Published in J Bacteriol on November 01, 1997
Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev (2001) 9.14
Structure, function, and evolution of bacterial ATP-binding cassette systems. Microbiol Mol Biol Rev (2008) 5.97
Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother (2001) 5.23
Molecular properties of bacterial multidrug transporters. Microbiol Mol Biol Rev (2000) 5.21
Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev (2006) 4.77
Macrolide resistance conferred by base substitutions in 23S rRNA. Antimicrob Agents Chemother (2001) 4.17
Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria. Antimicrob Agents Chemother (2000) 3.22
Discovery of a novel and potent class of FabI-directed antibacterial agents. Antimicrob Agents Chemother (2002) 2.14
AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis. Antimicrob Agents Chemother (2003) 1.98
The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria. Clin Microbiol Rev (2015) 1.81
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance. Clin Microbiol Rev (2012) 1.74
Antimicrobial resistance in Haemophilus influenzae. Clin Microbiol Rev (2007) 1.74
Structure and function of efflux pumps that confer resistance to drugs. Biochem J (2003) 1.66
BpeAB-OprB, a multidrug efflux pump in Burkholderia pseudomallei. Antimicrob Agents Chemother (2004) 1.58
Helicobacter pylori uptake and efflux: basis for intrinsic susceptibility to antibiotics in vitro. Antimicrob Agents Chemother (2000) 1.58
Effects of an efflux mechanism and ribosomal mutations on macrolide susceptibility of Haemophilus influenzae clinical isolates. Antimicrob Agents Chemother (2003) 1.48
Genetic and molecular characterization of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin. Antimicrob Agents Chemother (2004) 1.46
The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli. Antimicrob Agents Chemother (2004) 1.20
Laboratory detection of Haemophilus influenzae with decreased susceptibility to nalidixic acid, ciprofloxacin, levofloxacin, and moxifloxacin due to GyrA and ParC mutations. J Clin Microbiol (2004) 1.16
Identification of the Haemophilus influenzae tolC gene by susceptibility profiles of insertionally inactivated efflux pump mutants. Antimicrob Agents Chemother (2004) 1.15
Compound efflux in Helicobacter pylori. Antimicrob Agents Chemother (2005) 1.13
A Helicobacter pylori TolC efflux pump confers resistance to metronidazole. Antimicrob Agents Chemother (2005) 1.10
Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo. Antimicrob Agents Chemother (2010) 1.05
Role of the AcrAB-TolC efflux pump in determining susceptibility of Haemophilus influenzae to the novel peptide deformylase inhibitor LBM415. Antimicrob Agents Chemother (2005) 0.98
In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class. Antimicrob Agents Chemother (2006) 0.97
Mechanism of coupling drug transport reactions located in two different membranes. Front Microbiol (2015) 0.95
Drug-induced conformational changes in multidrug efflux transporter AcrB from Haemophilus influenzae. J Bacteriol (2007) 0.93
Different modes of action of naphthyridones in gram-positive and gram-negative bacteria. Antimicrob Agents Chemother (2006) 0.93
First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. Antimicrob Agents Chemother (2007) 0.90
Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae. J Bacteriol (2012) 0.89
Fmt bypass in Pseudomonas aeruginosa causes induction of MexXY efflux pump expression. Antimicrob Agents Chemother (2009) 0.89
In vitro validation of acetyltransferase activity of GlmU as an antibacterial target in Haemophilus influenzae. J Biol Chem (2011) 0.85
Effect of efflux on telithromycin and macrolide susceptibility in Haemophilus influenzae. Antimicrob Agents Chemother (2006) 0.84
High-throughput microarray technology in diagnostics of enterobacteria based on genome-wide probe selection and regression analysis. BMC Genomics (2010) 0.81
The methylome of the gut microbiome: disparate Dam methylation patterns in intestinal Bacteroides dorei. Front Microbiol (2014) 0.81
Clarithromycin Resistance Mechanisms of Epidemic β-Lactamase-Nonproducing Ampicillin-Resistant Haemophilus influenzae Strains in Japan. Antimicrob Agents Chemother (2016) 0.79
Effect of the inoculum size on carbapenem susceptibilities of beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae. Curr Microbiol (2008) 0.78
In vitro activities of oral cephem and telithromycin against clinical isolates of major respiratory pathogens in Japan. J Korean Med Sci (2007) 0.77
Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. Eur J Med Chem (2012) 0.76
Defining genetic fitness determinants and creating genomic resources for an oral pathogen. Appl Environ Microbiol (2017) 0.75
