Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithine.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMID 11142412)

Published in Cancer Epidemiol Biomarkers Prev on December 01, 2000

Authors

D S Alberts1, R T Dorr, J G Einspahr, M Aickin, K Saboda, M J Xu, Y M Peng, R Goldman, J A Foote, J A Warneke, S Salasche, D J Roe, G T Bowden

Author Affiliations

1: Arizona Cancer Center, University of Arizona, Tucson 85724, USA. dalberts@azcc.arizona.edu

Articles citing this

Phase IIB Randomized Study of Topical Difluoromethylornithine and Topical Diclofenac on Sun-Damaged Skin of the Forearm. Cancer Prev Res (Phila) (2015) 1.39

Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert Rev Mol Med (2013) 1.18

The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial. Cancer Epidemiol Biomarkers Prev (2008) 1.15

Recent advances in the development of polyamine analogues as antitumor agents. J Med Chem (2009) 1.06

A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer. Cancer Prev Res (Phila) (2010) 0.99

Actinic keratosis treatment as a key component of preventive strategies for nonmelanoma skin cancer. J Clin Aesthet Dermatol (2010) 0.96

Polyamines and nonmelanoma skin cancer. Toxicol Appl Pharmacol (2006) 0.92

Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem J (2003) 0.91

Cancer chemoprevention locks onto a new polyamine metabolic target. Cancer Prev Res (Phila) (2010) 0.89

Nonsurgical innovations in the treatment of nonmelanoma skin cancer. J Clin Aesthet Dermatol (2010) 0.89

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma. Front Oncol (2012) 0.89

Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans. Cancer Prev Res (Phila) (2010) 0.85

Skin Carcinogenesis Studies Using Mouse Models with Altered Polyamines. Cancer Growth Metastasis (2015) 0.84

DFMO: targeted risk reduction therapy for colorectal neoplasia. Best Pract Res Clin Gastroenterol (2011) 0.84

Gene expression analysis of HCT116 colon tumor-derived cells treated with the polyamine analog PG-11047. Cancer Genomics Proteomics (2009) 0.83

Difluoromethylornithine: the proof is in the polyamines. Cancer Prev Res (Phila) (2012) 0.81

Chemoprevention of human actinic keratoses by topical DL-alpha-tocopherol. Cancer Prev Res (Phila) (2009) 0.78

Therapy of murine squamous cell carcinomas with 2-difluoromethylornithine. J Carcinog (2004) 0.76

New agents for prevention of ultraviolet-induced nonmelanoma skin cancer. Semin Cutan Med Surg (2011) 0.76

Articles by these authors

(truncated to the top 100)

Outcomes of rapid defibrillation by security officers after cardiac arrest in casinos. N Engl J Med (2000) 6.42

Some fallacies in the computation of paternity probabilities. Am J Hum Genet (1984) 4.33

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature (1984) 4.28

Mannose residues on phagocytes as receptors for the attachment of Escherichia coli and Salmonella typhi. Biochem Biophys Res Commun (1977) 4.24

Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians' Network. N Engl J Med (2000) 4.08

Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder. Arch Gen Psychiatry (1999) 3.48

Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med (2001) 3.03

Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial. Neurology (2009) 2.76

Estimating effectiveness of cardiac arrest interventions: a logistic regression survival model. Circulation (1997) 2.37

The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors. Proc Natl Acad Sci U S A (1986) 2.28

Ion distribution in lysosomal suspensions. FEBS Lett (1973) 2.20

Deoxyoligonucleotide synthesis via the phosphoramidite method. Gene Amplif Anal (1983) 2.15

Predictors of treatment response from a first episode of schizophrenia or schizoaffective disorder. Am J Psychiatry (1999) 2.06

Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-trans-retinoic acid: a randomized trial. J Natl Cancer Inst (1994) 2.05

Skin ulceration from extravasation of low-osmolality contrast medium: a complication of automation. AJR Am J Roentgenol (1992) 2.01

Mannose-binding activity of Escherichia coli: a determinant of attachment and ingestion of the bacteria by macrophages. Infect Immun (1980) 1.98

Morphology of an Escherichia coli mutant with a temperature-dependent round cell shape. J Bacteriol (1978) 1.97

Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin. JAMA (1991) 1.93

Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial. Neurology (2004) 1.91

Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol Cell Biol (1997) 1.68

Clinical and metabolic features of thyrotoxic periodic paralysis in 24 episodes. Arch Intern Med (1999) 1.66

Profiling of human serum glycans associated with liver cancer and cirrhosis by IMS-MS. J Proteome Res (2008) 1.66

