Published in Neuron on April 01, 2001
New insights into neuron-glia communication. Science (2002) 3.80
Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J Cell Biol (2003) 3.80
Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nat Neurosci (2009) 3.42
Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. J Cell Biol (2001) 3.29
Overview of the voltage-gated sodium channel family. Genome Biol (2003) 3.10
Localization and targeting of voltage-dependent ion channels in mammalian central neurons. Physiol Rev (2008) 2.90
Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger. Proc Natl Acad Sci U S A (2004) 1.99
Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones. J Physiol (2005) 1.95
Oligodendrocytes: biology and pathology. Acta Neuropathol (2009) 1.81
Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J Cell Biol (2003) 1.79
Assembly and maintenance of nodes of ranvier rely on distinct sources of proteins and targeting mechanisms. Neuron (2012) 1.75
Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease. Neurosci Lett (2010) 1.73
Na Channel β Subunits: Overachievers of the Ion Channel Family. Front Pharmacol (2011) 1.69
Neurological perspectives on voltage-gated sodium channels. Brain (2012) 1.62
Glial and neuronal isoforms of Neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system. J Cell Biol (2008) 1.54
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A (2002) 1.52
FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels. Mol Cell Neurosci (2009) 1.51
BACE1 deficiency causes altered neuronal activity and neurodegeneration. J Neurosci (2010) 1.45
Presynaptic Na+ channels: locus, development, and recovery from inactivation at a high-fidelity synapse. J Neurosci (2005) 1.44
An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers. Neuroscientist (2008) 1.43
Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. Proc Natl Acad Sci U S A (2002) 1.28
A novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy. Neurobiol Dis (2014) 1.27
Early events in node of Ranvier formation during myelination and remyelination in the PNS. Neuron Glia Biol (2006) 1.14
An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier. J Neurosci (2012) 1.13
Use-dependent potentiation of the Nav1.6 sodium channel. Biophys J (2004) 1.09
Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures. Epilepsia (2008) 1.09
Action potential initiation and propagation: upstream influences on neurotransmission. Neuroscience (2008) 1.09
Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions. J Cell Biol (2002) 1.07
Oligodendrocytes assist in the maintenance of sodium channel clusters independent of the myelin sheath. Neuron Glia Biol (2004) 1.07
Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells. J Physiol (2010) 1.06
Organization and maintenance of molecular domains in myelinated axons. J Neurosci Res (2013) 1.06
Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits. J Biol Chem (2012) 1.03
Differential targeting and functional specialization of sodium channels in cultured cerebellar granule cells. J Physiol (2005) 1.02
Molecular determinants of emerging excitability in rat embryonic motoneurons. J Physiol (2002) 1.00
Molecular reconstruction of nodes of Ranvier after remyelination by transplanted olfactory ensheathing cells in the demyelinated spinal cord. J Neurosci (2006) 0.98
Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis. Mol Cell Neurosci (2008) 0.97
From fish to man: understanding endogenous remyelination in central nervous system demyelinating diseases. Brain (2008) 0.96
Myelin repair: the role of stem and precursor cells in multiple sclerosis. Philos Trans R Soc Lond B Biol Sci (2008) 0.93
Myelination and regional domain differentiation of the axon. Results Probl Cell Differ (2009) 0.90
Fibroblast Growth Factor Homologous Factors: New Roles in Neuronal Health and Disease. Neuroscientist (2014) 0.90
Oligodendrocytes regulate formation of nodes of Ranvier via the recognition molecule OMgp. Neuron Glia Biol (2006) 0.90
Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. J Cell Sci (2014) 0.89
Biophysical characterisation of the persistent sodium current of the Nav1.6 neuronal sodium channel: a single-channel analysis. Pflugers Arch (2010) 0.88
Remyelination of the injured spinal cord. Prog Brain Res (2007) 0.87
Syndecan-3 and syndecan-4 are enriched in Schwann cell perinodal processes. BMC Neurosci (2003) 0.85
Molecular identity of axonal sodium channels in human cortical pyramidal cells. Front Cell Neurosci (2014) 0.84
