Published in Proc Natl Acad Sci U S A on March 13, 2001
Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med (2002) 4.34
Distinct functional lineages of human V(alpha)24 natural killer T cells. J Exp Med (2002) 3.70
Harnessing invariant NKT cells in vaccination strategies. Nat Rev Immunol (2009) 2.79
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest (2008) 2.46
Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. Nat Immunol (2010) 2.42
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation. J Exp Med (2007) 2.37
Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc Natl Acad Sci U S A (2010) 2.19
CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire. Nat Immunol (2010) 2.13
The role of NKT cells in tumor immunity. Adv Cancer Res (2008) 2.05
Cellular immune responses against hepatitis C virus: the evidence base 2002. Clin Exp Immunol (2002) 1.81
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes. Nat Immunol (2010) 1.76
Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments. Blood (2010) 1.62
Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases. J Exp Med (2006) 1.57
Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma. Blood (2008) 1.45
Generation of PLZF+ CD4+ T cells via MHC class II-dependent thymocyte-thymocyte interaction is a physiological process in humans. J Exp Med (2009) 1.44
CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans. J Exp Med (2011) 1.43
MHC class II-restricted interaction between thymocytes plays an essential role in the production of innate CD8+ T cells. J Immunol (2011) 1.32
Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors. J Exp Med (2006) 1.32
Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis. Nat Rev Immunol (2011) 1.32
Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7. Proc Natl Acad Sci U S A (2004) 1.21
DOCK8 is critical for the survival and function of NKT cells. Blood (2013) 1.17
CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens. J Exp Med (2013) 1.16
Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection. J Virol (2003) 1.16
The regulatory role of invariant NKT cells in tumor immunity. Cancer Immunol Res (2015) 0.96
Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells. Proc Natl Acad Sci U S A (2013) 0.94
Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system. Proc Natl Acad Sci U S A (2011) 0.94
Invariant Valpha14 chain NKT cells promote Plasmodium berghei circumsporozoite protein-specific gamma interferon- and tumor necrosis factor alpha-producing CD8+ T cells in the liver after poxvirus vaccination of mice. Infect Immun (2005) 0.92
Ligand-independent assembly of recombinant human CD1 by using oxidative refolding chromatography. Proc Natl Acad Sci U S A (2001) 0.91
Cutting Edge: CD1a tetramers and dextramers identify human lipopeptide-specific T cells ex vivo. J Immunol (2013) 0.91
Essential role for autophagy during invariant NKT cell development. Proc Natl Acad Sci U S A (2014) 0.90
Roles for major histocompatibility complex glycosylation in immune function. Semin Immunopathol (2012) 0.88
Generation of CD1 tetramers as a tool to monitor glycolipid-specific T cells. Philos Trans R Soc Lond B Biol Sci (2003) 0.87
Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants. Expert Rev Vaccines (2008) 0.86
NK cells, innate immunity and hepatitis C infection after liver transplantation. Clin Infect Dis (2011) 0.86
Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production. ACS Chem Biol (2012) 0.83
Importance of N-linked glycosylation in the functional expression of murine CD1d1. Immunology (2007) 0.83
Contribution of Va24Vb11 natural killer T cells in Wilsonian hepatitis. Clin Exp Immunol (2005) 0.82
Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C. J Viral Hepat (2013) 0.81
CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells. Eur J Immunol (2013) 0.81
MHC class II-expressing thymocytes suppress invariant NKT cell development. Immunol Cell Biol (2008) 0.81
More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology (2015) 0.78
Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C. Eur J Immunol (2012) 0.78
Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: a Phase 1 Clinical Trial. Clin Cancer Res (2017) 0.78
Ex vivo purification and characterization of human invariant Natural Killer T cells. J Immunol Methods (2011) 0.76
A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model. J Immunol (2015) 0.75
Genotype-Associated Differential NKG2D Expression on CD56+CD3+ Lymphocytes Predicts Response to Pegylated-Interferon/Ribavirin Therapy in Chronic Hepatitis C. PLoS One (2015) 0.75
Right on target: novel approaches for the direct visualization of CD1-specific T cell responses. Proc Natl Acad Sci U S A (2001) 0.75
Phenotypic analysis of antigen-specific T lymphocytes. Science (1996) 24.26
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science (1997) 13.67
Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science (1997) 8.95
An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. J Exp Med (1994) 7.35
Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med (2000) 6.15
Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol (1999) 5.86
NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol (2000) 4.75
In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J Exp Med (2000) 4.37
Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove. Science (1997) 4.27
CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution. J Exp Med (1998) 4.15
