Published in EMBO J on May 01, 1997
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell (2002) 5.56
Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J (2002) 3.44
Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol (1999) 2.93
Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol Cell Biol (1998) 2.52
EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J Cell Biol (2001) 2.46
Extracellular matrix and integrin signalling: the shape of things to come. Biochem J (1999) 2.28
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol (1999) 2.21
Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. J Cell Biol (1999) 2.14
Division of labor among the alpha6beta4 integrin, beta1 integrins, and an E3 laminin receptor to signal morphogenesis and beta-casein expression in mammary epithelial cells. Mol Biol Cell (1999) 2.11
Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro. Proc Natl Acad Sci U S A (1999) 2.06
Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J Cell Biol (1999) 1.71
Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail. J Cell Biol (1999) 1.65
Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells. Cancer Cell (2014) 1.60
Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases. Proc Natl Acad Sci U S A (1998) 1.56
Calx, a Na-Ca exchanger gene of Drosophila melanogaster. Proc Natl Acad Sci U S A (1997) 1.54
Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo. J Cell Biol (1998) 1.54
Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis. Mol Cell Biol (2006) 1.51
Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. EMBO J (1998) 1.49
Inhibitory role of alpha 6 beta 4-associated erbB-2 and phosphoinositide 3-kinase in keratinocyte haptotactic migration dependent on alpha 3 beta 1 integrin. J Cell Biol (2001) 1.49
p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB. J Cell Biol (1999) 1.46
The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc Natl Acad Sci U S A (1998) 1.46
Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration. J Cell Biol (2006) 1.46
The role of laminins in basement membrane function. J Anat (1998) 1.45
Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Mol Cell Biol (2005) 1.44
Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1. Mol Biol Cell (2000) 1.41
beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1. Mol Biol Cell (2006) 1.32
A cell signal pathway involving laminin-5, alpha3beta1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation. Mol Biol Cell (1999) 1.28
Integrin alpha5/beta1 mediates fibronectin-dependent epithelial cell proliferation through epidermal growth factor receptor activation. Mol Biol Cell (2000) 1.28
Compartmentalization of integrin alpha6beta4 signaling in lipid rafts. J Cell Biol (2003) 1.23
Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP. EMBO J (2003) 1.17
Phosphoinositide-3 kinase-Rac1-c-Jun NH2-terminal kinase signaling mediates collagen I-induced cell scattering and up-regulation of N-cadherin expression in mouse mammary epithelial cells. Mol Biol Cell (2006) 1.17
Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formation. PLoS One (2007) 1.14
Laminin deposition in the extracellular matrix: a complex picture emerges. J Cell Sci (2009) 1.14
Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation. J Cell Biol (2002) 1.11
The biomechanical integrin. J Biomech (2009) 1.09
HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway. Mol Biol Cell (2006) 1.09
The short arm of laminin gamma2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin beta4 chain. Mol Biol Cell (2007) 1.06
Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes. Cell Tissue Res (2009) 1.05
SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion. Mol Cell Biol (2010) 1.04
β4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest (2013) 1.03
Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation. J Biol Chem (2010) 1.01
Integrin-mediated ras-extracellular regulated kinase (ERK) signaling regulates interferon gamma production in human natural killer cells. J Exp Med (1998) 1.00
MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma. Oncogenesis (2012) 1.00
Growth defects induced by perturbation of beta1-integrin function in the mammary gland epithelium result from a lack of MAPK activation via the Shc and Akt pathways. EMBO Rep (2001) 0.98
Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement. Mol Biol Cell (2001) 0.98
Clinical significance of the integrin α6β4 in human malignancies. Lab Invest (2015) 0.98
Integrin α6β4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation. Am J Physiol Cell Physiol (2011) 0.94
Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer. Cancer Res (2008) 0.94
Integrin beta4 attenuates SHP-2 and MAPK signaling and reduces human lung endothelial inflammatory responses. J Cell Biochem (2010) 0.93
Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer. J Exp Clin Cancer Res (2009) 0.92
PTHrP increases xenograft growth and promotes integrin alpha6beta4 expression and Akt activation in colon cancer. Cancer Lett (2007) 0.92
Laminin-5 beta3A expression in LNCaP human prostate carcinoma cells increases cell migration and tumorigenicity. Neoplasia (2004) 0.92
Differential role of beta(1C) and beta(1A) integrin cytoplasmic variants in modulating focal adhesion kinase, protein kinase B/AKT, and Ras/Mitogen-activated protein kinase pathways. Mol Biol Cell (2000) 0.92
Human papillomavirus type 6b virus-like particles are able to activate the Ras-MAP kinase pathway and induce cell proliferation. J Virol (2001) 0.92
Extracellular signal-regulated kinase 1/2 activity is not required in mammalian cells during late G2 for timely entry into or exit from mitosis. Mol Biol Cell (2006) 0.92
Critical role of S1PR1 and integrin β4 in HGF/c-Met-mediated increases in vascular integrity. J Biol Chem (2012) 0.91
Increased cell survival, migration, invasion, and Akt expression in PTHrP-overexpressing LoVo colon cancer cell lines. Regul Pept (2007) 0.91
Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties. PLoS One (2012) 0.91
N-glycosylation of ß4 integrin controls the adhesion and motility of keratinocytes. PLoS One (2011) 0.89
Adhesion and migration, the diverse functions of the laminin alpha3 subunit. Dermatol Clin (2010) 0.88
Transmembrane collagen XVII modulates integrin dependent keratinocyte migration via PI3K/Rac1 signaling. PLoS One (2014) 0.87
Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival. J Biol Chem (2014) 0.86
PTHrP contributes to the anti-proliferative and integrin alpha6beta4-regulating effects of 1,25-dihydroxyvitamin D(3). Steroids (2007) 0.84
Regulation of ERK-MAPK signaling in human epidermis. BMC Syst Biol (2015) 0.81
RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes. J Biol Chem (2010) 0.79
Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck. Mol Biol Cell (2003) 0.78
Endothelial cell-laminin interaction: modulation of LDH expression involves alpha6beta4 integrin-FAK-p38MAPK pathway. Glycoconj J (2008) 0.78
Elevated integrin α6β4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer. Hum Pathol (2016) 0.76
Role of met axis in head and neck cancer. Cancers (Basel) (2013) 0.75
Roles of Integrin α6β4 Glycosylation in Cancer. Cancers (Basel) (2017) 0.75
Improved retroviral vectors for gene transfer and expression. Biotechniques (1989) 19.48
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell (1994) 16.30
Protein modules and signalling networks. Nature (1995) 12.53
Integrins and signal transduction pathways: the road taken. Science (1995) 10.71
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev (1993) 10.01
Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell (1995) 9.30
Integrins: emerging paradigms of signal transduction. Annu Rev Cell Dev Biol (1995) 8.88
The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem (1995) 8.32
The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell (1995) 8.20
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell (1992) 6.86
An essential role for Rac in Ras transformation. Nature (1995) 5.34
Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Biotechniques (1990) 5.02
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature (1993) 4.54
Regulation of development and differentiation by the extracellular matrix. Development (1993) 4.13
The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell (1996) 3.82
The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells. J Cell Biol (1990) 3.82
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol (1996) 3.68
Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes. Cell (1991) 3.55
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science (1996) 3.18
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol Cell Biol (1996) 3.08
Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J Cell Biol (1990) 3.00
Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes. Proc Natl Acad Sci U S A (1990) 2.83
Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J Cell Sci (1995) 2.80
SH3 domains direct cellular localization of signaling molecules. Cell (1993) 2.73
SH2/SH3 signaling proteins. Curr Opin Genet Dev (1994) 2.69
Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J Cell Biol (1993) 2.59
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J Cell Biol (1996) 2.56