Experimental and therapeutic opportunities for stem cells in multiple sclerosis. Int J Mol Sci (2012) 0.84
Dual roles of voltage-gated sodium channels in development and cancer. Int J Dev Biol (2015) 0.84
Dopaminergic neurons derived from BG01V2, a variant of human embryonic stem cell line BG01. Restor Neurol Neurosci (2008) 0.84
Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system. Proc Natl Acad Sci U S A (2014) 0.84
Myelin damage and repair in pathologic CNS: challenges and prospects. Front Mol Neurosci (2015) 0.83
Role of the terminal domains in sodium channel localization. Channels (Austin) (2009) 0.83
Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin. J Cell Biol (2015) 0.83
Juxtanodin: an oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase trafficking. Proc Natl Acad Sci U S A (2005) 0.82
Mitochondria as crucial players in demyelinated axons: lessons from neuropathology and experimental demyelination. Autoimmune Dis (2011) 0.81
Acceleration of conduction velocity linked to clustering of nodal components precedes myelination. Proc Natl Acad Sci U S A (2015) 0.80
Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Neuron (2016) 0.80
Tandem gramicidin channels cross-linked by streptavidin. J Gen Physiol (2003) 0.79
Unmyelinated nerve fibers in the human dental pulp express markers for myelinated fibers and show sodium channel accumulations. BMC Neurosci (2012) 0.78
Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4. Toxins (Basel) (2014) 0.78
Sodium channel β2 subunit promotes filopodia-like processes and expansion of the dendritic tree in developing rat hippocampal neurons. Front Cell Neurosci (2013) 0.77
Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons. J Neurosci (2017) 0.76
Resistance to action potential depression of a rat axon terminal in vivo. Proc Natl Acad Sci U S A (2017) 0.75
Node of Ranvier length as a potential regulator of myelinated axon conduction speed. Elife (2017) 0.75
Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis. J Med Chem (2014) 0.75
Trapping by clusters of channels, receptors, and transporters: quantitative description. Biophys J (2014) 0.75
Mechanisms of sodium channel clustering and its influence on axonal impulse conduction. Cell Mol Life Sci (2015) 0.75
Age-Related Changes in Axonal and Mitochondrial Ultrastructure and Function in White Matter. J Neurosci (2016) 0.75
Activity of NaV1.2 promotes neurodegeneration in an animal model of multiple sclerosis. JCI Insight (2016) 0.75
Role of Sodium Channels in Epilepsy. Cold Spring Harb Perspect Med (2016) 0.75
Acute temperature sensitivity in optic nerve axons explained by an electrogenic membrane potential. Pflugers Arch (2015) 0.75
Pro-excitatory alterations in sodium channel activity facilitate subiculum neuron hyperexcitability in temporal lobe epilepsy. Neurobiol Dis (2017) 0.75
Control of synapse number by glia. Science (2001) 5.38
Programmed cell death and the control of cell survival: lessons from the nervous system. Science (1993) 4.63
Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron (1995) 3.51
Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses. Proc Natl Acad Sci U S A (2000) 3.41
Notch receptor activation inhibits oligodendrocyte differentiation. Neuron (1998) 3.30
Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. J Neurosci (1999) 3.05
Synaptic efficacy enhanced by glial cells in vitro. Science (1997) 2.94
Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med (2016) 2.89
Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons. Proc Natl Acad Sci U S A (1997) 2.75
Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon. Neuron (2001) 2.73
Purification of the tetrodotoxin-binding component associated with the voltage-sensitive sodium channel from Electrophorus electricus electroplax membranes. Proc Natl Acad Sci U S A (1978) 2.64
Tetrodotoxin binding to normal depolarized frog muscle and the conductance of a single sodium channel. J Physiol (1975) 2.57
Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins. J Neurosci (1998) 2.25
Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact. J Biol Chem (2000) 2.24
Principal glycopeptide of the tetrodotoxin/saxitoxin binding protein from Electrophorus electricus: isolation and partial chemical and physical characterization. Biochemistry (1983) 2.22
Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron (1998) 2.18