The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu Rev Immunol (1999) 4.10
Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature (1998) 4.10
Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J Exp Med (2000) 3.93
Requirements for CD1d recognition by human invariant Valpha24+ CD4-CD8- T cells. J Exp Med (1997) 3.74
Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. J Immunol (1999) 3.03
HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice. J Exp Med (1997) 3.03
Immunization with alpha-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis. Eur J Immunol (1999) 2.99
Immune suppression and skin cancer development: regulation by NKT cells. Nat Immunol (2000) 2.38
Mouse NK1+ T cells. Curr Opin Immunol (1995) 2.35
Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood. Curr Biol (1998) 2.21
Two classes of CD1 genes. Eur J Immunol (1989) 2.11
The minimum peptide epitope from the influenza virus matrix protein. Extra and intracellular loading of HLA-A2. J Immunol (1991) 1.96
Structural requirements for galactosylceramide recognition by CD1-restricted NK T cells. J Immunol (1998) 1.89
CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant V alpha 24 J alpha Q T cell receptor alpha chains. J Exp Med (1998) 1.80
Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. Proc Natl Acad Sci U S A (1986) 1.77
CD1-restricted T-cell responses and microbial infection. Nature (2000) 1.76
Oxidative refolding chromatography: folding of the scorpion toxin Cn5. Nat Biotechnol (1999) 1.69
Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. Proc Natl Acad Sci U S A (1987) 1.57
Dynamics of intra-hepatic lymphocytes in chronic hepatitis C: enrichment for Valpha24+ T cells and rapid elimination of effector cells by apoptosis. Eur J Immunol (1998) 1.54
HLA-peptide tetrameric complexes. Curr Opin Immunol (1998) 1.53
Human invariant valpha24+ natural killer T cells activated by alpha-galactosylceramide (KRN7000) have cytotoxic anti-tumour activity through mechanisms distinct from T cells and natural killer cells. Immunology (2000) 1.34
Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1. EMBO J (1988) 1.26
Activation of human Valpha24NKT cells by alpha-glycosylceramide in a CD1d-restricted and Valpha24TCR-mediated manner. Hum Immunol (1999) 1.25
Refolding chromatography with immobilized mini-chaperones. Proc Natl Acad Sci U S A (1997) 1.09
The identification of the beta 2-microglobulin binding antigen encoded by the human CD1D gene. Eur J Immunol (1991) 1.06
Alpha-glycosylceramides enhance the antitumor cytotoxicity of hepatic lymphocytes obtained from cancer patients by activating CD3-CD56+ NK cells in vitro. J Immunol (2000) 0.96
Ligand-independent assembly of recombinant human CD1 by using oxidative refolding chromatography. Proc Natl Acad Sci U S A (2001) 0.91
Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (1975) 83.56
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature (1998) 60.62
Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. Eur J Immunol (1976) 30.70
Antibodies to major histocompatibility antigens produced by hybrid cell lines. Nature (1977) 16.54
Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis. Cell (1978) 14.82
Preparation of monoclonal antibodies: strategies and procedures. Methods Enzymol (1981) 14.45
The genome sequence of Schizosaccharomyces pombe. Nature (2002) 14.26
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science (1997) 13.67
Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science (1998) 12.05
Massive gene decay in the leprosy bacillus. Nature (2001) 11.98
A possible precursor of immunoglobulin light chains. Nat New Biol (1972) 11.03
Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol (1979) 10.51
Eradication of schistosomiasis. Am J Public Health (1982) 10.26
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature (2000) 9.86
Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line. J Cell Biol (1982) 9.66
Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med (2000) 9.36
A BASIC MECHANISM IN THE BIOLOGICAL EFFECTS OF TEMPERATURE, PRESSURE AND NARCOTICS. Science (1942) 8.76
Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: differentiation antigens of rat lymphocytes. Cell (1977) 8.46
Complete sequence of constant and 3' noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing. Cell (1978) 8.20
Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc Natl Acad Sci U S A (1997) 8.05
Fusion between immunoglobulin-secreting and nonsecreting myeloma cell lines. Eur J Immunol (1976) 7.64
The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states. Kidney Int (2007) 6.99
Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med (2000) 6.15
Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell (1993) 5.91
Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol (1999) 5.86
Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG. Nature (1979) 5.69
Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior. Proc Natl Acad Sci U S A (1994) 5.61
Measurement of instantaneous left ventricular dimension and filling rate in man, using echocardiography. Br Heart J (1973) 5.61
Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur J Immunol (1978) 5.35
A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody. Eur J Immunol (1979) 5.17
Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science (1995) 4.80
Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus. J Virol (2001) 4.48
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci U S A (1988) 4.45
