Published in Control Clin Trials on April 01, 2001
A multiinstitutional phase 2 trial of pazopanib monotherapy in advanced anaplastic thyroid cancer. J Clin Endocrinol Metab (2012) 1.80
Early treatment of high risk chronic lymphocytic leukemia with alemtuzumab, rituximab and poly-(1-6)-beta-glucotriosyl-(1-3)- beta-glucopyranose beta-glucan is well tolerated and achieves high complete remission rates. Leuk Lymphoma (2015) 1.52
A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases. Clin Cancer Res (2013) 1.33
Phase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia. J Clin Oncol (2010) 1.18
Targeting MET and vascular endothelial growth factor receptor signaling in castration-resistant prostate cancer. Cancer J (2013) 1.09
A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas. Invest New Drugs (2008) 1.08
Optimal multistage designs for randomised clinical trials with continuous outcomes. Stat Med (2011) 1.03
Phase II study of bevacizumab in combination with sorafenib in recurrent glioblastoma (N0776): a north central cancer treatment group trial. Clin Cancer Res (2013) 0.92
A phase II study of cetuximab and radiation in elderly and/or poor performance status patients with locally advanced non-small-cell lung cancer (N0422). Ann Oncol (2010) 0.87
Dose-dense epirubicin and cyclophosphamide followed by docetaxel as adjuvant chemotherapy in node-positive breast cancer. Int J Breast Cancer (2013) 0.84
Point/counterpoint: randomized versus single-arm phase II clinical trials for patients with newly diagnosed glioblastoma. Neuro Oncol (2017) 0.82
Approaches to handling data when a phase II trial deviates from the pre-specified Simon's two-stage design. Stat Med (2008) 0.81
Gemcitabine and irinotecan as first-line therapy for carcinoma of unknown primary: results of a multicenter phase II trial. PLoS One (2012) 0.78
Denileukin diftitox in combination with rituximab for previously untreated follicular B-cell non-Hodgkin's lymphoma. Leukemia (2011) 0.77
Phase I/II Study of Temozolomide Plus Nimustine Chemotherapy for Recurrent Malignant Gliomas: Kyoto Neuro-oncology Group. Neurol Med Chir (Tokyo) (2016) 0.75
Randomized phase IIB evaluation of weekly paclitaxel versus weekly paclitaxel with oncolytic reovirus (Reolysin®) in recurrent ovarian, tubal, or peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol (2017) 0.75
A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med (2001) 7.59
Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers. J Natl Cancer Inst (1999) 3.46
Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors. Proc Natl Acad Sci U S A (2001) 2.77
Two different molecular organizations account for the single alpha-globin gene of the alpha-thalassemia-2 genotype. J Clin Invest (1980) 2.38
ICSH recommendations for the measurement of haemoglobin A2. Int J Lab Hematol (2011) 2.23
Genetic and clinical features of hemoglobin H disease in Chinese patients. N Engl J Med (2000) 2.07
A flexible design for multiple armed screening trials. Stat Med (2001) 1.90
Chemotherapy permits resection of metastatic colorectal cancer: experience from Intergroup N9741. Ann Oncol (2005) 1.67
The addition of continuous intravenous infusion of ketorolac to a patient-controlled analgetic morphine regime reduced postoperative myocardial ischemia in patients undergoing elective total hip or knee arthroplasty. Anesth Analg (1997) 1.52
Phase I study of the matrix metalloproteinase inhibitor, BAY 12-9566. Ann Oncol (2001) 1.52
A new strategy for prenatal diagnosis of homozygous alpha(0)-thalassemia. Ultrasound Obstet Gynecol (2006) 1.40
Phase II trial of irinotecan in patients with metastatic colorectal carcinoma. J Clin Oncol (1997) 1.31
Diagnostic accuracy of faecal immunochemical test for screening individuals with a family history of colorectal cancer. Aliment Pharmacol Ther (2013) 1.20
Randomized placebo-controlled evaluation of hydrazine sulfate in patients with advanced colorectal cancer. J Clin Oncol (1994) 1.18
Placebo-controlled trial of hydrazine sulfate in patients with newly diagnosed non-small-cell lung cancer. J Clin Oncol (1994) 1.18
Teaching residents how to teach: a one-year study. J Med Educ (1982) 1.16
Teaching in the clinical setting: factors influencing residents' perceptions, confidence and behaviour. Med Educ (1984) 1.14
An address-event vision sensor for multiple transient object detection. IEEE Trans Biomed Circuits Syst (2007) 1.13
Deep vein thrombosis and changes in coagulation and fibrinolysis after gynaecological operations in Chinese: the effect of oral contraceptives and malignant disease. Br J Haematol (1980) 1.11
Effect of environmental factors and gender on the heritability of bone mineral density and bone size. Ann Hum Genet (2006) 1.09
Evaluation of a prenatal screening procedure for beta-thalassaemia carriers in a Chinese population based on the mean corpuscular volume (MCV). Prenat Diagn (1985) 1.08
