Published in Neurology on January 23, 2001
History of the development of sleep medicine in the United States. J Clin Sleep Med (2005) 4.22
Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep. Neurology (2013) 2.79
Restless legs syndrome: pathophysiology, clinical presentation and management. Nat Rev Neurol (2010) 1.70
Diagnosis and management of iron deficiency anemia in patients with IBD. Nat Rev Gastroenterol Hepatol (2010) 1.56
Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome. Brain (2009) 1.53
Profile of altered brain iron acquisition in restless legs syndrome. Brain (2011) 1.48
Midlife migraine and late-life parkinsonism: AGES-Reykjavik study. Neurology (2014) 1.44
Algorithms for the diagnosis and treatment of restless legs syndrome in primary care. BMC Neurol (2011) 1.32
Neuroimaging insights into the pathophysiology of sleep disorders. Sleep (2008) 1.31
Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p. Am J Hum Genet (2004) 1.18
Neurotoxic lesions at the ventral mesopontine junction change sleep time and muscle activity during sleep: an animal model of motor disorders in sleep. Neuroscience (2008) 1.17
A delicate balance: Iron metabolism and diseases of the brain. Front Aging Neurosci (2013) 1.11
Association between sleep disorders, obesity, and exercise: a review. Nat Sci Sleep (2013) 1.10
Circadian and sleep disorders in Parkinson's disease. Exp Neurol (2012) 1.03
Neurophysiology of sleep and wakefulness: basic science and clinical implications. Curr Neuropharmacol (2008) 1.01
A randomized, double-blind, placebo-controlled trial of intravenous iron sucrose in restless legs syndrome. Sleep Med (2008) 0.99
Role of hepcidin in murine brain iron metabolism. Cell Mol Life Sci (2009) 0.99
Mitochondrial ferritin in the substantia nigra in restless legs syndrome. J Neuropathol Exp Neurol (2009) 0.97
Recent advances in the diagnosis, genetics and treatment of restless legs syndrome. J Neurol (2009) 0.96
Diurnal cycle influences peripheral and brain iron levels in mice. J Appl Physiol (1985) (2008) 0.93
Sleep and neurofunctions throughout child development: lasting effects of early iron deficiency. J Pediatr Gastroenterol Nutr (2009) 0.93
Ropinirole for the treatment of restless legs syndrome. Neuropsychiatr Dis Treat (2006) 0.90
Restless legs syndrome presenting as an acute exacerbation of multiple sclerosis. Mult Scler Int (2011) 0.90
Altered iron metabolism in lymphocytes from subjects with restless legs syndrome. Sleep (2008) 0.89
Iron deficiency anemia in infancy exerts long-term effects on the tibialis anterior motor activity during sleep in childhood. Sleep Med (2012) 0.87
Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome. J Exp Med (2013) 0.86
Sleep alterations and iron deficiency anemia in infancy. Sleep Med (2010) 0.86
Restless legs syndrome in pediatric patients with chronic kidney disease. Pediatr Nephrol (2008) 0.86
Linking restless legs syndrome with Parkinson's disease: clinical, imaging and genetic evidence. Transl Neurodegener (2012) 0.85
Treatment of restless legs syndrome. Neurotherapeutics (2014) 0.84
Restless legs syndrome and Parkinson's disease: is there an etiologic link? J Neurol (2006) 0.83
Possible association between vitamin D deficiency and restless legs syndrome. Neuropsychiatr Dis Treat (2014) 0.82
Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Restless Legs Syndrome. Medicine (Baltimore) (2015) 0.82
Restless Leg Syndrome and Periodic Limb Movements of Sleep. Curr Treat Options Neurol (2003) 0.82
Periodic Leg Movements in Sleep and Restless Legs Syndrome: Considerations in Geriatrics. Sleep Med Clin (2006) 0.82
Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology. Sleep Med Clin (2015) 0.81
Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells. Exp Neurol (2008) 0.81
