Published in Bioconjug Chem on April 23, 2001
The comparative efficacy and safety of peginterferon alpha-2a vs. 2b for the treatment of chronic HCV infection: a meta-analysis. Hepat Mon (2010) 1.57
Poly(ethylene glycol) hydrogels formed by thiol-ene photopolymerization for enzyme-responsive protein delivery. Biomaterials (2009) 1.56
Protein- and peptide-modified synthetic polymeric biomaterials. Biopolymers (2010) 1.26
Sortase-catalyzed transformations that improve the properties of cytokines. Proc Natl Acad Sci U S A (2011) 1.21
Biodegradable nanogels for oral delivery of interferon for norovirus infection. Antiviral Res (2010) 1.14
Peginterferon and ribavirin treatment for hepatitis C virus infection. World J Gastroenterol (2011) 1.10
Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications. J Drug Deliv (2012) 1.10
Pegylated interferons alpha2a and alpha2b in the treatment of chronic hepatitis C. Nat Rev Gastroenterol Hepatol (2010) 1.08
Pegylated interferon alpha-associated optic neuropathy. J Neuroophthalmol (2010) 1.06
Polymeric conjugates for drug delivery. Chem Mater (2012) 1.06
Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity. Endocrinology (2009) 1.04
HBV life cycle and novel drug targets. Hepatol Int (2011) 1.03
Sustained response to peginterferon alfa-2a (40 kD) with or without lamivudine in Asian patients with HBeAg-positive and HBeAg-negative chronic hepatitis B. Hepatol Int (2008) 1.01
Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin. BMC Biotechnol (2008) 0.97
Synthesis and in vivo pharmacokinetic evaluation of degradable shell cross-linked polymer nanoparticles with poly(carboxybetaine) versus poly(ethylene glycol) surface-grafted coatings. ACS Nano (2012) 0.97
PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins. Protein Eng Des Sel (2013) 0.97
Engineered nanomaterial uptake and tissue distribution: from cell to organism. Int J Nanomedicine (2013) 0.95
Site-specific PEGylation of engineered cysteine analogues of recombinant human granulocyte-macrophage colony-stimulating factor. Bioconjug Chem (2005) 0.94
Influence of the chemistry of conjugation of poly(ethylene glycol) to Hb on the oxygen-binding and solution properties of the PEG-Hb conjugate. Biochem J (2005) 0.92
A long-acting, mono-PEGylated human growth hormone analog is a potent stimulator of weight gain and bone growth in hypophysectomized rats. Endocrinology (2007) 0.90
PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity. J Control Release (2009) 0.88
Cell-penetrating peptides meditated encapsulation of protein therapeutics into intact red blood cells and its application. J Control Release (2013) 0.87
Effects of a 24-week course of interferon-alpha therapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma. World J Gastroenterol (2007) 0.87
Automated solid-phase peptide synthesis to obtain therapeutic peptides. Beilstein J Org Chem (2014) 0.86
Contrast-enhanced MRI-guided photodynamic cancer therapy with a pegylated bifunctional polymer conjugate. Pharm Res (2008) 0.85
Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity. Br J Pharmacol (2011) 0.84
Design, modeling, expression, and chemoselective PEGylation of a new nanosize cysteine analog of erythropoietin. Int J Nanomedicine (2011) 0.84
Design of homogeneous, monopegylated erythropoietin analogs with preserved in vitro bioactivity. Exp Hematol (2006) 0.84
Drug delivery: Relieving PEGylation. Nat Chem (2011) 0.83
Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors. Health Phys (2014) 0.81
A new direction for anticoagulants: inhibiting fibrin assembly with PEGylated fibrin knob mimics. Biotechnol Bioeng (2011) 0.81
Combination therapy with PEG-IFN-alpha and 5-FU inhibits HepG2 tumour cell growth in nude mice by apoptosis of p53. Br J Cancer (2007) 0.81
Pegylated interferon-α2a inhibits proliferation of human liver cancer cells in vitro and in vivo. PLoS One (2013) 0.80
Pharmacokinetics and pharmacodynamics of peginterferon and ribavirin: implications for clinical efficacy in the treatment of chronic hepatitis C. Gastroenterol Clin North Am (2010) 0.79
The role of consensus interferon in the current treatment of chronic hepatitis C viral infection. Gastroenterol Hepatol (N Y) (2008) 0.79
Long-term effects of peginterferon alfa-2a therapy in Japanese patients with chronic hepatitis B virus infection. Virol J (2015) 0.79
PEGylated G-CSF (BBT-015), GM-CSF (BBT-007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the hematopoietic syndrome of the acute radiation syndrome. Health Phys (2014) 0.79