Antimicrobial Activity of Adenine-Based Inhibitors of NAD(+)-Dependent DNA Ligase. ACS Med Chem Lett (2012) 0.75
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science (1995) 68.34
Multidrug efflux pumps of gram-negative bacteria. J Bacteriol (1996) 9.86
Defined nongrowth media for stage II development of competence in Haemophilus influenzae. J Bacteriol (1970) 8.51
AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J Bacteriol (1996) 8.50
Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol Microbiol (1995) 8.41
Identification of the outer membrane protein of E. coli that produces transmembrane channels in reconstituted vesicle membranes. Biochem Biophys Res Commun (1976) 7.31
Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1995) 6.65
Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa. Mol Microbiol (1997) 5.91
A versatile class of positive-selection vectors based on the nonviability of palindrome-containing plasmids that allows cloning into long polylinkers. Gene (1988) 5.83
Emr, an Escherichia coli locus for multidrug resistance. Proc Natl Acad Sci U S A (1992) 5.30
Multidrug resistance pumps in bacteria: variations on a theme. Trends Biochem Sci (1994) 5.21
Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology (1995) 4.93
Efflux pumps and drug resistance in gram-negative bacteria. Trends Microbiol (1994) 4.91
Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin. Antimicrob Agents Chemother (1994) 4.87
Active efflux mechanisms for antimicrobial resistance. Antimicrob Agents Chemother (1992) 4.82
Formation of large, ion-permeable membrane channels by the matrix protein (porin) of Escherichia coli. Biochim Biophys Acta (1978) 4.55
Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport. Mol Microbiol (1994) 4.16
Porins and specific channels of bacterial outer membranes. Mol Microbiol (1992) 2.99
Plasmid transfer in Haemophilus influenzae. J Bacteriol (1979) 2.44
Properties of the major outer membrane protein from Neisseria gonorrhoeae incorporated into model lipid membranes. Proc Natl Acad Sci U S A (1983) 2.20
Transmembrane permeability channels across the outer membrane of Haemophilus influenzae type b. J Bacteriol (1985) 1.96
Molecular basis of the non-beta-lactamase-mediated resistance to beta-lactam antibiotics in strains of Haemophilus influenzae isolated in Canada. Antimicrob Agents Chemother (1992) 1.55
Properties of the porin of Haemophilus influenzae type b in planar lipid bilayer membranes. Biochim Biophys Acta (1986) 1.23
The permeability barrier of Haemophilus influenzae type b against beta-lactam antibiotics. J Antimicrob Chemother (1983) 1.07
Outer membrane permeability of non-typable Haemophilus influenzae. J Antimicrob Chemother (1996) 0.84
Molecular basis of bacterial outer membrane permeability. Microbiol Rev (1985) 17.75
The envelope of mycobacteria. Annu Rev Biochem (1995) 9.33
AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J Bacteriol (1996) 8.50
Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol Microbiol (1995) 8.41
The outer membrane of Gram-negative bacteria. Adv Microb Physiol (1979) 7.72
Outer membranes of gram-negative bacteria. XIX. Isolation from Pseudomonas aeruginosa PAO1 and use in reconstitution and definition of the permeability barrier. J Bacteriol (1978) 7.66
Outer membrane of Salmonella typhimurium. Transmembrane diffusion of some hydrophobic substances. Biochim Biophys Acta (1976) 7.44
Protein composition of the outer membrane of Salmonella typhimurium: effect of lipopolysaccharide mutations. J Bacteriol (1974) 7.07
Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1995) 6.65
Outer membrane of Salmonella typhimurium: chemical analysis and freeze-fracture studies with lipopolysaccharide mutants. J Bacteriol (1975) 6.51
Porin channels in Escherichia coli: studies with beta-lactams in intact cells. J Bacteriol (1983) 6.29
Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J Bacteriol (1993) 6.24
Porin channels in Escherichia coli: studies with liposomes reconstituted from purified proteins. J Bacteriol (1983) 5.20
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell (2001) 5.19
Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology (1995) 4.93
Efflux pumps and drug resistance in gram-negative bacteria. Trends Microbiol (1994) 4.91
Diffusion of beta-lactam antibiotics through the porin channels of Escherichia coli K-12. Antimicrob Agents Chemother (1985) 4.88
Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin. Antimicrob Agents Chemother (1994) 4.87
Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides. Antimicrob Agents Chemother (1999) 4.57
The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals. Mol Microbiol (1996) 4.56
Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance. Antimicrob Agents Chemother (1994) 4.43
Role of beta-lactam hydrolysis in the mechanism of resistance of a beta-lactamase-constitutive Enterobacter cloacae strain to expanded-spectrum beta-lactams. Antimicrob Agents Chemother (1985) 4.43
Outer membrane of gram-negative bacteria. XII. Molecular-sieving function of cell wall. J Bacteriol (1976) 4.41
Pleiotropic transport mutants of Escherichia coli lack porin, a major outer membrane protein. Mol Gen Genet (1977) 4.15
Specificity of diffusion channels produced by lambda phage receptor protein of Escherichia coli. Proc Natl Acad Sci U S A (1980) 4.09
Active efflux of bile salts by Escherichia coli. J Bacteriol (1997) 4.00
Permeability of Pseudomonas aeruginosa outer membrane to hydrophilic solutes. J Bacteriol (1982) 3.94
Outer membrane of Salmonella XIV. Reduced transmembrane diffusion rates in porin-deficient mutants. Biochem Biophys Res Commun (1976) 3.78
Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1990) 3.74
Effect on solute size on diffusion rates through the transmembrane pores of the outer membrane of Escherichia coli. J Gen Physiol (1981) 3.72
Multidrug resistance mechanisms: drug efflux across two membranes. Mol Microbiol (2000) 3.71
Identification of the protein producing transmembrane diffusion pores in the outer membrane of Pseudomonas aeruginosa PA01. Biochim Biophys Acta (1979) 3.70
Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proc Natl Acad Sci U S A (1999) 3.53
Extended deletions in the histidine-rough-B region of the Salmonella chromosome. Proc Natl Acad Sci U S A (1967) 3.51
Outer membrane as a diffusion barrier in Salmonella typhimurium. Penetration of oligo- and polysaccharides into isolated outer membrane vesicles and cells with degraded peptidoglycan layer. J Biol Chem (1975) 3.34
Mutants of Escherichia coli that are resistant to certain beta-lactam compounds lack the ompF porin. Antimicrob Agents Chemother (1981) 3.17
Outer membrane of Salmonella typhimurium: accessibility of phospholipid head groups to phospholipase c and cyanogen bromide activated dextran in the external medium. Biochemistry (1976) 2.88
AcrA is a highly asymmetric protein capable of spanning the periplasm. J Mol Biol (1999) 2.82
cisRED: a database system for genome-scale computational discovery of regulatory elements. Nucleic Acids Res (2006) 2.75
Mycobacterial cell wall: structure and role in natural resistance to antibiotics. FEMS Microbiol Lett (1994) 2.73
Pore-forming activity of OmpA protein of Escherichia coli. J Biol Chem (1992) 2.65
Protein D2 channel of the Pseudomonas aeruginosa outer membrane has a binding site for basic amino acids and peptides. J Biol Chem (1990) 2.60
Purification and properties of Pseudomonas aeruginosa porin. J Biol Chem (1983) 2.55
Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria. FASEB J (1998) 2.53
Decreased outer membrane permeability in imipenem-resistant mutants of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1989) 2.52
Role of outer membrane barrier in efflux-mediated tetracycline resistance of Escherichia coli. J Bacteriol (1995) 2.52
Outer membrane of gram-negative bacteria. XVIII. Electron microscopic studies on porin insertion sites and growth of cell surface of Salmonella typhimurium. J Bacteriol (1978) 2.50
Mechanism of maltose transport in Escherichia coli: transmembrane signaling by periplasmic binding proteins. Proc Natl Acad Sci U S A (1992) 2.47
Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol (1999) 2.47
Imipenem- and meropenem-resistant mutants of Enterobacter cloacae and Proteus rettgeri lack porins. Antimicrob Agents Chemother (1991) 2.46
Permeability barrier to hydrophilic solutes in Mycobacterium chelonei. J Bacteriol (1990) 2.44
Sequence of the malK gene in E.coli K12. Nucleic Acids Res (1982) 2.43
The effects of diabetes on the risks of major cardiovascular diseases and death in the Asia-Pacific region. Diabetes Care (2003) 2.36
Role of permeability barriers in resistance to beta-lactam antibiotics. Pharmacol Ther (1985) 2.32
Outer membranes of gram-negative bacteria are permeable to steroid probes. Mol Microbiol (1992) 2.32
AcrD of Escherichia coli is an aminoglycoside efflux pump. J Bacteriol (2000) 2.24
Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra. Antimicrob Agents Chemother (1996) 2.22
Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli. J Bacteriol (2000) 2.17
Porins of Brucella species. Infect Immun (1984) 2.17
Purification and characterization of the membrane-associated components of the maltose transport system from Escherichia coli. J Biol Chem (1991) 2.16