An emerging role for Cullin-3 mediated ubiquitination in sleep and circadian rhythm: insights from Drosophila. Fly (Austin) (2013) 0.81
Normal regional brain iron concentration in restless legs syndrome measured by MRI. Nat Sci Sleep (2009) 0.81
T2 relaxometry using 3.0-tesla magnetic resonance imaging of the brain in early- and late-onset restless legs syndrome. J Clin Neurol (2014) 0.80
A novel locus for restless legs syndrome maps to chromosome 19p in an Irish pedigree. Neurogenetics (2012) 0.80
On the lorentzian versus Gaussian character of time-domain spin-echo signals from the brain as sampled by means of gradient-echoes: Implications for quantitative transverse relaxation studies. Magn Reson Med (2014) 0.80
The association of Restless Legs Syndrome with hypertension and cardiovascular disease. Med Sci Monit (2014) 0.79
Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease. Fluids Barriers CNS (2013) 0.79
Iron uptake and transport across physiological barriers. Biometals (2016) 0.78
Restless leg syndrome: is it a real problem? Ther Clin Risk Manag (2006) 0.78
Restless Legs Syndrome and Leg Motor Restlessness in Parkinson's Disease. Parkinsons Dis (2015) 0.78
Iron, dopamine, genetics, and hormones in the pathophysiology of restless legs syndrome. J Neurol (2017) 0.78
Restless legs syndrome: differential diagnosis and management with rotigotine. Neuropsychiatr Dis Treat (2009) 0.77
Low brain iron effects and reversibility on striatal dopamine dynamics. Exp Neurol (2014) 0.77
Sleep measured by polysomnography in patients receiving high-dose chemotherapy for multiple myeloma prior to stem cell transplantation. Oncol Nurs Forum (2013) 0.76
A comparison of MRI tissue relaxometry and ROI methods used to determine regional brain iron concentrations in restless legs syndrome. Med Devices (Auckl) (2015) 0.76
Magnesium, Iron, and Zinc Supplementation for the Treatment of Attention Deficit Hyperactivity Disorder: A Systematic Review on the Recent Literature. Int J Prev Med (2015) 0.76
Brain iron concentrations in regions of interest and relation with serum iron levels in Parkinson disease. J Neurol Sci (2017) 0.76
Restless leg syndrome, periodic limb movements, febrile seizures and Attention deficit hyperactivity disorder in an Indian family. Ann Indian Acad Neurol (2012) 0.75
Iron and restless legs syndrome: treatment, genetics and pathophysiology. Sleep Med (2016) 0.75
Update on the management of restless legs syndrome: existing and emerging treatment options. Nat Sci Sleep (2010) 0.75
A practical approach to the diagnosis and management of sleep disorders in patients with multiple sclerosis. Ther Adv Neurol Disord (2015) 0.75
DTI and VBM reveal white matter changes without associated gray matter changes in patients with idiopathic restless legs syndrome. Brain Behav (2015) 0.75
A Four-Year Longitudinal Study on Restless Legs Syndrome in Parkinson Disease. Sleep (2016) 0.75
Na(+)/H(+) Exchanger 9 Regulates Iron Mobilization at the Blood-Brain Barrier in Response to Iron Starvation. J Biol Chem (2017) 0.75
Ropinirole in restless legs syndrome and periodic limb movement disorder. Ther Clin Risk Manag (2010) 0.75
Microstructure of the Midbrain and Cervical Spinal Cord in Idiopathic Restless Legs Syndrome: A Diffusion Tensor Imaging Study. Sleep (2016) 0.75
Musculoskeletal pain is associated with restless legs syndrome in young adults. BMC Musculoskelet Disord (2015) 0.75
Animal models of RLS phenotypes. Sleep Med (2016) 0.75
Brain iron deficiency in idiopathic restless legs syndrome measured by quantitative magnetic susceptibility at 7 tesla. Sleep Med (2016) 0.75
Restless legs syndrome as the initial presentation of multiple sclerosis. Case Rep Med (2013) 0.75
Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor Other Hyperkinet Mov (N Y) (2016) 0.75
Sleep-related movement disorders. Neurol Sci (2011) 0.75
[Iron deficiency, Fatigue and Restless-Legs-Syndrome]. Wien Med Wochenschr (2016) 0.75