Transdermal clonidine for ameliorating post-orchiectomy hot flashes. J Urol (1994) 1.08
Interactions of phospholipid bilayer with chitosan: effect of molecular weight and pH. Biomacromolecules (2001) 1.06
Successful mismatched sibling cord blood transplant in Hb Bart's disease. Bone Marrow Transplant (2001) 1.04
Urinary thyroxine excretion as index of thyroid function. Lancet (1972) 1.03
Airway pressure triggered ventilation for preterm neonates. J Perinat Med (1991) 1.02
Familial lymphedema praecox: Meige's disease. Plast Reconstr Surg (1981) 1.01
Exercise test in muscle channelopathies and other muscle disorders. Muscle Nerve (2000) 1.01
Review article: colorectal cancer chemotherapy. Aliment Pharmacol Ther (2003) 1.00
Phase I and pharmacokinetic study of irinotecan and docetaxel in patients with advanced solid tumors: preliminary evidence of clinical activity. J Clin Oncol (2000) 1.00
Phase I dose-finding and pharmacokinetic trial of irinotecan hydrochloride (CPT-11) using a once-every-three-week dosing schedule for patients with advanced solid tumor malignancy. Clin Cancer Res (2000) 1.00
A double-blind comparison of ropivacaine 0.5%, 0.75%, 1.0% and bupivacaine 0.5%, injected epidurally, in patients undergoing abdominal hysterectomy. Can J Anaesth (1996) 1.00
Cost analysis of stapling versus suturing for skin closure. Am J Emerg Med (1995) 0.99
Regulation of peptide hormone receptors and gonadal steroidogenesis. Recent Prog Horm Res (1980) 0.99
Characterization of a new member of the TNF family expressed on antigen presenting cells. Biol Chem (1999) 0.99
Diabetes mellitus affects response to neoadjuvant chemoradiotherapy in the management of rectal cancer. Ann Surg Oncol (2008) 0.99
Synchronous intermittent mandatory ventilation modes compared with patient triggered ventilation during weaning. Arch Dis Child Fetal Neonatal Ed (1995) 0.97
Phase III evaluation of four doses of megestrol acetate as therapy for patients with cancer anorexia and/or cachexia. J Clin Oncol (1993) 0.93
A meta-analysis of two randomised trials of early chemotherapy in asymptomatic metastatic colorectal cancer. Br J Cancer (2005) 0.93
Incidence and evolution of oxaliplatin-induced peripheral sensory neuropathy in diabetic patients with colorectal cancer: a pooled analysis of three phase III studies. Ann Oncol (2009) 0.92
Huntington's disease in Hong Kong Chinese: epidemiology and clinical picture. Clin Exp Neurol (1994) 0.92
Sequence effect of irinotecan (CPT-11) and topoisomerase II inhibitors in vivo. Cancer Chemother Pharmacol (1998) 0.92
Consistent patterns of allelic loss in natural killer cell lymphoma. Am J Pathol (2000) 0.92
Effect of acute myocardial infarction on pituitary-testicular function. Clin Endocrinol (Oxf) (1978) 0.91
Homozygous alpha-thalassaemia: clinical presentation, diagnosis and management. A review of 46 cases. Br J Obstet Gynaecol (1985) 0.91
BamH I polymorphism in the Chinese: its potential usefulness in prenatal diagnosis of beta thalassaemia. Br Med J (Clin Res Ed) (1984) 0.91
Thyroid function in the neonate. Clin Endocrinol (Oxf) (1973) 0.90
Rapid reporting and review of an increased incidence of a known adverse event. J Natl Cancer Inst (2000) 0.89
Backboard versus mattress splint immobilization: a comparison of symptoms generated. J Emerg Med (1996) 0.89
Phase I and pharmacologic study of sequences of gemcitabine and the multitargeted antifolate agent in patients with advanced solid tumors. J Clin Oncol (2000) 0.89
Pituitary stone: two cases of densely calcified thyrotrophin-secreting pituitary adenomas. Clin Endocrinol (Oxf) (1994) 0.89
The effect of venous occlusion on antithrombin III, plasminogen activator and fibrinogen degradation product (fragment E) levels. Thromb Res (1979) 0.89
Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor. J Neurooncol (1996) 0.89
A multicentre trial of ropivacaine 7.5 mg x ml(-1) vs bupivacaine 5 mg x ml(-1) for supra clavicular brachial plexus anesthesia. Can J Anaesth (1999) 0.88
Gemcitabine and oxaliplatin for metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group phase II study. Ann Oncol (2003) 0.88
Positive end expiratory pressure in acute and chronic respiratory distress. Arch Dis Child (1992) 0.88
Direct inhibition of testicular function by gonadotropin-releasing hormone: mediation by specific gonadotropin-releasing hormone receptors in interstitial cells. Proc Natl Acad Sci U S A (1980) 0.87
Effect of surgical stress on pituitary-testicular function. Clin Endocrinol (Oxf) (1978) 0.87
Neuroendocrine differentiation is an independent prognostic factor in chemotherapy-treated nonsmall cell lung carcinoma. Cancer (1996) 0.86
Femoral nerve block and ketorolac in patients undergoing anterior cruciate ligament reconstruction. Can J Anaesth (1999) 0.86
