Protease-activated receptors in inflammation, neuronal signaling and pain.

Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest (2007) 2.66

Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell (2010) 2.19

Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am J Pathol (2002) 2.16

'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage. Nat Immunol (2007) 1.95

Mast cell activation contributes to sickle cell pathobiology and pain in mice. Blood (2013) 1.94

Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci U S A (2001) 1.84

PARticipation in inflammation. J Clin Invest (2003) 1.70

A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis. Proc Natl Acad Sci U S A (2005) 1.45

Roles of protease-activated receptors in a mouse model of endotoxemia. Blood (2006) 1.32

Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability. Proc Natl Acad Sci U S A (2003) 1.32

Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice. Br J Pharmacol (2008) 1.29

Arthritis and pain. Neurogenic origin of joint pain. Arthritis Res Ther (2006) 1.21

Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP. Blood (2005) 1.20

Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons. J Physiol (2003) 1.20

Retracted A role for proteinase-activated receptor-1 in inflammatory bowel diseases. J Clin Invest (2004) 1.15

Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. Br J Pharmacol (2006) 1.15

Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells. Immunology (2004) 1.13

Lymphatic system: a vital link between metabolic syndrome and inflammation. Ann N Y Acad Sci (2010) 1.11

Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br J Pharmacol (2004) 1.08

Mast cell function: a new vision of an old cell. J Histochem Cytochem (2014) 1.08

Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection. Am J Pathol (2006) 1.07

Basolateral PAR-2 receptors mediate KCl secretion and inhibition of Na+ absorption in the mouse distal colon. J Physiol (2002) 1.05

Expression of protease-activated receptor-1, -2, -3, and -4 in control and experimentally inflamed mouse bladder. Am J Pathol (2003) 1.04

Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli. Br J Pharmacol (2002) 1.03

Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome. Ann Gastroenterol (2014) 1.02

Mechanisms of protease-activated receptor 2-evoked hyperexcitability of nociceptive neurons innervating the mouse colon. J Physiol (2007) 1.00

Morphine stimulates cancer progression and mast cell activation and impairs survival in transgenic mice with breast cancer. Br J Anaesth (2014) 0.97

Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats. J Physiol (2003) 0.97

Dual effect mediated by protease-activated receptors on the mechanical activity of rat colon. Br J Pharmacol (2002) 0.97

Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo. Immunology (2009) 0.95

Hypersensitivity of pulmonary chemosensitive neurons induced by activation of protease-activated receptor-2 in rats. J Physiol (2006) 0.94

Modulation of visceral pain and inflammation by protease-activated receptors. Br J Pharmacol (2004) 0.93

Regulatory network of inflammation downstream of proteinase-activated receptors. BMC Physiol (2007) 0.93

Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering. FASEB J (2013) 0.92

Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol Pain (2010) 0.92

Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation. BMC Physiol (2007) 0.91

Enteric bacterial proteases in inflammatory bowel disease- pathophysiology and clinical implications. World J Gastroenterol (2013) 0.91

Emerging neuropeptide targets in inflammation: NPY and VIP. Am J Physiol Gastrointest Liver Physiol (2013) 0.89

Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin. J Physiol (2003) 0.89

Proteinases, proteinase-activated receptors (PARs) and the pathophysiology of cancer and diseases of the cardiovascular, musculoskeletal, nervous and gastrointestinal systems. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.89

Substance P activates both contractile and inflammatory pathways in lymphatics through the neurokinin receptors NK1R and NK3R. Microcirculation (2011) 0.88

Protein targets of inflammatory serine proteases and cardiovascular disease. J Inflamm (Lond) (2010) 0.88

Proteinase-activated receptor-2 up-regulation by Fcgamma-receptor activation in human neutrophils. FASEB J (2010) 0.86

Proteinase-activated receptor 2 activation modulates guinea-pig mesenteric lymphatic vessel pacemaker potential and contractile activity. J Physiol (2004) 0.86

Modulation of meningeal nociceptors mechanosensitivity by peripheral proteinase-activated receptor-2: the role of mast cells. Cephalalgia (2008) 0.86

Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation. BMC Immunol (2007) 0.85

Roles of platelets and proteinase-activated receptors in gastric ulcer healing. Dig Dis Sci (2005) 0.85

Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC). Clin Exp Med (2009) 0.84

Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2. Br J Pharmacol (2015) 0.83

Periodontal treatment downregulates protease-activated receptor 2 in human gingival crevicular fluid cells. Infect Immun (2013) 0.83

The role of kinin B1 and B2 receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice. Br J Pharmacol (2010) 0.83

Mast cell chymase and tryptase in abdominal aortic aneurysm formation. Trends Cardiovasc Med (2012) 0.83

A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium. Br J Pharmacol (2003) 0.82

Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior. Brain Res (2011) 0.82

Involvement of nitric oxide and tachykinins in the effects induced by protease-activated receptors in rat colon longitudinal muscle. Br J Pharmacol (2003) 0.81

The C-terminus of murine S100A9 protein inhibits hyperalgesia induced by the agonist peptide of protease-activated receptor 2 (PAR2). Br J Pharmacol (2006) 0.81

Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study. Arthritis Res Ther (2007) 0.81

Prognostic value of protease activated receptor-1 in children with acute lymphoblastic leukemia. Mediterr J Hematol Infect Dis (2014) 0.80

Putative therapeutic targets in the treatment of visceral hyperalgesia. Gut (2004) 0.80

Contribution of protease-activated receptor 1 in status epilepticus-induced epileptogenesis. Neurobiol Dis (2015) 0.80

Inflammatory targets of therapy in sickle cell disease. Transl Res (2015) 0.80

Activity dependent CAM cleavage and neurotransmission. Front Cell Neurosci (2015) 0.80