The structures of HsIU and the ATP-dependent protease HsIU-HsIV. Nature (2000) 4.46
Pregnancy and the risk of stroke. N Engl J Med (1996) 2.68
MR imaging of human brain at 3.0 T: preliminary report on transverse relaxation rates and relation to estimated iron content. Radiology (1999) 2.58
Diffusion- and perfusion-weighted brain magnetic resonance imaging in patients with neurologic complications after cardiac surgery. Arch Neurol (2001) 2.30
Diffusion magnetic resonance imaging: its principle and applications. Anat Rec (1999) 2.26
Phosphorus magnetic resonance spectroscopy of patients with mitochondrial cytopathies demonstrates decreased levels of brain phosphocreatine. Ann Neurol (1990) 2.24
Hypoperfusion of Wernicke's area predicts severity of semantic deficit in acute stroke. Ann Neurol (2001) 2.09
Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology (2003) 2.04
Iron and the restless legs syndrome. Sleep (1998) 1.87
Blockade of cannabinoid receptor 1 improves insulin resistance, lipid metabolism, and diabetic nephropathy in db/db mice. Endocrinology (2012) 1.81
Digital topological analysis of in vivo magnetic resonance microimages of trabecular bone reveals structural implications of osteoporosis. J Bone Miner Res (2001) 1.80
Crystal structure of NAD(+)-dependent DNA ligase: modular architecture and functional implications. EMBO J (2000) 1.78
Cerebral infarction in young adults: the Baltimore-Washington Cooperative Young Stroke Study. Neurology (1998) 1.75
Quantitative proton MR spectroscopic imaging of the human brain. Magn Reson Med (1996) 1.72
Subcortical aphasia and neglect in acute stroke: the role of cortical hypoperfusion. Brain (2002) 1.70
Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia. Circulation (1998) 1.65
Imaging of acute cerebral ischemia. Radiology (1999) 1.62
I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice. J Immunol (1999) 1.56
Crossed cerebellar diaschisis in acute stroke detected by dynamic susceptibility contrast MR perfusion imaging. AJNR Am J Neuroradiol (2009) 1.54
Restless legs syndrome: a review of clinical and pathophysiologic features. J Clin Neurophysiol (2001) 1.53
Oestrogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer. Lancet (1990) 1.49
Medication use in patients with restless legs syndrome compared with a control population. Eur J Neurol (2007) 1.46
Subclinical sensory neuropathy in late-onset restless legs syndrome. Neurology (2000) 1.45
Minimal hepatic encephalopathy in children: evaluation with proton MR spectroscopy. AJNR Am J Neuroradiol (2009) 1.42
Past pregnancy is associated with axillary node involvement in women with breast cancer. Cancer (1992) 1.42
Cancellous bone volume and structure in the forearm: noninvasive assessment with MR microimaging and image processing. Radiology (1998) 1.42
Imaging characteristics of oligodendrogliomas that predict grade. AJNR Am J Neuroradiol (2012) 1.39
Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family. Proc Natl Acad Sci U S A (2000) 1.34
Leukoencephalopathy, cerebral calcifications, and cysts: new observations. Neurology (2004) 1.33
Reproducibility and error sources of micro-MRI-based trabecular bone structural parameters of the distal radius and tibia. Bone (2004) 1.32
Fast 3D large-angle spin-echo imaging (3D FLASE). Magn Reson Med (1996) 1.29
Crystal structure of carboxylesterase from Pseudomonas fluorescens, an alpha/beta hydrolase with broad substrate specificity. Structure (1997) 1.29
Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology (2004) 1.28
Diffusion-negative stroke: a report of two cases. AJNR Am J Neuroradiol (2000) 1.27
Prediction of impending hemorrhagic transformation in ischemic stroke using magnetic resonance imaging in rats. Stroke (1998) 1.25
Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography. J Mol Biol (2001) 1.24