Synthesis of infective poliovirus in BSC-1 monkey cells enucleated with cytochalasin B. Science (1973) 1.66

Epidermal growth factor. Ability of tumor promoter to alter its degradation, receptor affinity and receptor number. J Biol Chem (1980) 1.65

Effect of the microenvironment on the mode of action of immobilized enzymes. Adv Enzymol Relat Areas Mol Biol (1971) 1.64

Rupture of rat liver lysosomes mediated by L-amino acid esters. Biochim Biophys Acta (1973) 1.63

Influence of codon context on UGA suppression and readthrough. J Mol Biol (1992) 1.57

Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. N Engl J Med (1979) 1.57

Randomized trial testing the effect of peer education at increasing fruit and vegetable intake. J Natl Cancer Inst (1999) 1.52

Papain-collodion membranes. I. Preparation and properties. Biochemistry (1968) 1.51

Randomized, double-blinded, placebo-controlled study of effect of wheat bran fiber and calcium on fecal bile acids in patients with resected adenomatous colon polyps. J Natl Cancer Inst (1996) 1.51

Abdominal wall hernias in patients with abdominal aortic aneurysmal versus aortoiliac occlusive disease. Am J Surg (1995) 1.50

1,25-dihydroxyvitamin D3 and the regulation of macrophage function. Calcif Tissue Int (1981) 1.47

Analogues of amonafide and azonafide with novel ring systems. J Med Chem (2000) 1.47

Kidney transplantation. A comparison of results using cadaver and related living donors. Am J Med (1969) 1.46

Expression of the metalloproteinase matrilysin in DU-145 cells increases their invasive potential in severe combined immunodeficient mice. Cancer Res (1993) 1.45

Peak selection from MALDI-TOF mass spectra using ant colony optimization. Bioinformatics (2007) 1.44

beta-Carotene treatment of cervical intraepithelial neoplasia: a phase II study. Cancer Epidemiol Biomarkers Prev (1996) 1.43

Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells. Oncogene (2006) 1.42

Ultraviolet B regulation of transcription factor families: roles of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in UVB-induced skin carcinogenesis. Curr Cancer Drug Targets (2007) 1.41

The DASH Diet, Sodium Intake and Blood Pressure Trial (DASH-sodium): rationale and design. DASH-Sodium Collaborative Research Group. J Am Diet Assoc (1999) 1.40

The difference in colon polyp size before and after removal. Gastrointest Endosc (1996) 1.40

Enhancement of phagocytosis - a newly found activity of substance P residing in its N-terminal tetrapeptide sequence. Biochem Biophys Res Commun (1980) 1.39

Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. Oncogene (2001) 1.36

Auditory sensory dysfunction in schizophrenia: imprecision or distractibility? Arch Gen Psychiatry (2000) 1.36

Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function. Cancer Treat Rev (1995) 1.36

Expression of metalloproteinase genes in human prostate cancer. J Cancer Res Clin Oncol (1991) 1.31

Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line. Br J Cancer (1991) 1.31

Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis (1999) 1.31

Intermediate filaments: possible functions as cytoskeletal connecting links between the nucleus and the cell surface. Ann N Y Acad Sci (1985) 1.30

A prospective study of early pregnancy loss. Hum Reprod (1996) 1.28

Comparison of two-stage epidermal carcinogenesis initiated by 7,12-dimethylbenz(a)anthracene or N-methyl-N'-nitro-N-nitrosoguanidine in newborn and adult SENCAR and BALB/c mice. Cancer Res (1981) 1.26

On the origin of macrophage heterogeneity: a hypothesis. J Reticuloendothel Soc (1983) 1.26

A quantitative analysis of C3 binding to O-antigen capsule, lipopolysaccharide, and outer membrane protein of E. coli 0111B4. J Immunol (1984) 1.26

Effects of resistance training on regional and total bone mineral density in premenopausal women: a randomized prospective study. J Bone Miner Res (1995) 1.26

Nonsurgical treatment of basal cell carcinomas with intralesional 5-fluorouracil/epinephrine injectable gel. J Am Acad Dermatol (1997) 1.24

A complex containing p34cdc2 and cyclin B phosphorylates the nuclear lamin and disassembles nuclei of clam oocytes in vitro. J Cell Biol (1991) 1.24

A bile acid-induced apoptosis assay for colon cancer risk and associated quality control studies. Cancer Res (1999) 1.24

Effect of repeated occupational exposure to lead, cessation of exposure, and chelation on levels of lead in bone. Am J Ind Med (1991) 1.24

Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression. Mol Carcinog (1988) 1.24

