Absence of mutations in marRAB or soxRS in acrB-overexpressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli.

PubWeight™: 1.55‹?› | Rank: Top 4%

🔗 View Article (PMC 90504)

Published in Antimicrob Agents Chemother on May 01, 2001

Authors

M A Webber1, L J Piddock

Author Affiliations

1: Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom.

Articles citing this

Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev (2006) 4.77

Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. Antimicrob Agents Chemother (2003) 3.00

Regulation of bacterial drug export systems. Microbiol Mol Biol Rev (2002) 3.00

The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes. Antimicrob Agents Chemother (2002) 1.92

Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. Antimicrob Agents Chemother (2003) 1.78

Expression of acrB, acrF, acrD, marA, and soxS in Salmonella enterica serovar Typhimurium: role in multiple antibiotic resistance. Antimicrob Agents Chemother (2004) 1.66

Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. Antimicrob Agents Chemother (2008) 1.65

Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections. Antimicrob Agents Chemother (2005) 1.47

mar Operon involved in multidrug resistance of Enterobacter aerogenes. Antimicrob Agents Chemother (2002) 1.23

Crystal structure of the transcriptional regulator AcrR from Escherichia coli. J Mol Biol (2007) 1.21

Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of RamA and other global regulators. Antimicrob Agents Chemother (2008) 1.20

Mechanism of action of and resistance to quinolones. Microb Biotechnol (2008) 1.16

Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm. Virulence (2013) 1.15

Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. Antimicrob Agents Chemother (2006) 1.14

Correlation of the expression of acrB and the regulatory genes marA, soxS and ramA with antimicrobial resistance in clinical isolates of Klebsiella pneumoniae endemic to New York City. J Antimicrob Chemother (2009) 1.12

The TolC homologue of Brucella suis is involved in resistance to antimicrobial compounds and virulence. Infect Immun (2006) 1.09

Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates. Antimicrob Agents Chemother (2005) 1.05

AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity. Proc Natl Acad Sci U S A (2015) 1.05

Role for tandem duplication and lon protease in AcrAB-TolC- dependent multiple antibiotic resistance (Mar) in an Escherichia coli mutant without mutations in marRAB or acrRAB. J Bacteriol (2006) 1.05

Structures of AcrR and CmeR: insight into the mechanisms of transcriptional repression and multi-drug recognition in the TetR family of regulators. Biochim Biophys Acta (2008) 0.98

Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. Antimicrob Agents Chemother (2007) 0.94

Mechanisms of fluoroquinolone resistance in Escherichia coli isolates from food-producing animals. Appl Environ Microbiol (2011) 0.92

Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates. Antimicrob Agents Chemother (2005) 0.89

Clinically relevant mutant DNA gyrase alters supercoiling, changes the transcriptome, and confers multidrug resistance. MBio (2013) 0.86

Genomics of rapid adaptation to antibiotics: convergent evolution and scalable sequence amplification. Genome Biol Evol (2014) 0.85

SecDF as part of the Sec-translocase facilitates efficient secretion of Bacillus cereus toxins and cell wall-associated proteins. PLoS One (2014) 0.82

Characterization of integron mediated antimicrobial resistance in Salmonella isolated from diseased swine. Can J Vet Res (2003) 0.82

Contributions of mutations in acrR and marR genes to organic solvent tolerance in Escherichia coli. AMB Express (2012) 0.81

Conformational change of the AcrR regulator reveals a possible mechanism of induction. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.81

Effects of Stress, Reactive Oxygen Species, and the SOS Response on De Novo Acquisition of Antibiotic Resistance in Escherichia coli. Antimicrob Agents Chemother (2015) 0.79

Global regulator SoxR is a negative regulator of efflux pump gene expression and affects antibiotic resistance and fitness in Acinetobacter baumannii. Medicine (Baltimore) (2017) 0.76

RNA-seq-based analysis of drug-resistant Salmonella enterica serovar Typhimurium selected in vivo and in vitro. PLoS One (2017) 0.75

Evaluation of Fluoroquinolone Activity against Emergence of Resistant Salmonella enterica serovar Typhimurium Using In Vitro Dynamic Models. Antimicrob Agents Chemother (2016) 0.75

