling aberrations in prostate cancer. Am J Transl Res (2009) 1.01
Tumor-initiating label-retaining cancer cells in human gastrointestinal cancers undergo asymmetric cell division. Stem Cells (2012) 0.99
Ki67 staining index and neuroendocrine differentiation aggravate adverse prognostic parameters in prostate cancer and are characterized by negligible inter-observer variability. World J Urol (2008) 0.97
Bombesin attenuates pre-mRNA splicing of glucocorticoid receptor by regulating the expression of serine-arginine protein p30c (SRp30c) in prostate cancer cells. Biochim Biophys Acta (2007) 0.93
Inverse baseline expression pattern of the NEP/neuropeptides and NFκB/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells. Cancer Cell Int (2011) 0.88
Neural regulation of hematopoiesis, inflammation, and cancer. Neuron (2015) 0.86
Casodex treatment induces hypoxia-related gene expression in the LNCaP prostate cancer progression model. BMC Urol (2005) 0.85
Chemoprevention activity of dipyridamole in the MMTV-PyMT transgenic mouse model of breast cancer. Cancer Prev Res (Phila) (2013) 0.85
Extracellular molecules involved in cancer cell invasion. Cancers (Basel) (2015) 0.85
Calcitonin receptor-stimulated migration of prostate cancer cells is mediated by urokinase receptor-integrin signaling. Clin Exp Metastasis (2007) 0.85
Selective amino acid restriction differentially affects the motility and directionality of DU145 and PC3 prostate cancer cells. J Cell Physiol (2008) 0.82
The Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling molecules. Biochim Biophys Acta (2012) 0.81
Neprilysin deficiency protects against fat-induced insulin secretory dysfunction by maintaining calcium influx. Diabetes (2013) 0.79
RTK/ERK pathway under natural selection associated with prostate cancer. PLoS One (2013) 0.79
Submaxillary gland androgen-regulated protein 3A expression is an unfavorable risk factor for the survival of oropharyngeal squamous cell carcinoma patients after surgery. Eur Arch Otorhinolaryngol (2012) 0.79
Regulation of SRC kinases by microRNA-3607 located in a frequently deleted locus in prostate cancer. Mol Cancer Ther (2014) 0.78
Adenoviral neutral endopeptidase gene delivery in combination with paclitaxel for the treatment of prostate cancer. Int J Oncol (2012) 0.77
Role of neprilysin in airway inflammation induced by diesel exhaust emissions. Res Rep Health Eff Inst (2011) 0.77
Evaluation of neprilysin sequence variation in relation to CSF β-Amyloid levels and Alzheimer disease risk. Int J Mol Epidemiol Genet (2010) 0.77
Epigenetic suppression of neprilysin regulates breast cancer invasion. Oncogenesis (2016) 0.76
Rational redesign of neutral endopeptidase binding to merlin and moesin proteins. Protein Sci (2009) 0.76
Opioids, Neutral Endopeptidase, its Inhibitors and Cancer: Is There a Relationship among them? Arch Immunol Ther Exp (Warsz) (2014) 0.75
Role of B Cell Development Marker CD10 in Cancer Progression and Prognosis. Mol Biol Int (2016) 0.75
Toward an integrative analysis of the tumor microenvironment in ovarian epithelial carcinoma. Cancer Microenviron (2011) 0.75
Neutral endopeptidase (NEP) is differentially involved in biological activities and cell signaling of colon cancer cell lines derived from various stages of tumor development. Tumour Biol (2016) 0.75
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature (1995) 8.25
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol (1994) 7.53
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature (2000) 7.03
GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. Science (1991) 6.06
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol (1995) 5.36
Membrane compartmentation is required for efficient T cell activation. Immunity (1998) 5.00
Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J Cell Sci (1996) 3.52
Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J Biol Chem (1996) 3.21
Focal adhesion kinase (p125FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes. Cell (1992) 2.92
Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol Cell Biol (1998) 2.52
Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration. J Biol Chem (1999) 1.91
Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma. Int J Cancer (1996) 1.79
Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key! Blood (1993) 1.77
Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt. J Biol Chem (1999) 1.71
Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression. Nat Med (1998) 1.69
Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases. Mol Biol Cell (1999) 1.67
Prostatic carcinoma cell migration via alpha(v)beta3 integrin is modulated by a focal adhesion kinase pathway. Cancer Res (1999) 1.66
Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase. J Cell Biol (1995) 1.57
CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. Proc Natl Acad Sci U S A (1991) 1.47
High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia. Blood (1999) 1.41
Expression of neutral endopeptidase (enkephalinase) in heterologous COS-1 cells. Characterization of the recombinant enzyme and evidence for a glutamic acid residue at the active site. J Biol Chem (1988) 1.40
Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1. J Biol Chem (1998) 1.29
Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells. J Biol Chem (1999) 1.17
Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists. J Cell Physiol (1998) 1.13
Bombesin stimulates the motility of human prostate-carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin-associated proteins. Int J Cancer (1997) 1.04
Androgen-induced growth inhibition of androgen receptor expressing androgen-independent prostate cancer cells is mediated by increased levels of neutral endopeptidase. Endocrinology (2000) 1.03