Site-specific PEGylation enhances the pharmacokinetic properties and antitumor activity of interferon beta-1b. J Interferon Cytokine Res (2013) 0.79
Noninvasive detection of passively targeted poly(ethylene glycol) nanocarriers in tumors. Mol Pharm (2011) 0.78
Multimeric peptide-based PEG nanocarriers with programmable elimination properties. Biomaterials (2009) 0.78
Recent developments in protein and peptide parenteral delivery approaches. Ther Deliv (2014) 0.78
A multiple-dose pharmacokinetics of polyethylene glycol recombinant human interleukin-6 (PEG-rhIL-6) in rats. J Zhejiang Univ Sci B (2011) 0.78
Nanomedicines in the treatment of chronic hepatitis C--focus on pegylated interferon alpha-2a. Int J Nanomedicine (2007) 0.77
PEGylation to Improve Protein Stability During Melt Processing. Macromol Biosci (2015) 0.77
Clinical significance of 4 patients with chronic hepatitis B achieving HBsAg clearance by treated with pegylated interferon alpha-2a for less than 1 year: a short report. Virol J (2009) 0.77
Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment. J Bone Miner Res (2016) 0.76
Drug development: Longer-lived proteins. Nature (2010) 0.76
Bioimaging of Hyaluronate-Interferon α Conjugates Using a Non-Interfering Zwitterionic Fluorophore. Biomacromolecules (2015) 0.76
HBV and HCV therapy. Viruses (2009) 0.76
Development of novel drug delivery systems using phage display technology for clinical application of protein drugs. Proc Jpn Acad Ser B Phys Biol Sci (2016) 0.75
Development of a novel DDS for site-specific PEGylated proteins. Chem Cent J (2011) 0.75
Preferential Interactions and the Effect of Protein PEGylation. PLoS One (2015) 0.75
A Bayesian Approach for Population Pharmacokinetic Modeling of Pegylated Interferon α-2a in Hepatitis C Patients. Clin Pharmacokinet (2017) 0.75
Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex. J Exp Med (1975) 7.64
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell (2001) 5.19
Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology (1995) 4.93
Driving avoidance and functional impairment in older drivers. Accid Anal Prev (1998) 2.83
cisRED: a database system for genome-scale computational discovery of regulatory elements. Nucleic Acids Res (2006) 2.75
The effects of diabetes on the risks of major cardiovascular diseases and death in the Asia-Pacific region. Diabetes Care (2003) 2.36
Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology (2001) 2.27
Thymectomy for myasthenia gravis: recent observations and comparisons with past experience. Ann Thorac Surg (1989) 2.24
The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump. J Bacteriol (1997) 2.12
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Proc Natl Acad Sci U S A (2000) 2.11
Pandemic dengue in Caribbean countries and the southern United States--past, present and potential problems. N Engl J Med (1971) 1.98
Observations on the etiology of ulcerative colitis: III. The distribution of lesions and its possible significance. Am J Pathol (1939) 1.90
Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR. Genes Immun (2003) 1.88
Tuberculosis of the oesophagus. Thorax (1969) 1.84
Detection of coronary artery disease by magnetic resonance myocardial perfusion imaging with various contrast medium doses: first European multi-centre experience. Eur Heart J (2004) 1.76
HLA gene and haplotype frequencies in the North American population: the National Marrow Donor Program Donor Registry. Transplantation (1997) 1.71
Secondary preventive medication persistence and adherence 1 year after stroke. Neurology (2011) 1.62
Novel natural products from soil DNA libraries in a streptomycete host. Org Lett (2000) 1.52
Human fetal enterocytes in vitro: modulation of the phenotype by extracellular matrix. Proc Natl Acad Sci U S A (1996) 1.49
Magnetic resonance imaging screening in women at genetic risk of breast cancer: imaging and analysis protocol for the UK multicentre study. UK MRI Breast Screening Study Advisory Group. Magn Reson Imaging (2000) 1.47
A scanned, focused, multiple transducer ultrasonic system for localized hyperthermia treatments. 1987. Int J Hyperthermia (2010) 1.41
Conventional digital subtraction x-ray angiography versus magnetic resonance angiography in the evaluation of carotid disease: patient satisfaction and preferences. Clin Radiol (2004) 1.40
Cell interactions between histoincompatible T and B lymphocytes. VIII. In vivo cooperative responses between lymphocytes are controlled by genes in the K-end of the H-2 complex. J Immunol (1975) 1.40
