Published in Circulation on April 17, 2001
Drug-induced long QT syndrome. Pharmacol Rev (2010) 2.55
Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias. Heart Rhythm (2006) 2.03
Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice. J Clin Invest (2008) 2.02
Early afterdepolarizations and cardiac arrhythmias. Heart Rhythm (2010) 1.86
Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion. Cardiovasc Res (2009) 1.77
Clinical and genetic determinants of torsade de pointes risk. Circulation (2012) 1.67
Calcium oscillations and T-wave lability precede ventricular arrhythmias in acquired long QT type 2. Heart Rhythm (2010) 1.66
A multiscale investigation of repolarization variability and its role in cardiac arrhythmogenesis. Biophys J (2011) 1.62
Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis. Heart Rhythm (2011) 1.31
Determinants of beat-to-beat variability of repolarization duration in the canine ventricular myocyte: a computational analysis. PLoS Comput Biol (2013) 1.30
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing. Br J Pharmacol (2012) 1.26
Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve. Cardiovasc Res (2013) 1.23
A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes. Br J Pharmacol (2006) 1.21
Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk. Br J Pharmacol (2011) 1.12
Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility. J Mol Cell Cardiol (2010) 1.11
Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials. Br J Pharmacol (2013) 1.09
Evolution of strategies to improve preclinical cardiac safety testing. Nat Rev Drug Discov (2016) 1.01
Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts. Br J Pharmacol (2008) 0.97
Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias. Circulation (2011) 0.95
In vitro models of proarrhythmia. Br J Pharmacol (2008) 0.95
Population of computational rabbit-specific ventricular action potential models for investigating sources of variability in cellular repolarisation. PLoS One (2014) 0.95
Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents. Br J Pharmacol (2009) 0.95
No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block. Br J Pharmacol (2006) 0.93
Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model. Br J Pharmacol (2008) 0.93
Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential. Br J Pharmacol (2009) 0.92
Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation. Br J Pharmacol (2007) 0.92
Blockade of I(Ca) suppresses early afterdepolarizations and reduces transmural dispersion of repolarization in a whole heart model of chronic heart failure. Br J Pharmacol (2012) 0.92
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. Br J Pharmacol (2012) 0.91
Absolute beat-to-beat variability and instability parameters of ECG intervals: biomarkers for predicting ischaemia-induced ventricular fibrillation. Br J Pharmacol (2014) 0.90
Drug-induced proarrhythmia: risk factors and electrophysiological mechanisms. Nat Rev Cardiol (2015) 0.90
Relevance of anaesthesia for dofetilide-induced torsades de pointes in alpha1-adrenoceptor-stimulated rabbits. Br J Pharmacol (2007) 0.89
Effects of n-3 Polyunsaturated Fatty Acids on Cardiac Ion Channels. Front Physiol (2012) 0.87
International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes. Br J Pharmacol (2008) 0.87
The role of the Na+/Ca2+ exchanger, I(Na) and I(CaL) in the genesis of dofetilide-induced torsades de pointes in isolated, AV-blocked rabbit hearts. Br J Pharmacol (2009) 0.86
Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue. Basic Res Cardiol (2014) 0.85
Stem cells can form gap junctions with cardiac myocytes and exert pro-arrhythmic effects. Front Physiol (2014) 0.85
Slow delayed rectifier K+ current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles. Br J Pharmacol (2008) 0.85
Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram. J Physiol (2013) 0.85
In silico screening of the key cellular remodeling targets in chronic atrial fibrillation. PLoS Comput Biol (2014) 0.84
Emerging treatments in the management of schizophrenia - focus on sertindole. Drug Des Devel Ther (2010) 0.84
Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century. J Physiol (2016) 0.83
The anti-addiction drug ibogaine and the heart: a delicate relation. Molecules (2015) 0.83
