Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.

PubWeight™: 0.93‹?›

🔗 View Article (PMID 11331003)

Published in Biochemistry on May 08, 2001

Authors

H Li1, C S Raman, P Martásek, B S Masters, T L Poulos

Author Affiliations

1: Departments of Molecular Biology & Biochemistry and Physiology & Biophysics and Program in Macromolecular Structure, University of California, Irvine 92697-3900, USA.

Articles citing this

Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases. Acc Chem Res (2009) 1.72

The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies. Proc Natl Acad Sci U S A (2003) 1.58

Statistical analysis of interface similarity in crystals of homologous proteins. J Mol Biol (2008) 1.55

Structural studies of constitutive nitric oxide synthases with diatomic ligands bound. J Biol Inorg Chem (2006) 1.28

Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide. Biochemistry (2009) 1.07

Calmodulin-induced structural changes in endothelial nitric oxide synthase. FEBS Lett (2012) 0.98

Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase. J Biol Chem (2008) 0.91

Endogenous nitric oxide regulates the recovery of the radiation-resistant bacterium Deinococcus radiodurans from exposure to UV light. Proc Natl Acad Sci U S A (2009) 0.91

NO binding to naphthalene dioxygenase. J Biol Inorg Chem (2005) 0.85

Holoenzyme structures of endothelial nitric oxide synthase - an allosteric role for calmodulin in pivoting the FMN domain for electron transfer. J Struct Biol (2014) 0.81

Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms. J Mol Model (2012) 0.77

Probing the Hydrogen Bonding of the Ferrous-NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance. J Phys Chem A (2015) 0.76

Mechanistic studies of inactivation of inducible nitric oxide synthase by amidines. Biochemistry (2015) 0.75

Kinetics of CO Recombination to the Heme in Geobacillus Stearothermophilus Nitric Oxide Synthase. Polyhedron (2013) 0.75

Articles by these authors

Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci U S A (1998) 4.94

Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections. Nat Genet (2007) 4.93

Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem (1997) 3.80

Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center. Cell (1998) 3.20

Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes. Proc Natl Acad Sci U S A (1997) 3.15

The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450. J Biol Chem (1985) 2.95

Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors. Proc Natl Acad Sci U S A (2001) 2.90

Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections. Circulation (2005) 2.77

Crystal structure of human heme oxygenase-1. Nat Struct Biol (1999) 2.64

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography. J Biol Chem (1976) 2.63

Crystal structure of yeast cytochrome c peroxidase refined at 1.7-A resolution. J Biol Chem (1984) 2.56

Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease. Am J Hum Genet (2009) 2.50

Crystal structure of horseradish peroxidase C at 2.15 A resolution. Nat Struct Biol (1997) 2.48

The stereochemistry of peroxidase catalysis. J Biol Chem (1980) 2.35

Structure of a cytochrome P450-redox partner electron-transfer complex. Proc Natl Acad Sci U S A (1999) 2.30

The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid. Nat Struct Biol (1997) 2.29

MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II. Hum Mol Genet (2007) 2.17

Femtomolar sensitivity of a NO sensor from Clostridium botulinum. Science (2004) 2.09

Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes. Nature (2008) 2.06

Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy. Proc Natl Acad Sci U S A (1996) 2.06

Isothermal titration calorimetry of protein-protein interactions. Methods (1999) 2.03

Structure of cytochrome P450eryF involved in erythromycin biosynthesis. Nat Struct Biol (1995) 2.01

Crystal structure of substrate-free Pseudomonas putida cytochrome P-450. Biochemistry (1986) 2.00

High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli. Proc Natl Acad Sci U S A (1995) 2.00

Inducible nitric-oxide synthase generates superoxide from the reductase domain. J Biol Chem (1998) 2.00

Structure of the CO sensing transcription activator CooA. Nat Struct Biol (2000) 1.96

Immunochemical evidence for an association of heme oxygenase with the microsomal electron transport system. J Biol Chem (1972) 1.91

Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide. Proc Natl Acad Sci U S A (1992) 1.85

Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. Biochemistry (1997) 1.76

Factors determining the selectivity of protein tyrosine nitration. Arch Biochem Biophys (1999) 1.75

An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase. J Biol Chem (1997) 1.73

Characterization of bovine endothelial nitric oxide synthase expressed in E. coli. Biochem Biophys Res Commun (1996) 1.71

Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase. J Biol Chem (1999) 1.65

Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus. J Biol Chem (2000) 1.63

Crystal structure of recombinant pea cytosolic ascorbate peroxidase. Biochemistry (1995) 1.62

Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect. Biochemistry (1998) 1.62

The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid. Structure (1995) 1.61

Protein engineering of subtilisin BPN': enhanced stabilization through the introduction of two cysteines to form a disulfide bond. Biochemistry (1987) 1.56

A metal-mediated hydride shift mechanism for xylose isomerase based on the 1.6 A Streptomyces rubiginosus structures with xylitol and D-xylose. Proteins (1991) 1.55

The crystal structure of peanut peroxidase. Structure (1996) 1.52

The crystal structure of manganese peroxidase from Phanerochaete chrysosporium at 2.06-A resolution. J Biol Chem (1994) 1.49

Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. J Biol Chem (1999) 1.49

20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. Circ Res (1993) 1.48

A redox-controlled molecular switch revealed by the crystal structure of a bacterial heme PAS sensor. J Biol Chem (2004) 1.48

A hypothetical model of the cytochrome c peroxidase . cytochrome c electron transfer complex. J Biol Chem (1980) 1.44