Endothelin receptor blockade potentiates FasL-induced apoptosis in rat colon carcinoma cells. Int J Cancer (2000) 1.03
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. J Exp Med (1998) 1.02
Methylation of the neutral endopeptidase gene promoter in human prostate cancers. Clin Cancer Res (2000) 1.02
Neurotensin is an autocrine trophic factor stimulated by androgen withdrawal in human prostate cancer. Proc Natl Acad Sci U S A (1994) 0.94
Expression of CD10 by human T cells that undergo apoptosis both in vitro and in vivo. Blood (1999) 0.94
Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase. Mol Biol Cell (1999) 0.93
Bombesin, vasopressin, lysophosphatidic acid, and sphingosylphosphorylcholine induce focal adhesion kinase activation in intact Swiss 3T3 cells. J Biol Chem (1998) 0.93
CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn src-related kinase. Blood (1996) 0.89
N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors. J Med Chem (1994) 0.86
Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism. Exp Cell Res (1999) 0.85
Small bioactive peptides and cell surface peptidases in androgen-independent prostate cancer. Cancer Invest (2000) 0.83
Insertion of hydrophilic amino acid residues in the signal peptide/membrane anchor domain of neprilysin (neutral endopeptidase-24.11) results in its cleavage: role of the position of insertion. Arch Biochem Biophys (1994) 0.83
Effects of neuropeptides on human lung fibroblast proliferation and chemotaxis. Am J Physiol (1995) 0.83
CD10 inhibitors increase f-Met-Leu-Phe-induced neutrophil transmigration. J Leukoc Biol (1998) 0.81
Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and Lyn kinase. Blood (1999) 0.79
Renal-cell carcinoma. N Engl J Med (1996) 11.46
Highly parallel SNP genotyping. Cold Spring Harb Symp Quant Biol (2003) 9.10
Specific protection against breast cancers by cyclin D1 ablation. Nature (2001) 6.94
The molecular basis of muscular dystrophy in the mdx mouse: a point mutation. Science (1989) 6.80
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature (1996) 4.05
The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell (1996) 3.82
A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell (1998) 3.56
Deformation and flow of membrane into tethers extracted from neuronal growth cones. Biophys J (1996) 3.42
Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes. Exp Cell Res (1985) 3.41
Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J (1997) 3.27
E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci U S A (1995) 2.99
Modulation of membrane dynamics and cell motility by membrane tension. Trends Cell Biol (1996) 2.94
Bone-targeted therapy for advanced androgen-independent carcinoma of the prostate: a randomised phase II trial. Lancet (2001) 2.85
Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab (2001) 2.79
Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium. Cancer Res (1997) 2.72
c-Abl kinase regulates the protein binding activity of c-Crk. EMBO J (1994) 2.68
A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1). J Biol Chem (1990) 2.58
Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone. J Clin Invest (2001) 2.49
EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J Cell Biol (2001) 2.46
Prevalence of Trypanosoma cruzi infection in pregnant Latin American women and congenital transmission rate in a non-endemic area: the experience of the Valencian Health Programme (Spain). Epidemiol Infect (2011) 2.45
Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. J Natl Cancer Inst (1999) 2.41
Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis Cartilage (2010) 2.39
The DIURNAL project: DIURNAL and circadian expression profiling, model-based pattern matching, and promoter analysis. Cold Spring Harb Symp Quant Biol (2007) 2.35
Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels. JAMA (2000) 2.26
Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1. Mol Biol Cell (1998) 2.26
Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood (1999) 2.26
The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. EMBO J (1997) 2.19
The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome. Gastroenterology (1997) 2.14
Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci U S A (1998) 2.13
Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J (1995) 2.00
Detection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodies. EMBO J (1984) 1.98
SRPDB (Signal Recognition Particle Database). Nucleic Acids Res (2001) 1.97
Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. J Biol Chem (2001) 1.97
Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med (1993) 1.95
Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle. Mol Cell (2001) 1.95
4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors. J Med Chem (2000) 1.94
Integrins and tumor cell dissemination. Cancer Cells (1989) 1.93
A new set of chemotaxis homologues is essential for Myxococcus xanthus social motility. Mol Microbiol (1998) 1.91
Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I. Mol Cell Biol (1991) 1.89
Cleavage of a 135 kD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectin. Exp Cell Res (1985) 1.86
Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol (1996) 1.78
A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol Cell Biol (1997) 1.77
Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure (1995) 1.76
Intestinal macrophages and response to microbial encroachment. Mucosal Immunol (2010) 1.76
The intracellular functions of alpha6beta4 integrin are regulated by EGF. J Cell Biol (1996) 1.73
Ras oncogene point mutation: an infrequent event in bronchioloalveolar cancer. J Thorac Cardiovasc Surg (1992) 1.72
The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. J Clin Endocrinol Metab (1998) 1.71
Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J Cell Biol (1999) 1.71
Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression. Nat Med (1998) 1.69
Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma. J Clin Oncol (2000) 1.67
Motility of fibronectin receptor-deficient cells on fibronectin and vitronectin: collaborative interactions among integrins. J Cell Biol (1992) 1.67
Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes. J Biol Chem (2001) 1.66
Adenosine-deaminase deficiency and combined immunodeficiency syndrome. Lancet (1972) 1.62
Technical advance in fungal biotechnology: development of a miniaturized culture method and an automated high-throughput screening. Lett Appl Microbiol (2009) 1.59
Statistical alignment: computational properties, homology testing and goodness-of-fit. J Mol Biol (2000) 1.59
Identification of a cellular protein that interacts and synergizes with the RTA (ORF50) protein of Kaposi's sarcoma-associated herpesvirus in transcriptional activation. J Virol (2001) 1.58
Filamin A mutations cause periventricular heterotopia with Ehlers-Danlos syndrome. Neurology (2005) 1.57
The US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III): prevalence of the metabolic syndrome in postmenopausal Latin American women. Climacteric (2007) 1.57
Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo. J Cell Biol (1998) 1.54
Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785). Biochem Pharmacol (1999) 1.53
Ca/Mg infusions for the prevention of oxaliplatin-related neurotoxicity in patients with colorectal cancer: a meta-analysis. Ann Oncol (2012) 1.53
Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. EMBO J (1998) 1.49
A role for Dictyostelium racE in cortical tension and cleavage furrow progression. J Cell Biol (1998) 1.49
A 135,000 molecular weight plasma membrane glycoprotein involved in fibronectin-mediated cell adhesion. Immunofluorescence localization in normal and RSV-transformed fibroblasts. Exp Cell Res (1986) 1.48
A recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins. J Cell Biol (1995) 1.46
Molecular cloning and expression of chicken C-terminal Src kinase: lack of stable association with c-Src protein. Proc Natl Acad Sci U S A (1992) 1.46
The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes. Mol Biol Cell (1993) 1.45
Cytokine regulation of chondrocyte functions. J Rheumatol Suppl (1995) 1.45
Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects. Lab Invest (2001) 1.43
Renal cell carcinoma. Curr Probl Cancer (1997) 1.43
Characterisation and validation of a novel panel of the six short tandem repeats for genetic counselling in Chinese haemophilia A pedigrees. Haemophilia (2012) 1.42
Complexity and specificity of integrin signalling. Nat Cell Biol (2000) 1.41
Expression of neutral endopeptidase (enkephalinase) in heterologous COS-1 cells. Characterization of the recombinant enzyme and evidence for a glutamic acid residue at the active site. J Biol Chem (1988) 1.40
Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex. EMBO J (1999) 1.39
E-cadherin expression as a marker of tumor aggressiveness in routinely processed radical prostatectomy specimens. Urology (1999) 1.37
Function of human cytomegalovirus glycoprotein B: syncytium formation in cells constitutively expressing gB is blocked by virus-neutralizing antibodies. Virology (1994) 1.36
The protein tyrosine phosphatase Shp-2 regulates RhoA activity. Curr Biol (2000) 1.35
Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. J Biol Chem (1999) 1.34
Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. J Biol Chem (1995) 1.34
Interleukin-10 production by human carcinoma cell lines and its relationship to interleukin-6 expression. Int J Cancer (1993) 1.31
Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunity. J Immunol (2001) 1.31
Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells. Mol Biol Cell (1993) 1.31
Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicate Crk-specific signaling pathways. Oncogene (1995) 1.30
Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markers. J Bone Miner Res (2000) 1.30
Analysis of ras oncogenes in malignant melanoma and precursor lesions: correlation of point mutations with differentiation phenotype. Oncogene (1989) 1.30
Fibronectin-plasma membrane interaction in the adhesion of hemopoietic cells. J Cell Biol (1986) 1.29
Exploration of the catalytic site of endopeptidase 24.11 by site-directed mutagenesis. Histidine residues 583 and 587 are essential for catalysis. FEBS Lett (1988) 1.29
Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 ORF50 gene product contains a potent C-terminal activation domain which activates gene expression via a specific target sequence. Arch Virol (2001) 1.29
Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. J Biol Chem (2000) 1.27
Patterns of compliance with once versus twice daily antihypertensive drug therapy in primary care: a randomized clinical trial using electronic monitoring. Can J Cardiol (1997) 1.26
Integrin-cytoskeletal interactions in neuronal growth cones. J Neurosci (1995) 1.25
Mutation and expression of the p53 gene in human malignant melanoma. Melanoma Res (1994) 1.24
Neuronal excitatory properties of human immunodeficiency virus type 1 Tat protein. Neuroscience (1998) 1.24
Androgen receptor CAG repeat lengths in prostate cancer: correlation with age of onset. J Clin Endocrinol Metab (1996) 1.22
Activation of p300 histone acetyltransferase activity and acetylation of the androgen receptor by bombesin in prostate cancer cells. Oncogene (2006) 1.21
Astrocytes contribute to the brain-metastatic specificity of melanoma cells by producing heparanase. Cancer Res (2000) 1.21
A DnaK homolog in Myxococcus xanthus is involved in social motility and fruiting body formation. J Bacteriol (1998) 1.20