Towards a better understanding of QT interval variability. Ther Adv Drug Saf (2011) 0.83
QT interval abnormalities: risk factors and perioperative management in long QT syndromes and Torsades de Pointes. J Anesth (2013) 0.83
In silico assessment of drug safety in human heart applied to late sodium current blockers. Channels (Austin) (2014) 0.81
Electrophysiological profile of propiverine--relationship to cardiac risk. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.81
Azithromycin, cardiovascular risks, QTc interval prolongation, torsade de pointes, and regulatory issues: A narrative review based on the study of case reports. Ther Adv Infect Dis (2013) 0.81
Decreasing the infusion rate reduces the proarrhythmic risk of NS-7: confirming the relevance of short-term variability of repolarisation in predicting drug-induced torsades de pointes. Br J Pharmacol (2005) 0.81
Leptin modulates electrophysiological characteristics and isoproterenol-induced arrhythmogenesis in atrial myocytes. J Biomed Sci (2013) 0.80
Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs. Br J Pharmacol (2008) 0.80
Voltage noise influences action potential duration in cardiac myocytes. Math Biosci (2006) 0.80
Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations. Br J Pharmacol (2015) 0.80
A new ECG biomarker for drug toxicity: a combined signal processing and computational modeling study. Conf Proc IEEE Eng Med Biol Soc (2010) 0.79
IKs protects from ventricular arrhythmia during cardiac ischemia and reperfusion in rabbits by preserving the repolarization reserve. PLoS One (2012) 0.79
Sex differences in the mechanisms underlying long QT syndrome. Am J Physiol Heart Circ Physiol (2014) 0.79
Biomarkers and endogenous determinants of dofetilide-induced torsades de pointes in α(1) -adrenoceptor-stimulated, anaesthetized rabbits. Br J Pharmacol (2010) 0.78
Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue. J Theor Biol (2014) 0.78
Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias. J Biol Chem (2012) 0.78
QT Adaptation and Intrinsic QT Variability in Congenital Long QT Syndrome. J Am Heart Assoc (2015) 0.78
Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization. Korean J Physiol Pharmacol (2015) 0.77
Regulation of intracellular Na(+) in health and disease: pathophysiological mechanisms and implications for treatment. Glob Cardiol Sci Pract (2013) 0.77
The virtual heart as a platform for screening drug cardiotoxicity. Br J Pharmacol (2015) 0.77
Oscillations of cardiac wave length and proarrhythmia. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.77
Pronounced effects of HERG-blockers E-4031 and erythromycin on APD, spatial APD dispersion and triangulation in transgenic long-QT type 1 rabbits. PLoS One (2014) 0.77
The high frequency relationship: implications for torsadogenic hERG blockers. Br J Pharmacol (2016) 0.76
Lysophosphatidic acid increases the electrophysiological instability of adult rabbit ventricular myocardium by augmenting L-type calcium current. PLoS One (2012) 0.76
A phenotypic in vitro model for the main determinants of human whole heart function. Biomaterials (2015) 0.76
A Novel Cardiotoxic Mechanism for a Pervasive Global Pollutant. Sci Rep (2017) 0.75
Dominant negative consequences of a hERG 1b-specific mutation associated with intrauterine fetal death. Prog Biophys Mol Biol (2016) 0.75
QRS-ST-T triangulation with repolarization shortening as a precursor of sustained ventricular tachycardia during acute myocardial ischemia. J Arrhythm (2014) 0.75
Mechano-electric feedback in the fish heart. PLoS One (2010) 0.75
The link between abnormal calcium handling and electrical instability in acquired long QT syndrome - Does calcium precipitate arrhythmic storms? Prog Biophys Mol Biol (2015) 0.75
Variability of Action Potentials Within and Among Cardiac Cell Clusters Derived from Human Embryonic Stem Cells. Sci Rep (2016) 0.75
Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus. Clin Med Insights Cardiol (2017) 0.75
Severe proarrhythmic potential of risperidone compared to quetiapine in an experimental whole-heart model of proarrhythmia. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.75
Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation. Pflugers Arch (2016) 0.75