Evidence for a bidomain structure of constitutive cerebellar nitric oxide synthase. J Biol Chem (1994) 1.43

Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation. Biochemistry (1991) 1.39

Optical difference spectrophotometry as a probe of rat brain nitric oxide synthase heme-substrate interaction. Biochemistry (1993) 1.38

Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats. J Pharmacol Exp Ther (1994) 1.38

The engineering of binding affinity at metal ion binding sites for the stabilization of proteins: subtilisin as a test case. Biochemistry (1988) 1.37

Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala. Biochemistry (1991) 1.37

The crystal structure of cytochrome c peroxidase. J Biol Chem (1980) 1.35

Prokaryotic expression of the heme- and flavin-binding domains of rat neuronal nitric oxide synthase as distinct polypeptides: identification of the heme-binding proximal thiolate ligand as cysteine-415. Biochemistry (1995) 1.34

Detection of superoxide anion using an isotopically labeled nitrone spin trap: potential biological applications. FEBS Lett (2000) 1.29

The structural basis for substrate-induced changes in redox potential and spin equilibrium in cytochrome P-450CAM. Biochemistry (1989) 1.27

Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria meningitidis and a comparison with mammalian heme oxygenase-1. Biochemistry (2001) 1.27

Crystal structure of lignin peroxidase. Proc Natl Acad Sci U S A (1993) 1.26

Substrate recognition sites in 14alpha-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51. J Inorg Biochem (2001) 1.25

Polypeptide halomethyl ketones bind to serine proteases as analogs of the tetrahedral intermediate. X-ray crystallographic comparison of lysine- and phenylalanine-polypeptide chloromethyl ketone-inhibited subtilisin. J Biol Chem (1976) 1.25

Redox control of the catalytic cycle of flavocytochrome P-450 BM3. Biochemistry (1997) 1.22

Functional implications of interleukin-1 beta based on the three-dimensional structure. Proteins (1992) 1.22

Crystal structure of the carbon monoxide-substrate-cytochrome P-450CAM ternary complex. Biochemistry (1989) 1.21

The C termini of constitutive nitric-oxide synthases control electron flow through the flavin and heme domains and affect modulation by calmodulin. J Biol Chem (2000) 1.20

Immunochemical studies on electron transport chains involving cytochrome P-450. I. Effects of antibodies to pig liver microsomal reduced triphosphopyridine nucleotide-cytochrome c reductase and the non-heme iron protein from bovine adrenocortical mitochondria. J Biol Chem (1971) 1.20

Identification of a porphyrin pi cation radical in ascorbate peroxidase compound I. Biochemistry (1995) 1.18

Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical. Free Radic Biol Med (2001) 1.15

Proteases of enhanced stability: characterization of a thermostable variant of subtilisin. Proteins (1986) 1.14

Crystal structure of Nitrosomonas europaea cytochrome c peroxidase and the structural basis for ligand switching in bacterial di-heme peroxidases. Biochemistry (2001) 1.12

Involvement of the reductase domain of neuronal nitric oxide synthase in superoxide anion production. Biochemistry (1997) 1.11

N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem (1999) 1.11

Role of the proximal ligand in peroxidase catalysis. Crystallographic, kinetic, and spectral studies of cytochrome c peroxidase proximal ligand mutants. J Biol Chem (1994) 1.10

Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem (2001) 1.09

Porphyrinogens in urine in various types of porphyrias. J Clin Chem Clin Biochem (1982) 1.08

Structural basis of hereditary coproporphyria. Proc Natl Acad Sci U S A (2005) 1.08

Disruption of an active site hydrogen bond converts human heme oxygenase-1 into a peroxidase. J Biol Chem (2000) 1.07

Stereochemistry of the chloroperoxidase active site: crystallographic and molecular-modeling studies. Chem Biol (1998) 1.07

Recruitment of governing elements for electron transfer in the nitric oxide synthase family. Proc Natl Acad Sci U S A (2005) 1.06

The oxidative metabolism of arachidonic acid by purified cytochromes P-450. Biochem Biophys Res Commun (1981) 1.06

Heme enzyme crystal structures. Adv Inorg Biochem (1988) 1.06

Characterization of recombinant Bacillus megaterium cytochrome P-450 BM-3 and its two functional domains. J Biol Chem (1991) 1.06

Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences. Int Immunol (1997) 1.06

S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo. J Biol Chem (1995) 1.05

Some effects of selenium deficiency on the hepatic microsomal cytochrome P-450 system in the rat. Arch Biochem Biophys (1975) 1.04

The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding. J Biol Chem (1998) 1.04

Aspartate residue 7 in amyloid beta-protein is critical for classical complement pathway activation: implications for Alzheimer's disease pathogenesis. Nat Med (1997) 1.02

The history, properties, and function of NADPH-cytochrome P-450 reductase. Pharmacol Ther (1980) 1.02

The mechanism of 1- and 2-electron transfers catalyzed by reduced triphosphopyridine nucleotide-cytochrome c reductase. J Biol Chem (1965) 1.02

The role of Thr268 in oxygen activation of cytochrome P450BM-3. Biochemistry (1995) 1.00

Modeling protein-substrate interactions in the heme domain of cytochrome P450(BM-3). Acta Crystallogr D Biol Crystallogr (1995) 1.00

Homozygous variegate porphyria. Lancet (1984) 0.99

Ligand binding and structural perturbations in cytochrome c peroxidase. A crystallographic study. J Biol Chem (1990) 0.98

Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries. Circ Res (1991) 0.98

Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases. J Med Chem (2000) 0.96