Adverse cardiac outcomes after noncardiac surgery in patients with prior percutaneous transluminal coronary angioplasty. Anesth Analg (1999) 0.86
Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res (1999) 0.86
Urinary tri-iodothyronine excretion as index of thyroid function. Lancet (1972) 0.86
Comparison of two triiodothyronine uptake techniques for the assessment of thyroid function. J Clin Pathol (1972) 0.86
Hydrops fetalis due to an unusual form of Hb H disease. Blood (1985) 0.86
Pituitary-thyroid responses to surgical stress. Acta Endocrinol (Copenh) (1978) 0.86
Genetic analysis of adenovirus E1A: induction of genetic instability and altered cell morphologic and growth characteristics are segregatable functions. Mutat Res (1998) 0.85
Thyrotoxicosis: relations between clinical state and biochemical changes during carbimazole treatment. Br Med J (1977) 0.85
Characterization of factor VIII related protein synthesized by human endothelial cell: a study of structure and function. Thromb Haemost (1982) 0.85
Antithrombin III in fresh and cultured human endothelial cells: a natural anticoagulant from the vascular endothelium. Thromb Res (1979) 0.85
The identification and localization of antithrombin III in human tissues. Thromb Res (1979) 0.85
Report of a joint WHO/WFH meeting on the control of haemophilia: carrier detection and prenatal diagnosis. Blood Coagul Fibrinolysis (1993) 0.85
Gemcitabine and oxaliplatin for patients with advanced or metastatic pancreatic cancer: a North Central Cancer Treatment Group (NCCTG) phase I study. Ann Oncol (2002) 0.85
Haemophilia: strategies for carrier detection and prenatal diagnosis. Bull World Health Organ (1993) 0.84
Characteristics and distribution of beta thalassemia haplotypes in South China. Hum Genet (1986) 0.84
Comparison of helium dilution and nitrogen washout measurements of functional residual capacity in premature infants. Pediatr Pulmonol (1993) 0.84
Qualitative and quantitative magnetic resonance imaging in haemoglobin H disease: screening for iron overload. Clin Radiol (1999) 0.84
The determination of antithrombin III by radioimmunoassay and its clinical application. Br J Haematol (1979) 0.83
Phase II study of amonafide in patients with recurrent glioma. J Neurooncol (1995) 0.83
Effect of hyperthermia on the action of cis-diamminedichloroplatinum(II), rhodamine 123(2) [tetrachloroplatinum(II)], rhodamine 123, and potassium tetrachloroplatinate in vitro and in vivo. Cancer Res (1988) 0.83
Combination of three alpha-globin gene loci deletions and hemoglobin New York results in a severe hemoglobin H syndrome. Am J Hematol (1987) 0.83
Essential thrombocythemia with BCR/ABL rearrangement. Cancer Genet Cytogenet (1996) 0.82
Bioelectronic detection of point mutations using discrimination of the H63D polymorphism of the Hfe gene as a model. Mol Diagn (2000) 0.82
Antithrombin III, the major modulator of intravascular coagulation, is synthesized by human endothelial cells. Thromb Haemost (1981) 0.81
Effects of oestrogen on urinary thyrosine excretion. Br Med J (1972) 0.81
Ultrasonographic prediction of homozygous alpha0-thalassemia using placental thickness, fetal cardiothoracic ratio and middle cerebral artery Doppler: alone or in combination? Ultrasound Obstet Gynecol (2010) 0.81
A review of Hib epidemiology in Asia. Southeast Asian J Trop Med Public Health (2000) 0.81
Modeling complex disease with demographic and environmental covariates and a candidate gene marker. Genet Epidemiol (2001) 0.81
Divergent effects of prolactin on estrogen and progesterone production by granulosa cells of rat Graafian follicles. Endocrinology (1982) 0.81
Effect of heat on the cytotoxicity and interaction with DNA of a series of platinum complexes. Int J Radiat Oncol Biol Phys (1989) 0.80
Measurable or assessable disease in lung cancer trials: does it matter? J Clin Oncol (1994) 0.80
Antithrombin III and fibrinogen degradation product (fragment E) in diabetic nephropathy. J Clin Pathol (1982) 0.80
Psychosocial impact of Huntington's disease on Hong Kong Chinese families. Acta Psychiatr Scand (1994) 0.80
Organization of the zeta-alpha genes in Chinese. Br J Haematol (1986) 0.80
Pharmacokinetics of three doses of epidural ropivacaine during hysterectomy and comparison with bupivacaine. Can J Anaesth (1998) 0.80
Assessment of thyroid function during pregnancy. Br J Obstet Gynaecol (1975) 0.80
The effect of heroin addiction on pituitary-testicular function. Clin Endocrinol (Oxf) (1978) 0.80
Alpha-thalassaemia. Semin Fetal Neonatal Med (2008) 0.80
Alleviation of cancer anorexia and cachexia: studies of the Mayo Clinic and the North Central Cancer Treatment Group. Semin Oncol (1990) 0.80
Stability of thyroxine and triiodothyronine in biological fluids. J Clin Pathol (1975) 0.80