Augmentation of the restless legs syndrome with carbidopa/levodopa. Sleep (1996) 1.23
Cross-sectional study of osteopenia with quantitative MR imaging and bone densitometry. Radiology (2000) 1.23
Measurement of phosphorus content in normal and osteomalacic rabbit bone by solid-state 3D radial imaging. Magn Reson Med (2006) 1.22
The crystal structure of a triacylglycerol lipase from Pseudomonas cepacia reveals a highly open conformation in the absence of a bound inhibitor. Structure (1997) 1.22
Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference. Magn Reson Med (1996) 1.21
Reperfusion of specific brain regions by raising blood pressure restores selective language functions in subacute stroke. Brain Lang (2001) 1.21
A noncontact, nondestructive method for quantifying intratissue deformations and strains. J Biomech Eng (2002) 1.21
MR perfusion imaging reveals regions of hypoperfusion associated with aphasia and neglect. Neurology (2000) 1.20
Topological analysis of trabecular bone MR images. IEEE Trans Med Imaging (2000) 1.20
A pilot randomized trial of induced blood pressure elevation: effects on function and focal perfusion in acute and subacute stroke. Cerebrovasc Dis (2003) 1.17
Absence of 185delAG mutation of the BRCA1 gene and 6174delT mutation of the BRCA2 gene in Ashkenazi Jewish men with prostate cancer. Br J Cancer (1998) 1.16
In vivo MR micro imaging with conventional radiofrequency coils cooled to 77 degrees K. Magn Reson Med (2000) 1.14
Restoring blood pressure reperfused Wernicke's area and improved language. Neurology (2001) 1.14
Quantitative proton MR spectroscopic imaging of normal human cerebellum and brain stem. Magn Reson Med (2001) 1.12
Diffusion tensor MR imaging of the brain: effect of diffusion weighting on trace and anisotropy measurements. AJNR Am J Neuroradiol (2001) 1.10
N-acetyl aspartate--a neuronal marker? Ann Neurol (2001) 1.09
Measurement of R'2 in the presence of multiple spectral components using reference spectrum deconvolution. J Magn Reson (1998) 1.09
Tumor trapping of 5-fluorouracil: in vivo 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits. Proc Natl Acad Sci U S A (1990) 1.07
High-speed spectroscopic imaging for cancellous bone marrow R(2)* mapping and lipid quantification. Magn Reson Imaging (2000) 1.06
Multi-modality study of the compositional and mechanical implications of hypomineralization in a rabbit model of osteomalacia. Bone (2007) 1.05
Can proton MR spectroscopic and perfusion imaging differentiate between neoplastic and nonneoplastic brain lesions in adults? AJNR Am J Neuroradiol (2007) 1.04
Impaired CD4 T cell activation due to reliance upon B cell-mediated costimulation in nonobese diabetic (NOD) mice. J Immunol (2000) 1.03
Intracranial assessment of incontinentia pigmenti using magnetic resonance imaging, angiography, and spectroscopic imaging. Arch Pediatr Adolesc Med (1995) 1.03
Diffusion-weighted MRI and proton MR spectroscopic imaging in the study of secondary neuronal injury after intracerebral hemorrhage. Stroke (2000) 1.01
Illicit drug-associated ischemic stroke in the Baltimore-Washington Young Stroke Study. Neurology (1998) 1.01
Impaired activation of islet-reactive CD4 T cells in pancreatic lymph nodes of B cell-deficient nonobese diabetic mice. J Immunol (2001) 1.00
Proton magnetic resonance spectroscopy of choroid plexus tumors in children. J Magn Reson Imaging (2001) 1.00
Multi-slice proton MR spectroscopy and diffusion-weighted imaging in methylmalonic acidemia: report of two cases and review of the literature. AJNR Am J Neuroradiol (2001) 0.96
Neuroimaging studies in Rett syndrome. Brain Dev (2001) 0.96
Homocyst(e)ine and risk of cerebral infarction in a biracial population : the stroke prevention in young women study. Stroke (1999) 0.95
A traumatic pseudoaneurysm of the superficial temporal artery. Yonsei Med J (1998) 0.95
