Published in J Biol Chem on January 10, 2001
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans. Matrix Biol (2015) 1.91
Extracellular matrix molecules: potential targets in pharmacotherapy. Pharmacol Rev (2009) 1.90
Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis (2008) 1.82
The role of the cartilage matrix in osteoarthritis. Nat Rev Rheumatol (2010) 1.54
Proteoglycans and more--from molecules to biology. Int J Exp Pathol (2009) 1.53
Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation. J Proteome Res (2007) 1.46
The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly. FEBS J (2013) 1.33
Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach. Arthritis Res Ther (2006) 1.27
Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians. Arthritis Res Ther (2006) 1.27
Association of the asporin D14 allele with lumbar-disc degeneration in Asians. Am J Hum Genet (2008) 1.22
A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans. Am J Hum Genet (2010) 1.22
Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site. Arthritis Res Ther (2006) 1.19
Genetic polymorphisms associated with intervertebral disc degeneration. Spine J (2013) 1.15
Biglycan and fibromodulin have essential roles in regulating chondrogenesis and extracellular matrix turnover in temporomandibular joint osteoarthritis. Am J Pathol (2009) 1.13
Quantitative proteomic analysis of eight cartilaginous tissues reveals characteristic differences as well as similarities between subgroups. J Biol Chem (2012) 0.99
Molecular therapy of the intervertebral disc. Eur Spine J (2006) 0.99
Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese. Arthritis Res Ther (2011) 0.98
Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc. Arthritis Res Ther (2009) 0.97
The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors. J Biol Chem (2009) 0.97
Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development. J Cell Physiol (2006) 0.94
Decorin is processed by three isoforms of bone morphogenetic protein-1 (BMP1). Biochem Biophys Res Commun (2009) 0.93
Binding characteristics of the osteoarthritis-associated protein asporin. J Bone Miner Metab (2010) 0.92
Proteomic analysis of human dental cementum and alveolar bone. J Proteomics (2013) 0.87
Asporin expression is highly regulated in human chondrocytes. Mol Med (2011) 0.86
Gene expression profiling of preovulatory follicle in the buffalo cow: effects of increased IGF-I concentration on periovulatory events. PLoS One (2011) 0.84
Asporin repeat polymorphism in rheumatoid arthritis. Ann Rheum Dis (2006) 0.83
Decorin: A Growth Factor Antagonist for Tumor Growth Inhibition. Biomed Res Int (2015) 0.82
Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer. Clin Cancer Res (2015) 0.82
Asporin Is a Fibroblast-Derived TGF-β1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer. PLoS Med (2015) 0.82
Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice. Osteoarthritis Cartilage (2009) 0.82
Genetics in osteoarthritis. Curr Genomics (2008) 0.80
Lumican Peptides: Rational Design Targeting ALK5/TGFBRI. Sci Rep (2017) 0.80
Proteoglycans in liver cancer. World J Gastroenterol (2016) 0.78
The dual role of asporin in breast cancer progression. Oncotarget (2016) 0.77
Secretome Analysis of Skeletal Myogenesis Using SILAC and Shotgun Proteomics. Int J Proteomics (2011) 0.76
Collagen Type IV and Laminin Expressions during Cartilage Repair and in Late Clinically Failed Repair Tissues from Human Subjects. Cartilage (2016) 0.76
Asporin enhances colorectal cancer metastasis through activating the EGFR/src/cortactin signaling pathway. Oncotarget (2016) 0.75
IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration. Sci Rep (2017) 0.75
Cartilage Intermediate Layer Protein and Asporin Polymorphisms Are Independent Risk Factors of Lumbar Disc Degeneration in Male Collegiate Athletes. Cartilage (2014) 0.75
The Tyrosine Sulfate Domain of Fibromodulin Binds Collagen and Enhances Fibril Formation. J Biol Chem (2016) 0.75
Gene profiling the window of implantation: Microarray analyses from human and rodent models. J Reprod Health Med (2016) 0.75
