PubRank

R J Deshaies

Author PubWeight™ 118.73‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 1997 8.97
2 How proteolysis drives the cell cycle. Science 1996 8.59
3 Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 1999 5.98
4 Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes. Mol Biol Cell 2000 5.19
5 A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum. J Cell Biol 1987 4.94
6 Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes Dev 2001 4.91
7 Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 2001 4.82
8 Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 1997 4.18
9 Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34. Genes Dev 1999 4.17
10 Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast. J Cell Biol 1989 4.13
11 Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J 1993 4.10
12 Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell 1999 3.98
13 Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Science 2001 3.87
14 Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast. Genes Dev 1997 2.77
15 SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol Cell Biol 2001 2.56
16 Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. Proc Natl Acad Sci U S A 2001 2.39
17 SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities. Mol Biol Cell 1997 2.38
18 Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex. Proc Natl Acad Sci U S A 2001 2.24
19 SEC11 is required for signal peptide processing and yeast cell growth. J Cell Biol 1988 2.08
20 Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle. Genes Dev 1999 2.07
21 Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein. Proc Natl Acad Sci U S A 1998 2.02
22 A proteasome howdunit: the case of the missing signal. Cell 2000 1.99
23 Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly. Nat Cell Biol 2001 1.89
24 Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit. Mol Cell 2001 1.88
25 Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast. Mol Cell Biol 2001 1.87
26 Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk. Mol Cell 2001 1.82
27 The Tem1 small GTPase controls actomyosin and septin dynamics during cytokinesis. J Cell Sci 2001 1.78
28 The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p. BMC Biochem 2001 1.62
29 Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins. Proc Natl Acad Sci U S A 1995 1.62
30 Exercising self-restraint: discouraging illicit acts of S and M in eukaryotes. Cell 1993 1.57
31 Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4. EMBO J 2000 1.54
32 The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum. EMBO J 1993 1.50
33 A multidimensional electrospray MS-based approach to phosphopeptide mapping. Anal Chem 2001 1.36
34 The role of stress proteins in membrane biogenesis. Trends Biochem Sci 1988 1.23
35 Characterization of the Net1 cell cycle-dependent regulator of the Cdc14 phosphatase from budding yeast. J Biol Chem 2001 1.19
36 Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer. Oncogene 2008 1.17
37 Genetic dissection of the early stages of protein secretion in yeast. Trends Genet 1989 1.15
38 Cell-free ubiquitination of cell cycle regulators in budding yeast extracts. Methods Enzymol 1997 1.11
39 Characterization of a dominant negative mutant of the cell cycle ubiquitin-conjugating enzyme Cdc34. J Biol Chem 1995 1.08
40 Cks1 is required for G(1) cyclin-cyclin-dependent kinase activity in budding yeast. Mol Cell Biol 2000 1.05
41 Assaying degradation and deubiquitination of a ubiquitinated substrate by purified 26S proteasomes. Methods Enzymol 2005 0.99
42 COP1 patrols the night beat. Nat Cell Biol 2000 0.90