Long-term treatment of malignant gliomas with intramuscularly administered polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose: an open pilot study. Neurosurgery (1996) 1.39
Surfactant-mediated growth revisited. Phys Rev Lett (2007) 1.38
Time of symptom onset of eight common medical emergencies. J Emerg Med (1995) 1.37
Structural brain abnormalities in male schizophrenics reflect fronto-temporal dissociation. Psychol Med (1997) 1.32
Lysosome-associated membrane proteins: characterization of LAMP-1 of macrophage P388 and mouse embryo 3T3 cultured cells. Arch Biochem Biophys (1985) 1.32
A mechanism for the induction and regulation of human fibroblastoid interferon genetic expression. J Gen Virol (1977) 1.31
The isolation and amino acid/sugar composition of human fibroblastoid interferon. J Biol Chem (1979) 1.28
Temporal lobe rating scale: application to Alzheimer's disease and frontotemporal dementia. J Neurol Neurosurg Psychiatry (2001) 1.26
Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides (1999) 1.26
The little finger superficialis--clinical investigation of its anatomic and functional shortcomings. J Hand Surg Am (1981) 1.25
Spatial patterns of pulmonary tuberculosis incidence and their relationship to socio-economic status in Vitoria, Brazil. Int J Tuberc Lung Dis (2010) 1.24
Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls. Peptides (2001) 1.23
Derivation and validation of diagnostic criteria for chronic inflammatory demyelinating polyneuropathy. J Neurol Sci (2008) 1.23
Primary structure and functional activity of a phosphatidylinositol-glycan-specific phospholipase D. Science (1991) 1.22
Impact of school-based health centers on children with asthma. J Adolesc Health (2005) 1.20
Development of antibody to measles virus polypeptides during complicated and uncomplicated measles virus infections. J Virol (1984) 1.20
Loss-of-function mutations in the mtr efflux system of Neisseria gonorrhoeae. Microbiology (1998) 1.18
Kinetics of toluene degradation by a nitrate-reducing bacterium isolated from a groundwater aquifer. Biotechnol Bioeng (1997) 1.17
Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation. Phytomedicine (2007) 1.17
Purification and in vitro labeling of interferon from a human fibroblastoid cell line. J Biol Chem (1978) 1.13
Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP. Biochem Biophys Res Commun (1994) 1.13
Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression. Endocrinology (2000) 1.13
Structural determination of lipid-bound ApoA-I using fluorescence resonance energy transfer. J Biol Chem (2000) 1.13
Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states: gene structure and 5'-flanking sequence. Diabetes (1996) 1.12
Predicting composition of leg sections with anthropometry and bioelectrical impedance analysis, using magnetic resonance imaging as reference. Clin Sci (Lond) (1999) 1.11
Differential endothelial cell gene expression by African Americans versus Caucasian Americans: a possible contribution to health disparity in vascular disease and cancer. BMC Med (2011) 1.11
Prediabetes is associated with abnormal circadian blood pressure variability. J Hum Hypertens (2008) 1.10
Let-7/miR-98 regulate Fas and Fas-mediated apoptosis. Genes Immun (2011) 1.09
The plastic envelope method, a simplified technique for culture diagnosis of trichomoniasis. J Clin Microbiol (1992) 1.08
Purification and characterization of glycosyl-phosphatidylinositol-specific phospholipase D. J Biol Chem (1990) 1.07
Human fibroblastoid interferon: immunosorbent column chromatography and N-terminal amino acid sequence. Biochemistry (1980) 1.06
Isolation of microsomal poly(A)-RNA from rat brain directing the synthesis of the myelin encephalitogenic protein in Xenopus oocytes. Biochim Biophys Acta (1974) 1.06
Dynamic regulation of leptin entry into brain by the blood-brain barrier. Regul Pept (2000) 1.05
Assessment of limb muscle and adipose tissue by dual-energy X-ray absorptiometry using magnetic resonance imaging for comparison. Int J Obes Relat Metab Disord (1999) 1.05
Virologic, immunologic, and clinical observations on a patient during the incubation, acute, and convalescent phases of infectious mononucleosis. Clin Immunol Immunopathol (1984) 1.05
Chronomics, neuroendocrine feedsidewards and the recording and consulting of nowcasts--forecasts of geomagnetics. Biomed Pharmacother (2005) 1.03
Pharmacodynamics and pharmacokinetics of single doses of subcutaneous pegylated human G-CSF mutant (Ro 25-8315) in healthy volunteers: comparison with single and multiple daily doses of filgrastim. Am J Hematol (2001) 1.02
