Published in J Cardiovasc Pharmacol on August 01, 1990
Drug-induced long QT syndrome. Pharmacol Rev (2010) 2.55
Drug-induced torsades de pointes and implications for drug development. J Cardiovasc Electrophysiol (2004) 2.05
Electrophysiologic basis for the antiarrhythmic actions of ranolazine. Heart Rhythm (2011) 2.02
Genetics of acquired long QT syndrome. J Clin Invest (2005) 1.96
Effects of MS-551, a new class III antiarrhythmic drug, on action potential and membrane currents in rabbit ventricular myocytes. Br J Pharmacol (1993) 1.13
Combined pharmacological block of I(Kr) and I(Ks) increases short-term QT interval variability and provokes torsades de pointes. Br J Pharmacol (2007) 1.11
Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes. Br J Pharmacol (2002) 1.05
Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts. Br J Pharmacol (2008) 0.97
Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model. Br J Pharmacol (2008) 0.93
Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967. Heart Rhythm (2013) 0.92
Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation. Br J Pharmacol (2007) 0.92
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. Br J Pharmacol (2012) 0.91
Use-dependent block of the delayed K+ current in rabbit ventricular myocytes. Cardiovasc Drugs Ther (1993) 0.89
Relevance of anaesthesia for dofetilide-induced torsades de pointes in alpha1-adrenoceptor-stimulated rabbits. Br J Pharmacol (2007) 0.89
Selective IK blockade as an antiarrhythmic mechanism: effects of UK66,914 on ischaemia and reperfusion arrhythmias in rat and rabbit hearts. Br J Pharmacol (1993) 0.86
Long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H1 blocker terfenadine-induced torsades de pointes arrhythmias. Br J Pharmacol (2006) 0.86
Literature-based evaluation of four 'hard endpoint' models for assessing drug-induced torsades de pointes liability. Br J Pharmacol (2008) 0.82
Electropharmacological effects of berberine on canine cardiac Purkinje fibres and ventricular muscle and atrial muscle of the rabbit. Br J Pharmacol (1993) 0.81
Pharmacological characteristics and clinical applications of K201. Curr Clin Pharmacol (2009) 0.81
Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs. Br J Pharmacol (2008) 0.80
Biomarkers and endogenous determinants of dofetilide-induced torsades de pointes in α(1) -adrenoceptor-stimulated, anaesthetized rabbits. Br J Pharmacol (2010) 0.78
Assessment of proarrhythmic activity of chloroquine in in vivo and ex vivo rabbit models. J Pharmacol Pharmacother (2013) 0.75
Diclofenac prolongs repolarization in ventricular muscle with impaired repolarization reserve. PLoS One (2012) 0.75
Unremodelled and Bradycardic Heart of the Anaesthetized Rabbit Is Applicable for Detection of Drug-induced Torsades de Pointes Arrhythmias. Br J Pharmacol (2017) 0.75
Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic. Circulation (2001) 2.11
Selective Ik blocker almokalant exhibits class III--specific effects on the repolarization and refractoriness of the human heart: a study of healthy volunteers using right ventricular monophasic action potential recordings. J Cardiovasc Pharmacol (1995) 1.93
Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations. Cardiovasc Res (1993) 1.78
Antiarrhythmic effects of potassium channel openers in rhythm abnormalities related to delayed repolarization. Circulation (1992) 1.73
Gender disparity in cardiac electrophysiology: implications for cardiac safety pharmacology. Pharmacol Ther (2010) 1.08
Effect of ischaemic on the adrenergic neurons of the rat heart: a fluorescence histochemical and biochemical study. Cardiovasc Res (1981) 0.97
Cellular localization of monoamine oxidase in rat salivary glands. Acta Physiol Scand (1966) 0.97
Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential? J Pharmacol Exp Ther (1997) 0.96
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. Br J Pharmacol (2012) 0.91
Distribution of the collateral blood flow at the lateral border of the ischemic myocardium after acute coronary occlusion in the pig and the dog. Basic Res Cardiol (1984) 0.90
Release of noradrenaline in myocardial ischemia--importance of local inactivation by neuronal and extraneuronal mechanisms. J Cardiovasc Pharmacol (1986) 0.88
Electrophysiological and inotropic effects of H 234/09 (almokalant) in vitro: a comparison with two other novel IK blocking drugs, UK-68,798 (dofetilide) and E-4031. Cardiovasc Res (1993) 0.87
Increased perioperative risk following repair of congenital heart disease in Down's syndrome. Anesthesiology (1986) 0.86
