Published in Diabetes Care on May 01, 2001
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev (1992) 7.66
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet (1997) 5.47
Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science (1988) 5.29
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes (1999) 5.10
Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Biotechniques (1990) 5.02
Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet (1997) 4.40
The glucagon-like peptides. Endocr Rev (1999) 3.51
Retracted Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains. EMBO J (1990) 3.29
Pre-proparathyroid hormone: a direct translation product of parathyroid messenger RNA. Proc Natl Acad Sci U S A (1974) 3.24
Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology (1995) 3.17
Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol (1996) 2.98
Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes (2001) 2.95
IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J (1994) 2.89
Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci U S A (1987) 2.79
Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest (1987) 2.70
Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes. Circ Res (2001) 2.56
Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature (1993) 2.52
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes (2000) 2.50
Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis. J Clin Endocrinol Metab (2001) 2.49
The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes (1999) 2.44
Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins. Proc Natl Acad Sci U S A (1988) 2.40
Pre-proparathyroid hormone: analysis of radioactive tryptic peptides and amino acid sequence. Biochemistry (1976) 2.25
Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem (1986) 2.22
Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects. Diabetes Care (1992) 2.21
Cyclic adenosine 3',5'-monophosphate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins. Endocr Rev (1993) 2.21
C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc Natl Acad Sci U S A (1993) 2.09
Pre-proparathyroid hormone; amino acid sequence, chemical synthesis, and some biological studies of the precursor region. Proc Natl Acad Sci U S A (1978) 2.07
Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. Am J Physiol (1993) 2.06
Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology (1996) 2.06
Inhibition of histamine-, pentagastrin-, and insulin-stimulated canine gastric secretion by pure "gastric inhibitory polypeptide". Gastroenterology (1972) 2.05
Parathyroid hormone: secretion and metabolism in vivo. Proc Natl Acad Sci U S A (1971) 2.04
Proparathyroid hormone: identification of a biosynthetic precursor to parathyroid hormone. Proc Natl Acad Sci U S A (1972) 1.97
Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes (1997) 1.96
Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A (1984) 1.93
Structural determinants for transcriptional activation by cAMP-responsive DNA elements. J Biol Chem (1988) 1.93
Prevention of the glucose intolerance of thiazide diuretics by maintenance of body potassium. Diabetes (1983) 1.89
Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest (1999) 1.89
An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene. Mol Cell Biol (1990) 1.81
Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology (2000) 1.81
Parathyroid Hormone in Human Plasma: IMMUNOCHEMICAL CHARACTERIZATION AND BIOLOGICAL IMPLICATIONS. J Clin Invest (1972) 1.77
Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression. J Biol Chem (1987) 1.75
Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat. J Clin Invest (1986) 1.73
Impact of age on weight goals. Ann Intern Med (1985) 1.73
Pre-proparathyroid hormone. Evidence for an early biosynthetic precursor of proparathyroid hormone. J Biol Chem (1976) 1.67
Leptin receptors expressed on pancreatic beta-cells. Biochem Biophys Res Commun (1996) 1.67
Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab (1996) 1.62
The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes (Lond) (2010) 1.61
The adipoinsular axis: effects of leptin on pancreatic beta-cells. Am J Physiol Endocrinol Metab (2000) 1.61
An epidemiological test of the hyperinsulinemia-hypertension hypothesis. J Clin Endocrinol Metab (1993) 1.56
Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats. Endocrinology (2000) 1.56
Proglucagon processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic mouse tumor. Diabetes (1990) 1.55
Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms. Exp Cell Res (2001) 1.54
Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem. Proc Natl Acad Sci U S A (1982) 1.54
Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Invest (1998) 1.51
Transcription factors C/EBP alpha, C/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo. J Invest Dermatol (1998) 1.51
Structural analysis of human proparathyroid hormone by a new microsequencing approach. Nature (1974) 1.50
Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept. Trends Biochem Sci (1992) 1.50
Novel cyclic adenosine 3',5'-monophosphate (cAMP) response element modulator theta isoforms expressed by two newly identified cAMP-responsive promoters active in the testis. Endocrinology (2000) 1.50
Events surrounding the early development of Euglena chloroplasts: cellular origins of chloroplast enzymes in euglena. J Gen Microbiol (1974) 1.48
Glucagonlike peptide I (7-37) actions on endocrine pancreas. Diabetes (1989) 1.48
Impaired proinsulin processing is a characteristic of transplanted islets. Am J Transplant (2009) 1.48
cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37). J Biol Chem (1999) 1.47
Proparathyroid hormone: biosynthesis by human parathyroid adenomas. Science (1972) 1.47
Cyclic AMP signaling and gene regulation. Annu Rev Nutr (1998) 1.46
The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regul Pept (1994) 1.46
Phosphorylation of the cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding affinity, conformation, and increases net charge. Biochemistry (1998) 1.45
Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced amino acid sequence of rat preproparathyroid hormone. J Biol Chem (1984) 1.45
Primary structure of the gene encoding rat preprosomatostatin. Proc Natl Acad Sci U S A (1984) 1.44
Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice. Cell (1985) 1.44
CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol Cell Biol (1999) 1.43
Calcitonin messenger RNA encodes multiple polypeptides in a single precursor. Science (1981) 1.43
Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP). J Clin Invest (1992) 1.42
Biosynthesis of parathyroid hormone (second of two parts). N Engl J Med (1978) 1.42
Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology (1992) 1.42
Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter. Endocrinology (1999) 1.41
Synthetic pre-proparathyroid hormone leader sequence inhibits cell-free processing of placental, parathyroid, and pituitary prehormones. J Biol Chem (1980) 1.40
Modulation of CCAAT/enhancer-binding protein-alpha gene expression by metabolic signals in rodent adipocytes. Endocrinology (1999) 1.39
Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes (2001) 1.38
Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription. Mol Cell Biol (1999) 1.38
Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice. Proc Natl Acad Sci U S A (1999) 1.37
Calcium-dependent intracellular degradation of parathyroid hormone: a possible mechanism for the regulation of hormone stores. Endocrinology (1975) 1.37
Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab (1999) 1.37
Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines. J Clin Invest (1987) 1.36
Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins. Mol Cell Biol (1988) 1.35
Glucagon gene sequence. Four of six exons encode separate functional domains of rat pre-proglucagon. J Biol Chem (1984) 1.34
Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations. Diabetologia (1999) 1.34
Transcriptional regulation of the thyrotropin subunit genes by thyroid hormone. J Biol Chem (1985) 1.33
The gonadotropin alpha-gene contains multiple protein binding domains that interact to modulate basal and cAMP-responsive transcription. J Biol Chem (1988) 1.33
Developmental stage-specific expression of cyclic adenosine 3',5'-monophosphate response element-binding protein CREB during spermatogenesis involves alternative exon splicing. Mol Endocrinol (1991) 1.33
Studies in the distribution of body fat: I. Effects of age, sex, and obesity. J Gerontol (1989) 1.32
Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action, and metabolism. Physiol Rev (1984) 1.31
Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas. Diabetes (2001) 1.31
Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes (1999) 1.31
Anglerfish islet pre-proglucagon II. Nucleotide and corresponding amino acid sequence of the cDNA. J Biol Chem (1983) 1.30
Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. Diabetes (1998) 1.30