Insulin-promoter-factor 1 is required for pancreas development in mice. Nature (1994) 10.13
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc Res (2003) 5.39
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature (2010) 4.52
Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells. J Mol Biol (1977) 4.31
Selective assay of monomeric and filamentous actin in cell extracts, using inhibition of deoxyribonuclease I. Cell (1978) 3.74
Roentgen stereophotogrammetric analysis as a predictor of mechanical loosening of knee prostheses. J Bone Joint Surg Br (1995) 3.00
Anti-actin specificity of human smooth muscle antibodies in chronic active hepatitis. Clin Exp Immunol (1976) 2.24
Reorganization of actin in platelets stimulated by thrombin as measured by the DNase I inhibition assay. Proc Natl Acad Sci U S A (1979) 2.02
Desmin is essential for the tensile strength and integrity of myofibrils but not for myogenic commitment, differentiation, and fusion of skeletal muscle. J Cell Biol (1997) 1.94
Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. J Clin Endocrinol Metab (1998) 1.89
Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry. Leukemia (2011) 1.79
Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations. Cardiovasc Res (1993) 1.78
Antiarrhythmic effects of potassium channel openers in rhythm abnormalities related to delayed repolarization. Circulation (1992) 1.73
Postoperative inflammatory response after autologous and allogeneic blood transfusion. Anesthesiology (1997) 1.67
The heparin-binding domain of extracellular superoxide dismutase C and formation of variants with reduced heparin affinity. J Biol Chem (1992) 1.55
Null mutation in the desmin gene gives rise to a cardiomyopathy. J Mol Cell Cardiol (1997) 1.44
Crystallization of a non-muscle actin. J Mol Biol (1976) 1.40
Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro. J Virol (2000) 1.38
Expression of the LIM-homeobox gene LH2 generates immortalized steel factor-dependent multipotent hematopoietic precursors. EMBO J (1998) 1.35
On the dynamics of the microfilament system in HeLa cells. J Cell Biol (1982) 1.34
Removal torques for polished and rough titanium implants. Int J Oral Maxillofac Implants (1988) 1.29
ADP-ribosylation of the Mr 83,000 stress-inducible and glucose-regulated protein in avian and mammalian cells: modulation by heat shock and glucose starvation. Proc Natl Acad Sci U S A (1983) 1.28
Hydroxyapatite coating versus cemented fixation of the tibial component in total knee arthroplasty: prospective randomized comparison of hydroxyapatite-coated and cemented tibial components with 5-year follow-up using radiostereometry. J Arthroplasty (1999) 1.27
QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions. J Cardiovasc Pharmacol (1990) 1.22
alpha-Actinin promotes polymerization of actin from profilactin. Eur J Biochem (1980) 1.18
Increased expression of aquaporin 3 in atopic eczema. Allergy (2006) 1.16
Pulsatile intravenous growth hormone (GH) infusion to hypophysectomized rats increases insulin-like growth factor I messenger ribonucleic acid in skeletal tissues more effectively than continuous GH infusion. Endocrinology (1988) 1.10
Gender disparity in cardiac electrophysiology: implications for cardiac safety pharmacology. Pharmacol Ther (2010) 1.08
V-region directed selection in differentiating B lymphocytes. EMBO J (1993) 1.07
Differential effects of growth hormone and insulin-like growth factor I on colony formation of epiphyseal chondrocytes in suspension culture in rats of different ages. Endocrinology (1987) 1.04
A monoclonal antibody-enzyme immunoassay for serum carcinoembryonic antigen with increased specificity for carcinomas. Proc Natl Acad Sci U S A (1983) 1.02
Quantitative sequence-activity models (QSAM)--tools for sequence design. Nucleic Acids Res (1993) 1.02
A gene family encoding heterogeneous histone H1 proteins in Trypanosoma cruzi. Mol Biochem Parasitol (1994) 1.00
Interferon-alpha promotes survival of human primary B-lymphocytes via phosphatidylinositol 3-kinase. Biochem Biophys Res Commun (2001) 0.99
Establishment and functional implications of B-cell connectivity. Immunol Rev (1989) 0.99
A potential role of R-cadherin in striated muscle formation. Dev Biol (1997) 0.98