Local release of myocardial norepinephrine during acute ischemia: an experimental study in the isolated perfused rat heart. J Cardiovasc Pharmacol (1985) 0.85
Effects of ganglionic blockade on noradrenaline release and cell injury in the acutely ischemic rat myocardium. J Cardiovasc Pharmacol (1982) 0.85
Local noradrenaline release in acute myocardial ischemia: influence of catecholamine synthesis inhibition and beta-adrenoceptor blockade on ischemic injury. J Cardiovasc Pharmacol (1981) 0.83
Coronary collateral blood flow in acute myocardial ischemia is not increased by dihydropyridine-induced coronary vasodilatation. J Cardiovasc Pharmacol (1985) 0.82
Potassium and calcium current blocking properties of the novel antiarrhythmic agent H 345/52: implications for proarrhythmic potential. Cardiovasc Res (2001) 0.81
Adrenergic innervation of coronary arteries and ventricular myocardium in the pig: fluorescence microscopic appearance in the normal state and after ischemia. Basic Res Cardiol (1985) 0.81
The occurrence and functional significance of dopamine in some peripheral adrenergic nerves of the rat. Naunyn Schmiedebergs Arch Pharmacol (1973) 0.81
(+)-sotalol causes significant occupation of beta-adrenoceptors at concentrations that prolong cardiac repolarization. Naunyn Schmiedebergs Arch Pharmacol (1990) 0.80
Attenuation of proarrhythmias related to delayed repolarization by low-dose lidocaine in the anesthetized rabbit. J Pharmacol Exp Ther (1993) 0.79
On the disposition of [3H]metaraminol in the rat salivary gland. J Pharm Pharmacol (1967) 0.79
Release of 3H-metaraminol by adrenergic nerve stimulation in reserpine-treated rats. Eur J Pharmacol (1970) 0.79
Degeneration secretion and noradrenaline disappearance in rat salivary glands following proximal or distal axotomy. Acta Physiol Scand (1976) 0.79
Effects of gonadectomy and hormone replacement on brain monoamine synthesis in male rats. Pharmacol Biochem Behav (1979) 0.79
Relative importance of neuronal and extraneuronal mechanisms for the uptake and retention of noradrenaline in different tissues of the rat. Naunyn Schmiedebergs Arch Pharmakol (1971) 0.78
Effects of metoprolol on adrenergic mechanisms during long- and short-term antihypertensive treatment of spontaneously hypertensive rats. Acta Med Scand Suppl (1979) 0.78
Rhythm anomalies related to delayed repolarization in vivo: influence of sarcolemmal Ca++ entry and intracellular Ca++ overload. J Pharmacol Exp Ther (1996) 0.78
Induction of rhythm abnormalities in the fetal rat heart. A tentative mechanism for the embryotoxic effect of the class III antiarrhythmic agent almokalant. Cardiovasc Res (1994) 0.78
Prolonged action potential duration and positive inotropy induced by the novel class III antiarrhythmic agent H 234/09 (Almokalant) in isolated human ventricular muscle. J Cardiovasc Pharmacol (1991) 0.78
Ischemia-induced local release of myocardial noradrenaline. J Cardiovasc Pharmacol (1985) 0.78
Lidocaine and nisoldipine attenuate almokalant-induced dispersion of repolarization and early afterdepolarizations in vitro. J Cardiovasc Electrophysiol (1996) 0.78
Effects of intracoronary nifedipine on blood flow and segment shortening in normal and ischemic myocardium: potentiation by ischemia of the negative inotropic effect. J Cardiovasc Pharmacol (1985) 0.78
Torsades de pointes with Almokalant, a new class III antiarrhythmic drug. Am Heart J (1993) 0.78
Functional significance of synthesis of noradrenaline in adrenergic nerves of rat salivary glands. J Pharm Pharmacol (1974) 0.77
Reduced adrenal amine synthesis in spontaneously hypertensive rats after long-term treatment with propranolol. Br J Pharmacol (1977) 0.77
Beta-adrenoceptor agonists do not cause tremor in the conscious rat. Acta Physiol Scand (1985) 0.77
Increased brain serotonergic and noradrenergic activity after repeated systemic administration of the beta-2 adrenoceptor agonist salbutamol, a putative antidepressant drug. Psychopharmacology (Berl) (1981) 0.76
alpha- and beta-adrenoreceptor-mediated control of brain noradrenaline neurons and antihypertensive therapy. Clin Sci (Lond) (1980) 0.75
Effects of nifedipine on collateral blood flow at the lateral border of the acutely ischemic myocardium. Basic Res Cardiol (1987) 0.75
Wash-out of noradrenaline and its metabolites by calcium-free reperfusion after ischaemia: support for the concept of ischaemia-induced noradrenaline release. Br J Pharmacol (1984) 0.75
Effects of induced hypothermia on organ blood flow in a hibernator and a nonhibernator. Cryobiology (1986) 0.75