Proteins forming large channels from bacterial and mitochondrial outer membranes: porins and phage lambda receptor protein. Methods Enzymol (1983) 2.14
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Proc Natl Acad Sci U S A (2000) 2.11
Mitochondrial outer membrane contains a protein producing nonspecific diffusion channels. J Biol Chem (1980) 2.06
Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis? Antimicrob Agents Chemother (1995) 2.01
Rational design of a potent, long-lasting form of interferon: a 40 kDa branched polyethylene glycol-conjugated interferon alpha-2a for the treatment of hepatitis C. Bioconjug Chem (2001) 1.89
Outer membrane of gram-negative bacteria. XVII. Secificity of transport process catalyzed by the lambda-receptor protein in Escherichia coli. Biochem Biophys Res Commun (1977) 1.87
Permeability of the outer membrane of bacteria. Angew Chem Int Ed Engl (1979) 1.78
Biosynthesis of cell wall lipopolysaccharide in mutants of Salmonella. V. A mutant of Salmonella typhimurium defective in the synthesis of cytidine diphosphoabequose. J Bacteriol (1969) 1.78
Porin channels in intact cells of Escherichia coli are not affected by Donnan potentials across the outer membrane. J Biol Chem (1988) 1.77
High-level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA. Antimicrob Agents Chemother (2000) 1.75
Overproduction, solubilization, and reconstitution of the maltose transport system from Escherichia coli. J Biol Chem (1990) 1.73
Epidemiology and molecular basis of penicillin-resistant Neisseria meningitidis in Spain: a 5-year history (1985-1989). Clin Infect Dis (1992) 1.73
OmpA protein of Escherichia coli outer membrane occurs in open and closed channel forms. J Biol Chem (1994) 1.72
Partitioning of hydrophobic probes into lipopolysaccharide bilayers. Biochim Biophys Acta (1990) 1.72
In vitro trimerization of OmpF porin secreted by spheroplasts of Escherichia coli. Proc Natl Acad Sci U S A (1990) 1.68
Diffusion of solutes through channels produced by phage lambda receptor protein of Escherichia coli: inhibition by higher oligosaccharides of maltose series. Biochem Biophys Res Commun (1980) 1.65
Mycolic acid structure determines the fluidity of the mycobacterial cell wall. J Biol Chem (1996) 1.63
Lipopolysaccharide structure required for in vitro trimerization of Escherichia coli OmpF porin. J Bacteriol (1991) 1.62
Secondary preventive medication persistence and adherence 1 year after stroke. Neurology (2011) 1.62
Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nat Genet (1999) 1.61
Secondary structure of the outer membrane proteins OmpA of Escherichia coli and OprF of Pseudomonas aeruginosa. J Bacteriol (1996) 1.60
Loss of OmpC porin in a strain of Salmonella typhimurium causes increased resistance to cephalosporins during therapy. J Infect Dis (1987) 1.60
Genetic determination of enzymes synthesizing O-specific sugars of Salmonella lipopolysaccharides. J Bacteriol (1966) 1.58
A MATE family multidrug efflux transporter pumps out fluoroquinolones in Bacteroides thetaiotaomicron. Antimicrob Agents Chemother (2001) 1.55
Asymmetric localization of lipopolysaccharides on the outer membrane of Salmonella typhimurium. J Bacteriol (1980) 1.53
Novel natural products from soil DNA libraries in a streptomycete host. Org Lett (2000) 1.52
Outer membrane of Salmonella typhimurium. Identification of proteins exposed on cell surface. Biochim Biophys Acta (1977) 1.52
Genetic diversity of penicillin G-resistant Neisseria meningitidis from Spain. Infect Immun (1989) 1.50
Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump. J Bacteriol (1996) 1.50
Consequences of deletion mutations joining two operons of opposite polarity. J Mol Biol (1969) 1.48
Fluidity of the lipid domain of cell wall from Mycobacterium chelonae. Proc Natl Acad Sci U S A (1995) 1.47
Amino acid sequence homology among the major outer membrane proteins of Escherichia coli. Proc Natl Acad Sci U S A (1984) 1.45
Determinants of OmpF porin antigenicity and structure. J Biol Chem (1990) 1.44
Targeting of porin to the outer membrane of Escherichia coli. Rate of trimer assembly and identification of a dimer intermediate. J Biol Chem (1988) 1.42
Extensive homology between membrane-associated components of histidine and maltose transport systems of Salmonella typhimurium and Escherichia coli. J Biol Chem (1982) 1.39
[Functionality of von Willebrand factor present in Fanhdi: adhesion to the vascular subendothelium in vitro]. Sangre (Barc) (1997) 1.39
Surfactant-mediated growth revisited. Phys Rev Lett (2007) 1.38
Time of symptom onset of eight common medical emergencies. J Emerg Med (1995) 1.37
Nonspecific and specific diffusion channels in the outer membrane of Escherichia coli. J Supramol Struct (1980) 1.34