Gut pain & visceral hypersensitivity. Br J Pain (2013) 0.78

Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase. Pflugers Arch (2014) 0.78

Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.78

Protease-activated Receptor-2 (PAR-2)-mediated Nf-κB Activation Suppresses Inflammation-associated Tumor Suppressor MicroRNAs in Oral Squamous Cell Carcinoma. J Biol Chem (2016) 0.78

Modulation of protease-activated receptor expression by Porphyromonas gingivalis in human gingival epithelial cells. BMC Oral Health (2015) 0.77

Activation of protease activated receptor 2 by exogenous agonist exacerbates early radiation injury in rat intestine. Int J Radiat Oncol Biol Phys (2010) 0.76

The effects of trypsin on rat brain astrocyte activation. Iran J Neurol (2013) 0.76

Thymoquinone Inhibits IL-1β-Induced Inflammation in Human Osteoarthritis Chondrocytes by Suppressing NF-κB and MAPKs Signaling Pathway. Inflammation (2015) 0.76

Rational design of matrix metalloproteinase-13 activatable probes for enhanced specificity. ACS Chem Biol (2013) 0.76

The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease. J Immunol Res (2017) 0.75

Inhibition of interleukin-12 expression by alpha-thrombin in human peripheral blood mononuclear cells: a potential mechanism for modulating Th1/Th2 responses. Br J Pharmacol (2003) 0.75

Adjunctive therapies to reduce thrombotic events in patients with a history of myocardial infarction: role of vorapaxar. Drug Des Devel Ther (2015) 0.75

Effects of thrombin, PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro. Reprod Biol Endocrinol (2005) 0.75

Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology (1989) 7.59

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol (2000) 4.29

Membrane receptors and hormone action. Adv Protein Chem (1976) 3.73

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med (2000) 3.71

Insulin and epidermal growth factor. Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake. J Biol Chem (1975) 3.60

Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol (1998) 3.54

Epidermal growth factor: receptors in human fibroblasts and modulation of action by cholera toxin. Proc Natl Acad Sci U S A (1973) 3.44

Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nat Med (2001) 3.17

The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex. Proc Natl Acad Sci U S A (2000) 2.69

Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes. J Neurosci (1996) 2.65

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J (1996) 2.55

The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48

Sucrose: a novel permeability marker for gastroduodenal disease. Gastroenterology (1993) 2.46

Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br J Pharmacol (2007) 2.35

Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues. Arch Biochem Biophys (1974) 2.34

Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2. J Clin Invest (1996) 2.31

A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology (1995) 2.30

The isolation of the native hormone-binding proteins from bovine pituitary posterior lobes. Crystallization of neurophysin-I and-II as complexes with [8-arginine]-vasopressin. Biochem J (1968) 2.24

Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest (1997) 2.04

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo. Proc Natl Acad Sci U S A (1996) 2.03

Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc Natl Acad Sci U S A (1997) 1.99

Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. J Biol Chem (1996) 1.99

Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: activation of PAR2 by PAR1-targeted ligands. J Pharmacol Exp Ther (1999) 1.93

Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br J Pharmacol (1996) 1.93

Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci U S A (2001) 1.84

Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. Br J Pharmacol (1999) 1.83

Suppression of fever at near term is associated with reduced COX-2 protein expression in rat hypothalamus. Am J Physiol Regul Integr Comp Physiol (2002) 1.80

T cell gelatinases mediate basement membrane transmigration in vitro. J Immunol (1995) 1.78

Regulatory mechanisms that modulate signalling by G-protein-coupled receptors. Biochem J (1997) 1.77

Affinity chromatography and structural analysis of Vibrio cholerae enterotoxin-ganglioside agarose and the biological effects of ganglioside-containing soluble polymers. Biochemistry (1973) 1.74

Potent ulcerogenic actions of platelet-activating factor on the stomach. Nature (1986) 1.73

Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation. Proc Natl Acad Sci U S A (1994) 1.72

Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation. Gastroenterology (1997) 1.69

Insulin receptor: interaction with nonreceptor glycoprotein from liver cell membranes. Proc Natl Acad Sci U S A (1978) 1.68

Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport. Proc Natl Acad Sci U S A (1998) 1.61

Representation of three-dimensional objects by the rat perirhinal cortex. Hippocampus (2012) 1.60

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterol Motil (2010) 1.60

Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest (1999) 1.59

Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract. J Neurosci (1996) 1.58

Epidermal growth factor-urogastrone, a polypeptide acquiring hormonal status. Vitam Horm (1979) 1.58

Dissociation of oxytocin and vasopressin from their carrier protein by chromatography on sephadex G-25. Br J Pharmacol Chemother (1966) 1.56

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Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell (1995) 1.52

Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can J Physiol Pharmacol (1995) 1.52

Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Am J Physiol Lung Cell Mol Physiol (2000) 1.52

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Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase. Exp Dermatol (1999) 1.45

Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis. Br J Pharmacol (2007) 1.45

Nitric oxide synthesis inhibition increases epithelial permeability via mast cells. Am J Physiol (1994) 1.44

Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells. J Neurosci (1994) 1.40

Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. Proc Natl Acad Sci U S A (2001) 1.39

Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor. J Biol Chem (1999) 1.38

Reactivation of hapten-induced colitis and its prevention by anti-inflammatory drugs. Am J Physiol (1995) 1.36

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The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat. J Immunol (2001) 1.32

Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2. J Physiol (1999) 1.31

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Proteinase-activated receptor 2 (PAR(2)): development of a ligand-binding assay correlating with activation of PAR(2) by PAR(1)- and PAR(2)-derived peptide ligands. J Pharmacol Exp Ther (1999) 1.27

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