Journey to the surface of the cell: Fos regulation and the SRE. EMBO J (1995) 2.43
Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science (1996) 2.38
Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain. EMBO J (1990) 2.23
Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J (1995) 2.00
Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science (1994) 1.89
The alpha 6 beta 1 (VLA-6) and alpha 6 beta 4 protein complexes: tissue distribution and biochemical properties. J Cell Sci (1990) 1.83
Axonal regulation of Schwann cell integrin expression suggests a role for alpha 6 beta 4 in myelination. J Cell Biol (1993) 1.74
The alpha 6 beta 4 integrin is a receptor for both laminin and kalinin. Exp Cell Res (1994) 1.69
A recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins. J Cell Biol (1995) 1.46
Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein. J Cell Biol (1996) 1.42
Formation of hemidesmosomes in cells of a transformed murine mammary tumor cell line and mechanisms involved in adherence of these cells to laminin and kalinin. J Cell Sci (1993) 1.40
Altered expression in squamous carcinoma cells of an orientation restricted epithelial antigen detected by monoclonal antibody A9. Cancer Res (1986) 1.34
Proteolytic processing of endogenous and recombinant beta 4 integrin subunit. J Cell Biol (1992) 1.34
Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells. Mol Biol Cell (1993) 1.31
Integrin-mediated adhesion and signaling in tumorigenesis. Biochim Biophys Acta (1994) 1.30
Signal transduction by the alpha 6 beta 4 integrin: charting the path between laminin binding and nuclear events. J Cell Sci (1996) 1.25
Altered antigen expression predicts outcome in squamous cell carcinoma of the head and neck. J Natl Cancer Inst (1990) 1.17
Developmentally regulated expression of the beta 4 integrin on immature mouse thymocytes. J Immunol (1992) 0.97
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene (2007) 11.85
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science (1997) 6.50
Increasing complexity of Ras signaling. Oncogene (1998) 5.71
Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci U S A (1982) 5.39
Biological and biochemical properties of human rasH genes mutated at codon 61. Cell (1986) 5.05
p21ras is modified by a farnesyl isoprenoid. Proc Natl Acad Sci U S A (1989) 4.80
Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol Cell Biol (1995) 4.78
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature (1997) 4.66
Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science (1988) 4.58
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex. J Cell Biol (1992) 4.34
Understanding Ras: 'it ain't over 'til it's over'. Trends Cell Biol (2000) 3.86
The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell (1996) 3.82
An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. Cell (1987) 3.78
A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell (1998) 3.56
Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes. Exp Cell Res (1985) 3.41
Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science (1997) 3.32
Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. J Cell Biol (1991) 3.22
Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation. Cell (1989) 3.12
Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol Cell Biol (1997) 3.09
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell (1993) 2.92
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell (2001) 2.89
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol (1996) 2.69
The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J Biol Chem (1996) 2.60
A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1). J Biol Chem (1990) 2.58
Increasing complexity of the Ras signaling pathway. J Biol Chem (1998) 2.56
Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J Cell Biol (1995) 2.56
Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation. J Biol Chem (1997) 2.55
EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J Cell Biol (2001) 2.46
The Ras branch of small GTPases: Ras family members don't fall far from the tree. Curr Opin Cell Biol (2000) 2.38
Critical role of Rho in cell transformation by oncogenic Ras. Oncogene (1995) 2.37
Dbl family proteins. Biochim Biophys Acta (1997) 2.36
Altered gene products are associated with activation of cellular rasK genes in human lung and colon carcinomas. Cell (1983) 2.27
Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1. Mol Biol Cell (1998) 2.26
Biological assays for Ras transformation. Methods Enzymol (1995) 2.16
Human cell hybrids: analysis of transformation and tumorigenicity. Science (1982) 2.16