DPP-IV inhibition enhances the antilipolytic action of NPY in human adipose tissue. Diabetes Obes Metab (2009) 0.98
Birth weight, adulthood BMI, and subsequent weight gain in relation to leptin levels in Swedish women. Obes Res (1999) 0.98
Osseointegration of titanium implants. Acta Orthop Scand (1986) 0.97
Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential? J Pharmacol Exp Ther (1997) 0.96
Actin filament formation in pancreatic beta-cells during glucose stimulation of insulin secretion. FEBS Lett (1980) 0.96
Measuring fit at the implant prosthodontic interface. J Prosthet Dent (1996) 0.95
Tibial component fixation in porous- and hydroxyapatite-coated total knee arthroplasty: a radiostereo metric evaluation of migration and inducible displacement after 5 years. J Arthroplasty (2000) 0.95
In vivo kinematics of total knee arthroplasty: flat compared with concave tibial joint surface. J Orthop Res (2000) 0.94
Subsidence of a non-polished stem in revisions of the hip using impaction allograft. Evaluation with radiostereometry and dual-energy X-ray absorptiometry. J Bone Joint Surg Br (1999) 0.94
The response of molecular isoforms of growth hormone to acute exercise in trained adult males. J Clin Endocrinol Metab (2001) 0.93
A network-based analysis of allergen-challenged CD4+ T cells from patients with allergic rhinitis. Genes Immun (2006) 0.93
Multipotent hematopoietic progenitor cells immortalized by Lhx2 self-renew by a cell nonautonomous mechanism. Exp Hematol (2001) 0.93
Core temperature measured in the auricular canal: comparison between four different tympanic thermometers. Acta Anaesthesiol Scand (1992) 0.93
Loads and designs of screw joints for single crowns supported by osseointegrated implants. Int J Oral Maxillofac Implants (1992) 0.92
The unpolymerised form of actin in non-muscle cells. Methods Achiev Exp Pathol (1979) 0.92
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. Br J Pharmacol (2012) 0.91
Distribution of the collateral blood flow at the lateral border of the ischemic myocardium after acute coronary occlusion in the pig and the dog. Basic Res Cardiol (1984) 0.90
Biomechanical characterization of osseointegration: an experimental in vivo investigation in the beagle dog. J Orthop Res (1998) 0.90
Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry: results of an international survey. Cardiovasc Res (2001) 0.89
Fluconazole therapy for fungal peritonitis in continuous ambulatory peritoneal dialysis (CAPD): a case report. Perit Dial Int (1989) 0.89
Well-informed patients with end-stage renal disease prefer peritoneal dialysis to hemodialysis. Perit Dial Int (1993) 0.88
Release of noradrenaline in myocardial ischemia--importance of local inactivation by neuronal and extraneuronal mechanisms. J Cardiovasc Pharmacol (1986) 0.88
Electrophysiological and inotropic effects of H 234/09 (almokalant) in vitro: a comparison with two other novel IK blocking drugs, UK-68,798 (dofetilide) and E-4031. Cardiovasc Res (1993) 0.87
Increased perioperative risk following repair of congenital heart disease in Down's syndrome. Anesthesiology (1986) 0.86
Plasma growth hormone pattern regulates epidermal growth factor (EGF) receptor messenger ribonucleic acid levels and EGF binding in the rat liver. Endocrinology (1989) 0.85
Local release of myocardial norepinephrine during acute ischemia: an experimental study in the isolated perfused rat heart. J Cardiovasc Pharmacol (1985) 0.85
Ceramic coating improves tibial component fixation in total knee arthroplasty. J Arthroplasty (1998) 0.84
Autoantibodies to prostasomes as new markers for prostate cancer. Ups J Med Sci (2001) 0.84
Low growth hormone secretion in patients with fibromyalgia--a preliminary report on 10 patients and 10 controls. J Rheumatol (1998) 0.84
Morphometrical studies of human femoral condyles. J Biomed Eng (1989) 0.83
Growth hormone (GH) assays: influence of standard preparations, GH isoforms, assay characteristics, and GH-binding protein. Clin Chem (1997) 0.83
Recombinant human erythropoietin in preoperative autologous blood donation did not influence the haemoglobin recovery after surgery. Acta Anaesthesiol Scand (2003) 0.83
Osseointegrated knee prostheses. An experimental study in rabbits. Scand J Plast Reconstr Surg Hand Surg (1989) 0.82