Articles cited by this

Multidrug efflux pumps of gram-negative bacteria. J Bacteriol (1996) 9.86

AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J Bacteriol (1996) 8.50

Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol Microbiol (1995) 8.41

Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J Bacteriol (1993) 6.24

Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli. J Bacteriol (1996) 5.58

Efflux pumps and drug resistance in gram-negative bacteria. Trends Microbiol (1994) 4.91

The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals. Mol Microbiol (1996) 4.56

Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulon. Nucleic Acids Res (1991) 4.50

Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon. Antimicrob Agents Chemother (1997) 4.40

Gene in the major cotransduction gap of the Escherichia coli K-12 linkage map required for the expression of chromosomal resistance to tetracycline and other antibiotics. J Bacteriol (1983) 4.37

Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals. Antimicrob Agents Chemother (1996) 4.15

Antibiotic resistance caused by gram-negative multidrug efflux pumps. Clin Infect Dis (1998) 3.85

Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli. J Bacteriol (1997) 3.81

Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA. J Bacteriol (2000) 3.27

Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coli. Antimicrob Agents Chemother (1998) 2.59

Activation of multiple antibiotic resistance and binding of stress-inducible promoters by Escherichia coli Rob protein. J Bacteriol (1995) 2.53

Identification for mar mutants among quinolone-resistant clinical isolates of Escherichia coli. Antimicrob Agents Chemother (1996) 2.34

A novel binding protein of the origin of the Escherichia coli chromosome. J Biol Chem (1993) 2.12

Promoter discrimination by the related transcriptional activators MarA and SoxS: differential regulation by differential binding. Mol Microbiol (2000) 1.46

Defining a rob regulon in Escherichia coli by using transposon mutagenesis. J Bacteriol (2000) 1.27

Two efflux systems expressed simultaneously in multidrug-resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother (2000) 1.18

Articles by these authors

Quinolone-resistant Salmonella typhi in Viet Nam: molecular basis of resistance and clinical response to treatment. Clin Infect Dis (1997) 4.53

Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals. Antimicrob Agents Chemother (1996) 4.15

Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. International Ascites Club. J Hepatol (2000) 3.43

Cloning, sequencing and analysis of the structural gene and regulatory region of the Pseudomonas aeruginosa chromosomal ampC beta-lactamase. Biochem J (1990) 3.20

A comparison of methods used for measuring the accumulation of quinolones by Enterobacteriaceae, Pseudomonas aeruginosa and Staphylococcus aureus. J Antimicrob Chemother (1991) 2.64

Mutations in gyrA gene of quinolone-resistant Salmonella serotypes isolated from humans and animals. Antimicrob Agents Chemother (1996) 2.64

In vitro activity of Ro 15-8074 and Ro 19-5247, two orally administered cephalosporin metabolites. Antimicrob Agents Chemother (1986) 2.45

Development of a standardized susceptibility test for campylobacter with quality-control ranges for ciprofloxacin, doxycycline, erythromycin, gentamicin, and meropenem. Microb Drug Resist (2004) 1.97

A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimurium. FEMS Microbiol Lett (1995) 1.90

Ciprofloxacin resistant Campylobacter spp. in humans: an epidemiological and laboratory study. J Antimicrob Chemother (1996) 1.69

Quinolone resistance in salmonella: clinical experience. Lancet (1990) 1.59

Quinolone/ureidopenicillin cross-resistance. Lancet (1987) 1.43

Adaptive mutations produce resistance to ciprofloxacin. Antimicrob Agents Chemother (1997) 1.37

The effect of imipenem on strains of Enterobacteriaceae expressing Richmond & Sykes class I beta-lactamases. J Antimicrob Chemother (1987) 1.31

The accumulation of five quinolone antibacterial agents by Escherichia coli. J Antimicrob Chemother (1990) 1.26

Fluoroquinolone resistance: overuse of fluoroquinolones in human and veterinary medicine can breed resistance. BMJ (1998) 1.23

The accumulation of five antibacterial agents in porin-deficient mutants of Escherichia coli. J Antimicrob Chemother (1993) 1.22

In vitro activity of CGP 31608, a new penem. Antimicrob Agents Chemother (1987) 1.21

Properties of the penicillin-binding proteins of four species of the genus Bacteroides. Antimicrob Agents Chemother (1986) 1.19

Two efflux systems expressed simultaneously in multidrug-resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother (2000) 1.18