Neuromuscular and cardiovascular advantages of combinations of mivacurium and rocuronium over either drug alone. Anaesthesia (1996) 2.03
Induction of sodium channel clustering by oligodendrocytes. Nature (1997) 2.03
Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. J Lipid Res (2001) 2.02
The binding of tritiated tetrodotoxin to squid giant axons. Philos Trans R Soc Lond B Biol Sci (1975) 1.98
A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development. Neuron (2001) 1.92
Anaesthesia by the n-alkanes. A comparative study of nerve impulse blockage and the properties of black lipid bilayer membranes. Biochim Biophys Acta (1977) 1.91
A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction. J Neurosci (2004) 1.77
Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes. Cardiovasc Res (2005) 1.75
Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. Neuron (1996) 1.73
Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes. Circulation (2001) 1.73
The adult rat brain beta 1 subunit modifies activation and inactivation gating of multiple sodium channel alpha subunits. J Biol Chem (1994) 1.67
Potassium channel distribution, clustering, and function in remyelinating rat axons. J Neurosci (1998) 1.62
Purification and characterization of adult oligodendrocyte precursor cells from the rat optic nerve. J Neurosci (1998) 1.60
Clustering of Na+ channels and node of Ranvier formation in remyelinating axons. J Neurosci (1995) 1.60
Dynamic potassium channel distributions during axonal development prevent aberrant firing patterns. J Neurosci (1999) 1.59
Molecular organization of the nodal region is not altered in spontaneously diabetic BB-Wistar rats. J Neurosci Res (2001) 1.56
Purification and characterization of astrocyte precursor cells in the developing rat optic nerve. J Neurosci (1999) 1.51
Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture. Mol Cell Neurosci (2004) 1.47
Immunolocalization of sodium channel isoform NaCh6 in the nervous system. J Comp Neurol (2000) 1.46
Two genetically separable phases of growth inhibition induced by blue light in Arabidopsis seedlings. Plant Physiol (1998) 1.44
The relationship between neuronal survival and regeneration. Annu Rev Neurosci (2000) 1.44
Molecular size of the tetrodotoxin binding site estimated by irradiation inactivation. Nat New Biol (1973) 1.42
Immunocytochemical localization of sodium channel distributions in the excitable membranes of Electrophorus electricus. Proc Natl Acad Sci U S A (1982) 1.42
Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis. Glycobiology (2001) 1.41
Modulation of cardiac Na+ channel expression in Xenopus oocytes by beta 1 subunits. J Biol Chem (1995) 1.41
Contribution of sialic acid to the voltage dependence of sodium channel gating. A possible electrostatic mechanism. J Gen Physiol (1997) 1.40
Neuraminidase treatment modifies the function of electroplax sodium channels in planar lipid bilayers. Neuron (1990) 1.39
Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene (2011) 1.38
Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit. J Biol Chem (1998) 1.35
Identification of a large molecular weight peptide associated with a tetrodotoxin binding protein from the electroplax of Electrophorus electricus. Biochem Biophys Res Commun (1980) 1.34
"Bundle blot" purification and initial protein characterization of hair cell stereocilia. Proc Natl Acad Sci U S A (1989) 1.33
The clustering of axonal sodium channels during development of the peripheral nervous system. J Neurosci (1996) 1.31
Contactin associates with Na+ channels and increases their functional expression. J Neurosci (2001) 1.27
Induction of astrocyte differentiation by endothelial cells. J Neurosci (2001) 1.27
Na+ channel subunits and Ig domains. Nature (1996) 1.26
Tenascin-R is a functional modulator of sodium channel beta subunits. J Biol Chem (1999) 1.25
Invulnerability of retinal ganglion cells to NMDA excitotoxicity. Mol Cell Neurosci (2004) 1.23
K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve. J Neurocytol (2000) 1.23
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro. J Neurosci (1998) 1.23
Purified and unpurified sodium channels from eel electroplax in planar lipid bilayers. J Gen Physiol (1987) 1.23
The purity of tritiated tetrodotoxin as determined by bioassay. Philos Trans R Soc Lond B Biol Sci (1975) 1.20
Decrease in inflammatory hyperalgesia by herpes vector-mediated knockdown of Nav1.7 sodium channels in primary afferents. Hum Gene Ther (2005) 1.20