Perfusion-weighted MRI as a marker of response to treatment in acute and subacute stroke. Neuroradiology (2003) 0.95
Neurochemistry of brain lesions determined by spectroscopic imaging in systemic lupus erythematosus. J Rheumatol (1997) 0.94
Carotid arterial stiffness as a surrogate for aortic stiffness: relationship between carotid artery pressure-strain elastic modulus and aortic pulse wave velocity. Ultrasound Med Biol (1999) 0.94
Structural MRI of carotid artery atherosclerotic lesion burden and characterization of hemispheric cerebral blood flow before and after carotid endarterectomy. NMR Biomed (2006) 0.94
Proton MR spectroscopy in acute middle cerebral artery stroke. AJNR Am J Neuroradiol (1996) 0.94
Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice. Endocrinology (2013) 0.94
MRI and proton MRSI in women heterozygous for X-linked adrenoleukodystrophy. Neurology (2003) 0.93
Classification of childhood white matter disorders using proton MR spectroscopic imaging. AJNR Am J Neuroradiol (2008) 0.93
A single-scan imaging technique for measurement of the relative concentrations of fat and water protons and their transverse relaxation times. J Magn Reson (1997) 0.93
Spectroscopic evidence of cerebral axonopathy in patients with "pure" adrenomyeloneuropathy. Neurology (2005) 0.92
Proton MR spectroscopy in patients with seizure disorders. AJNR Am J Neuroradiol (1994) 0.92
Family history study of the restless legs syndrome. Sleep Med (2002) 0.92
Hand-assisted laparoscopic vertical banded gastroplasty: early results. Surg Endosc (2000) 0.92
31P saturation transfer and phosphocreatine imaging in the monkey brain. Proc Natl Acad Sci U S A (1991) 0.91
Multislice proton magnetic resonance spectroscopic imaging in X-linked adrenoleukodystrophy. Ann Neurol (1994) 0.91
Intraocular silicone oil: in vitro and in vivo MR and CT characteristics. AJNR Am J Neuroradiol (1994) 0.90
Influence of age and postmenopausal estrogen replacement therapy on carotid arterial stiffness in women. Cardiovasc Res (1999) 0.90
Enhanced IL-18 expression in common skin tumors. Immunol Lett (2001) 0.90
Androgenic involvement in conditioned taste aversion. Horm Behav (1978) 0.89
Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome. Neurology (2002) 0.89
Cerebral metabolites in patients with acute and subacute strokes: concentrations determined by quantitative proton MR spectroscopy. AJR Am J Roentgenol (1995) 0.89
Correction of motional artifacts in diffusion-weighted images using a reference phase map. Magn Reson Med (1995) 0.89
Alcohol intake, type of beverage, and the risk of cerebral infarction in young women. Stroke (2001) 0.88
A direct method for the calculation of alloreactive CD4+ T cell precursor frequency. Transplantation (1999) 0.88
Magnetic resonance spectroscopy and spectroscopic imaging for the study of brain metabolism. Ann N Y Acad Sci (1997) 0.88
Proton MR spectroscopic imaging predicts lesion progression on MRI in X-linked adrenoleukodystrophy. Neurology (2002) 0.88
Contribution of the innate immune system to autoimmune diabetes: a role for the CR1/CR2 complement receptors. Cell Immunol (1999) 0.87
Irreversible regional cerebral ischemia: serial MR imaging and proton MR spectroscopy in a nonhuman primate model. AJNR Am J Neuroradiol (1993) 0.87
Multiple tuning of birdcage resonators. Magn Reson Med (1997) 0.87
Renal protective effects of toll-like receptor 4 signaling blockade in type 2 diabetic mice. Endocrinology (2013) 0.87
Quantitative proton MR spectroscopic imaging in acute disseminated encephalomyelitis. AJNR Am J Neuroradiol (2001) 0.86
Proton T1rho-dispersion imaging of rodent brain at 1.9 T. J Magn Reson Imaging (1998) 0.86
Effects of prior exposure on conditioned taste aversion in the rat: androgen- and estrogen-dependent events. J Comp Physiol Psychol (1979) 0.86