Accumulation and killing kinetics of fifteen quinolones for Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. J Antimicrob Chemother (1993) 1.17

Quinolone resistance in veterinary isolates of Salmonella. J Antimicrob Chemother (1994) 1.16

The in-vitro activity of Ro 17-2301, a new monobactam, compared with other antimicrobial agents. J Antimicrob Chemother (1985) 1.16

In-vitro activity of quinolones and macrolides against mycobacteria. J Antimicrob Chemother (1994) 1.15

Interaction of divalent cations, quinolones and bacteria. J Antimicrob Chemother (1994) 1.05

Characterization of fluoroquinolone resistance among veterinary isolates of avian Escherichia coli. Antimicrob Agents Chemother (2000) 1.04

High-level quinolone resistance amongst clinical isolates of Escherichia coli and Klebsiella pneumoniae from Spain. J Antimicrob Chemother (1993) 1.03

Cefoxitin resistance in Bacteroides species: evidence indicating two mechanisms causing decreased susceptibility. J Antimicrob Chemother (1987) 0.99

The effect of mutations in the SOS response on the kinetics of quinolone killing. J Antimicrob Chemother (1989) 0.99

The effect of altered porin expression in Escherichia coli upon susceptibility to 4-quinolones. J Antimicrob Chemother (1986) 0.98

Quinolone resistance in Salmonella spp: veterinary pointers. Lancet (1990) 0.98

An investigation of the hydrophobicity of the quinolones. J Antimicrob Chemother (1985) 0.97

Quinolone resistance in Escherichia coli. Vet Res (2001) 0.97

Accumulation of rifampicin by Escherichia coli and Staphylococcus aureus. J Antimicrob Chemother (1998) 0.97

Newer mechanisms of resistance to beta-lactam antibiotics in gram-negative bacteria. J Antimicrob Chemother (1985) 0.96

Selection of quinolone-resistant mutants of Haemophilus influenzae and Streptococcus pneumoniae. J Antimicrob Chemother (1992) 0.95

Effect of carbon dioxide on testing of susceptibilities of respiratory tract pathogens to macrolide and azalide antimicrobial agents. Antimicrob Agents Chemother (1999) 0.93

The killing action of fleroxacin upon Bacteroides fragilis. J Antimicrob Chemother (1989) 0.93

Role of gyrA mutation and loss of OprF in the multiple antibiotic resistance phenotype of Pseudomonas aeruginosa G49. FEMS Microbiol Lett (1996) 0.89

The control of class I beta-lactamase expression in Enterobacteriaceae and Pseudomonas aeruginosa. J Antimicrob Chemother (1991) 0.87

Accumulation of norfloxacin by Bacteroides fragilis. Antimicrob Agents Chemother (2000) 0.86

In vitro studies of S-25930 and S-25932, two new 4-quinolones. Eur J Clin Microbiol (1986) 0.85

gyrA of ofloxacin-resistant clinical isolates of Mycobacterium tuberculosis from Hong Kong. J Antimicrob Chemother (1996) 0.84

Ciprofloxacin resistance in Salmonella serotypes. J Antimicrob Chemother (1990) 0.81

Nalidixic acid-resistant salmonellae. Vet Rec (1990) 0.79

Antibacterial efflux systems. Microbiologia (1997) 0.79

Induction of beta-lactamases in gram-negative bacilli. J Antimicrob Chemother (1987) 0.79

The antimicrobial activity of cefpirome, a new cephalosporin. J Antimicrob Chemother (1985) 0.79

Accumulation of norfloxacin by Mycobacterium aurum and Mycobacterium smegmatis. Antimicrob Agents Chemother (1998) 0.78

High-level quinolone resistance in Pseudomonas aeruginosa. J Antimicrob Chemother (1992) 0.77

Cross-resistance of nalidixic acid resistant Enterobacteriaceae to new quinolones and other antimicrobials. Eur J Clin Microbiol (1986) 0.76

Implications of quinolone resistance in veterinary isolates of salmonella. Vet Rec (1999) 0.75

The mode of action of Sch 34343: affinity for the penicillin binding proteins of Escherichia coli K-12 and Bacteroides fragilis. J Antimicrob Chemother (1985) 0.75

The PBPs of Bacteroides fragilis. J Antimicrob Chemother (1983) 0.75