Hippocampal involvement in spatial and working memory: a structural MRI analysis of patients with unilateral mesial temporal lobe sclerosis. Brain Cogn (1999) 1.01
Models of total and presumed wildlife sources of fecal coliform bacteria in coastal ponds. J Environ Manage (2006) 1.00
Calf compartment pressures in the Lloyd-Davies position: a cause for concern? Anaesthesia (2002) 0.99
Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. Biochem Biophys Res Commun (2000) 0.99
Identification of a conserved switch residue responsible for selective constitutive activation of the beta2-adrenergic receptor. J Biol Chem (1998) 0.98
Chronomics: circadian lead of extrapineal vs. pineal melatonin rhythms with an infradian hypothalamic exploration. Biomed Pharmacother (2005) 0.97
Reversible H-induced switching of the magnetic easy axis in Ni/Cu(001) thin films. Phys Rev Lett (2004) 0.97
Regulation of HIV-1 infection in astrocytes: expression of Nef, TNF-alpha and IL-6 is enhanced in coculture of astrocytes with macrophages. J Neurovirol (1996) 0.97
Triple ribozyme-mediated down-regulation of the retinoblastoma gene. Carcinogenesis (1998) 0.96
Loss-of-function EA2 mutations are associated with impaired neuromuscular transmission. Neurology (2001) 0.96
More problems with drug names. CMAJ (1992) 0.96
Assessment of a disc stack centrifuge for use in mammalian cell separation. Biotechnol Bioeng (1995) 0.96
Transglutaminase-3, an esophageal cancer-related gene. Int J Cancer (2000) 0.95
Optimization of metal artefact reduction (MAR) sequences for MRI of total hip prostheses. Clin Radiol (2010) 0.95
Peptides crossing the blood-brain barrier: some unusual observations. Brain Res (1999) 0.95
Activation of urocortin transport into brain by leptin. Peptides (2000) 0.93
Purification of Hodgkin's disease tumor-associated antigens. Proc Natl Acad Sci U S A (1973) 0.93
Late auditory evoked potentials can occur without brain stem potentials. Electroencephalogr Clin Neurophysiol (1983) 0.92
Defining the substrate specificity of cdk4 kinase-cyclin D1 complex. Carcinogenesis (1999) 0.92
Serological survey of nasopharyngeal carcinoma in 21 cities of south China. Chin Med J (Engl) (1995) 0.92
Positional isomers of monopegylated interferon alpha-2a: isolation, characterization, and biological activity. Anal Biochem (1997) 0.91
Proton diffusion in the active site of triosephosphate isomerase. Biochemistry (1990) 0.91
Feeding peptides interact in several ways with the blood-brain barrier. Curr Pharm Des (2003) 0.91
Overexpression of the c-erbB-2/neu-encoded p185 protein in primary lung cancer. Mol Carcinog (1992) 0.91
Associations of clinical features and prognosis with age at disease onset in patients with systemic lupus erythematosus. Lupus (2013) 0.90
Uptake and degradation of blood-borne insulin by the olfactory bulb. Peptides (1999) 0.90
Chronomics affirm extending scope of lead in phase of duodenal vs. pineal circadian melatonin rhythms. Biomed Pharmacother (2005) 0.89
Transcription and sequence studies of a 4.3-kbp fragment from a ds-DNA eukaryotic algal virus. Virology (1990) 0.88
Development of PCR primers for nine polymorphic American mink Mustela vison microsatellite loci. Mol Ecol (1996) 0.88
Albuterol increases lean body mass in ambulatory boys with Duchenne or Becker muscular dystrophy. Neurology (2007) 0.88
Mitogen-activated protein kinase signalling pathways triggered by the hepatitis C virus envelope protein E2: implications for the prevention of infection. Cell Prolif (2007) 0.88
DNA segments sensitive to single-strand-specific nucleases are present in chromatin of mitotic cells. Exp Cell Res (1996) 0.88
Nurse triage in accident and emergency departments. BMJ (1992) 0.88
The mechanical triggers of plaque rupture: shear stress vs pressure gradient. Br J Radiol (2009) 0.88
Chronic hypoxic pulmonary hypertension in the guinea pig: effect of three levels of hypoxia. J Appl Physiol (1985) (1993) 0.87
Computer program to predict likelihood of finding and HLA-matched donor: methodology, validation, and application. Biol Blood Marrow Transplant (1996) 0.87
Nucleo-cytoplasmic relationships of high-molecular-weight ribonucleic acid, including polyadenylated species, in the developing rat brain. Biochem J (1976) 0.87
Phosphatidylcholine-specific phospholipase D-derived 1,2-diacylglycerol does not initiate protein kinase C activation in the RBL 2H3 mast-cell line. Biochem J (1992) 0.86
Effects of fasting on hematologic and clinical chemical values in cynomolgus monkeys (Macaca fascicularis). J Med Primatol (2010) 0.86