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature (1984) 4.45
Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment. Lancet (2000) 4.34
Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood (2001) 4.22
Mutation drift and repertoire shift in the maturation of the immune response. Immunol Rev (1987) 4.16
CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution. J Exp Med (1998) 4.15
Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J Exp Med (2000) 3.93
Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet (1997) 3.89
Man-made antibodies. Nature (1991) 3.88
Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5' non-coding region. Nucleic Acids Res (1986) 3.86
Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment. J Immunol (2001) 3.79
Reduced naphthylphthalamic acid binding in the tir3 mutant of Arabidopsis is associated with a reduction in polar auxin transport and diverse morphological defects. Plant Cell (1997) 3.78
Assembly of MHC class I molecules analyzed in vitro. Cell (1990) 3.77
Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitis. J Infect Dis (1981) 3.76
p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science (1995) 3.74
Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc Natl Acad Sci U S A (2000) 3.66
Antigenic oscillations and shifting immunodominance in HIV-1 infections. Nature (1995) 3.61
Natural history of paroxysmal nocturnal hemoglobinuria. N Engl J Med (1995) 3.60
Murine CD1d-restricted T cell recognition of cellular lipids. Immunity (2000) 3.57
Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat Med (2001) 3.56
Origin of antibody variation. Nature (1966) 3.50
Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes. J Immunol (1998) 3.48
The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Nature (1999) 3.44
The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat Med (2001) 3.39
CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained. Eur J Immunol (2000) 3.36
The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. J Clin Invest (1994) 3.30
Kinetic maturation of an immune response. Nature (1991) 3.26
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology (2007) 3.26
Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science (2000) 3.20
T-lymphocyte heterogeneity in the rat: separation of functional subpopulations using a monoclonal antibody. J Exp Med (1978) 3.20
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity (1998) 3.16
Linked groups of residues in immunoglobulin k chains. Nature (1967) 3.12
Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell (1994) 3.06
Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes. J Exp Med (1998) 3.04
Inhibition of erythroid progenitor cells by anti-Kell antibodies in fetal alloimmune anemia. N Engl J Med (1998) 3.04
Glycolipid antigen processing for presentation by CD1d molecules. Science (2001) 3.04
Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. J Immunol (1999) 3.03
Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II. Cell (1995) 3.01
Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells. J Clin Invest (1999) 3.00
High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals. J Exp Med (1999) 2.98
Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells. Proc Natl Acad Sci U S A (1998) 2.96
The use of corticosteroids in the treatment of acute asthma. Q J Med (1975) 2.95
CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells. J Exp Med (1998) 2.94
The complete amino acid sequence of a mouse kappa light chain. Biochem J (1972) 2.94
Sequence variability in the 5' non-coding region of hepatitis C virus: identification of a new virus type and restrictions on sequence diversity. J Gen Virol (1993) 2.87
The use of swift, brief isolation as a group control device for institutionalized delinquents. Behav Res Ther (1967) 2.85
Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin. Nature (2000) 2.84
Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83
Regression of murine lung tumors by the let-7 microRNA. Oncogene (2009) 2.83
Physical activity social support and middle- and older-aged minority women: results from a US survey. Soc Sci Med (1999) 2.79
Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses. Proc Natl Acad Sci U S A (2000) 2.79
Molecular events during maturation of the immune response to oxazolone. Nature (1985) 2.78
Comparative effectiveness of full-length and B-domain deleted factor VIII for prophylaxis--a meta-analysis. Haemophilia (2003) 2.72
mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification. Nature (1983) 2.72
Measles vaccination and antibody response in autism spectrum disorders. Arch Dis Child (2008) 2.71
Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J Exp Med (2001) 2.67
Structural analysis of the X-linked gene encoding human glucose 6-phosphate dehydrogenase. EMBO J (1986) 2.64
Structural studies of immunoglobulin G. Nature (1969) 2.63
Correlates of HIV infection among young adult short-term injection drug users. AIDS (2000) 2.63
Structure-activity relationship of alpha-galactosylceramides against B16-bearing mice. J Med Chem (1995) 2.62
Hepatitis C virus genotypes: an investigation of type-specific differences in geographic origin and disease. Hepatology (1994) 2.60
High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo. J Exp Med (1998) 2.58
Post-marketing surveillance of enalapril: experience in 11,710 hypertensive patients in general practice. J R Coll Gen Pract (1987) 2.57