Antiproliferative and antitumor activity of the 2-cyanoaziridine compound imexon on tumor cell lines and fresh tumor cells in vitro. J Natl Cancer Inst (1992) 1.23

Subhepatic appendicitis. Am Fam Physician (1989) 1.22

A set of cassette cloning vectors for rapid and versatile adaptation of restriction fragments. Biotechniques (1991) 1.21

Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors. Proc Natl Acad Sci U S A (1992) 1.20

Human tumor models in the severe combined immune deficient (scid) mouse. Cancer Chemother Pharmacol (1997) 1.20

Pharmacokinetics of very high-dose oral melphalan in cancer patients. Am J Clin Oncol (1990) 1.20

Anatomic and physiologic age changes in the kidney. Exp Gerontol (1986) 1.19

Other method for adjustment of multiple testing exists. BMJ (1999) 1.19

Secreted phosphoprotein mRNA is induced during multi-stage carcinogenesis in mouse skin and correlates with the metastatic potential of murine fibroblasts. Int J Cancer (1990) 1.18

The global diabetes model: user friendly version 3.0. Diabetes Res Clin Pract (2000) 1.17

Stromelysin/transin and tumor progression. Semin Cancer Biol (1990) 1.17

Correlates of substance misuse in patients with first-episode schizophrenia and schizoaffective disorder. Acta Psychiatr Scand (2001) 1.16

Classical syndromes in occupational medicine. Peripheral nerve entrapment syndromes and ergonomic factors. Am J Ind Med (1983) 1.16

Factors prognostic for survival in patients with malignant melanoma spread to the regional lymph nodes. Ann Surg (1982) 1.15

Antibacterial agents specifically inhibiting lipopolysaccharide synthesis. Nature (1987) 1.14

Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis. Proc Natl Acad Sci U S A (1999) 1.13

UVB irradiation-induced activator protein-1 activation correlates with increased c-fos gene expression in a human keratinocyte cell line. J Biol Chem (1998) 1.13

Immunosuppressant therapy adherence and graft failure among pediatric renal transplant recipients. Am J Transplant (2009) 1.12

A differential response elicited in macrophages on interaction with lectins. Exp Cell Res (1976) 1.12

Adhesion molecules, extracellular matrix, and proteases in prostate carcinoma. J Cell Biochem Suppl (1994) 1.12

Lack of impact of therapy on extent of Barrett's esophagus in 67 patients. Dig Dis Sci (1990) 1.12

Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice. Cell Growth Differ (1994) 1.12

Screening for bacterial vaginosis in pregnancy. Am J Prev Med (2001) 1.11

The silent abdominal abscess: role of the radiologist. AJR Am J Roentgenol (1983) 1.11

A program for balancing the allocation of subjects to treatment in a clinical trial. Comput Biomed Res (1982) 1.10

The regulation of intermediate filament reorganization in mitosis. p34cdc2 phosphorylates vimentin at a unique N-terminal site. J Biol Chem (1991) 1.10

Analysis of the p53 gene in human precancerous actinic keratosis lesions and squamous cell cancers. Cancer Lett (1994) 1.10

Dose-response studies on the ability of 7,12-dimethylbenz(alpha)anthracene and benz(alpha)anthracene to initiate skin tumors. J Natl Cancer Inst (1974) 1.08

Inhibition of ultraviolet B-induced activator protein-1 (AP-1) activity by aspirin in AP-1-luciferase transgenic mice. J Biol Chem (1997) 1.08

Histologic features relating to prognosis in synovial sarcoma. Cancer (1987) 1.08

Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum. Gene (2000) 1.08

Marketing 'mind mechanics': decoding antidepressant drug advertisements. Soc Sci Med (1986) 1.08

Fat or lean tissue mass: which one is the major determinant of bone mineral mass in healthy postmenopausal women? J Bone Miner Res (1997) 1.08

Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation. J Biol Chem (2001) 1.08

Activation of p38 MAP kinase and ERK are required for ultraviolet-B induced c-fos gene expression in human keratinocytes. Oncogene (1999) 1.07

Kinetic behavior of a two-enzyme membrane carrying out a consecutive set of reactions. J Theor Biol (1971) 1.07

Predictors for cutaneous basal- and squamous-cell carcinoma among actinically damaged adults. Int J Cancer (2001) 1.07

Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo. Carcinogenesis (1991) 1.07

A randomized, double blind, Phase III trial using oral beta-carotene supplementation for women with high-grade cervical intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev (2001) 1.06

Implementing a 5-a-day peer health educator program for public sector labor and trades employees. Health Educ Behav (2000) 1.06