Asporin stably expressed in the surface layer of mandibular condylar cartilage and augmented in the deeper layer with age. Bone Rep (2017) 0.75
Copy number loss in the region of the ASPN gene in patients with acetabular dysplasia: ASPN CNV in acetabular dysplasia. Bone Joint Res (2017) 0.75
Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS One (2017) 0.75
An updated meta-analysis of the asporin gene D-repeat in knee osteoarthritis: effects of gender and ethnicity. J Orthop Surg Res (2017) 0.75
Aberrant connective tissue differentiation towards cartilage and bone underlies human keloids in African Americans. Exp Dermatol (2016) 0.75
IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation. J Immunol (1999) 3.15
Oligosaccharides on proteoglycans from the swarm rat chondrosarcoma. J Biol Chem (1980) 2.89
The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis. Arthritis Rheum (1993) 2.35
Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc Natl Acad Sci U S A (1993) 2.10
The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. J Clin Invest (1992) 2.04
Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain. J Biol Chem (1991) 2.02
Degradation of cartilage aggrecan by collagenase-3 (MMP-13). FEBS Lett (1996) 1.97
Structure of proteoglycans from different layers of human articular cartilage. Biochem J (1983) 1.88
Swelling pressures of proteoglycans at the concentrations found in cartilaginous tissues. Biorheology (1979) 1.87
The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B. J Biol Chem (1992) 1.85
Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium. Lab Invest (1992) 1.74
Induction of nitric oxide synthase in human chondrocytes. Biochem Biophys Res Commun (1993) 1.73
The development of articular cartilage: I. The spatial and temporal patterns of collagen types. J Anat (1996) 1.63
Age-related changes in the composition and structure of human articular-cartilage proteoglycans. Biochem J (1978) 1.58
Modulation of native chondroitin sulphate structure in tissue development and in disease. J Cell Sci (1990) 1.57
The primary structure of link protein from rat chondrosarcoma proteoglycan aggregate. J Biol Chem (1986) 1.56
Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins. J Biol Chem (1991) 1.55
The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding. J Biol Chem (2001) 1.55
Effect of oxidation on the properties of apolipoproteins A-I and A-II. J Lipid Res (1988) 1.52
Aggrecan turnover in human articular cartilage: use of aspartic acid racemization as a marker of molecular age. Arch Biochem Biophys (1998) 1.51
Characterization of the dermatan sulfate proteoglycans, DS-PGI and DS-PGII, from bovine articular cartilage and skin isolated by octyl-sepharose chromatography. J Biol Chem (1989) 1.51
Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain. Biochem J (1993) 1.49
Hyaluronic acid in human articular cartilage. Age-related changes in content and size. Biochem J (1988) 1.46
Age-related accumulation of Maillard reaction products in human articular cartilage collagen. Biochem J (2000) 1.43
The development of articular cartilage: II. The spatial and temporal patterns of glycosaminoglycans and small leucine-rich proteoglycans. J Anat (1996) 1.39
Signal amplification using "spot-on-a-chip" technology for the identification of proteins via MALDI-TOF MS. Anal Chem (2001) 1.39
The STR/ort mouse and its use as a model of osteoarthritis. Osteoarthritis Cartilage (2001) 1.37
Further studies on the composition of human femoral head cartilage. Ann Rheum Dis (1980) 1.34
The composition of normal and osteoarthritic articular cartilage from human knee joints. With special reference to unicompartmental replacement and osteotomy of the knee. J Bone Joint Surg Am (1984) 1.32
A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age. J Biol Chem (1998) 1.26
Hyaluronan concentration in non-inflamed and rheumatoid synovium. Br J Rheumatol (1994) 1.22
Isolation of proteoglycans from human articular cartilage. Biochem J (1978) 1.22
Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage. Arthritis Rheum (1997) 1.19
The properties of proteoglycan prepared from human articular cartilage by using associative caesium chloride gradients of high and low starting densities. Biochem J (1985) 1.15
Uridine diphosphoglucose dehydrogenase activity in normal and rheumatoid synovium: the description of a specialized synovial lining cell. Int J Exp Pathol (1993) 1.12
The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissues. J Biol Chem (1995) 1.12
Structural organization of distinct domains within the non-collagenous N-terminal region of collagen type XI. J Biol Chem (2000) 1.11
Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage. Biochem J (1996) 1.09
Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan. Biochem J (1994) 1.09
Delayed aggregation of proteoglycans in adult human articular cartilage. Biosci Rep (1984) 1.09
Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis. Osteoarthritis Cartilage (2002) 1.09
Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice. Arthritis Rheum (2001) 1.08
The large proteoglycans of the human intervertebral disc. Changes in their biosynthesis and structure with age, topography, and pathology. Spine (Phila Pa 1976) (1995) 1.08
Phenotypic modulation in sub-populations of human articular chondrocytes in vitro. J Cell Sci (1990) 1.07
Chondrocyte cytokine and growth factor expression in murine osteoarthritis. Osteoarthritis Cartilage (1997) 1.05
The synovium-cartilage junction of the normal human knee. Implications for joint destruction and repair. Arthritis Rheum (1990) 1.05
Changes in glycosaminoglycan epitope levels in knee joint fluid following injury. Arthritis Rheum (1995) 1.05
Heme biosynthesis in mammalian systems: evidence of a Schiff base linkage between the pyridoxal 5'-phosphate cofactor and a lysine residue in 5-aminolevulinate synthase. Protein Sci (1993) 1.04
Age-related accumulation of the advanced glycation endproduct pentosidine in human articular cartilage aggrecan: the use of pentosidine levels as a quantitative measure of protein turnover. Matrix Biol (2001) 1.03
Electrophoresis of 35S-labeled proteoglycans on polyacrylamide-agarose composite gels and their visualization by fluorography. Anal Biochem (1986) 1.03
N- and O-linked keratan sulfate on the hyaluronan binding region of aggrecan from mature and immature bovine cartilage. J Biol Chem (1995) 1.02
An amino acid sequence common to both cartilage proteoglycan and link protein. J Biol Chem (1985) 1.02
Identification of the keratan sulfate attachment sites on bovine fibromodulin. J Biol Chem (1990) 1.02
Monoclonal antibodies that detect biochemical markers of arthritis in humans. Arthritis Rheum (1995) 1.01
A role for hyaluronan in joint development. J Anat (1990) 1.01
A herpesvirus saimiri membrane protein required for interleukin-2 independence forms a stable complex with p56lck. J Virol (1996) 1.01
Studies on cathepsin B in human articular cartilage. Biochem J (1978) 1.00
Alterations in hyaluronan synthesis during developing joint cavitation. J Histochem Cytochem (1995) 1.00
The amino-terminal part of PRELP binds to heparin and heparan sulfate. J Biol Chem (2000) 1.00
Basement membrane composition of cartilage canals during development and ossification of the epiphysis. Anat Rec (1995) 0.99
A conserved cysteine in molybdenum oxotransferases. J Biol Chem (1990) 0.99
Zonal distribution of chondroitin-4-sulphate/dermatan sulphate and chondroitin-6-sulphate in normal and diseased human synovium. Ann Rheum Dis (1994) 0.97
Isolation and expression of murine and rabbit cDNAs encoding an alpha 1,2-mannosidase involved in the processing of asparagine-linked oligosaccharides. J Biol Chem (1994) 0.96
Renal medullary cystic disease or familial juvenile nephronophthisis: a renal tubular disease. Biochemical findings in two siblings. Am J Med (1970) 0.96
Morphological localization of hyaluronan in normal and diseased synovium. J Rheumatol (1991) 0.96