Recovery of dopamine in peripheral adrenergic nerves after reserpine treatment. Naunyn Schmiedebergs Arch Pharmacol (1976) 0.75
The influence of noradrenaline synthesis inhibition on the disposition of 3 H-metaraminol in peripheral adrenergic nerves. Acta Physiol Scand (1971) 0.75
Correlation of the recovery of the granular uptake-storage mechanism and the nerve impulse induced release of ( 3 H)noradrenaline after reserpine. J Pharm Pharmacol (1971) 0.75
Reduced brain serotonergic activity after repeated treatment with beta-adrenoceptor antagonists. Psychopharmacology (Berl) (1982) 0.75
The effect of corticosterone on extraneuronal amine uptake and effector response in rat salivary glands. J Pharm Pharmacol (1973) 0.75
Ischaemia-induced release of noradrenaline and creatine kinase in the isolated, working rat heart. Acta Physiol Scand (1987) 0.75
The effect of protriptyline on uptake and retention of dl-3H-noradrenaline in different tissues of the rat. Acta Physiol Scand (1971) 0.75
Recording of monophasic action potentials in the horizontally perfused guinea pig heart. An in vitro method to study drug-induced changes in cardiac electrophysiology. J Pharmacol Methods (1987) 0.75
Electrophysiologic and hemodynamic effects of H 234/09 (almokalant), quinidine, and (+)-sotalol in the anesthetized dog. J Cardiovasc Pharmacol (1992) 0.75
Modulation of oxotremorine-induced tremor by central beta-adrenoceptors. Acta Physiol Scand (1987) 0.75
Effects of adrenergic beta-blockers and a membrane stabilizing agent on ouabain-induced cardiac arrhythmias in anaesthetized guinea pigs. Acta Pharmacol Toxicol (Copenh) (1979) 0.75
On the role of the adrenergic receptors for extraneuronal amine uptake and retention in rat salivary glands in vitro. Naunyn Schmiedebergs Arch Pharmacol (1974) 0.75
The effect of protriptyline on the disappearance and nerve impulse induced release of labelled metaraminol in the rat. Acta Physiol Scand (1971) 0.75
Uptake and retention of 14C-bretylium in degenerating postganglionic sympathetic nerves of the rat. Acta Pharmacol Toxicol (Copenh) (1976) 0.75
Effects of propranolol on the locomotor stimulation induced by activation of postsynaptic catecholamine receptors. Psychopharmacology (Berl) (1981) 0.75
Computerized evaluation of drug-induced changes in guinea-pig epicardial monophasic action potentials. Pharmacol Toxicol (1988) 0.75
The influence of nerve impulses on the subcellular distribution of metaraminol. Acta Pharmacol Toxicol (Copenh) (1967) 0.75
Ischemia-induced noradrenaline release in the isolated rat heart: influence of perfusion substrate and duration of ischemia. J Mol Cell Cardiol (1983) 0.75
Effects of felodipine, a new dihydropyridine vasodilator, on regional myocardial blood flow during acute coronary occlusion in the pig. J Cardiovasc Pharmacol (1983) 0.75
Functional significance of neuronal and extraneuronal transmitter uptake in rat salivary glands. The effect of protriptyline and normetanephrine. Naunyn Schmiedebergs Arch Pharmacol (1974) 0.75
Release of 3H-metaraminol from subcellular fractions of rat salivary glands by nerve stimulation. Eur J Pharmacol (1969) 0.75
Antiarrhythmic effect of reducing myocardial noradrenaline stores with alpha-methyl-meta-tyrosine. J Cardiovasc Pharmacol (1985) 0.75
Reduced brain monoamine synthesis by systemic treatment with terbutaline, a beta 2-receptor agonist. J Neural Transm (1980) 0.75
Reduced variation of [3H]noradrenaline uptake into rat submaxillary glands by atropine pretreatment. J Pharm Pharmacol (1970) 0.75
Electropharmacologic effects and pharmacokinetics of almokalant, a new class III antiarrhythmic, in patients with healed or healing myocardial infarcts and complex ventricular arrhythmias. Am J Cardiol (1992) 0.75
Assessment of frequency dependency of the class III effects of almokalant: a study using programmed stimulation and recording of monophasic action potentials and ventricular paced QT intervals. Cardiovasc Drugs Ther (1996) 0.75
[The DA240-4 discrete biochemical autoanalyser]. Med Tekh (1980) 0.75
Neuronal and extraneuronal uptake of 3H-noradrenaline in rat portal vein in vitro. Acta Physiol Scand (1981) 0.75
Influence of synthesis and membrane pump inhibition on the nerve impulse induced disappearance of noradrenaline from rat salivary glands. Acta Physiol Scand (1971) 0.75
Tolerance and effects of almokalant, a new selective Ik blocking agent, on ventricular repolarization and on sino-atrial and atrioventricular nodal function in the heart: a study in healthy, male volunteers utilizing transesophageal atrial stimulation. J Cardiovasc Pharmacol (1995) 0.75