In vivo load measurements on osseointegrated implants supporting fixed or removable prostheses: a comparative pilot study. Int J Oral Maxillofac Implants (1991) 0.82
Individually tailored treatment with epirubicin and paclitaxel with or without capecitabine as first-line chemotherapy in metastatic breast cancer: a randomized multicenter trial. Breast Cancer Res Treat (2011) 0.82
Pegylated liposomal doxorubicin as first-line monotherapy in elderly women with locally advanced or metastatic breast cancer: novel treatment predictive factors identified. Cancer Lett (2011) 0.82
Coronary collateral blood flow in acute myocardial ischemia is not increased by dihydropyridine-induced coronary vasodilatation. J Cardiovasc Pharmacol (1985) 0.82
Potassium and calcium current blocking properties of the novel antiarrhythmic agent H 345/52: implications for proarrhythmic potential. Cardiovasc Res (2001) 0.81
Identification of dipeptidyl peptidase IV as the antigen of a monoclonal anti-prostasome antibody. Prostate (1999) 0.81
DNA microarrays to study gene expression in allergic airways. Clin Exp Allergy (2002) 0.81
Identification of a fetal hematopoietic precursor with B cell, T cell, and macrophage potential. Immunity (1998) 0.81
Genes for histone H3 in Trypanosoma cruzi. Mol Biochem Parasitol (1994) 0.81
Growth hormone insensitivity associated with elevated circulating growth hormone-binding protein in children with Alagille syndrome and short stature. J Clin Endocrinol Metab (1993) 0.81
Greater increase in cytokine concentration after salvage with filtered whole blood than with washed red cells, but no difference in postoperative hemoglobin recovery. Transfusion (1999) 0.81
Nutritional rehabilitation in Bangladesh--the importance of zinc. Am J Clin Nutr (1988) 0.81
(+)-sotalol causes significant occupation of beta-adrenoceptors at concentrations that prolong cardiac repolarization. Naunyn Schmiedebergs Arch Pharmacol (1990) 0.80
Colchicine treatment of HeLa cells alters the G/F actin ratio. FEBS Lett (1981) 0.80
Cardioprotective effects of recombinant human extracellular-superoxide dismutase type C in rat isolated heart subjected to ischemia and reperfusion. J Cardiovasc Pharmacol (1991) 0.80
Attenuation of proarrhythmias related to delayed repolarization by low-dose lidocaine in the anesthetized rabbit. J Pharmacol Exp Ther (1993) 0.79
Angiogenic factors in relation to clinical effect in a phase II trial of weekly paclitaxel. Breast (2013) 0.79
Micromotion of a noncemented tibial component with screw fixation. An in vivo roentgen stereophotogrammetric study of the Miller-Galante prosthesis. Clin Orthop Relat Res (1993) 0.79
Eosinophilic inflammation assessed by induced sputum in corticosteroid-dependent asthma. Respir Med (1999) 0.79
Prostasome-like granules from the PC-3 prostate cancer cell line increase the motility of washed human spermatozoa and adhere to the sperm. Eur J Obstet Gynecol Reprod Biol (2001) 0.79
Influence of joint area design on tibial component migration: comparison among a fixed symmetrical, asymmetrical, and moveable bearing. J Knee Surg (2007) 0.79
Mechanisms of local noradrenaline release in acute myocardial ischemia. Acta Physiol Scand Suppl (1987) 0.78
Cemented versus hydroxyapatite fixation of the femoral component of the Freeman-Samuelson total knee replacement: a radiostereometric analysis. J Bone Joint Surg Br (2007) 0.78
Female gender does not influence the magnitude of ibutilide-induced repolarization delay and incidence of torsades de pointes in an in vivo rabbit model of the acquired long QT syndrome. J Cardiovasc Pharmacol Ther (2001) 0.78
Two proteins involved in kinetoplast compaction. FEBS Lett (1993) 0.78
Pulsatile growth hormone secretory pattern: autofeedback regulation and effects on growth factors. Acta Paediatr Scand Suppl (1990) 0.78
Treatment of a Class II Division 1 malocclusion with macrodontia of the maxillary central incisors. Am J Orthod Dentofacial Orthop (2001) 0.78
Induction of rhythm abnormalities in the fetal rat heart. A tentative mechanism for the embryotoxic effect of the class III antiarrhythmic agent almokalant. Cardiovasc Res (1994) 0.78
Breast milk zinc and copper concentrations in Bangladesh. Br J Nutr (1990) 0.78