Differences in the rates of aggregation of proteoglycans from human articular cartilage and chondrosarcoma. Biochem J (1983) 0.96
In vitro method for measuring synthesis rates in the intervertebral disc. J Orthop Res (1986) 0.95
Age-related effects of TGF-beta on proteoglycan synthesis in equine articular cartilage. Biochem Biophys Res Commun (2000) 0.95
Integrated microanalytical technology enabling rapid and automated protein identification. Anal Chem (2000) 0.94
TSG-6 interacts with hyaluronan and aggrecan in a pH-dependent manner via a common functional element: implications for its regulation in inflamed cartilage. FEBS Lett (1998) 0.93
Extracellular matrix adhesion-promoting activities of a dermatan sulfate proteoglycan-associated protein (22K) from bovine fetal skin. J Cell Sci (1991) 0.93
Human aggrecan keratan sulfate undergoes structural changes during adolescent development. J Biol Chem (1998) 0.93
Differential distribution of lumican and fibromodulin in tooth cementum. Connect Tissue Res (1996) 0.93
The proteoglycan lectin domain binds sulfated cell surface glycolipids and promotes cell adhesion. J Biol Chem (1999) 0.93
Hyaluronan-binding region of aggrecan from pig laryngeal cartilage. Amino acid sequence, analysis of N-linked oligosaccharides and location of the keratan sulphate. Biochem J (1992) 0.92
Structural aspects of skeletal keratan sulphates. Biochem Soc Trans (1990) 0.92
Effects of growth factors and cytokines on proteoglycan turnover in articular cartilage. Br J Rheumatol (1992) 0.91
Human articular surface chondrocytes initiate alkaline phosphatase and type X collagen synthesis in suspension culture. J Cell Sci (1992) 0.91
Link protein shows species variation in its susceptibility to proteolysis. J Orthop Res (1992) 0.90
Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training. Osteoarthritis Cartilage (2009) 0.89
Neonatal exposure to DDT and its fatty acid conjugate: effects on cholinergic and behavioural variables in the adult mouse. Neurotoxicology (1990) 0.88
Degradation of cartilage type II collagen precedes the onset of osteoarthritis following anterior cruciate ligament rupture. Arthritis Rheum (1999) 0.88
Chondromodulin I and pleiotrophin gene expression in bovine cartilage and epiphysis. Matrix Biol (2000) 0.88
Biochemical and histological changes in osteoarthritic synovial membrane. Ann Rheum Dis (1986) 0.88
Changes in proteoglycan turnover in experimental canine osteoarthritic cartilage. Matrix (1992) 0.88
Expression of cartilage-specific molecules is retained on long-term culture of human articular chondrocytes. J Cell Sci (1995) 0.88
Post-translational processing of bovine chondromodulin-I. J Biol Chem (2001) 0.88
Evidence for sequential appearance of cartilage matrix proteins in developing mouse limbs and in cultures of mouse mesenchymal cells. Differentiation (1987) 0.87
Age-related changes in the synthesis and mRNA expression of decorin and aggrecan in human meniscus and articular cartilage. Osteoarthritis Cartilage (2001) 0.87
Isolation and characterization of disulfide-bonded peptides from the three globular domains of aggregating cartilage proteoglycan. J Biol Chem (1990) 0.87
Age-related changes in the sulphation of the chondroitin sulphate linkage region from human articular cartilage aggrecan. Biochem J (2001) 0.87
Age-related changes in the synthesis of link protein and aggrecan in human articular cartilage: implications for aggregate stability. Biochem J (1999) 0.87
Regulation of proteoglycan synthesis rate in cartilage in vitro: influence of extracellular ionic composition. Biochim Biophys Acta (1989) 0.86
Expression of clusterin in the superficial zone of bovine articular cartilage. Arthritis Rheum (2001) 0.86
Correlation of x-ray deduced and experimental amino acid sequences of trimethylamine dehydrogenase. J Biol Chem (1992) 0.86
Human growth hormone enhances chondrogenesis and osteogenesis in a tissue culture system of chondroprogenitor cells. Endocrinology (1989) 0.86
Chondroitin sulphation patterns in synovial fluid in osteoarthritis subsets. Ann Rheum Dis (1999) 0.85