The Ras signal transduction pathway. Cancer Metastasis Rev (1994) 2.13
Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc Natl Acad Sci U S A (1992) 2.10
Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal. Science (1989) 2.04
Direct transformation of rodent fibroblasts by jaagsiekte sheep retrovirus DNA. Proc Natl Acad Sci U S A (2001) 2.01
Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J (1995) 2.00
Rho family proteins and Ras transformation: the RHOad less traveled gets congested. Oncogene (1998) 1.99
Isoprenoid modification of rab proteins terminating in CC or CXC motifs. Proc Natl Acad Sci U S A (1991) 1.99
Detection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodies. EMBO J (1984) 1.98
The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. J Biol Chem (1997) 1.98
Lck regulates Vav activation of members of the Rho family of GTPases. Mol Cell Biol (1997) 1.96
Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle. Mol Cell (2001) 1.95
GTP binding by class II transactivator: role in nuclear import. Science (1999) 1.94
Vav2 is an activator of Cdc42, Rac1, and RhoA. J Biol Chem (2000) 1.93
Integrins and tumor cell dissemination. Cancer Cells (1989) 1.93
Two distinct Raf domains mediate interaction with Ras. J Biol Chem (1995) 1.88
Cleavage of a 135 kD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectin. Exp Cell Res (1985) 1.86
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. Proc Natl Acad Sci U S A (1990) 1.84
Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway. J Biol Chem (1999) 1.82
Activation of ras genes in human tumors does not affect localization, modification, or nucleotide binding properties of p21. Cell (1984) 1.76
Aberrant function of the Ras signal transduction pathway in human breast cancer. Breast Cancer Res Treat (1995) 1.75
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. J Biol Chem (1995) 1.75
rasH mutants deficient in GTP binding. Mol Cell Biol (1986) 1.73
The intracellular functions of alpha6beta4 integrin are regulated by EGF. J Cell Biol (1996) 1.73
Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J Cell Biol (1999) 1.71
Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential. Mol Cell Biol (1988) 1.69
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci U S A (1994) 1.67
Motility of fibronectin receptor-deficient cells on fibronectin and vitronectin: collaborative interactions among integrins. J Cell Biol (1992) 1.67
Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes. J Biol Chem (2001) 1.66
The six amino-terminal amino acids of p60src are sufficient to cause myristylation of p21v-ras. Mol Cell Biol (1988) 1.65
Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras. Mol Cell Biol (1994) 1.60
ras-induced neuronal differentiation of PC12 cells: possible involvement of fos and jun. Mol Cell Biol (1989) 1.59
Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. Bioessays (1995) 1.57
Emerging concepts in the Ras superfamily of GTP-binding proteins. FASEB J (1993) 1.56
Regulation of RasGRP via a phorbol ester-responsive C1 domain. Mol Cell Biol (1998) 1.55
Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo. J Cell Biol (1998) 1.54
Protein prenylation: more than just glue? Curr Opin Cell Biol (1992) 1.54
Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. J Biol Chem (1999) 1.53
The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. Mol Cell Biol (1991) 1.52
Biological assays for cellular transformation. Methods Enzymol (1994) 1.51
SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance. Nat Genet (1999) 1.50
Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected]. J Biol Chem (1996) 1.50
Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. EMBO J (1998) 1.49
A 135,000 molecular weight plasma membrane glycoprotein involved in fibronectin-mediated cell adhesion. Immunofluorescence localization in normal and RSV-transformed fibroblasts. Exp Cell Res (1986) 1.48
Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites. Oncogene (1994) 1.48
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways. Mol Med (2001) 1.46
A recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins. J Cell Biol (1995) 1.46
Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells. Proc Natl Acad Sci U S A (1996) 1.46
Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett (2001) 1.45
The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes. Mol Biol Cell (1993) 1.45
RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. J Biol Chem (2001) 1.44
Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity. Proc Natl Acad Sci U S A (1994) 1.44