Cloning, localization, and functional expression of sodium channel beta1A subunits. J Biol Chem (2000) 1.19
Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. J Neurosci (1999) 1.18
Clustering of voltage-sensitive sodium channels on axons is independent of direct Schwann cell contact in the dystrophic mouse. J Neurosci (1997) 1.16
A possible role for nerve growth factor in the augmentation of sodium channels in models of chronic pain. Brain Res (2000) 1.15
The molecular mechanisms of anaesthesia. Nature (1977) 1.13
Sodium channel accumulation in humans with painful neuromas. Neurology (1996) 1.12
Sequence-specific DNA recognition by the Myb-like domain of plant telomeric protein RTBP1. J Biol Chem (2000) 1.12
Nr-CAM and neurofascin interactions regulate ankyrin G and sodium channel clustering at the node of Ranvier. Curr Biol (2001) 1.10
The molecular form of acetylcholinesterase as determined by irradiation inactivation. Biochem J (1974) 1.09
Clustering of neuronal sodium channels requires contact with myelinating Schwann cells. J Neurocytol (2000) 1.08
The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit. J Neurochem (2001) 1.07
Astrocytes induce oligodendrocyte processes to align with and adhere to axons. Mol Cell Neurosci (2000) 1.07
TTX-sensitive dendritic sodium channels underlie oscillatory discharge in a vertebrate sensory neuron. J Neurosci (1994) 1.05
Rapid sodium channel augmentation in response to inflammation induced by complete Freund's adjuvant. Brain Res (1998) 1.04
Programmed cell death and the control of cell survival. Philos Trans R Soc Lond B Biol Sci (1994) 1.04
Degradable polyethylenimines as DNA and small interfering RNA carriers. Expert Opin Drug Deliv (2009) 1.04
Electron microscopic visualization of the tetrodotoxin-binding protein from Electrophorus electricus. Proc Natl Acad Sci U S A (1982) 1.03
Up a notch: instructing gliogenesis. Neuron (2000) 1.01
Changed distribution of sodium channels along demyelinated axons. Proc Natl Acad Sci U S A (1990) 0.98
What the fly's glia tell the fly's brain. Cell (1995) 0.98
Retinal ganglion cells lose trophic responsiveness after axotomy. Neuron (1999) 0.98
A rapid and precise assay for tetrodotoxin binding to detergent extracts of excitable tissues. Anal Biochem (1979) 0.97
New views on synapse-glia interactions. Curr Opin Neurobiol (1996) 0.96
Anti-protozoal efficacy of high performance liquid chromatography fractions of Torilis japonica and Sophora flavescens extracts on Neospora caninum and Toxoplasma gondii. Vet Parasitol (2004) 0.96
Alpha 2-adrenergic receptors accelerate Na+/H+ exchange in neuroblastoma X glioma cells. J Biol Chem (1987) 0.95
Real-value representation in inversion-recovery NMR imaging by use of a phase-correction method. Magn Reson Med (1986) 0.95
Effects of nonylphenol, bisphenol A, and their mixture on the viviparous swordtail fish (Xiphophorus helleri). Environ Toxicol Chem (2001) 0.93
Altered expression of the fragile histidine triad gene in primary gastric adenocarcinomas. Biochem Biophys Res Commun (2001) 0.93
Cultivation of the carotenoid-hyperproducing mutant 2A2N of the red yeast Xanthophyllomyces dendrorhous (Phaffia rhodozyma) with molasses. J Biosci Bioeng (2001) 0.93
Sequence-specific binding property of Arabidopsis thaliana telomeric DNA binding protein 1 (AtTBP1). FEBS Lett (2001) 0.93
Biosynthesis of electroplax sodium channels in Electrophorus electrocytes and Xenopus oocytes. Biochemistry (1987) 0.92
Sodium channel distribution in axons of hypomyelinated and MAG null mutant mice. J Neurosci Res (1997) 0.92
Increased numbers of sodium channels form along demyelinated axons. Brain Res (1991) 0.92
Na+ channel accumulation on axolemma of afferent endings in nerve end neuromas in Apteronotus. Neurosci Lett (1989) 0.91
The sodium channel from Electrophorus electricus. Ann N Y Acad Sci (1986) 0.91
Monocyclic carotenoid biosynthetic pathway in the yeast Phaffia rhodozyma (Xanthophyllomyces dendrorhous). J Biosci Bioeng (1999) 0.90
Analysis of hABC1 gene 5' end: additional peptide sequence, promoter region, and four polymorphisms. Biochem Biophys Res Commun (2000) 0.90
Neurotoxin-modulated uptake of sodium by highly purified preparations of the electroplax tetrodotoxin-binding glycopeptide reconstituted into lipid vesicles. J Membr Biol (1987) 0.86
Clusters of axonal Na+ channels adjacent to remyelinating Schwann cells. J Neurocytol (1996) 0.86
Disruption and reorganization of sodium channels in experimental allergic neuritis. Muscle Nerve (1998) 0.86